PLINEST®

PLINEST®

Manufacturer: Mastelli Active Substance(s): POLYNUCLEOTIDES HPT Pack…

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$69.00

PLINEST® EYE

Manufacturer: Mastelli PLINEST® EYE is a…

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$79.00

PLINEST® FAST (2ml)

Manufacturer: Mastelli Active Substance(s): POLYNUCLEOTIDES HPT PLINEST®…

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$89.00

PLINEST® HAIR

Manufacturer: Mastelli PLINEST® HAIR is a…

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$79.00

PLINEST® ONE

Manufacturer: Mastelli Plinest One is an…

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$69.00

Key Benefits of PLINEST® Products

Plinest is clinically proven to improve multiple skin parameters, making it an effective option for both aesthetic enhancement and tissue regeneration. Powered by polynucleotides derived from the proprietary HPT technology, it stimulates cellular repair, increases dermal hydration, and restores elasticity.

These actions help smooth superficial wrinkles, refine texture, and improve areas affected by scarring or fibrosis. Its favorable safety profile ensures minimal discomfort for patients, with most reporting a quick recovery time after each session. The formulation’s regenerative properties also make it a valuable complement to dermal fillers, enhancing overall treatment outcomes.

Clinical highlights:

• 91% of subjects showed visible improvement in fine lines and superficial wrinkles
• +14.7% increase in skin hydration after treatment
• +21.8% improvement in dermal elasticity from baseline
• 16.7% reduction in skin roughness within 30 days
• Effective for bio-repair in fibrotic tissue, including acne scars
• Enhances outcomes when combined with laser therapy, fillers, radiofrequency, microneedling, or chemical peels

PLINEST® Ingredients

The primary active ingredient in Plinest is PN-HPT™, a proprietary formulation of polynucleotides derived through advanced biotechnological processes. This highly purified DNA-based polymer supports cellular repair, stimulates fibroblast activity, and enhances skin hydration.

The purification process ensures maximum safety by removing proteins, endotoxins, and other potential contaminants, reducing the risk of immune reactions in patients. The formulation’s viscoelastic properties allow it to integrate seamlessly into dermal tissue, making it an ideal regenerative option in both standalone treatments and in combination with dermal fillers.

Plinest contains a concentration of 40 mg of polynucleotides per 2 mL solution, offering potent bioactive effects in each session. The injectable gel is sterile, pyrogen-free, and composed primarily of purified nucleotides suspended in water for injection. Its molecular structure is optimized for prolonged activity within the dermis, ensuring sustained hydration and gradual tissue repair.

By promoting extracellular matrix regeneration and improving microcirculation, PN-HPT™ addresses early aging signs, fine lines, and texture irregularities while complementing the volumizing role of traditional fillers.

Composition highlights:

• Active substance: Deoxyribonucleotide polymers (PN-HPT™)
• Concentration: 40 mg polynucleotides / 2 mL solution
• Form: Viscoelastic sterile injectable gel
• Other components: Water for injection, absence of pyrogens
• Free from: Proteins, endotoxins, and other immunogenic contaminant

PLINEST® Administration Technique

Plinest is administered exclusively by licensed medical professionals with training in advanced aesthetic injection protocols. The product is delivered into the intradermal plane to stimulate tissue regeneration and improve skin quality through the action of polynucleotides.

This approach is ideal for patients with early signs of aging, fine lines, or sagging tissue who seek regenerative improvements rather than volumizing effects from traditional dermal fillers. The procedure is designed to be quick and minimally invasive, allowing for a comfortable treatment experience with minimal downtime.

The standard protocol typically uses 2 mL per session, with adjustments based on treatment areas and desired outcomes. For aging skin, practitioners generally recommend 3–4 sessions spaced 1–2 weeks apart, followed by maintenance every 1–3 months. Treatment plans are tailored to individual needs, ensuring consistent and natural-looking results.

Key administration parameters:

• Injection depth: Intradermal plane
• Needle size: 30G ½
• Standard volume: 2 mL per session
• Total treatment volume: Up to 4 mL per session for combined areas

Technique Options

Different injection methods allow for precise targeting of specific concerns. The micro-droplet technique involves approximately 30 injection points, with 0.1–0.2 mL delivered per site. This method disperses polynucleotides evenly to boost hydration, elasticity, and radiance. It is particularly effective for diffuse skin improvement across the face, neck, and décolleté.

The linear retrograde technique is preferred in contour areas where sagging or structural support loss is more pronounced. In this method, the needle is inserted along defined lines, and Plinest is injected as the needle is withdrawn. This provides subtle lift and tissue reinforcement without adding excess volume.

Both techniques can be combined in a single session for comprehensive rejuvenation, complementing the results of other fillers or dermal fillers in a multimodal treatment plan.

PLINEST Newest Product Range

The Plinest portfolio features four specialized formulations, each designed to address a specific anatomical area or clinical indication. These dermal bio-repair solutions complement traditional dermal fillers by focusing on regenerative stimulation rather than volumization. This approach allows physicians to tailor treatment for patients seeking natural skin, hair, and eye rejuvenation outcomes.

PLINEST®

The standard Plinest formulation contains PN-HPT™ 40 mg/2 ml in a viscoelastic gel, making it ideal for generalized facial and neck bio-repair. It is indicated for treating fine wrinkles, skin laxity, and acne scars.

The product is injected intradermally using either a micro-droplet or linear retrograde technique. Treatments are usually performed in a series of 3–4 sessions, spaced 1–2 weeks apart, to achieve optimal tissue regeneration.

• Improves skin texture and hydration
• Reduces superficial wrinkles
• Enhances elasticity and firmness

PLINEST® EYE

Plinest Eye is formulated for the delicate periocular region, where skin is thinner and more prone to fine lines. It restores radiance, firmness, and hydration in the under-eye and lateral canthal zones.

Delivered in small-volume injections, it is used to reduce periorbital laxity and smooth fine rhytides. This variant is ideal for patients seeking subtle yet noticeable rejuvenation without adding bulk from fillers.

• Targets fragile under-eye skin
• Improves elasticity and hydration
• Softens fine lines conservatively

PLINEST® HAIR

Plinest Hair focuses on scalp health and follicular regeneration. By improving the microenvironment and activating regenerative pathways, it supports patients with androgenetic alopecia or telogen effluvium.

Treatments involve superficial microinjections across the scalp, often performed over several sessions to maximize results. This formulation offers a regenerative approach that complements other hair restoration therapies.

• Enhances follicular environment
• Promotes hair growth and density
• Suitable for both men and women

PLINEST® ONE

Plinest One provides a 2 ml monodose format for targeted applications, such as localized acne scars or surgical scar remodeling. It allows precise control over treatment volume, making it suitable for focused rejuvenation or aesthetic priming before multimodal procedures.

Physicians can integrate this product seamlessly with dermal fillers for enhanced regenerative and volumizing results.

• Enables site-specific skin repair
• Ideal for scars and small treatment zones
• Flexible for combination protocols

Clinical Indications for PLINEST

Plinest, developed by Mastelli, is a regenerative solution designed for advanced aesthetics treatments. Unlike volumizing dermal fillers, Plinest works through tissue bio-repair and regenerative priming, making it highly versatile in skin, hair, and eye rejuvenation protocols. Its biophysical mechanisms involve deep hydration, structural reinforcement of the extracellular matrix, and stimulation of fibroblast activity to promote collagen and elastin synthesis. These actions result in gradual but noticeable improvements in texture, tone, and elasticity for patients seeking natural-looking results.

It can be integrated into preventive and corrective treatment plans to enhance overall skin quality and prime tissues for further procedures. Clinicians frequently incorporate Plinest products into combination therapies, maximizing benefits before or after dermal fillers, energy-based devices, or surgical interventions.

Key Clinical Indications

• Fine Lines & Superficial Wrinkles – Softens visible signs of early skin aging.
• Dermal Dehydration & Elasticity Loss – Restores moisture balance and improves skin firmness.
• Acne Scars & Fibrotic Skin Texture – Supports tissue remodeling for smoother appearance.
• Pre-Procedure Priming – Prepares skin before surgical or device-based aesthetic treatments for better outcomes.
• Maintenance Therapy – Helps preserve youthful skin characteristics through periodic treatments.

By addressing multiple aesthetic concerns, Plinest provides physicians with a flexible, scientifically backed option that can be customized for different patients and treatment goals.

PLINEST® Storage Conditions

Maintaining correct storage conditions is essential to preserve the stability, safety, and effectiveness of Plinest. As a premium aesthetics solution developed by Mastelli, these dermal fillers and regenerative products require adherence to strict preservation protocols to ensure optimal results for patients. Improper storage may compromise the integrity of the active components, reducing their ability to enhance skin, hair, or eye rejuvenation outcomes.

Storage Guidelines

• Temperature Control: Store according to the temperature range specified on the Plinest product label. Avoid exposure to extreme heat or freezing conditions, as these can degrade the solution.
• Sterility Maintenance: Keep the product in its original packaging until ready for use to maintain a sterile environment.
• Packaging Integrity: Ensure the blister seal and syringe remain intact to prevent contamination or leakage.
• Expiration Awareness: Always check the expiry date before use to guarantee safety and effectiveness for patients.

By following these storage protocols, practitioners can ensure Plinest retains its full regenerative potential, supporting consistent results in both dermal fillers and skin rejuvenation procedures.

PLINEST® Side Effects

Clinical studies confirm that Plinest offers a strong safety profile, making it a reliable choice for patients seeking aesthetics solutions such as dermal fillers, skin boosters, and treatments for hair or eye rejuvenation.

Most side effects are mild, short-lived, and resolve without intervention. In a clinical study involving 143 patients, no severe adverse events or hypersensitivity reactions were attributed to the products. Injection sessions were well-tolerated, with low pain scores, and the effects Plinest delivers on skin health significantly outweigh the minimal treatment risks.

Common Side Effects

• Transient erythema (temporary redness at the injection site)
• Mild edema or swelling at the injection site
• Ecchymosis (bruising)
• Temporary tenderness in treated areas

Rare Side Effects

• Prolonged swelling lasting more than 72 hours
• Minor nodule formation at the injection site
• Mild allergic reactions not directly linked to the product
• Delayed onset of localized inflammation

FAQs About PLINEST®

Medical professionals and patients may have various questions regarding PLINEST treatments. These may include queries, such as:

What Differentiates PLINEST® from Standard HA-Based Fillers?

Unlike traditional dermal fillers that primarily restore lost volume by occupying space, Plinest works through a unique biostimulation process. This product contains highly purified polynucleotides that stimulate the body’s own collagen and elastin production, improving skin elasticity, hydration, and overall health from within. Rather than acting as a temporary volumizer, Plinest encourages long-term tissue repair and regeneration.

Because of this mechanism, Plinest products are ideal for patients who want to address early signs of aging without adding unnecessary fillers. The treatment is particularly effective for improving skin texture, tone, and resilience, making it a suitable choice for both preventive care and visible rejuvenation.

Is PLINEST® Appropriate for Combination Protocols?

Yes. Clinical evidence supports the use of Plinest in combination protocols for enhanced results. As a priming agent, it prepares the skin for other treatments such as energy-based devices, chemical peels, and even dermal fillers. This preparation improves skin booster absorption and accelerates the regeneration process, allowing combination treatments to deliver more noticeable outcomes.

A session Plinest can be incorporated into a multi-step aesthetic plan, where its collagen-stimulating effects complement the results of other products. This synergy makes it highly valued among practitioners who aim to deliver natural yet significant improvements to patients.

How Soon Are Clinical Effects Observed?

Most patients notice visible improvements in skin hydration, smoothness, and luminosity within 2–4 weeks after starting Plinest treatments. This is due to increased dermal hydration and the early activation of collagen production.

However, the most significant changes—such as improved elasticity, firmness, and refined texture—are typically observed after completing the recommended session Plinest protocol. For many, results continue to improve as the biostimulation process progresses.

Is PLINEST® Suitable for Younger Patients?

Yes. Plinest products are not limited to mature patients. They are also recommended for younger individuals as part of preventive protocols. By stimulating collagen and elastin early, these treatments help maintain healthy skin structure and delay visible aging signs.

For younger patients, using Plinest as part of a long-term skincare strategy can enhance skin resilience and quality, reducing the need for more invasive fillers later in life.

Are Touch-Up Treatments Required?

To maintain results, patients are advised to schedule maintenance sessions every 2–3 months. These follow-up treatments keep collagen production active and help preserve skin elasticity and hydration.

The frequency of touch-ups may vary based on the products used, the session Plinest protocol, and the individual’s skin condition. Some may also combine maintenance with other boosters or dermal fillers for a more comprehensive approach.

Where to Shop PLINEST® Online

You can buy Plinest only from authorized distributors and licensed medical suppliers to ensure product authenticity and safety. Purchasing from trusted sources guarantees that Plinest products meet strict quality standards and are stored under proper conditions.

These products are designed for professional use and must be administered by certified healthcare providers who understand their correct application.

On platforms like Medica Depot, you can shop for different Plinest products, check prices Plinest, and conveniently add items to your cart. The website allows you to view product details, including bottle size, formulation, and packaging. All prices typically include or clearly list the VAT, so professionals can budget accordingly before placing an order.

Buying through regulated online channels ensures compliance with medical device regulations and reduces the risk of counterfeit goods.

Order PLINEST Hair, PLINEST Eye, & Other Products At Medica Depot

Medica Depot offers a complete range of Plinest products, including Plinest Fast, Plinest Eye, and other formulations designed to address different patient needs. Each product is supplied in a 2ml bottle for precise and professional applications, and ordering through their platform ensures that all products are sourced directly from the official manufacturer. By purchasing here, practitioners benefit from competitive prices Plinest and secure shipping options.

The ordering process is straightforward—simply view your preferred Plinest products, add them to your basket, confirm the quantity, and proceed to checkout. This allows you to order Plinest for immediate delivery to your clinic, ensuring you have the necessary supplies when needed.

With Medica Depot’s reliable sales system, professionals can keep their practice stocked while guaranteeing that every product used meets industry safety and quality standards.