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NUCLEOFILL™, renowned for its advanced cross-linked hyaluronic acid technology, stands as a top-tier option for aesthetic treatments, including wrinkle reduction and lip augmentation. Its line of dermal fillers provides effective solutions for individuals seeking non-surgical facial rejuvenation. You can buy NUCLEOFILL™ at Medica Depot. Continue reading to access comprehensive details about its applications, potential side effects, and product availability.


What is Nucleofill, And Where Can These Dermal Fillers Be Used?

Nucleofill is a series of high-viscosity Italian biostimulating gels based on natural polynucleotides designed to protect and rejuvenate the skin. This injectable drug has a unique effect that offers four different types of skin stimulation:

  • Skin regeneration;
  • Deep cleansing through increased blood circulation and removal of free radicals;
  • Intracellular hydration;
  • Strengthening of skin turgor and contour correction.

How Does It Work?

Nucleofill is manufactured from the unique PDRN complex obtained from salmon cells and undergoes a multi-stage purification process.

PDNRs are unique microparticles, fragments of DNA chains that penetrate intracellularly and repair damaged links at the molecular level. Currently, there are no analogs to these microscopic “saviors.” Polynucleotides are not only effective but are also as safe and natural as possible, coming from the cells of salmon fish.

First, the product affects the receptors on skin fibroblasts. Due to such stimulation, they turn into myofibroblasts. This stimulates the production process of type I collagen and elastin, which causes skin tightening and lifting.

After that, the drug “eliminates” free radicals and antioxidant activity.

And finally, polynucleotides bind water and provide long-term isosmotic hydration of the extracellular matrix. What does this mean? The skin will be included in the biostimulation process, which will help it regenerate, thicken and strengthen.

Additional antioxidant and hydrating benefits will help in effective skin rejuvenation. Thanks to this, the skin tone will improve, small wrinkles will decrease, and the skin will become moisturized and elastic.

The Nucleofill line includes the following products:

  • Medium – for deep cell regeneration. It strengthens turgor, moisturizes, and stimulates collagen production. The drug acts at a cellular level, so the effect of pronounced rejuvenation is guaranteed for a long time;
  • Strong – for deep skin renewal and bio-restructuring. This innovative treatment has a lifting and antioxidizing effect and moisturizes the skin;
  • Soft Plus – for the area around the eyes, smoothes wrinkles, lightens dark circles, tightens the skin, and increases its density;
  • Medium Plus – product for the treatment of the lower face and neck;
  • Touch – reduces the appearance of expression wrinkles, giving a fresher and younger look.

Nucleofill’s cost varies depending on which product you choose. In general, the Nucleofill dermal fillers line is indicated for patients who have the following conditions they wish to address:

  • Skin laxity;
  • Small wrinkles;
  • Slowed blood circulation;
  • Dryness and dehydration;
  • Signs of oxidative stress;
  • Cuperosis;
  • Acne and post-acne;
  • Pigmentation;
  • Stretch marks;
  • Scars;
  • Loss of clear facial contours, ptosis.

Numerous positive Nucleofill reviews prove that these injectables are recognized for successfully solving aesthetic concerns by patients and cosmetology professionals.

Nucleofill injections provide moisturization and biorevitalization and kickstart the biostimulation processes and growth of type 1 collagen fibers.

The process of administering Nucleofill involves a series of injections performed by a qualified medical professional.

The recommended course consists of two procedures with an interval of two to four weeks between sessions, but in some cases, up to four procedures can be performed with the same gap between them. The volume of 2.5 ml is enough to treat the face. You will need an additional dose to treat the neck, décolleté, and hands.

The drug is injected intradermally at a medium depth using the retrograde-linear papular technique.

During the procedure, Nucleofill dermal fillers are administered into specific face areas using a fine needle or cannula. The injections are usually well-tolerated, but a topical anesthetic or numbing agent may be applied to minimize discomfort.

Once injected, the solution integrates with the tissues and starts attracting water molecules, providing immediate volume enhancement and smoothing out wrinkles. The results are noticeable right after the treatment, although there may be some temporary swelling or redness at the injection sites.

You can find more detailed descriptions of each product and price on particular product pages on our website.

How Long Do The Results Last?

The longevity of results can vary depending o the individual’s metabolism, the treated area, and the patient’s lifestyle factors.

Typically, the results last from three to six months. After this period, maintenance treatments may be recommended to sustain the desired results over time.

Is It Safe?

Nucleofill products are entirely natural and safe, and they do not contain substances with sensitizing potential.

While well-tolerated by most individuals, specific contraindications may make it unsuitable for some patients. These may include:

  • Pregnancy and lactation;
  • Oncology;
  • Systemic diseases;
  • Epilepsy;
  • Blood clotting problems;
  • Taking anticoagulants;
  • Tendency to keloid formation;
  • Temporary inflammation;
  • Damage to the surface of the skin.

When buying Nucleofill online, choose only official Nucleofill suppliers like Medica Depot to ensure the product’s originality and safety. Delivery quotes are also provided through these sources.

Nucleofill Benefits

Nucleofill offers several benefits for patients seeking aesthetic improvements and facial rejuvenation. Here are some of the main advantages of using Nucleofill:

  • Nucleofill smoothens the skin and provides a more refreshed and rejuvenated appearance when injecting it into areas where wrinkles are prominent, such as the nasolabial folds or marionette lines.
  • It can enhance and define facial contours, improving overall facial harmony, and is great at treating areas such as the cheekbones, chin, and jawline.
  • Nucleofill treatments are typically time-efficient and convenient, often completed in a single office visit. The product’s injections are performed with a fine needle or cannula, and the entire procedure is very short. This makes it a convenient option for individuals with busy lifestyles.
  • Nucleofill is designed to provide natural-looking results boosting collagen and elastin levels and stimulating dermal remodeling over time. The results are typically subtle and enhance the existing features without appearing overdone.

Side Effects

As with any dermal filler treatment, there are potential side effects and risks to consider. Common adverse effects may include temporary redness, swelling, bruising, or tenderness at the injection sites.

Serious complications are rare but can occur, so it’s essential to follow post-treatment care instructions and seek prompt medical attention if any concerning symptoms arise.

Using cannulas during the procedure is recommended to reduce the risk of complications.


Proper aftercare ensures delivery of optimal results and minimizes potential complications after Nucleofill treatment. Here is the list of guidelines that your patients can follow:

  • Treat the areas of injections with care. Refrain from touching, rubbing, and applying pressure to the injected sites for 24 to 48 hours after the procedure. Excessive manipulation can displace the filler and interfere with the desired outcome.
  • A cold compress or ice pack wrapped in a thin cloth applied to the treated areas can help reduce swelling and minimize bruising. Apply the cold for short intervals, around 10 minutes at a time, several times a day during the first 24 to 48 hours after the procedure.
  • Avoid vigorous exercise or activities that can increase blood flow and elevate body temperature for at least 24 hours post-treatment. Increased blood flow may lead to increased swelling and bruising.
  • Protect the skin from direct sunlight and UV radiation. Apply a broad-spectrum sunscreen with a high sun protection factor to the treated areas when exposed to the sun, wear a wide-brimmed hat, or use a sun umbrella for additional protection.
  • Avoid hot temperatures like saunas, hot tubs, steam rooms, and activities that expose a person to excessive heat for at least one week following treatment. Heat can increase blood flow and potentially impact the filler’s integrity.
  • Refrain from applying makeup or skincare products on the treated areas for the first 24 hours after the procedure to let the skin heal properly and reduce the risk of irritation or infection.
  • Stay hydrated – drink plenty of water daily to keep the body and skin hydrated, promoting overall skin health and healing.

Nucleofill Ingredients

Nucleofill products come in the form of transparent gel and are mainly composed of polymerized polynucleotides.


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