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CRESPINE® is an orthopedic injectable filler formulated to ease the symptoms of osteoarthritis. You can buy CRESPINE® fillers from Medica Depot. It is manufactured by BioPolymer, an industry leader in the research, development, and manufacturing of medical devices. CRESPINE® is available as a sterile, viscoelastic, and biocompatible gel implant made of cross-linked hyaluronic acid. It works by forming a protective layer over worn-out bones, reducing erosion and allowing joint movements to be smoother and more flexible. It is trusted as a minimally invasive treatment with few side effects and a speedy recovery.

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Buy Crespine Products from Wholesaler at Low Prices

Crespine Gel is a renowned injectable solution utilized in orthopedic medicine for its regenerative properties. It offers a non-surgical approach to joint pain relief, making it a sought-after product in medical practices worldwide.

If you’re a medical professional seeking to enhance patient care, this guide aims to provide valuable insights into purchasing Crespine and optimizing its benefits.

What Is Crespine Gel and How Does It Work?

Crespine is a brand that specializes in orthopedic medical devices, particularly intra-articular implants and is used in osteoarthritis treatments.

The brand aims to provide innovative solutions for joint disorders and improve the quality of life of patients suffering from these conditions. Crespine’s manufacturer BioPolymer is a company that focuses on the research, development, and production of medical devices for various applications.

The company offers osteoarthritis treatment gels, such as Crespine Gel (which contains only cross-linked hyaluronic acid) and Crespine Gel Plus (which contains cross-linked HA and non-cross-linked HA).

Both products are classified as medical devices under “Classification III” and are designed to be administered as a single injection into the affected joint. Their effectiveness is derived from the unique structure of the hyaluronic acid they contain.

While Crespine Gel and Crespine Gel Plus work similarly, the latter has the added advantage of containing a local anesthetic substance that makes the injection process more comfortable for patients.

There are 3 types of joints in the human body:

  • fibrous,
  • cartilaginous,
  • synovial.

Fibrous joints are held in place by tissues such as collagen fibers and cannot move freely.  Cartilaginous joints are connected by cartilages and are semi-movable. Finally, synovial joints are encapsulated within a synovial membrane that is flexible and allows for complete freedom of movement.

The bones within the membrane have a very thin but sturdy layer of articular cartilage covering them, which ensures friction-free movement. In addition, there is synovial fluid between the bones, which serves as both a lubricant and a shock absorber.

Crespine Gel replenishes the lost synovial fluid that lubricates joints to allow for a wide range of motion.

Prilocaine ensures a painless injection experience while the hyaluronic acid reduces friction through lubrication and enhances mobility in affected joints, such as hips, knees, and other areas.

The synthetic gel is biocompatible, and resorbable, while also being viscoelastic and completely sterile. It contains no endotoxins or animal sources.

What Are the Main Uses for Crespine?

Crespine Gel can be used to treat immobility and pain that come with degenerative osteoarthritis disorders.

The hyaluronic acid in the gel helps safeguard bones by protecting the sensitive ends with a special layer. This layer allows for joints to become more flexible, allowing for more freedom of movement, while protecting against bone erosion.

How To Use Crespine Product

Crespine products are intended for intra-articular injection, which means gel is injected directly into the joint. Therefore, the application should be performed aseptically and under sterile conditions.

The Crespine dosage and the injection frequency depend on the patient’s condition; the doctor determines them during the appointment.

Before using Crespine products, you should carefully read the product instructions and be trained in the injection technique. You should also ensure that the patient is aware of the potential benefits and risks of the product and that they give informed consent for the procedure.

It is important to note that Crespine products are not suitable for all patients and medical conditions. Therefore, before using them, you must thoroughly evaluate the patient’s medical history, current medications, allergies, and contraindications.

Crespine Aftercare

After receiving a Crespine injection, patients should follow certain aftercare instructions to ensure the best possible results. Below are some guidelines for Crespine aftercare:

  • Avoiding strenuous activities: Patients should avoid physical activities for at least 48 hours after the injection to allow the joint to rest and recover.
  • Icing the joint: Applying ice to the joint for 15–20 minutes every few hours can help reduce swelling and discomfort.
  • Avoiding hot baths or saunas: Patients should avoid those for at least 48 hours after the injection, as heat can increase inflammation and swelling.
  • Taking pain relievers if necessary: Over-the-counter pain relievers (such as acetaminophen or ibuprofen) can relieve discomfort after the injection. However, patients should consult with their doctor before taking any medication.


Patients should follow up with the doctor as scheduled to monitor the progress of their joint pain and determine if any further treatment is necessary. It is important to note that specific aftercare instructions may vary depending on the patient’s needs and the type of Crespine product used.

How Long Do Crespine Effects Last?

It typically takes between five and seven days after the initial treatment to start seeing the beneficial effects of a Crespine Gel treatment.

Patients can expect the effect to last for around six to eight months after which repeat injections can be used to extend the effects. However, results may differ from patient to patient.

If you are interested in Crespine’s price, please visit the product page on our website.

Is Crespine Safe?

Crespine has been rigorously tested and proven to be safe for use. The main ingredient of this implant gel is hyaluronic acid, a substance our bodies naturally produce. This means the treatments are minimally invasive and our bodies will accept them with a minimum of adverse side effects, ensuring a speedy joint recovery. 

However, Crespine has several contraindications doctors and patients should be aware of:

  • Hypersensitivity to hyaluronic acid or any of its components;
  • Active infections or skin diseases in the area of the injection site;
  • Pregnancy or breastfeeding;
  • Being a minor;
  • Bleeding disorders or taking blood-thinning medications.

It is crucial to take special care with the joints that are being treated, and avoid direct injections into infected or inflamed areas of the joints, as this will only worsen the situation and produce more adverse side effects.

Also, it is vital to use authentic products; that’s why if you want to buy Crespine online, do it only from trusted sources, like our website. Medica Depot is a certified Crespine supplier, so you can be sure your purchases here are safe.

Crespine Advantages

Crespine’s main benefit is that it can help reduce pain and improve joint mobility, thus improving patients’ overall quality of life. The main benefits are: 

  • Reducing pain in the affected joint;
  • Improving joint mobility and function;
  • Improving the overall quality of life for patients;
  • Non-surgical option for the treatment of osteoarthritis.

However, like all medical treatments, there are also potential side effects to be aware of.

  • Pain or swelling at the injection site;
  • Skin irritation or rashes;
  • Headaches;
  • Dizziness;
  • Nausea or vomiting;
  • Allergic reactions;
  • Infections at the injection site (rare).

It is crucial to note that not all patients will experience side effects, and those who do may only experience mild symptoms that subside on their own.

What Is Crespine Made Of?

Each Crespine Gel package comes with a product information leaflet, four traceability labels, and a 2 mL syringe that’s preloaded with the solution.  It is important to store this injection item in sanitary conditions and keep the storage room between 2 and 25 degrees Celsius.

Crespine ingredients: cross-linked hyaluronic acid at a concentration of 14mg/mL, non-cross-linked hyaluronic acid at 1mg/mL, and prilocaine at 3mg/mL.


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