VIP (6mg)
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99% PURITY GUARANTEE
Each peptide batch is tested and verified to meet or exceed 98–99% purity (HPLC). Full analytical reports are available in the Certificate of Analysis section.
Preparation & Handling Notice
The product is delivered in powdered (lyophilized) form and must be properly reconstituted prior to research use.
RESEARCH USE ONLY
This product is intended for research use only. It is not for human or veterinary use, not for diagnostic or therapeutic purposes, and should only be handled by qualified professionals.
Strength: 6 mg
CAS: 37221-79-7
Chemical Formula: C₁₄₇H₂₃₇N₄₃S
Molecular weight: 3326.8 g/mol
Peptide Sequence: HSDAVFTDNYTRLRKQMAVKKYLNSILN
Synonyms: Vasoactive Intestinal Peptide, Intestinal Peptide, PHM-27
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.
VIP is a 28-amino-acid neuropeptide that activates VPAC receptors to stimulate cAMP/PKA signaling. Research explores its modulation of neuroimmune interactions, dendritic/T-cell responses, epithelial barrier integrity, and vascular tone in preclinical models of inflammation, colitis, and neurodegeneration.
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INFORMATION
What is VIP (6 mg)?
VIP (6 mg), or vasoactive intestinal peptide, is a synthetic neuropeptide composed of 28 amino acids. It is commonly studied in research related to brain, cognitive function, and nootropic peptides. VIP is naturally found throughout the brain, peripheral nerves, and gastrointestinal tract, where it helps regulate blood vessel tone, smooth muscle relaxation, and communication between the nervous and immune systems.
In laboratory research, VIP is used to explore neuroimmune signaling, epithelial barrier function, and how peptide signaling can influence inflammation and tissue balance in the brain, gut, and other organ systems.
Product Specifications
- Synonyms: Vasoactive Intestinal Peptide; Intestinal Peptide; PHM-27
- CAS Number: 37221-79-7
- Peptide Sequence: HSDAVFTDNYTRLRKQMAVKKYLNSILN (28 amino acids)
- Chemical Formula: C₁₄₇H₂₃₇N₄₃S
- Molecular Weight: 3326.8 g/mol
- Purity: ≥99% (research grade; HPLC/MS verified)
- Packaging Format: 6 mg lyophilized powder in a sealed research-grade vial
- Storage Conditions (unreconstituted): Store at −20 °C, protect from light, keep vial tightly closed
- Intended Use: For laboratory research use only; not for human or veterinary use
Key Characteristics of VIP (6 mg)
- Endogenous Neuropeptide and Neuromodulator: VIP is naturally encoded by the VIP gene and belongs to the secretin/glucagon peptide family. It acts as a ligand for VPAC1 and VPAC2 receptors found in the nervous system, gut, and immune-related tissues.
- cAMP/PKA-Linked Signaling: When VIP binds to VPAC receptors, it activates adenylate cyclase, increasing intracellular cAMP and triggering PKA-linked signaling changes. These pathways are important for studying effects on secretion, smooth muscle tone, and immune cell behavior.
- Neuroimmune and Inflammation Research: VIP is widely used to explore its effects on cytokine signaling and immune cell behavior, including shifts toward more regulatory profiles and reduced pro-inflammatory responses in models of autoimmunity and intestinal inflammation.
- Barrier and Epithelial Regulation: In models of intestinal injury, such as necrotizing enterocolitis and colitis, VIP has been linked to improved barrier integrity, reduced tight-junction disruption, and decreased inflammatory-cell infiltration, making it useful in gut barrier studies.
- Neurotrophic and Synaptic Effects: VIP has been studied for its potential to promote neurotrophic factor expression, synaptic maintenance, and neuronal survival in preclinical systems, connecting VIP research to cognitive function and neuroprotection.
- High-Purity, Verified Material: VIP (6 mg) is supplied as a synthetic peptide with HPLC and mass spectrometry confirmation, ensuring ≥99% purity and reliable batch-to-batch consistency for research applications.
How VIP (6 mg) Supports Research
VIP (6 mg) is used as a research probe to study neuroimmune signaling and barrier regulation, not as an approved therapy. In neuroscience research, VIP helps scientists explore how neuropeptides influence neuronal excitability, synaptic plasticity, and neurotrophic signaling through VPAC1/VPAC2 → cAMP/PKA pathways.
In immunology, VIP is used to investigate how immune responses can shift from pro-inflammatory to more regulatory states, including changes in cytokine production and in immune cell phenotypes (e.g., dendritic cells and T-cells). In gastrointestinal research, VIP is frequently included in studies of tight junction proteins, epithelial permeability, and leukocyte trafficking in models such as experimental colitis and necrotizing enterocolitis.
Research Applications & Usage Information
VIP (6 mg) is commonly used in preclinical and mechanistic studies across various areas, including:
- Neuroimmune and Cytokine Network Studies: Investigating how VIP affects cytokine profiles (e.g., TNF-α, IL-6, IL-10), dendritic cell behavior, and T-cell differentiation in models of inflammation and autoimmunity.
- Brain, Cognitive, and Neuroprotection Research: Studying the effects of VIP on neurotrophic factors (e.g., BDNF), neuronal survival, and synaptic plasticity in models of neuroinflammation or neurodegeneration.
- Gut and Epithelial Barrier Models: Measuring epithelial permeability, tight-junction organization, and inflammatory cell infiltration in models of NEC and chemically induced colitis.
- Vascular Tone and Smooth Muscle Studies: Using vessel ring preparations and microcirculation models to study vasodilation and smooth muscle relaxation signals.
- Fibrosis and Tissue Remodeling: Exploring changes in fibrosis-related gene expression, including extracellular matrix pathways in models of cardiac or pulmonary fibrosis.
- Second-Messenger Pathway Analysis: Mapping downstream signaling after VPAC receptor activation (cAMP/PKA and related transcriptional pathways) in different cell types.
Note: Experimental parameters (such as concentration, exposure time, and model systems) are determined by researchers based on study goals and institutional standards. No human or veterinary dosing guidance is provided or implied.
Handling and Storage Recommendations
- Store sealed vials at −20 °C, protected from light, tightly sealed.
- Allow the vial to reach room temperature before opening to reduce condensation.
- For short-term storage, keep at 2–8 °C.
- If preparing solutions, use aseptic technique and follow your lab’s SOPs for aliquoting, stability controls, and disposal.
Research Use Only Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in‑vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Seo S, Miyake H, Alganabi M, et al. Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis. J Pediatr Surg. 2019;54(12):2520-2523. doi:10.1016/j.jpedsurg.2019.08.038
- Delgado M, Gonzalez-Rey E, Ganea D. Vasoactive intestinal peptide: the dendritic cell –> regulatory T cell axis. Ann N Y Acad Sci. 2006;1070:233-238. doi:10.1196/annals.1317.020
- Lu J, Zheng MH, Yan J, Chen YP, Pan JP. Effects of vasoactive intestinal peptide on phenotypic and functional maturation of dendritic cells. Int Immunopharmacol. 2008;8(10):1449-1454. doi:10.1016/j.intimp.2008.06.002
- Voice JK, Grinninger C, Kong Y, Bangale Y, Paul S, Goetzl EJ. Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice. J Immunol. 2003;170(1):308-314. doi:10.4049/jimmunol.170.1.308
- Hao H, Zak DE, Sauter T, Schwaber J, Ogunnaike BA. Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene induction. Biophys J. 2006;90(5):1560-1571. doi:10.1529/biophysj.105.065250
What is VIP (6 mg)?
VIP (6 mg), or vasoactive intestinal peptide, is a synthetic neuropeptide composed of 28 amino acids. It is commonly studied in research related to brain, cognitive function, and nootropic peptides. VIP is naturally found throughout the brain, peripheral nerves, and gastrointestinal tract, where it helps regulate blood vessel tone, smooth muscle relaxation, and communication between the nervous and immune systems.
In laboratory research, VIP is used to explore neuroimmune signaling, epithelial barrier function, and how peptide signaling can influence inflammation and tissue balance in the brain, gut, and other organ systems.
Product Specifications
- Synonyms: Vasoactive Intestinal Peptide; Intestinal Peptide; PHM-27
- CAS Number: 37221-79-7
- Peptide Sequence: HSDAVFTDNYTRLRKQMAVKKYLNSILN (28 amino acids)
- Chemical Formula: C₁₄₇H₂₃₇N₄₃S
- Molecular Weight: 3326.8 g/mol
- Purity: ≥99% (research grade; HPLC/MS verified)
- Packaging Format: 6 mg lyophilized powder in a sealed research-grade vial
- Storage Conditions (unreconstituted): Store at −20 °C, protect from light, keep vial tightly closed
- Intended Use: For laboratory research use only; not for human or veterinary use
Key Characteristics of VIP (6 mg)
- Endogenous Neuropeptide and Neuromodulator: VIP is naturally encoded by the VIP gene and belongs to the secretin/glucagon peptide family. It acts as a ligand for VPAC1 and VPAC2 receptors found in the nervous system, gut, and immune-related tissues.
- cAMP/PKA-Linked Signaling: When VIP binds to VPAC receptors, it activates adenylate cyclase, increasing intracellular cAMP and triggering PKA-linked signaling changes. These pathways are important for studying effects on secretion, smooth muscle tone, and immune cell behavior.
- Neuroimmune and Inflammation Research: VIP is widely used to explore its effects on cytokine signaling and immune cell behavior, including shifts toward more regulatory profiles and reduced pro-inflammatory responses in models of autoimmunity and intestinal inflammation.
- Barrier and Epithelial Regulation: In models of intestinal injury, such as necrotizing enterocolitis and colitis, VIP has been linked to improved barrier integrity, reduced tight-junction disruption, and decreased inflammatory-cell infiltration, making it useful in gut barrier studies.
- Neurotrophic and Synaptic Effects: VIP has been studied for its potential to promote neurotrophic factor expression, synaptic maintenance, and neuronal survival in preclinical systems, connecting VIP research to cognitive function and neuroprotection.
- High-Purity, Verified Material: VIP (6 mg) is supplied as a synthetic peptide with HPLC and mass spectrometry confirmation, ensuring ≥99% purity and reliable batch-to-batch consistency for research applications.
How VIP (6 mg) Supports Research
VIP (6 mg) is used as a research probe to study neuroimmune signaling and barrier regulation, not as an approved therapy. In neuroscience research, VIP helps scientists explore how neuropeptides influence neuronal excitability, synaptic plasticity, and neurotrophic signaling through VPAC1/VPAC2 → cAMP/PKA pathways.
In immunology, VIP is used to investigate how immune responses can shift from pro-inflammatory to more regulatory states, including changes in cytokine production and in immune cell phenotypes (e.g., dendritic cells and T-cells). In gastrointestinal research, VIP is frequently included in studies of tight junction proteins, epithelial permeability, and leukocyte trafficking in models such as experimental colitis and necrotizing enterocolitis.
Research Applications & Usage Information
VIP (6 mg) is commonly used in preclinical and mechanistic studies across various areas, including:
- Neuroimmune and Cytokine Network Studies: Investigating how VIP affects cytokine profiles (e.g., TNF-α, IL-6, IL-10), dendritic cell behavior, and T-cell differentiation in models of inflammation and autoimmunity.
- Brain, Cognitive, and Neuroprotection Research: Studying the effects of VIP on neurotrophic factors (e.g., BDNF), neuronal survival, and synaptic plasticity in models of neuroinflammation or neurodegeneration.
- Gut and Epithelial Barrier Models: Measuring epithelial permeability, tight-junction organization, and inflammatory cell infiltration in models of NEC and chemically induced colitis.
- Vascular Tone and Smooth Muscle Studies: Using vessel ring preparations and microcirculation models to study vasodilation and smooth muscle relaxation signals.
- Fibrosis and Tissue Remodeling: Exploring changes in fibrosis-related gene expression, including extracellular matrix pathways in models of cardiac or pulmonary fibrosis.
- Second-Messenger Pathway Analysis: Mapping downstream signaling after VPAC receptor activation (cAMP/PKA and related transcriptional pathways) in different cell types.
Note: Experimental parameters (such as concentration, exposure time, and model systems) are determined by researchers based on study goals and institutional standards. No human or veterinary dosing guidance is provided or implied.
Handling and Storage Recommendations
- Store sealed vials at −20 °C, protected from light, tightly sealed.
- Allow the vial to reach room temperature before opening to reduce condensation.
- For short-term storage, keep at 2–8 °C.
- If preparing solutions, use aseptic technique and follow your lab’s SOPs for aliquoting, stability controls, and disposal.
Research Use Only Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in‑vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Seo S, Miyake H, Alganabi M, et al. Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis. J Pediatr Surg. 2019;54(12):2520-2523. doi:10.1016/j.jpedsurg.2019.08.038
- Delgado M, Gonzalez-Rey E, Ganea D. Vasoactive intestinal peptide: the dendritic cell –> regulatory T cell axis. Ann N Y Acad Sci. 2006;1070:233-238. doi:10.1196/annals.1317.020
- Lu J, Zheng MH, Yan J, Chen YP, Pan JP. Effects of vasoactive intestinal peptide on phenotypic and functional maturation of dendritic cells. Int Immunopharmacol. 2008;8(10):1449-1454. doi:10.1016/j.intimp.2008.06.002
- Voice JK, Grinninger C, Kong Y, Bangale Y, Paul S, Goetzl EJ. Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice. J Immunol. 2003;170(1):308-314. doi:10.4049/jimmunol.170.1.308
- Hao H, Zak DE, Sauter T, Schwaber J, Ogunnaike BA. Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene induction. Biophys J. 2006;90(5):1560-1571. doi:10.1529/biophysj.105.065250
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