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Joint pain significantly worsens the quality of people’s lives, reduces work capacity at a young age, and leads to early disability due to untimely treatment.

Therefore, modern aspects of the study of diseases of the musculoskeletal system accompanied by joint pain, and introducing new treatment methods, are becoming more and more relevant on a global scale. 

What Is Hyalgan and How Does It Work?

In the early stages of damage or destruction of articular cartilage, intra-articular injections of hyaluronic acid drugs can relieve pain and speed up recovery.

Hyalgan is an injection solution recommended for musculoskeletal system pathologies, particularly in arthritis of the knee joint of mild and moderate severity. Hyalgan is manufactured by Fidia Farmaceutici S.p.A., an Italian pharmaceutical company headquartered in Abano Terme, Padua.

Hyaluronic acid has an astringent effect on synovial fluid, which improves joint mobility and relieves pain. Hyalgan eliminates inflammatory processes in the epithelium of the joint and stimulates the formation of hyaluronic acid inside it.

Such an injection makes the fluid inside the joint more dense and viscous, thanks to which:

  • cartilaginous tissue is better protected from wear and tear;
  • reduced load on the cartilage surfaces of the joint;
  • inflammatory processes are reduced;
  • progression of degenerative changes is limited;
  • nutrition and restoration of cartilage tissue are observed.

The list of symptoms for Hyalgan use is quite long:

  • Acute joint pain;
  • Inflammation of joints and tendons – such diseases as bursitis, synovitis, and tendinitis (in stages close to acute, the injection is carried out together with anti-inflammatory drugs);
  • Arthritis;
  • Arthrosis;
  • Gout;
  • Tunnel syndrome;
  • Adhesive capsulitis;
  • Recovery period after joint injuries;
  • Rehabilitation period after joint arthroscopy.

Thanks to intra-articular injections of HA preparations, the patient can avoid a complex operation: endoprosthesis (joint replacement), but only if they consult a doctor in time.

Hyaluronic acid is a component in high concentrations in articular cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity of synovial fluid, and it is also necessary for the formation of proteoglycans in articular cartilage.

Because of the normalization of the quality of the synovial fluid and the activation of tissue renewal processes in the articular cartilage, the drug improves the function of the joints.

Hyalgan has an anti-inflammatory effect on the epithelium of the joint and stimulates the natural formation of hyaluronic acid inside the joint. Hyaluronic acid is efficiently metabolized in the body, quickly removed from the bloodstream, and rapidly destroyed in the liver.

After administration, the body eliminates metabolites primarily through urine. Within 24 hours, the liver determines 42% of the administered dose. The drug is detectable in synovial fluid within 2 hours and in articular cartilage within 6 hours. Cartilage is the most permanent place for hyaluronic acid.

How To Use Hyalgan?

Only a surgeon or orthopedic traumatologist can perform Hyalgan injections. The biggest challenge of executing this procedure is achieving precise access to the joint gap, so completing it under ultrasound guidance is essential. 

Several cases also involve pumping out synovial fluid from the joint, which the doctor will send for analysis.

Immediately after the injection, it is necessary to do light physical exercises – this will help the uniform distribution of fluid inside the joint.

With the duration of treatment and the number of injections, everything is purely individual and depends on the specific case. However, as a rule, the treatment course lasts for one year, and the number of injections can vary from 1 to 2–3 weeks to 3-5 per week.

The procedure has some side effects, including:

  • painful sensations, redness, and slight swelling at the injection site;
  • itching, burning after administration of the drug;
  • hemorrhage into the joint cavity;
  • pain in the tissues around the joint;
  • hematoma under the skin at the injection site.

How Long Does Hyalgan Last?

According to Hyalgan reviews, this product provides most patients with long-lasting pain relief for up to six months. Five injections with one-week intervals are usually enough to reach this result.

If you are interested in Hyalgan’s cost, please visit the product page on our website.

Is Hyalgan Safe?

There are a few contraindications to the procedure:

  • Pregnancy and lactation period;
  • Minor age;
  • Infectious diseases in the acute period.

This manipulation is not used if the patient has an acute period of inflammation of the joints, skin diseases over the joints, or the integrity of the skin at the injection site is broken.

You may cancel the procedure if the patient shows signs of an increased sensitivity to the primary substance or components of the drug, as this will cause an allergic reaction.

To ensure the product won’t harm the patient’s health, only buy Hyalgan online from certified Hyalgan suppliers, like Medica Depot. 

Hyalgan Benefits

The benefits of Hyalgan include pain relief and increased mobility for patients with osteoarthritis. The product is administered directly into the knee joint and helps reduce inflammation, lubricate the joint, and cushion the affected area.

Hyalgan Side Effects

As with any medical treatment, Hyalgan can have side effects. Common side effects of Hyalgan include pain, swelling, warmth, and redness at the injection site. However, these effects are usually mild and resolve on their own within a few days.

Less common side effects of Hyalgan include headaches, nausea, dizziness, and fever. In rare cases, an allergic reaction to the injection can occur, which can cause difficulty breathing, hives/swelling of the face, lips, tongue, and throat.

Hyalgan Aftercare

Hyalgan aftercare includes the following rules:

  • Avoiding strenuous activities for the first 48 hours after treatment. This minimizes the risk of any adverse effects and enhances the effectiveness of the treatment.
  • Applying an ice pack to the joint can help reduce swelling and discomfort. Your patient can do this for 10–20 minutes every hour or two for the first 48 hours after treatment.
  • Over-the-counter pain relievers like acetaminophen or ibuprofen can help relieve any pain or discomfort after the treatment.
  • Keeping the injection site clean and dry after treatment to avoid infection. The patient should avoid touching the area or applying creams, lotions, or ointments without consulting the doctor.

Hyalgan Ingredients

Active substance: 

  • Hyaluronic acid; 2 ml of a solution containing 20 mg of the HA sodium salt.


  • sodium chloride,
  • sodium dihydrogen phosphate,
  • dihydrate,
  • sodium hydrogen phosphate,
  • dodecahydrate,
  • water for injections.

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