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DUROLANE® is a single injection hyaluronic acid treatment for mild to moderate knee and hip osteoarthritis. Millions of medical professionals buy DUROLANE® due to its proven efficacy in matching the power of five injection therapies. Buy DUROLANE® online on Medica Depot. The hyaluronic acid in DUROLANE® is made with a safe and renowned stabilization technology called NASHA. It works by cushioning and lubricating the joint, reducing joint erosion and pain.

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What is Durolane?

Durolane is a hyaluronic acid-based product designed for intra-articular injection as a symptomatic treatment for mild to moderate knee and hip osteoarthritis. This product must be administered by a certified physician or other specialist authorized by local law.

HA is similar in all living organisms. It is a natural polysaccharide in all body tissues, with exceptionally high concentrations in synovial fluid and skin. Durolane consists of HA obtained by biosynthesis, which undergoes purification and stabilization stages.

Durolane is broken down in the body by the same metabolic pathway as endogenous hyaluronic acid.

Durolane is a sterile, clear, viscoelastic solution supplied in a 3 ml glass syringe and intended for single use only. You can find the best Durolane pricing on Medica Depot.

How Does This Treatment Work?

As a result of osteoarthritis, hyaluronic acid in the synovial fluid of the affected joint loses the necessary concentration, and its quality deteriorates faster, decreasing its protective properties.

This process is accompanied by increased inflammation in the affected joint, which leads to cartilage degradation.

Due to the inflammation in the joint, pain receptors are activated even during normal physical movement. Pain often forces patients with osteoarthritis to restrict joint movement.

Since physical activity is necessary for healthy joint structure and regular synovial fluid activity, restricting joint movement leads to further joint damage and decreases synovial fluid protective properties.

This process can turn into a vicious circle, where osteoarthritis progresses, and the patient’s quality of life is significantly reduced.

Durolane is a medication used as a single injection to relieve osteoarthritis pain by replenishing the less healthy HA in the affected joint. Hyaluronic acid is a natural molecule that provides lubrication and cushioning in a normal, healthy joint. The hyaluronic acid in Durolane is made with a safe and proven stabilization technology called NASHA.

What Is It Used For?

Hyaluronic acid is a component of natural synovial fluid. It is a lubricant for cartilage and ligaments in the joints and has a cushioning function. Hyaluronic acid injections into the joint aim to restore the synovial fluid’s viscosity and elasticity while reducing pain and improving joint mobility.

Medica Depot, as a reliable Durolane supplier, provides only original products for the treatment of osteoarthritis and offers affordable Durolane prices.

How to Use This Product?

  • • Durolane may only be injected by a licensed physician (or other professionals as required by local law) trained to inject medications into the synovial joint and in a medical facility equipped to perform intra-articular injections.
  • • When administering Durolane, it is necessary to follow the asepsis principles strictly.
  • • Durolane should only be injected into the joint cavity.
  • • Injections into some synovial joints require imaging to ensure accurate needle placement and to avoid damage to adjacent vital structures.
  • • Needle trajectory for intra-articular injections, with or without imaging, must be chosen to avoid damage to adjacent vital structures.
  • • If the joint has an effusion, it should be removed before DUROLANE is injected.
  • • Using needles with a diameter of 18-22 G and sufficient length is recommended. Needles of smaller diameter increase the pressure required to administer the solution.

How Long Do The Results Last?

According to the official website, Durolane can have a long-lasting effect of 6 months on average. The Effect result may differ in duration and last for a longer or a shorter period, depending on factors such as weight, age, and physical activity.

Is Durolane Safe?

Most patients report minimal discomfort during the injection. Some physicians use a superficial skin anesthetic before Durolane insertion to minimize pain and discomfort.

Durolane repeated injection safety is clinically proven. To purchase Durolane online, check out the product page on Medica Depot, and for more information on Durolane clinical safety studies, visit the official website of the Durolane manufacturer.

Treatment Benefits

Clinical trials of Durolane for knee and hip osteoarthritis treatment have demonstrated significant benefits, such as decreased joint pain in the knee and hip joints and improved mechanical function, six months after application compared to the patient’s baseline condition.

Tests analyzing the re-treatment of joints six months after the first treatment showed no increase in the incidence of adverse events.

Controlled trials of Durolane on osteoarthritis revealed a significant benefit of its use as measured by the response rate compared to saline. Also, they demonstrated results similar to those achieved with corticosteroids.

Clinical trials of other hyaluronic acid (HA) products similar to Durolane for knee and hip joint osteoarthritis treatment have found average treatment benefit values above baseline values.

Some trials have also shown that treatment efficacy was higher in the HA group than in the control treatment groups (saline and corticosteroids). Reduced sensation and improved mechanical joint function were observed six months after treatment.

Side Effects and Adverse Reactions

Most adverse reactions reported in clinical studies of knee and hip osteoarthritis were described as transient pain, swelling, and/or limitation of joint mobility.

The intensity of these adverse reactions was mild to moderate, and only in a few cases the reactions required painkillers or non-steroidal anti-inflammatory drugs.

In most cases, Durolane injections did not cause any unwanted side effects. Possible side effects are infrequent and do not require medical attention. However, in some patients, the body may react to hyaluronic acid or other ingredients.

Сommon Side Effects

  • • Fatigue
  • • Muscle pain
  • • Swelling at the insertion site
  • • Pain at the insertion site
  • • Headache
  • • Stiffness

Acute Side Effects

  • • Severe pain
  • • Swelling
  • • Nausea, vomiting
  • • Fever
  • • Purulent discharge
  • • Rash
  • • Prolonged bleeding

If the above effects occur, the patient should contact a doctor immediately.


  • • Durolane should be used cautiously in venous or lymphatic leg stasis patients.
  • • Durolane has not been tested on pregnant or nursing women or children.
  • • A doctor should use a separate syringe of Durolane for each joint.
  • • As with any invasive joint treatment, there is a small risk of infection.
  • • Durolane should not be administered to patients with a diagnosed sensitivity to hyaluronic acid-based products.
  • • Don’t use local anesthetics in patients with hypersensitivity or allergies to the ingredients.
  • • If the patient has a history of allergic reactions or hypersensitivity to the contrast agent, an injection under fluoroscopic control with a contrast agent should not be performed.
  • • An increase in pressure during the procedure may indicate that the needle is in the wrong position, has moved out of the joint, or is overinflated.
  • • The efficacy of Durolane after arthroscopy for diagnostic and research purposes has yet to be established.


After the procedure, the patient should follow the following recommendations:

  • • Ensure the injection site stays dry and cover it with a clean bandage for 24 hours.
  • • Do not take a bath, Jacuzzi, sauna, swim or immerse in water for two days after the procedure.
  • • The injection site may be sore for several days. It is better to consult your doctor if you can take pain medication.
  • • Ask your doctor if you need to refrain from any activities or movements, such as standing, jogging, or lifting weights.
  • • Do not apply warm or hot compresses to the injection site for one day after the procedure.
  • • There may be a feeling of stiffness in the knee, or a springy sensation may occur when walking. It may last for 2 to 3 days.
  • • A cold compress may be applied to the same area for 10-15 minutes every 4 hours to relieve the discomfort.
  • • Avoid using creams or topical medications at the injection site for 24 hours.

Feel free to leave a Durolane review on our website if these aftercare tips are helpful.


Durolane contains stabilized HA of non-animal origin dissolved in sodium chloride buffered physiological solution with a pH of 7 at 20 mg/ml concentration.


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