NUCLEOFILL™

NUCLEOFILL™ 20

Manufacturer: Promoitalia Group S.p.A. Active Substance(s): POLYNUCLEOTIDE…

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$89.00

NUCLEOFILL™ 25

Manufacturer: Promoitalia Group S.p.A. Active Substance(s): POLYNUCLEOTIDE…

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$89.00

NUCLEOFILL™ EYES

Manufacturer: Promoitalia Group S.p.A. Active Substance(s): POLYNUCLEOTIDE…

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$109.00

NUCLEOFILL™ HAIR

Manufacturer: Promoitalia Group S.p.A. Active Substance(s): POLYNUCLEOTIDE…

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$99.00

NUCLEOFILL™ MEDIUM

Manufacturer: Promoitalia Active Substance(s): POLYMERISED POLYNUCLEOTIDE…

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$119.00

NUCLEOFILL™ MEDIUM PLUS

Manufacturer: Promoitalia Active Substance(s): POLYMERISED POLYNUCLEOTIDE…

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$90.00

NUCLEOFILL™ SOFT PLUS

Manufacturer: Promoitalia Active Substance(s): POLYMERISED POLYNUCLEOTIDE…

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$106.00

NUCLEOFILL™ STRONG

Manufacturer: Promoitalia Active Substance(s): POLYMERISED POLYNUCLEOTIDE…

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$119.00

NUCLEOFILL Indications and Ingredients

Nucleofill is an advanced Italian treatment developed by Promoitalia Laboratories, formulated as high-viscosity biostimulating gels containing natural polynucleotides Nucleofill. Designed for aesthetics and skin revitalization, this innovative product helps improve the skin’s structure, elasticity, and hydration while addressing early and advanced signs of aging.

Unlike traditional dermal fillers, Nucleofill focuses on cellular bio-restructuring, stimulating fibroblasts, enhancing microcirculation, and promoting antioxidant activity for long-term skin health.

Indications for Nucleofill include:

• Improving skin firmness and elasticity
• Reducing visible signs of aging, such as fine lines and loss of volume
• Supporting post-procedure recovery in aesthetics
• Restoring hydration and turgor in dehydrated or stressed skin

Key ingredients and their functions:

• Polynucleotides Nucleofill: Natural DNA fragments that activate cellular repair and collagen synthesis
• High viscosity gel base: Provides lasting structural support and improved tissue integration
• Antioxidant components: Neutralize free radicals to protect against oxidative stress
• Hydrating agents: Promote deep and sustained moisturization

By combining potent bio-restructuring capabilities with targeted skin support, Nucleofill offers a regenerative approach that complements traditional fillers while enhancing natural beauty through advanced medical aesthetics.

Read our comprehensive article about the Nucleofill BAP Technique.

How Does NUCLEOFILL Work For Skin?

Nucleofill is a biostimulating gel derived from the unique PDRN complex extracted from salmon cells. It undergoes a multi-stage purification process to ensure safety and efficacy. These Nucleofill injections contain highly purified polynucleotides, which are microscopic DNA fragments capable of penetrating skin cells and repairing damaged structures at the molecular level. This makes them both safe and naturally compatible with human tissue.

The effects of Nucleofill treatments occur through several key mechanisms:

• Fibroblast Activation

The product targets receptors on skin fibroblasts, stimulating their transformation into myofibroblasts. This process increases the production of type I collagen and elastin, leading to noticeable skin tightening, lifting, and improved elasticity.

• Antioxidant Action

The derma-restoring formulation neutralizes free radicals and enhances antioxidant activity. This protects the skin from oxidative stress, which is a major factor in premature aging.

• Deep Hydration

Polynucleotides bind water within the extracellular matrix, delivering long-term isosmotic hydration. This sustained moisture retention helps restore the skin barrier, making it thicker, stronger, and more resilient.

Through these combined skin booster actions, Nucleofill promotes regeneration, improves tone, reduces fine lines, and enhances firmness.

Consistent use as part of professional dermal filler or skin booster protocols can significantly improve skin health and slow visible aging, providing both immediate and lasting results.

NUCLEOFILL Product Line

The Nucleofill range offers advanced biostimulation treatments designed for targeted skin rejuvenation and repair. Each formulation is developed for specific aesthetic concerns, enabling medical professionals to customize dermal filler protocols according to patient needs. These products contain purified polynucleotides that work at the cellular level to promote collagen production, hydration, and antioxidant protection.

The Nucleofill line includes:

• Nucleofill Medium: Designed for deep cell regeneration, this formulation enhances skin turgor, stimulates collagen synthesis, and restores hydration. It acts at the cellular level, ensuring long-lasting rejuvenation effects.
• Nucleofill Strong: Developed for intensive skin bio-restructuring, this product offers a lifting effect, combats oxidative stress, and provides profound moisturization. It is ideal for patients requiring significant dermal renewal.
• Nucleofill Soft Plus: Formulated for the delicate eye area, it smooths fine lines, reduces dark circles, improves skin density, and restores firmness.
• Nucleofill Medium Plus: Tailored for the lower face and neck, this product targets sagging and loss of elasticity, improving contour definition.
• Nucleofill Touch: A specialized option for reducing expression lines, delivering a refreshed and youthful appearance without adding volume.

By offering precise formulations—from Nucleofill Soft for sensitive areas to Nucleofill Strong for advanced rejuvenation—this dermal product line ensures versatile and effective treatments for various stages of skin aging.

What Are The Benefits Of This Dermal Filler?

Nucleofill is a regenerative injectable designed to address multiple signs of aging and skin damage through advanced biostimulation. Packaged in a sterile bottle, each formulation in the Nucleofill products range works at a cellular level to improve skin quality and structure. This treatment is suitable for various areas of the face and body, offering results that go beyond traditional volumizing dermal fillers by enhancing natural regeneration.

The key benefits of Nucleofill include:

• Improved Skin Firmness – Effectively treats skin laxity and restores elasticity.
• Wrinkle Reduction – Smooths fine lines and small wrinkles for a rejuvenated appearance.
• Enhanced Circulation – Stimulates microcirculation, improving nutrient and oxygen supply to tissues.
• Deep Hydration – Corrects dryness and dehydration for a healthier skin texture.
• Antioxidant Protection – Minimizes signs of oxidative stress, slowing premature aging.
• Skin Repair – Addresses couperosis, acne, post-acne marks, and scars.
• Pigmentation Correction – Helps reduce visible pigmentation and even out skin tone.
• Stretch Mark Improvement – Supports tissue regeneration for smoother texture.
• Facial Contour Definition – Restores clearer contours and reduces signs of ptosis.

According to both clinical evidence and patient feedback, Nucleofill injections provide powerful moisturization, trigger biorevitalization, and stimulate the production of type I collagen fibers. These combined actions promote healthier, more resilient skin over time.

NUCLEOFILL Treatment Protocol

The Nucleofill treatment follows a structured protocol to ensure safety, precision, and optimal results in aesthetics. A qualified medical professional administers the products through a series of targeted injections.

The recommended course usually consists of two sessions spaced two to four weeks apart. In certain cases, up to four sessions may be performed with the same interval. A single 2ml syringe is generally enough to treat the face, while additional doses are required for the neck, décolleté, or hands.

The dermal fillers are injected intradermally at a medium depth using the retrograde-linear papular technique. The specialist may use a fine needle or cannula to target specific skin areas, ensuring even distribution of the solution.

Most patients tolerate the injections well; however, a topical anesthetic can be applied to minimize discomfort. Once injected, Nucleofill integrates with the tissues, binds water molecules, and stimulates collagen production.

This process provides immediate hydration, a subtle lifting effect, and improved skin elasticity. While results may be visible right after the treatment, mild redness or swelling may temporarily occur.

Aftercare

Following proper aftercare helps maintain results and reduce the risk of complications after Nucleofill treatment. Patients should handle the treated areas with care and avoid actions that could interfere with the filler’s placement. Key recommendations include:

• Avoid touching or pressing the injection sites for 24–48 hours. Excessive manipulation can disrupt the filler’s positioning and compromise the desired results.
• Apply a cold compress or ice pack wrapped in a soft cloth for 10-minute intervals several times during the first two days to reduce swelling and bruising.
• Refrain from intense exercise or activities that raise body temperature for at least 24 hours, as these can increase swelling and bruising.
• Protect the skin from sun exposure by applying broad-spectrum sunscreen, wearing a wide-brimmed hat, or using a sun umbrella.
• Avoid heat sources such as saunas, steam rooms, or hot tubs for one week post-procedure to prevent changes in the filler’s integrity.
• Do not apply makeup or skincare products to the treated areas for 24 hours to allow healing and reduce infection risk.
• Stay hydrated by drinking enough water daily to support skin health and recovery.

By closely following these aftercare instructions, patients can maximize the rejuvenating effects of Nucleofill while maintaining the integrity and longevity of the dermal fillers.

You can find more detailed descriptions of each product and price on the particular product pages on our website.

How Long Do The Results Last?

The duration of results from Nucleofill treatments depends on individual factors such as metabolism, the treated area, and lifestyle habits. Most patients experience visible improvements in skin quality for about three to six months. This is due to the product’s ability to stimulate natural regeneration and hydration, enhancing overall aesthetics over time.

To maintain the benefits of these dermal fillers, follow-up sessions may be recommended once the effects begin to fade. Consistent maintenance helps prolong the rejuvenating effects and supports the skin’s structural health. High-quality products like Nucleofill, when used in a tailored treatment plan, ensure longer-lasting, natural-looking results.

Is It Safe?

Nucleofill treatments use biocompatible products formulated without substances known to cause sensitization, making them generally safe for most patients. These dermal fillers support natural regeneration while maintaining high aesthetics standards in skin care. Clinical studies and patient reports confirm their favorable safety profile when administered by trained professionals.

However, certain conditions may make these treatments unsuitable. Nucleofill is not recommended for individuals with:

• Pregnancy or lactation
• Active oncology
• Severe systemic diseases
• Epilepsy
• Blood clotting disorders or anticoagulant use
• Keloid formation tendency
• Active inflammation
• Open wounds or damaged skin in the treatment area

To ensure product authenticity and patient safety, purchase only from official Nucleofill distributors or verified medical suppliers. Reputable sources, such as Medica Depot, provide genuine products with proper delivery documentation, safeguarding treatment quality and results.

NUCLEOFILL Side Effects

Like other dermal fillers, Nucleofill treatments may cause mild and temporary side effects, which are typically part of the normal healing process.

Common reactions include:

• Slight redness
• Swelling
• Bruising
• Tenderness at the injection site

These effects usually resolve within a few days and do not interfere with the overall aesthetics of the treated skin.

Although rare, serious complications can occur. To minimize risks, practitioners often recommend using cannulas during the procedure, as this technique can reduce trauma and improve safety.

Patients should follow all post-treatment care instructions provided by their aesthetic professional and seek immediate medical attention if they notice unusual or worsening symptoms. Choosing authentic Nucleofill products from trusted suppliers also helps ensure the highest treatment quality and safety.

Read our dedicated article about Nucleofill side effects.

Where To Shop NUCLEOFILL Injections Online

You can buy Nucleofill injections from reputable medical aesthetic suppliers to ensure product authenticity and patient safety. Leading online platforms allow licensed professionals to add the desired products to their cart Nucleofill and complete a secure checkout. For clinics or professionals who want to buy Nucleofill wholesale, some suppliers offer bulk pricing and special group purchase benefits.

Always shop from authorized distributors that provide verified supplies, clear product descriptions, and transparent VAT details to avoid counterfeit items. Choosing a trusted direct source guarantees you receive high-quality products suitable for professional use.

Order NUCLEOFILL At Medica Depot

Medica Depot is a recognized distributor where licensed practitioners can buy genuine Nucleofill injections. Their platform allows you to add items to your cart Nucleofill easily and proceed with an order in just a few steps. Professionals can also buy Nucleofill wholesale through Medica Depot to optimize inventory and reduce costs. The shop offers secure transactions, competitive pricing, and detailed product information.

Medica Depot includes transparent VAT calculations and efficient delivery options, ensuring your supplies arrive promptly. By ordering from this trusted direct distributor, clinics can maintain safety and quality in their aesthetic procedures.