SYNVISC®

SYNVISC ONE®

Manufacturer: Sanofi Genzyme Active Substance(s): HYLAN GF…

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$359.00

SYNVISC®

Manufacturer: Sanofi Genzyme Active Substance(s): HYLAN…

ADD TO CART VIEW PRODUCT

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$397.00

What is SYNVISC?

Synvisc is an advanced injection therapy designed to relieve joint pain caused by osteoarthritis or other degenerative joint disorders. The treatment helps improve knee joint function by restoring lubrication where natural synovial fluid has decreased in quantity or quality.

It is available in two forms: classic Synvisc, administered as a series of three injections, and Synvisc One, a single-dose treatment that provides long-lasting relief. This medication aims to enhance patient health by reducing stiffness and improving mobility without the need for immediate surgical intervention.

Clinicians can find detailed usage and dosage information on the product label and official site to ensure safe and effective application.

How does it work?

Synvisc and Synvisc One work by mimicking the properties of natural synovial fluid to improve the knee joint’s lubrication and cushioning. This viscoelastic injection creates a smooth gliding motion between joint surfaces, reducing friction and absorbing mechanical shocks during movement. By supplementing the joint’s natural fluid, it alleviates pain and enhances comfort during walking or bending.

According to clinical data, patients treated with Synvisc medications often experience significant improvement in joint function and reduced reliance on oral pain medications.

This mechanism of action supports better health outcomes and helps delay more invasive procedures, making Synvisc a practical choice for long-term joint care.

SYNVISC Composition

Synvisc contains hylan G-F 20, a biocompatible and viscoelastic gel composed of hylan A and B molecules—derivatives of hyaluronan. These molecules are extracted and purified from chicken combs and are chemically cross-linked to form a stable, high-molecular-weight polymer.

The composition includes a repeating chain of sodium (Na)-glucuronate-N-acetylglucosamine disaccharide units, giving the gel its elasticity and durability.

This unique formulation provides longer-lasting joint cushioning compared to standard hyaluronic acid-based supplies. The label notes that classic Synvisc and Synvisc One are both sterile, non-pyrogenic medications intended for knee joint use.

Their formulation opens the possibility for improved joint performance, enhanced comfort, and sustained pain relief, offering an effective non-surgical treatment option for osteoarthritis patients.

SYNVISC Ideal Candidates

Synvisc is usually given to patients having problems with knee joints after they have failed to respond to conservative nonpharmacologic therapy or simple analgesics. Including other treatments you can recommend the patient try before or as alternatives to using Synvisc, such as:

1. ‘Nonsteroidal anti-inflammatory’ (NSAID) agents and other treatments for reducing inflammation, such as aspirin
2. Exercising
3. Physical therapy
4. Use of another knee- injectable drug like Corticosteroids

Contraindications

Having decided to treat the patient with Synvisc, you need to assess them further, make yourself aware of:

1. Whether they have any allergies —for example, to hyluronan, birds, feathers, or other poultry products —and their reactions to them.
2. Anaphylactic and anaphylactoid reactions, anaphylactic shock, and angioedema are some of the known allergic responses associated with Synvisc.
3. An infection around the knee joint, with the problem of the skin around the joint.
4. Blood illnesses, clots, or circulation problems, especially around your legs.

Since there is no knowledge of Synvisc effects on unborn babies and pregnant women, ensure your patient is not pregnant, and they should tell you in case they are planning to.

• Synvisc’s effects on babies are also unknown; therefore, inform the patient whether they are breastfeeding, as hyluronan will pass through breast milk.
• Typically, Synvisc is not given to pediatric patients or persons under 21 years of age, as its effects in these patients have not yet been established.

SYNVISC Dosage and Administration

Generally, for productive results, Synvisc is administered by an intra-articular injection once in a week for three weeks and each time you should ensure strict ascetic technique. However, do not inject Synvisc extra-articularly or through the synovial tissues and capsule as it may result to adverse results in the injected area. Also, intravascular injections may cause major adverse effects.

Injection Technique

Here is a simple procedure which you can follow to ensure the success of Synvisc administration:

• Use an 18-22 gauge needle. Remove synovial fluid or effusion before injecting Synvisc into the patient.
• The same size of gauge (18-22) should be used to administer the drug. However, you should use a new gauge to administer Synvisc; use only 2 milliliters in one knee.
• To minimize product leakage, twist the cap tip before pulling it off.
• Synvisc is then injected into the injection site of the joint area with the problem. To ensure there is no leakage during administration, secure the needle tightly while steadily holding the luer hub.

Nevertheless, you should avoid breaking the syringe by applying too much force when attaching or removing the needle or the needle guard. In addition, you need to be more cautious, especially when there are signs of lymphatic or venous stasis in the leg that is to be treated.

When does the patient start feeling better?

Our bodies being different, relief from pain will vary; however, after the dose is over, most patients are known to experience relief after six months, and some after the first 6-12 weeks from the first injection.

Although it is essential that a patient finishes the dose regardless of how soon they feel well before completion of the dose.

Other Health and Safety Precautions

After administering Synvisc to your patient, advise them to avoid any strenuous activities such as participating in sports, carrying of heavy items or standing for more than an hour.

Do not provide a patient with Synvisc that is from a damaged or already opened package also, ensure it is original. It is normally provided in a glass syringe of 2.25 milliliter with 2 milliliter or 16 gm of sterile and nonpyrogenic content.

Use the syringe immediately you get it out from its package plus, the content in it is for a single use. Synvisc should be stored away from direct light and under room temperature; do not freeze.

Inform the patient that they should not use skin disinfectants with quaternary ammonium as it would react with hyaluronan and precipitate on the skin.

Possible Side Effects of SYNVISC

Here are a few of the known side effects the patient may experience:

1. Muscle pain which may cause trouble walking
2. Feeling fatigue
3. Headache, dizziness or both
4. Swelling, warmth and redness where the drug was administered
5. Skin irritation on the skin around the treatment area
6. Numbness, feeling tingly
7. Fever, nausea, chills

Advise the patient that in case of even more serious side effects like joint effusion, swelling or pain at the joint; or reactions such as swelling of the tongue, lips and throat, hives and breathing difficulty, they should visit the emergency room or call you immediately.

Overdose and Other Interactions

Any other interactions of Synvisc and food or other substances have not been established. Overdoses on the other hand, are rare occurrences as administering of the drug is done by a certified medical officer. However, in case it happens, medical attention should be sought immediately.

Order SYNVISC Products Online at a Wholesale Price

Healthcare professionals can easily buy Synvisc wholesale through trusted distributors such as Medica Depot. The site provides authentic orthopedic supplies that meet strict quality and safety standards. By ordering in bulk, clinics can maintain stock efficiency and provide cost-effective treatments to their patients. Wholesale purchasing enhances affordability for both practitioners and patients while ensuring the consistent availability of viscosupplementation products like Synvisc One.

The platform also allows each doctor to review product information, official label details, and dosage instructions before confirming the order. This ensures every purchase Synvisc transaction aligns with medical preferences and practice needs. With a streamlined interface and detailed product data, professionals can save time and guarantee that the right supplies are always available for use in clinical settings.

Purchase SYNVISC and SYNVISC One Medication at Medica Depot

Clinicians can confidently purchase Synvisc and Synvisc One medication from Medica Depot’s verified online site, which provides clear product description and clinical details. These formulations are designed to restore joint lubrication and cushioning, supporting joint health and mobility for patients suffering from osteoarthritis. The cost Synvisc depends on the quantity ordered, making it ideal for practitioners who prioritize both quality and affordability in their treatment inventory.

Before placing an order, it is essential for healthcare providers to review product usage, confirm label accuracy, and ensure the medication matches the patient’s therapeutic requirements. By sourcing from an authorized distributor, consumers and professionals alike benefit from genuine supplies, transparent pricing, and reliable delivery tailored to specific doctor preferences. Medica Depot’s efficient service allows practitioners to confidently stock Synvisc products, ensuring continuity of care for all patients.