empty medical bottles and a syringe

Different Botox Brands and Types

Botox / By  marketing_team

25 May

Botox has emerged as a popular choice worldwide when it comes to rejuvenating treatments.   However, the realm of botulinum toxins encompasses a variety of brands and types, each with its unique characteristics. From the renowned Botox, which initiated the phenomenon, to alternatives like Dysport, Xeomin, and Jeuveau, the market presents a range of choices.

These various formulations of botulinum toxin type A offer different nuances in terms of composition, onset of action, and even brand-specific dosing units. Join us as we delve into the world of Botox brands, exploring their medical and cosmetic applications, mechanisms of action, and considerations for safe and effective use.

What Is Botulinum Toxin Type A?

Botulinum toxin type A is a neurotoxic protein produced by the bacterium Clostridium botulinum. It is one of several types of botulinum toxin produced by different strains of the bacterium. Botulinum toxin type A is the most widely known and extensively used form of botulinum toxin for medical and cosmetic purposes, and the Botox brand name is most commonly used as a shorthand for these kinds of products.

Botulinum toxin type A functions by inhibiting the release of acetylcholine, a neurotransmitter responsible for transmitting signals between nerve cells. By blocking the release of acetylcholine, the toxin interferes with the normal communication between nerve cells and muscles, resulting in temporary muscle paralysis or weakening.

In medical applications, botulinum toxin type A is primarily used for its muscle-relaxing properties. It is employed in the treatment of various medical conditions, including muscle spasms, chronic migraines, excessive sweating (hyperhidrosis), overactive bladder, and certain movement disorders like cervical dystonia.

Botulinum toxin type A is also popularly used in cosmetic procedures to reduce the appearance of wrinkles and fine lines on the face in a similar fashion to dermal fillers. By injecting small amounts of the toxin into specific facial muscles, it can temporarily relax them, resulting in a smoother and more youthful appearance. It has become so popular that over 6 million procedures a year involve Botox injections.

Types of Botox

Over the years, researchers have discovered multiple subtypes of botulinum toxin type A. Several of them are currently available; each is produced by a different manufacturer.

In this section, we’ll go over the most common types and explain how they differ.


The most common and widely recognized botulinum toxin is synonymous with the Botox brand. It’s manufactured by Allergan Aesthetics, now part of the AbbVie group. OnabotulinumtoxinA is highly valuable in medical and cosmetic applications. Medically, it is used to treat muscle spasms, dystonias, chronic migraines, hyperhidrosis, and overactive bladder. In the realm of aesthetics, it is used for facial wrinkle reduction.


The formulation of AbobotulinumtoxinA is slightly different from OnabotulinumtoxinA, which allows it to have a faster onset of action, but also broader diffusion and lower potency. It has a lower protein and is often referred to as a “naked” formulation. The most notable manufacturer is the French company Ipsen, which manufactures Dysport.


IncobotulinumtoxinA is another type of botulinum toxin type A. It is considered a “naked” toxin without complexing proteins, potentially reducing the risk of antibody formation and making it a choice for individuals who have developed resistance to other botulinum toxin products. Xeomin is the most notable brand, produced by Merz Pharmaceuticals and approved for use in multiple countries.


PrabotulinumtoxinA, marketed under the brand names Nabota and Jeuveau, is a type A botulinum toxin formulation. It shares similarities with other types of Botox brands regarding the mechanism of action but has a slightly different protein structure and recommended dosage.

It’s worth noting that while these different brands may have slight differences in their formulation or properties, they all primarily function by inhibiting muscle contractions and work in a similar manner. However, the dosing and units may vary between brands, which we’ll explain in more detail in the following sections.

Best Botox Brands in 2023

The specialization of botox manufacturers led to them leading the charge in the field of medical and cosmetic injections. We’re talking about these four brands specifically: Botox, Dysport, Jeuveau, and Xeomin.

1. Botox

Botox is, without a doubt, the most well-known cosmetic injectable in the world. Developed in the 1970s as a treatment for cross eyes, it later became a cosmetic injectable thanks to its muscle-relaxing features. It was also the first neurotoxin that got FDA approval for cosmetic use. Today, Botox is so popular that, when people talk about getting a non-invasive cosmetic treatment, they pretty much always think about Botox.

2. Dysport

Alongside Botox, Dysport has been around for many years and has been included in the top 10 Botox brands ever since. It was developed in 1984 by Porton International as a cure for dystonic conditions like cervical dystonia and writer’s cramp. Six years later, Dysport was approved in Europe for medical treatments and earned global recognition soon after.

3. Jeuveau

One of the “youngest” botulinum toxins in this list, Jeuveau is a purified botulinum toxin type A formulation and prescription medicine. It’s primarily used for correcting frown (eyebrow) lines, including severe cases of glabellar lines. Jeuveau got its FDA certification in early 2019.

4. Xeomin

Xeomin was the fourth neurotoxin to get FDA approval for cosmetic use. Originally used for treating blepharospasm and cervical dystonia in adults, Xeomin nowadays also has cosmetic applications. What sets it apart from other products here is that it’s genuinely pure botulinum toxin, making it the best Botox brand for people with allergies and developed immunity to other brands.

What is the Difference Between Botox, Dysport, Xeomin, and Jeuveau?

So far, we’ve seen a lot of similarities between these four Botox brands. They’re made from basically the same ingredients, so it comes as no surprise that they share many similarities, too. Their results, specifically, are the same – muscle relaxation, leading to reduction of fine lines and wrinkles, along with other therapeutic benefits.

But they’re not really the same. Since each of them is made from a slightly different type of botulinum toxin, they each have a different onset and duration. Dysport and Jeuveau have the fastest onset – just three hours, with noticeable effects appearing within 3-7 days. Compared to these, Botox and Xeomin are drastically slower, as their onsets are 72 and 96 hours, respectively.

We’ve previously mentioned patients developing a “resistance” to these injectables. This is most common in Botox and Dysport. Additives in these two types of Botox can trigger autoimmune reactions in certain patients, causing the body to simply not accept the injections.

As for the dosage, Dysport proved to be the “weakest” of the bunch. If you inject Dysport, you’ll typically need a 2-3 times higher dosage than other injectable neurotoxins. That also leads us to price – Botox is, by far, the most expensive product of this kind, while Jeuveau provides the best value. On the other hand, Jeuveau isn’t FDA-certified for medical applications, only for cosmetic procedures.

Lastly, one advantage Xeomin has over the other Botox brands is that it can be stored at room temperature, while other injectables require refrigeration. The reason for this is simple – Xeomin doesn’t contain any additives, including lactose, so it doesn’t spoil outside a cooled environment. It’s the purest form of incobotulinomtoxinA.

What to Expect During Treatment

A typical Botox treatment involves a few simple and quick steps. It all starts with a consultation, where the patient’s desires and physical profile are taken into account when selecting the type of injectable to use.

Afterward, the treated area should be cleansed and then numbed using a topical anesthetic. Using specialized fine needles, the surgeon administers a series of injections directly into the muscles of the treated area. Some patients report a slight stinging sensation during the procedure but nothing to be afraid of.

The whole procedure usually takes about 15 minutes or less, depending on the number of injections. Patients can freely continue their daily activities after the Botox injection while taking care not to touch or put any pressure on the treated area. The effects of Botox last for three to six months, and the same can be said for other brands.


Patients seeking relief from muscle spasms or desiring a smoother, more youthful appearance have a range of choices and different Botox brands to meet their specific needs. Whether it’s the well-known Botox, the alternative options like Dysport, Xeomin, or the newer contender PrabotulinumtoxinA (Nabota/Jeuveau), each brand has its unique characteristics and considerations. Understanding the differences between the various botulinum toxin formulations can help individuals make informed decisions and achieve their desired outcomes.


Which brand is best for Botox?

This depends on the desired effects and whether the patient has developed immunity to traditional botulinum toxin injections. Xeomin is the purest form of these injections, while Dysport and Jeuveau provide the fastest results.

What brands of Botox last longer?

According to various studies, Dysport provides the longest-lasting results. These usually last five to eight months, while Botox effects rarely last longer than six months.

What are the 3 types of Botox?

The most common Botox brands, besides Botox itself, are Dysport, Jeuveau, and Xeomin.


Botulinum Toxin Type A: History and Current Cosmetic Use in the Upper Face; Alastair Carruthers (MD) and Jean Carruthers (MD); 2001


Clinical use of botulinum toxin; Adam Scheinberg; Aust Prescr 2009;32:39–42


Botulinum Toxin; P K Nigam and Anjana Nigam; Jan-Mar 2010


Comparison and Overview of Currently Available Neurotoxins; Thomas J. Walker (MD) and Steven H. Dayan (MD); Feb 2014


AbobotulinumtoxinA (Dysport®), OnabotulinumtoxinA (Botox®), and IncobotulinumtoxinA (Xeomin®) Neurotoxin Content and Potential Implications for Duration of Response in Patients; Malgorzata Field, Andrew Splevins, Philippe Picaut, Marcel van der Schans, Jan Langenberg, Daan Noort, and Keith Foster; Feb 2019


botox vials picked by a hand in glove

What Is Preventative Botox, And When Is It Recommended?

Botox / By  marketing_team

11 May

Like any medical procedure, botulinum therapy is performed according to specific indications, but not necessarily to treat existing wrinkles. Sometimes, doctors may prescribe injections as a preventive measure. This is especially common for individuals with expressive faces who wish to avoid wrinkles as they age. 

Does this mean they will keep a smooth face forever? No, mimic wrinkles will appear, but later than they normally would, and they will not be so deep. Therefore, such measures will significantly facilitate the work of a cosmetologist in five, ten, and fifteen years afterward.

How Does Preventative Botox Work?

Preventive Botox injections are used to retrain facial muscles and improve the “posture” of the face, which causes the appearance of wrinkles. 

Neuromodulator helps affect certain muscles that stretch the skin. As a result, the skin and muscles recover faster from wrinkles caused by active movements, such as laughter and anger.

Experts usually recommend treating wrinkles in two stages: first, they recommend using retinol to boost collagen production and strengthen the skin. After that, they suggest incorporating a Botulinum toxin neuromodulator, such as Botox or other comparable neurotoxins, to further address wrinkles and fine lines. This approach can yield excellent results and effectively combat the signs of aging.

Most people delay seeking botulinum toxin injections until the wrinkles become more visible, but preventative treatment uses Botox to prevent wrinkles from appearing. You can effectively prevent the formation of wrinkles by injecting Botox into ​​the muscles that typically cause wrinkles around the mouth, eyes, and eyebrows. This technique slows down these muscles, neutralizing the development of wrinkles (or at least dramatically slowing them down) before they even form.

Botox works by blocking nerve signals, causing muscles to contract. The injected muscle does not contract, and this causes the wrinkles to relax and soften.

Botox is an effective way to prevent the early formation of wrinkles by blocking the movement of facial muscles and practicing facial relaxation. This is applicable even after the product wears off, making it an indispensable tool for people of all ages. 

Wrinkles form due to repetitive skin movements. By introducing neuromodulators early on, you can prevent them from appearing altogether, instead of trying to correct them after they’ve already formed. Think of it like a marathon: minor treatments and care over time will lead to more natural long-term results.

One of the most common places for prophylactic Botox injections is the forehead, between the eyebrows, and the crow’s feet zone. Preventive Botox can avert deep wrinkles that make the person look older and more tired, and are so difficult to treat.

How Many Units Are Needed for Preventative Botox?

You might think you would use less Botox than with an older patient just because of age, but you would be wrong. Regardless of age, the dosage depends on the muscle mass, the visibility of lines on the face, and how deep they are. In addition, the injection protocol is the same as for an older patient, and placing injections depends on the person’s muscles. 

It is also vital to comply with the manufacturer’s instructions relating to particular areas of the face. However, the amount of product used should be based on the patient’s muscle mass.

It is crucial to remember that neurotoxins cannot be used to prevent other signs of aging, like dry skin, pigmentation, and vascular abnormalities. But preventative Botox injections can and should be used alongside a medical-grade skincare regime to prevent visible aging. 

In addition, various non-invasive procedures can improve skin health and reduce the need for injections at an early age. For example, treatments like laser therapy and medical-grade facials can effectively enhance skin quality, tone, and texture, resulting in a more youthful appearance. 

Incorporating these treatments into a regular skincare routine can help prevent the development of fine lines and wrinkles, while reducing the frequency of Botox injections. In addition, these non-surgical options can be combined with a healthy lifestyle to ensure long-term skin health and a more youthful-looking complexion.

It’s important to proceed cautiously when patients in their early twenties request Botox injections as a preventative measure. To ensure that their intentions are not the result of pressure from social media, or body dysmorphia, it’s crucial to carefully evaluate their motives. 

Therefore, providing appropriate patient care and conducting a comprehensive consultation is essential to determine the best course of action for their individual needs.

Benefits of Preventative Botox

The benefit of Botox for wrinkle prevention is very noticeable. This treatment can save the person from developing deep wrinkles in the future or significantly slow down their progression. The best time to fight wrinkles is when they first appear.

Some dermatologists suggest treating Botox as another part of the beauty routine, along with sunscreen and moisturizers.

The benefit of preventative Botox is that it helps keep the muscles lean, which means you don’t need as much Botox as a person ages. 

It is also important to note that Botox does not work for all wrinkles. If your patient has permanent or static wrinkles, Botox will not remove them. It’s never too late to start Botox, even if your client already has static wrinkles. Botox effectively softens existing wrinkles, prevents further deepening, and prevents new ones from appearing. 

Finally, Botox is convenient and affordable. The appointment is brief, taking only 20 to 30 minutes, and the patient will see the final effect two weeks after the treatment. Most patients experience noticeable improvements within the first few days and continue to see positive changes throughout the two weeks.

Preventative Botox vs. Baby Botox

Preventative Botox is aimed at dynamic muscles for lines and wrinkles that have not yet formed but may form in the future. Such injections preserve the skin’s quality and “train” the muscles to become less active over time.

Baby Botox can create a subtle and rejuvenating effect. So what exactly does the term “baby Botox” mean? Simply put, this method involves injecting a minimal (about a quarter of the standard dose) amount of botulinum toxin to ensure minimal muscle movement. 

By incorporating microdosing into your skin treatment regimen, you can effectively address the early onset of wrinkles and fine lines while maintaining a natural appearance. This also provides an affordable option for clients seeking to enhance their natural beauty. After all, the smaller the amount of the drug used, the lower the price of the procedure.

This treatment is perfect for individuals seeking a subtle enhancement of fine lines and wrinkles while still keeping the ability to make facial expressions with no hindrance.

When Is The Best Time To Start Botox?

Determining the ideal age to start receiving Botox injections for optimum results is a tricky area that most experts refrain from commenting on. Individual differences in physiology and other factors make it challenging to pinpoint a specific age that would apply to all patients. 

We use our facial muscles in very different ways: some people use their forehead all the time, and by the time they’re in their 20s, they’ll have etched lines. Others rarely use their forehead and may have almost no forehead wrinkles when they are over 40. Genetics and general skin condition are also important.

The quality of the skin is also crucial – for example, UV rays and damage from smoking can significantly worsen wrinkles.

There is no particular age for starting Botox. Regardless of whether your patient is 25 or 35, the best time to start treatment is before the appearance of wrinkles on the resting face.


Preventative Botox is a popular cosmetic treatment that aims to delay the onset of wrinkles by targeting the underlying muscles that cause them.

The concept of using Botox as a preventative measure is still relatively new; many individuals are opting for this treatment to maintain a youthful appearance. While there are potential side effects, many patients consider preventative Botox benefits worth the risk.


Can Botox really be preventative?

Can Botox prevent wrinkles? Yes, Botox can be used preventatively to slow down or stop the formation of wrinkles caused by repetitive muscle movements. 

By temporarily relaxing the targeted muscles, Botox can prevent the deepening of wrinkles resulting from repeated facial expressions, such as frowning or squinting. They commonly use this preventative effect on the forehead, frown lines, and crow’s feet around the eyes. 

However, it is essential to understand that the effectiveness of Botox preventative treatment can vary depending on factors like age, skin type, and the frequency and intensity of muscle movements.

Is preventative Botox different from regular Botox?

Preventative Botox is not different from regular Botox in terms of the substance used. In both cases, it is botulinum toxin type A. The difference lies in the treatment goal and the timing of the injections.

Preventative Botox aims to prevent wrinkles formation by injecting small amounts of Botox into particular muscles before they become overactive and create lines and wrinkles. It is typically administered to younger patients who do not yet have visible wrinkles but want to maintain a youthful appearance.

Regular Botox treats existing wrinkles and lines by relaxing the muscles that cause them. It is usually administered to older patients with already visible signs of aging.

What are the side effects of preventative Botox?

The side effects of prophylactic Botox are generally the same as regular Botox injections. These may include the following symptoms at the injection site:

  • Temporary bruising;
  • Swelling;
  • Redness;
  • Pain. 

In rare cases, patients may experience drooping eyelids, dry eyes, or double vision. 

Some people may also get headaches or flu-like symptoms after treatment, but these side effects are usually mild and temporary. 


Small R. Botulinum toxin injection for facial wrinkles. Am Fam Physician. 2014 Aug 1;90(3):168-75. PMID: 25077722. https://pubmed.ncbi.nlm.nih.gov/25077722/.

Freeman M, Sayegh F, Sarosi A, et al. Millennials Are Interested in Botulinum Toxin Injections for Prevention of Facial Rhytids. FACE. 2021;2(1):94-98. doi:10.1177/2732501620984761.

Mobayed N, Nguyen JK, Jagdeo J. Minimally Invasive Facial Cosmetic Procedures for the Millennial Aesthetic Patient. J Drugs Dermatol. 2020 Jan 1;19(1):100-103. doi: 10.36849/ JDD.2020.4641. PMID: 32395973.

Pellizzari R, Rossetto O, Schiavo G, Montecucco C. Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses. Philos Trans R Soc Lond B Biol Sci. 1999;354(1381):259-268. https://doi.org/10.1098/rstb.1999.0377.

MEDICATION GUIDE BOTOX®. January 2016. Accessed January 6, 2020. https://www.fda.gov/media/77359/download.

Humphrey S. Neurotoxins: evidence for prevention. J Drugs Dermatol JDD. 2017;16(6):s87-s90. https://journals.sagepub.com/doi/full/10.1177/2732501620984761#body-ref-bibr12-2732501620984761.

Alam M, Tung R. Injection technique in neurotoxins and fillers: indications, products, and outcomes. J Am Acad Dermatol. 2018;79(3):423-435. https://doi.org/10.1016/j.jaad.2018.01.037.

young woman in a botox treatment

Botox Statistics and Trends for 2023

Botox General Public / By  marketing_team

03 May

From an accidental discovery, through an eye-sight medication, to the hottest product in the world of non-surgical cosmetics, Botox needs no special introduction. 

Based on botulinum toxin type A, this product has been a topic of interest for millions of people worldwide and has found its way into pop culture, including “Sex and the City” and similar TV shows.

Today we will look at the latest Botox statistics, examining the growing popularity of this treatment, as well as its various uses and demographics. Continue reading to learn more about the industry around this product.

Botox Usage Statistics

We first need to analyze the current market trends to get the full perspective on how widely accepted Botox is as a cosmetic product. In this section, we will look at the number of procedures performed each year, the frequency of Botox treatments, and the average costs that patients can expect.

1. Plastic surgeons perform 6.2 million Botox procedures annually.


Botox is still the dominant non-surgical aesthetic procedure. According to statistics, it’s in front of hyaluronic dermal fillers, hair removal procedures, and even fat reduction procedures. While this number is several hundred percent higher than at the turn of the century, it’s slightly lower than Botox stats from 2017. That year alone, over 7 million people underwent the procedure.

2. In the United States alone, over 3.6 million people get Botox yearly.


The US continues to be the leading market for neurotoxins, including Botox. Just like it’s dominant on the global scale, Botox is the leading treatment in the US, too, and twice as popular as hyaluronic-based dermal fillers

3. On average, a single Botox procedure costs $409.


Some good news for patients looking into getting Botox – it’s now among the more affordable cosmetic procedures, especially the nonsurgical ones. For example, getting Botox is more affordable than getting hyaluronic-based dermal fillers, making it an obvious choice for patients on a tighter budget.

4. Regular Botox patients undergo the treatment every four months.

(Advanced Dermatology Center)

Like every cosmetic procedure, Botox doesn’t last forever. If patients want to maintain their youthful look and stay wrinkle-free, they must regularly visit their cosmetic surgeon and redo their Botox treatments. So how often do people get Botox? Every four months, it turns out. But, it’s worth mentioning that patients who regularly do Botox take longer breaks between their treatments.

5. Practitioners inject between 10 and 30 units of Botox per appointment.


Each part of the face requires a different amount of Botox. On top of that, the patient’s age and state of facial features also dictate how much Botox the injector has to administer during an appointment. For patients who have never had this procedure, standard practice is to start at a lower dosage and then proceed to manufacturer-recommended dosages if the patient is satisfied with the initial effects.

Botox Demographics

We’ve already seen how many people get Botox, and the industry around botulinum toxins is growing exponentially. Let’s then dive deeper and see who are the people who have this procedure done.

6. 79% of surveyed Americans know about Botox or have undergone this treatment.


The American population, specifically women, is well aware of Botox and the procedures involving this product. Only 21% of surveyed people said they have never heard about it, while 15% said they either have done Botox or are planning to. This all shows that the popularity of Botox has never been higher.

7. Among Botox patients, 94% are women.

(American Society of Plastic Surgeons)

It comes as no surprise that Botox is more popular among the female population. After all, most beauty products are. Still, the difference between how many women get Botox and how many men do this procedure is astounding. Botox treatments for men exist and provide as good results as those for women, but their popularity among the male population is still stagnating.

8. Most Botox patients, 57%, are between 40 and 54 years old.

(American Society of Plastic Surgeons)

The average age for Botox patients has been shifting these past several years. Previously, the majority of people that decided to get Botox were in their 30s, but nowadays, the patients are in their late 40s and early 50s. Just 1% of patients are under 30 years old, while patients aged 55 and over comprise 23% of all Botox patients.

9. The majority of Botox patients are Caucasian – 82% of them.

(American Society of Plastic Surgeons)

Another surprising statistic is that very few BIPOC people undergo cosmetic treatments, including Botox injections. The vast majority of patients are Caucasian, while African-Americans and Asian Americans account for 4% of patients each. The Hispanic population accounts for 7% of Botox patients, with other ethnicities accounting for the remaining 3%.

10. 96% of Botox patients say they are satisfied with the results.


Clearly, the more a product is on the market, the more it’s refined, and the more people will be satisfied with it. Over the past few decades, surgeons and medical practitioners have perfected their Botox injection techniques and now provide their patients with near-perfect facelift results.

Botox Facts and History

Despite being around for a few decades, Botox hasn’t always been popular. In fact, for a long time, the public frowned upon the mention of this drug. So, when did Botox become popular, and what can it cure now? Read on.

11. Botox was originally called Oculinum and was used for treating crossed eyes.

(TIME Magazine)

An ophthalmologist actually invented Botox, Dr. Alan B. Scott, who was looking for a cure for the cross-eyed disorder strabismus. In 1978, he introduced the drug Oculinum to the public, and in 1989, the drug became FDA-certified for treating cross-eyedness. Later on, Dr. Scott sold his company to Allergan, who renamed the drug Botox.

12. In 2002, Botox got FDA approval for treating fine lines and wrinkles.

(TIME Magazine)

We could consider this the turning point for Botox, and the moment it became popular. During the 90s, Allergan examined the effectiveness of botulinum toxin in cosmetic procedures. By the time it got its certification, the drug was already making a $310 million annual profit to the manufacturer.

13. Botox treats almost 800 different physical issues, not just cosmetic ones.

(TIME Magazine)

Over the years, a question arose – why do people get Botox? It turns out that the answer to this question is “for pretty much anything.” Botox has been found to cure excessive sweating, back pain, migraines, overactive bladder, neck spasms, and even erectile dysfunction. Nearly every procedure that includes muscle relaxation turned out to be compatible with this drug, allowing doctors around the world to provide relief to their patients in multiple ways.

14. The market value of Botox is $2.2 billion.

(US Securities and Exchange Commission)

Over the past two decades, such massive growth has led to quite a turnover for the manufacturers of botulinum toxin injections. With patients spending more than $2 billion a year on Botox, this procedure now accounts for 10% of all plastic surgery earnings.

15. The most common Botox injection sites are the forehead, chin, and neck.

(Westlake Dermatology)

Facial features are the most commonly treated with Botox. Using this injectable, plastic surgeons can treat anything from crow’s feet and gummy smiles to nasolabial folds. Depending on the treated area, the amount of Botox required for treatment varies from 2 to 4 units up to 50 units.


As you can see, we’re no longer wondering “how common is Botox,” but instead trying to find even more uses for this substance. With massive market growth during the 21st century and affordable prices, Botox is truly the signature drug of this millennium.


Is Botox becoming more common?

Yes, absolutely. Millions of people around the world get Botox each year, and the drug has found more applications besides cosmetic treatments. Within the first 15 years of the 21st century, the number of Botox patients grew by 759%.

What percentage of 30-year-olds get Botox?

Thirty-year-olds aren’t getting Botox as much as their older peers. This demographic accounts for 18% of all Botox patients. People in their forties and early fifties are the most frequent patients.

How many people do Botox a year?

According to the latest Botox statistics, over 6 million people a year do Botox. This number oscillates year-by-year and has reached 7 million at one point, but ‌the number of people interested in this procedure is steadily increasing.



Advanced Dermatology Center

American Society of Plastic Surgeons


TIME Magazine

US Securities and Exchange Commission

Man`s face gets botox injection for men near the eye

Botox for Men: Benefits and Side Effects

Botox Face Forehead Lips Wrinkles / By  Medicadepot Editor

25 Apr

Cosmetology has long since ceased to be a woman’s only service. It’s no wonder the popularity of Botox among men has increased: men also want to correct signs of aging, eliminate skin imperfections, and be attractive for themselves and in the eyes of others.

It’s no secret that even in business, it’s important to have some chemistry between people, and even more so in social communications. Minor cosmetic adjustments can significantly help with this – such as botulinum therapy, and that’s why men turn to Botox.

Men’s skin differs from women’s – it’s thicker, so the aging process is slower. But, mostly, signs of skin aging in men appear sharply and in a relatively concentrated manner. We use Botulinum therapy for men to remove wrinkles and correct other imperfections.

The Science of Botox

Botox is a medication based on botulinum neurotoxin type A, produced by Allergan (USA). This word is also used to refer to all its analogs. Botox binds to the nerve endings that release acetylcholine when injected into a muscle. 

It prevents the release of acetylcholine, which in turn prevents the muscle from contracting. As a result, the muscle becomes temporarily paralyzed and relaxed. The botulinum toxin injection procedure became popular at the end of the 20th century, and has remained the most popular non-surgical rejuvenation technique ever since. 

Botulinum toxin can smooth out wrinkles in almost any facial area. However, Botox has the most significant effect on the upper third of the face. Thus, it can eliminate horizontal and vertical wrinkles on the forehead and in the interbrow, crows feet, wrinkles on the bridge of the nose, and neck wrinkles. The most common places men get Botox are:

  • Interbrow crease;
  • Forehead;
  • Corners of the eyes;
  • Chin.

Top-class specialists also use Botox for:

  • Correcting the shape of the eyebrows and their height;
  • Narrowing the wings of the nose and raising the tip;
  • Lifting the lowered corners of the lips;
  • Lengthening the chin visually;
  • Correction of facial asymmetry resulting from blepharospasm and other spastic effects.

Botulinum toxin is often injected into the feet, palms, and armpits to reduce sweating. This procedure is indicated for people with hyperhidrosis but is often used in anticipation of summer by healthy patients.

When Can We See the Effect?

We can see the first results just a few hours after the procedure. After a few days, the effect is visible. The final result will take about two weeks to develop.

If the result is sufficient and satisfies both the beautician and the patient, then no more manipulations are performed. Otherwise, a correction session with a small dose of botulinum toxin is carried out if there is a slight asymmetry.

How Long Does Botox Last?

Men’s Botox can last 4–6 months. Gradually during this period, the muscle and nerve fibers recover. Six months after injections, the procedure can be entirely repeated.

Several courses of Botox injections for men can increase the patient’s tolerance to botulinum toxin, so subsequent treatments will require more of the drug; and they will act 1.5-2 times shorter in time.

Tolerance increases if Botox is injected more frequently than once every four months. Regaining the body’s sensitivity is possible, and the patient should take a break from injections for at least one year.

Benefits of Botox for Men

Botox is a revolutionary treatment that can help men get an enhanced, refreshed appearance. With Botox injections, men can say goodbye to wrinkles, fine lines, and facial asymmetry while improving their confidence and self-esteem.

Reduction of wrinkles and fine lines

Botox can help men achieve a more youthful appearance by reducing the appearance of wrinkles and fine lines. By relaxing the muscles that cause these imperfections to form, Botox can provide a smoother, more refreshed look.

Improvement of facial asymmetry

If your patients are concerned about facial asymmetry, Botox can help. By relaxing the muscles on one side of the face, Botox can improve facial symmetry and bring both sides of the face into better alignment.

Relief of migraines and other medical conditions

Botox isn’t just about looks, it can also relieve various medical conditions, including migraines, chronic pain, and muscle spasms. If patients suffer from any of these conditions, Botox may help.

Boost confidence and self-esteem

Taking steps to care for appearance and well-being can help your patients feel more confident and self-assured personally and professionally. With Botox, men can enjoy a smoother, more youthful appearance and the confidence that comes with looking and feeling their best.

Considerations for Treating Male Patients

Men’s forehead wrinkles are usually much deeper because their muscles are stronger on the body and face. Only when wrinkles have been visible for a considerable amount of time do men tend to turn to the expertise of a beautician. 

The interbrow area in men is also different. The eyebrows are more “overhanging” over the eyes and have a horizontal, almost unbent shape. The brow arches are expressed due to the bone component and tonus of the muscle itself. All this is expressed in vertical interbrow wrinkles and noticeable horizontal wrinkles between the eyebrows.

Therefore, most male patients who come for Botox treatment understand that it is impossible to eliminate these wrinkles completely with Botulinum Toxin alone. 

Generally, men don’t like people knowing that they’ve had any kind of procedure done. Hence, it should be done in such a way that everyone thinks it’s down to him being rested, eating healthily, exercising or simply being in a good mood.

Most men want to maintain a horizontal brow line, not raise it like almost all women want to; it’s something to keep in mind when we block the interbrow area. Always add at least a little Botox for men’s forehead lateral parts so there is no compensatory brow elevator. This also depends on the anatomy of an individual patient; the doctor should discuss this issue with the patient beforehand.

Concerning the technical side of botulinum therapy for men: As a rule of thumb, twice as much medication is needed for the procedure than for women. Therefore, its material cost increases as well. It is also necessary to clarify whether the patients want to leave a small amount of mobility in the forehead or block it completely.

Side Effects

Botox injections have potential side effects and complications, like any medical treatment. Discussing these risks with male patients before beginning treatment is crucial. They must fully understand what to expect, so that they can make an informed decision about their care.

The most common Botox side effects:

  • Injection site reactions. This can include pain, swelling, redness, and bruising at the injection site.
  • Headaches. Some patients may experience a headache after Botox injections, particularly in the first few days after treatment.
  • Muscle weakness. Botox works by relaxing the muscles, but sometimes, this can lead to temporary muscle weakness or drooping.
  • Dry mouth or difficulty swallowing. In rare cases, Botox injections can affect the muscles involved in swallowing, leading to dry mouth or difficulty swallowing.
  • Allergic reactions. Some patients may experience an allergic reaction to Botox, including itching, hives, and difficulty breathing.


In conclusion, Botox can be a revolutionary treatment for men wanting an enhanced, refreshed appearance. It helps reduce wrinkles, fine lines, and facial asymmetry while improving overall confidence and self-esteem. 

It is crucial to consider the unique needs of male patients when using Botox, as men’s skin is thicker; they have stronger facial muscles and want to maintain a natural-looking appearance after treatment. 

Therefore, it is essential to have an experienced practitioner carry out the procedure, discuss the treatment’s goals, and be familiar with the nuances of Botox for the male facial structure. With the right approach, men can enjoy the benefits of Botox, look and feel younger, and remain confident in their personal and professional lives.


Is Botox a good idea for men?

Botox can be a good idea for men looking to reduce wrinkles and fine lines, improve facial asymmetry, and boost their confidence and self-esteem.

Men get Botox injections because they can provide a smoother, more refreshed look by relaxing the muscles that cause these imperfections to form. Botox can also relieve medical conditions like migraines, chronic pain, and muscle spasms.

How long does Botox last in men?

The effects of Botox can last anywhere from 3 to 6 months in most people. However, some men may experience longer-lasting results, up to 8 months or more. 

At what age should men get Botox?

There is no specific age at which men should start getting Botox, and it depends on the individual’s skin and personal goals. Botox is often used to treat wrinkles and fine lines caused by repeated muscle movements, such as frowning or squinting: Therefore, men with these signs of aging who want to reduce their appearance may consider getting Botox injections.

Pretty woman receives botox and filler injections in two sides of the face to compare them

Comparing Botox and Fillers: Which Treatment is Right for Your Patients?

Botox Dermal Fillers / By  Medicadepot Editor

25 Apr

Botox and fillers are two of cosmetic medicine’s most popular non-surgical treatments for reducing signs of aging.

As a medical professional, it is crucial to understand the similarities and differences between these treatments to ensure that patients receive the best possible care.

This article will compare dermal fillers vs. Botox, exploring their uses, treatment process, and potential side effects.

What is Botox?

Sometimes patients ask: is Botox a dermal filler? The answer is: no. Botox (short for Botulinum toxin) is a neurotoxin protein produced by the bacterium Clostridium botulinum.

It is a medication commonly used for medical and cosmetic purposes, such as treating muscle spasticity, reducing wrinkles, and preventing excessive sweating.

Botox blocks nerve signals that cause muscle contractions, leading to temporary muscle paralysis. When injected into a specific muscle, it prevents that muscle from contracting; and thus reduces or prevents wrinkles, fine lines, and other signs of aging.

Botox effects typically last several months, after which the muscle function gradually returns to normal. However, the exact duration of the results may vary from patient to patient.

What Are Fillers?

Dermal fillers are gel-like products based on collagen, hyaluronic acid, or synthetic bases for filling soft tissue spaces and correcting facial skin defects. Naturally-based products retain the effect for up to a year, while synthetic-based products retain the effect for up to 3 years.

Fillers are most commonly used to combat wrinkles and scars. However, they are also excellent for correcting the face, lips, and chin shape. Fillers are usually injected with a fine needle (cannula) with minimal discomfort.

The depth of injection depends on the wrinkle depth in the treatment area. Health professionals use thicker filler injections with thicker needles for deeper wrinkles, so anesthesia is required. Sessions usually last about half an hour.

Indications: Botox vs. Dermal Fillers

Both treatments are popular and well-known in cosmetology. They may be used interchangeably, but they have different indications. Here we will discuss them.

Indications for Botox:

Botox is commonly used to treat wrinkles and fine lines caused by repeated facial expressions: it is especially effective at reducing forehead wrinkles, frown lines, and crow’s feet. In addition to its cosmetic benefits, Botox treats various medical conditions, including excessive sweating, muscle spasms, and migraines.

Indications for Fillers:

Fillers are most commonly used to restore volume to the face, particularly in areas where the skin has lost volume due to aging.

They are used to fill deep wrinkles, such as those around the mouth (nasolabial folds), and to plump up hollow areas of the face, such as the cheeks and under the eyes. In addition to their cosmetic benefits, fillers can also correct certain medical conditions, such as scars and asymmetry of the face.

Botox and fillers are both popular cosmetic treatments used to enhance facial aesthetics. However, they are used to address different concerns. Botox is primarily used to treat wrinkles caused by repeated facial expressions, while fillers are best suited for restoring volume.

Despite their various indications, there is some overlap in their use. When used together, they can achieve optimal results.

Procedure for Botox and Fillers

Step-by-step Botox injections treatment process:

1. Patient evaluation and consultation. Before the procedure, the patient must undergo a thorough evaluation and consultation to determine if they are a suitable candidate for Botox injections. The practitioner should discuss the patient’s medical history, potential contraindications, and desired effects

2. Preparation The practitioner cleanses the skin and applies topical anesthetic or ice to minimize discomfort if needed. They map out the injection sites using anatomical landmarks, ensuring the patient understands the areas they will treat.

3. Injection technique. The practitioner injects Botox into the predetermined areas using a sterile, fine-gauge needle. They must use the correct technique to avoid blood vessels while ensuring they place the Botox within the targeted muscle belly. Multiple injections are typically required to treat each area. They tailor the injection depth, and amount of Botox used to the patient’s needs.

4. Post-injection care The patient should not manipulate the treated areas and lie flat for several hours to prevent diffusing the Botox to adjacent areas. Patients should also avoid exercise and alcohol for 24 hours, preventing the risk of bruising.

Step-by-step Dermal Fillers treatment process:

• Patient evaluation and consultation. Before the procedure, the patient should undergo a thorough evaluation and consultation to determine if they are a suitable candidate for dermal fillers.

The practitioner should discuss the patient’s medical history, potential contraindications, and desired outcomes.

• Preparation. After the consultation, the practitioner preps the patient for the procedure. They cleanse the skin and apply topical anesthetic or ice to minimize discomfort if needed. The practitioner then maps out the injection sites using anatomical landmarks.

The practitioner then injects the dermal filler into the predetermined areas using a sterile, fine-gauge needle or cannula. They must use proper techniques to avoid blood vessels and ensure they place the filler within the targeted layers of the skin or subcutaneous tissue. Multiple injections are typically required to treat each area, and they tailor the injection depth and amount of filler used to the patient’s needs.

• Post-injection care. After the injections, the practitioner will advise the patient not to manipulate the treated areas and to lie flat for several hours to prevent diffusing the filler to adjacent areas. Patients should also avoid exercise and alcohol for 24 hours, preventing the risk of bruising.

• Monitoring and adjustments. The practitioner should closely monitor the patient after the procedure to ensure the desired outcome is achieved and that there are no adverse effects. Sometimes, the practitioner may need to adjust the injection sites or the amount of filler used to optimize the result.

Botox vs. Fillers: Comparison and Side Effects

The most common side effects include injection site pain, bruising, and swelling. More severe complications can occur if the toxin spreads beyond the injection site, such as drooping eyelids or difficulty swallowing. Practitioners need to be highly skilled in this procedure. They must carefully evaluate and select patients to minimize risks and side effects.

The most common side effects include injection site pain, swelling, and bruising. More severe complications can occur if they inject the filler into a blood vessel, causing tissue damage or blindness. Practitioners must use proper techniques and avoid high-risk areas to minimize risks and side effects.

Both procedures involve careful evaluation, mapping, and injection techniques to achieve optimal results while minimizing the risks and side effects of dermal fillers and Botox treatments.

Practitioners must be highly trained and skilled while continuously evaluating and adjusting their techniques. They must adequately screen and inform patients of potential risks and benefits before treatment.

Results of Botox and Fillers

Regarding the results of Botox and fillers, there are a few key factors to consider. First, it’s essential to understand that both treatments take time to show their full effect. With Botox, patients typically see results within a few days, but it can take up to two weeks to see the full effect.

Fillers, however, usually provide immediate results that continue to improve over a few days as swelling or bruising subsides.

In terms of longevity, Botox typically lasts around 3 to 4 months before the effects begin to wear off, and the patient needs to return for another treatment. Fillers can last anywhere from 6 to 18 months, depending on the specific product used and the area of the face treated.

Comparing dermal fillers and Botox injection results depends on the patient’s needs and goals. Botox is best for smoothing out wrinkles and fine lines caused by repetitive facial movements, such as crow’s feet or frown lines.

Fillers, however, are better suited for adding volume to areas of the face that have lost fullness over time, such as the cheeks or lips. Both treatments can effectively achieve a more youthful, rejuvenated appearance. Still, it’s essential to tailor the treatment plan to the specific patient to achieve the best possible results.

Patient Selection for Botox and Fillers

When selecting Botox and dermal fillers, essential factors include patient goals, medical history, and skin condition.

Botox is ideal for addressing wrinkles caused by repetitive facial movements, but not recommended for pregnant or breastfeeding patients or those with certain medical conditions.

Dermal fillers are best suited for restoring lost volume and improving skin elasticity. Health professionals do not recommend them for patients with autoimmune or bleeding disorders; or pregnant or breastfeeding patients.

Careful selection based on individual needs and goals achieves optimal results and patient satisfaction.

In conclusion, Botox and fillers are popular cosmetic treatments used to address signs of aging and improve facial appearance. However, there are essential differences between the two treatments.

One significant difference is their mechanism of action. Botox temporarily relaxes the muscles, which causes wrinkles and fine lines. Fillers add volume to the skin and plump up areas of the face that have lost fullness.

Another essential difference between Botox and fillers is the duration of the results. Botox typically lasts 3 to 4 months before the effects wear off, and the patient will need another treatment. Fillers can last anywhere from 6 to 18 months, depending on the specific product used and the area of the face treated.

Despite these differences, both procedures achieve a more youthful, rejuvenated appearance.

The final decision to choose fillers or Botox should depend on the individual patient’s needs and goals, as well as their medical history and skin condition. A consultation with a qualified provider can help determine the best course of treatment to achieve the desired results.


Is it better to get dermal filler or botox?

The choice between Botox and fillers depends on the patient’s goals. Botox treats wrinkles caused by repetitive facial movements, while fillers restore volume to areas that have lost fullness. A consultation with a qualified provider can help determine the best treatment plan for achieving the desired results.

Is filler or botox more expensive?

Fillers are ‌more expensive than Botox because they require more products. However, Botox and filler costs vary depending on the product used, the provider’s experience, and the patient’s needs. We recommend the patient discuss the price with a qualified provider to determine the most appropriate treatment plan.

Which is safer: filler or botox?

When a qualified medical professional with the proper training and experience administers Botox and fillers, one can ‌‌consider them safe. However, some potential risks and side effects associated with both treatments exist. Each treatment’s safety depends on the patient’s medical history, needs, and goals.

*Disclaimer: The contents of this article are not to be constructed as medical advice but for informational purposes only. MedicaDepot staff does not review any of these articles for medical validity. Opinions and views expressed in this article are not endorsed by MedicaDepot. Please always consult your doctor for professional medical advice.

A woman gets botox injection in forehead by doctor to explain the dosage for treatment

Botox Dosage for Forehead Treatment: How Many Units Should Be Used?

Botox Forehead / By  Medicadepot Editor

25 Apr

Disclaimer: Botox is manufactured to be used by certified professionals with special training. It can only be sold to licensed aesthetic doctors and special beauty clinics. Independent unprofessional use of Botox could harm your health.

More than a third of all botulinum therapy procedures are injections of Botox or similar drugs into the forehead. Injections in this area are performed more often than in any other part of the face or body simply because wrinkles form here earlier than anywhere else.

With so many factors to consider, including the patient’s age, skin type, and severity of wrinkles, it can be challenging to determine how many units of Botox for the forehead are needed for optimal results. However, choosing the correct dosage is crucial in achieving the desired outcome and avoiding potential complications.

What Is Botulinum Therapy?

Botulinum therapy is an injection procedure with botulinum toxin type A, aimed at reducing the visibility of wrinkles and skin folds, mainly on the face. Botulinum toxin blocks the neuromuscular transmission of nerve impulses and relaxes the muscles that have been injected. This method of correcting age wrinkles and other cosmetic defects is called Beauty Injections.

Injections are a reliable method used for 20 years in cosmetology to eliminate wrinkles and imperfections.

An accurate, immediate result, solving aesthetic and physiological problems that other injection methods cannot correct, a short period of rehabilitation, speed, and painlessness of the procedure are solid arguments for using botulinum therapy in the fight for your patients’ beauty and youth.

The high visibility of these skin folds further enhances the effect. If in some places (for example, in the corners of the eyes) wrinkles are small and visually smoothed out by eyelashes, eyes, and sometimes hair, the forehead occupies most of the face. Any skin defects here are unavoidably noticeable.

For this reason, wrinkles on the forehead often require measures to be taken even earlier than the classic Botox “interbrow area.”

Botox was the first commercially successful botulinum toxin preparation and is still, to this day, the unchanging sales leader among analogs.

Forehead Muscles and Botox

Deformation of the upper part of the face leads to a tired look, and a decrease in elasticity also affects functional capabilities. Changes associated with complex aging – atrophy of the subcutaneous tissue, skin dehydration, and muscle fiber deformation – all lead to the formation of parallel horizontal folds across the entire forehead and vertical wrinkles on the upper part of the nose bridge.

The first wrinkles can be seen before the age of 27-30. After 35, the folds are clearly visible, and the changes lead to a shift in the eyebrow line. By the age of 45-50, deep furrows form on the forehead, and swelling of the eyelids leads to drooping of the outer corners of the eyes.

Let’s take a moment to look into the anatomy of the forehead muscle, also known as the frontalis. It is responsible for unsightly horizontal lines on the forehead, and its primary function is to raise the eyebrows and skin of the forehead while opposing the depressor action of the glabella. It is the only muscle responsible for lifting in the upper third of the face.

However, injecting the forehead without simultaneously treating the frown line muscles can lead to undesirable results. If the ability of the frontalis to lift is taken away without also addressing the depressor action of the glabella, a heavy brow and hooded eyes look can easily result. Therefore, a skilled injector is cautious when treating the forehead to avoid such complications.

Botox, like any other botulinum toxin product, does not directly affect the wrinkles themselves. It does not fill them like fillers, so it does not stretch and smooth the skin (like peelings and reinforcing threads). Instead, the principle of Botox action is different: the drug denerves the muscles responsible for contraction wrinkles of the skin, which then form creases on it.

Muscle relaxation occurs due to the main effect of botulinum toxin: it disrupts the transmission of nerve impulses in neuromuscular synapses – places of contact between nerve endings and muscle cells.

Here, in the synapses, the incoming nerve impulse stimulates the release of acetylcholine, which causes the muscle fiber to contract. When botulinum toxin enters the synapse, acetylcholine ceases to be released, and the muscle does not contract, regardless of the neurons’ activity.

After the Botox injection, the forehead does NOT wrinkle during involuntary muscle contractions or even when someone tries to do it on purpose. Some unwanted effects of botulinum therapy are related to this, which will be overviewed below.

Factors Influencing Botox Dosage

Several factors influence how many units of Botox you will need to use for the forehead. Still, ultimately it boils down to the size and strength of the muscles being the most crucial.

The dosage is calculated taking into account the body’s characteristics and the skin’s type and condition: thin and dry skin requires less product than oily, and women need less than men.

Other factors influencing Botox dosage are the following:

• Sex (men tend to require more units);
• Cosmetic goals (the ultra-smooth look requires more Botox than just maintaining a complete range of facial movement);
• Metabolism (the faster it is, the more units you need to use).

Personalized Dosage Determination

A consultation must precede the Botox procedure. Ask your patient about their illnesses, intolerance to injections, allergies, and skin features: feature susceptibility to couperosis, hyperpigmentation, and scarring. During the examination, ask the patient to frown and raise eyebrows. Take pictures of the face in a frowning and relaxed state.

The average cost of Botox for the forehead varies from patient to patient, depending on how many units of the product they will need.

The muscles that cause the formation of forehead wrinkles are usually strong and can vary in length; the optimal dose may differ from person to person. While 20-units may be adequate for many people, those with longer and stronger muscles may require a higher dosage for optimal results, up to 40–50 units.

Under-dosing a muscle not only leads to unsatisfactory results but also reduces the longevity of the treatment, which should ideally last for 3–4 months. Inadequate dosing in the frown lines can also cause the muscles to remain active, leading to noticeable bulges at the muscles’ ends, which is undesirable.

Recommended Dosage Range for Forehead Botox

All drugs containing botulinum toxin are labeled with the number of units.

Unit is an amount of botulinum toxin presented in the product, not the total amount of liquid in a vial. Units of Botox aren’t equal to units of its analogs.

Why counting in units is essential? They help to understand how much active ingredient is injected in the area. Navigating by milliliters is not convenient because bottles are produced in different volumes.

Allergan has general recommendations on how much Botox for the forehead is needed: 4 Units (0.1 ml) of reconstituted Botox into each of 5 sites in the frontalis muscle intramuscularly for a total dose of 20 Units. Forehead lines should be treated in conjunction with glabellar lines (20 Units), so it is 40 Units for the whole procedure.

Post-Injection Recovery and Efficacy

After botulinum therapy, the patient must avoid touching the injection sites, kneading or massaging the area, or applying decorative cosmetics. To consolidate the effect and prevent unwanted consequences, it is also necessary to:

• 4 hours – stay in a vertical position;
• 24 hours – not sleep face down;
• 14–15 days – refrain from visiting saunas, swimming pools and taking hot baths;
• Two weeks – avoid face massage;
• Seven days – not consume alcoholic beverages.

Common Side Effects

If the injection is done correctly and with the proper dosage, there should be no complications. But individual reactions can arise.

The most common complications include hematomas, drooping eyebrows, and swelling. The reason may be due to incorrectly chosen injection points, an incorrect number of Botox units for the forehead, and failure to follow the doctor’s recommendations after the procedure.

Also, the patient may temporarily experience dizziness, headache, and general malaise, which usually passes within a few days. An allergic reaction may also occur.

With an overdose of the drug, the patient may experience facial asymmetry associated with uneven muscle numbness.

When a large dose is administered, it could lead to anaphylactic shock.

Timeline for Onset and Duration of Efficacy

In general, patients can see the effects of Botox in 3 to 4 days after injection. Most Botox therapy patients will see results within 10 to 14 days. Still, they should wait two weeks for maximum results; the effect lasts 3–6 months after treatment.

To determine how long the effect of injected Botox for forehead wrinkles will last, the medical professional must study the patient’s lifestyle – do they play sports, go to the sauna, how old they are, do they have an intensive metabolism, and so on.

The effect won’t last as long if all these factors are present. However, the result will last slightly longer for older patients – with a less active metabolism and neuromuscular transmission, which slowly recovers.

Tips for Optimizing Forehead Botox Treatment Outcomes and Minimizing Adverse Effects

To optimize Botox’s effect, recommend the following to your patients:

• Avoiding sun damage;
• Low-intensity workouts;
• Reducing stress levels;
Moisturizing skin;
• Avoiding nicotine;
• Taking a Zinc supplement.

Similar Products to Consider

The second most popular product is Dysport. One unit is about 2.5 times weaker than one unit of Botox but also simultaneously cheaper. So, the cost of regular treatment of these toxins is the same for the patient. Xeomin, Neuronox, and other products are identical in effect to Botox, but each has its peculiarities.

For example, Xeomin is cleaner and safer but also more expensive. Therefore, when choosing a specific drug, the cosmetologist evaluates its properties and the specifics of a particular patient and uses the product that will be most effective at maximum safety.


So, we know that the standard dosage of Botox for the forehead is 20 units. Still, this procedure can require 10 to 50 units depending on the severity of your patient’s wrinkles and other factors.

It is essential to remember that some patients fall outside the general parameters of standard Botox dosing. Therefore, preparing individualized treatment plans and proper dosing is crucial in Botox treatment.


How long does Botox last on the forehead?

Injections of Botox in the forehead last for approximately four months.

The traditional Botox schedule to treat the forehead calls for new injections every 3–4 months. But studies show that less frequent Botox injections can achieve a good result after two years of treatment.

Are 20 units of Botox enough for the forehead?

Allergan suggests the following dosage of forehead Botox injections: 4 units each in five sites on the forehead, totaling 20 units.


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2. Abramo AC. Muscle Insertion and Strength of the Muscle Contraction as Guidelines to Enhance Duration of the Botulinum Toxin Effect in the Upper Face. Aesthetic Plast Surg. 2018 Oct;42(5):1379-1387. doi: 10.1007/s00266-018-1157-3. Epub 2018 Jul 9. PMID: 29987485.

3. Abramo AC, Do Amaral TP, Lessio BP, De Lima GA. Anatomy of Forehead, Glabellar, Nasal and Orbital Muscles, and Their Correlation with Distinctive Patterns of Skin Lines on the Upper Third of the Face: Reviewing Concepts. Aesthetic Plast Surg. 2016 Dec;40(6):962-971. doi: 10.1007/s00266-016-0712-z. Epub 2016 Oct 14. PMID: 27743084.

4. Min P, Zhang Z, Grassetti L, Perdanasari AT, Torresetti M, Pu Z, Zhang Y, Han S, Marsili R, Zhang YX, di Benedetto G, Lazzeri D. Alteration of Skin Mechanical Properties in Patients Undergoing Botulinum Toxin Type A Injections of Forehead Rhytides. Aesthetic Plast Surg. 2016 Jun;40(3):410-20. doi: 10.1007/s00266-016-0629-6. Epub 2016 Mar 4. PMID: 26944891.

5. Jia Z, Lu H, Yang X, Jin X, Wu R, Zhao J, Chen L, Qi Z. Adverse Events of Botulinum Toxin Type A in Facial Rejuvenation: A Systematic Review and Meta-Analysis. Aesthetic Plast Surg. 2016 Oct;40(5):769-77. doi: 10.1007/s00266-016-0682-1. Epub 2016 Aug 5. PMID: 27495260.

*Disclaimer: The contents of this article are not to be constructed as medical advice but for informational purposes only. MedicaDepot staff does not review any of these articles for medical validity. Opinions and views expressed in this article are not endorsed by MedicaDepot. Please always consult your doctor for professional medical advice.

A pretty redhead woman explains How Long Botox Last

How Long Does Botox Last?

Botox / By  Medical Community

10 Sep

Botox is an undeniably effective treatment for facial wrinkles, folds, and lines. It has been proven to significantly reduce the formation of new lines and wrinkles become with sustained injections.

In addition, Botox has several long-term effects that contribute to the overall self-satisfaction by patients who choose to undergo this treatment.

It is important to gauge how long Botox lasts to prepare for how often maintenance treatments are necessary, to preserve and extend its effects.

What is Botox?

Botox is a brand of neurotoxin injectable used to reduce signs of aging by inhibiting and suspending targeted muscles from contracting and forming lines, wrinkles, and folds. It is also known as Onobotulinum toxin A, derived from the neurotoxin Clostridium botulinum.

Despite being dubbed as the deadliest toxin in the world, this particular type of botulinum toxin has numerous medical and scientific applications. In 2002, it was approved by the Food and Drug Administration to be a safe, minimally invasive procedure to address moderate to severe frown lines in adults.

It is used to minimize the appearance of frown lines, eliminate horizontal forehead creases, relax the lines around the eyes (crow ’s feet), lift the lines at the corners of the mouth and smoothen out glabellar lines.

How Does Botox Work?

Once injected deep under the skin, the active ingredient in Botox blocks a signal from the nerves of the targeted facial muscles. The absence of this signal prevents these muscles from contracting, which results in a relaxed, softened state of the paralyzed muscles. What were once lines and creases formed from the duress of everyday expressions gradually disappear.

Botox takes several days to fully exhibit its effects because it takes time for the treatment to take over the process of nerves and muscles coordinating to contract muscles to express facial expressions. Botox silences the particular chemical messenger called acetylcholine which is responsible for signaling the muscles to move and contract according to the facial expressions expressed by the individual.

How Long Does Botox Last?

It generally takes three to five days to notice the effects of Botox injections, but it takes ten to fourteen days to see and feel the full effects of the treatment. By this time, the skin fully projects a naturally-looking, youthful appearance free of fine lines and wrinkles.

Botox lasts for an estimate of three to six months before it gets safely disposed by the body. Its actual duration on the skin depends on the size of the dosage and area targeted. The higher the dose, the longer the effects last.

After this period, muscle action may resume and lines and wrinkles can begin to reappear once more. However, the facial muscles gradually shrink and fewer wrinkles reappear with every repeat treatment. After months of muscles at a relaxed state, Botox makes the body aware of how much muscles it takes to make every movement. The body responds to this by easing into less movement in the forehead and smile lines.

Long-term use of Botox also causes the muscles to weaken from lessened muscle activity, therefore shrinking and having a less prominent appearance. This may lead to needing less Botox over time. The most important long-term effect of Botox with continued use without interruption is looking years younger naturally.

How much does Botox cost?

Botox treatments are priced per the number of units used, but some clinics may price it per target area. Depending on the healthcare provider, one unit of Botox is priced around $10 – $15. A typical forehead treatment that uses 20 units may cause around $200 – $300. Other treatments can also include brow and neck lifts, jaw slimming and many others to name a few, all with different costs.

To have a more comprehensive assessment of the onset, duration, and costs, it is best to schedule with a licensed healthcare provider for a consultation on what to expect when undertaking Botox injections.

a curly-hair woman shows the sign OK because she understood the Similarities and Differences between Botox vs Dysport

Botox vs Dysport: Similarities and Differences Reviewed

Botox / By  Medical Community

09 Jul

Both Dysport and Botox Contain Botulinum Toxin

In 2009, a new competitor for Botox was approved for the US market, under the brand Dysport (abobotulinumtoxinA). Like Botox, Dysport is a botulinum toxin treatment indicated for wrinkle correction as well as certain movement disorders like spasticity and cervical dystonia. However, these two botulinum neurotoxin preparations were manufactured and purified via distinct, proprietary manufacturing processes. As such, Dysport and Botox have different properties in terms of duration of results, diffusion, adverse event profile, and potency.

Botox (onabotulinumtoxin a) is primarily known as a cosmetic injectable that treats wrinkles like glabellar lines; however, it has many more therapeutic uses. As a neurotoxin, it causes chemical denervation in cholinergic neurons, thus impacting signal transmission between these nerves to other cells. It is for this reason that Botox has many therapeutic applications. For instance, Botox is indicated in the treatment of various neuromuscular disorders like cervical dystonia and blepharospasm, and recently has been implicated in conditions associated with pain, like chronic migraines, and urologic conditions affecting bladder control, like overactive bladder. Botox has immense therapeutic benefits for patients from a wide spectrum of neurological disorders.

Differences Between Botox and Dysport Preparations

As stated previously, both products are very similar; they are both type A botulinum toxins with similar modes of action and established safety profiles. However, studies examining the composition of these 2 preparations have demonstrated notable differences in the structure of the active substrates. Botulinum toxin type A exists in nature as a 150-kDa protein surrounded by nontoxic, accessory proteins. These accessory proteins, together with the toxin, form complexes as a way to confer stability and prevent degradation. This difference in composition has striking effects on each preparation’s clinical activity and adverse event profile via its impact on diffusion potential.

Differences in Dosing for Botox and Dysport

It is well-established in the literature and through clinical use that these two preparations do not have the same bioactivity and are not bioequivalent to each other. In other words, one unit of Botox is not the same as one unit of Dysport. Various clinical studies have been conducted to elucidate the clinical equivalence of the two formulations for various indications. For these cases, Dysport-Botox ratios used ranged from 3:1 to 6:1 and for the most part, produced similar results to each other in the patients. The dose equivalency ratio of botulinum toxin preparations like Botox and Dysport is an issue that is still being debated on and studied to date.

A study on the actual doses used in clinical settings for cervical dystonia and blepharospasm determined that Dysport to Botox ratios used in clinical practice ranged from a low of 2:1 to a high of 11:1. As well, 31% of patients fell into the Dysport-to-Botox group of 5:1 to less than 6:1, while 30% of patients were in the Dysport-to-Botox group of 4:1 to less than 5:1, and 21% of patients studied were treated with a Dysport-to-Botox dose ratio between 3:1 to less than 4:1. Taken together, this data suggests that a consensus for an empirically-derived ratio that will deliver consistent, reliable effects has not been reached currently, which further implies that a simple conversion factor does not exist.

Dysport Diffuses More Than Botox

The physical characteristics of the neurotoxins differ as well. Practitioners have noted the tendency of Dysport to diffuse, or spread more easily, than Botox. In a published study by Ranoux et al., the authors noted an increase in side effects with Dysport, and posited that the cause behind the increased adverse event profile may be associated with the higher diffusion rate Dysport has compared with Botox. This was further evidenced in a study by Nüβgens and Roggenkämper, which resulted in a similar enhanced adverse event profile with Dysport in the form of a significant increase in occurrence of ptosis.

With the previously mentioned study, this was suggested to be due to the difference in diffusibility of the 2 preparations. In a review by de Almeida and de Boulle, it was suggested, from an analysis of studies examining the diffusion characteristics of neurotoxin properties including Dysport and Botox, that Botox appeared to diffuse less than Dysport. Differences in diffusion has its own advantages and disadvantages, and will perform differently in different applications. Some practitioners find the increased diffusion rate of Dysport useful when treating larger areas, like in men or in the forehead, while Botox is considered better for situations where precision in placement is important.

In conclusion, various clinical studies with head-to-head comparisons of Botox with Dysport have found significant differences in their composition, which further translated to application differences like diffusion potential, potencies, adverse event profile, and duration of effect. Aesthetic practitioners should always keep in mind the non-bioequivalency of these two preparations it prohibits dose-conversion between each other.

a pregnant woman explains What studies say about Botox and Pregnancy

Botox and Pregnancy: What do studies say? Review

Botox / By  Medical Community

19 Jul

There are various aspects of interest when discussing the use of Botox on pregnant women. For example, would ongoing Botox treatments on the mother have a negative effect on the fetus? Could it cause a miscarriage or malformation to her baby?. Other interesting questions would happen after giving birth to the child and can often refer to breastfeeding. In this article, we’ll review what studies have found in situations where pregnant women have continuously received Botox injections and other studies involving animal tests.

Women of childbearing age often use Botox

Because Botox is a cosmetic treatment, the majority of patients who receive Botox injections are women of childbearing age. Additionally, many patients receive Botox injections regularly to alleviate symptoms associated with medical conditions. Given the high frequency of Botox use among fertile women, it is therefore important that safety of Botox use during pregnancy be established, as many patients in the early stages of pregnancy may not be aware that they are pregnant at the time of treatment.

What does Allergan say about using Botox on pregnant women?

In the patient label for Botox, it is stated that to date, no adequate data or studies are present on the likelihood of developmental risks, birth defects and miscarriage associated with use of Botox in pregnant women. However, it was shown in a study involving rabbits that daily doses of Botox in days 8–18 of pregnancy resulted in abortions, fetal malformations, and maternal toxicity. The mechanism by which this occurred is not known, but further animal studies suggest that botulinum toxin does not cross the placenta, possibly because of its large size. In one study involving pregnant rabbits, no measurable levels of botulinum toxin were present in the placenta or foetuses of mothers given a highly lethal intravenous dose.

A study found comparable results between pregnant women using Botox and not using Botox

The most recent and comprehensive study on pregnancy outcomes following Botox exposure was done in 2015 by Brin et al. In this retrospective study, the authors analysed pregnancy outcome data culled from the Allergan Global Safety Database collected over a 24-year period (1990–2013) and compared the rate of fetal defects in mothers exposed to Botox with background rates in the general population. Of the 110 live births included in this study, 106 or 96.4% of them resulted in normal births, while four had abnormal birth outcomes, consisting of one major fetal defect, one birth complication, and two minor fetal malformations. The resultant prevalence rate for overall fetal defects, 2.7%, was found to be comparable to rates found in the general population (2–4%). The authors concluded that the rates of abnormal pregnancy outcomes in pregnant women who received Botox treatment were similar to background rates in the general population. In addition, the study did not identify any new safety concerns, nor did they observe any consistent organ malformations.

No association found between fetal harm or to mother using Botox while pregnant another survey found

A preliminary survey done by Morgan et al. in 2006 asked physicians if they had injected pregnant women with Botox, as well as their comfort level with administering Botox to pregnant women. Of the 900 physicians surveyed, 12 out of the 396 physicians who responded reported injecting a total of 16 expecting women with botulinum toxin. While the data was limited (16 pregnant women), it seemed to indicate that the treatment appears to be quite safe for both expectant mother and fetus as no definite qualitative association of fetal harm with the mother receiving Botox injections was discovered.

Women used Botox for cervical dystonia while pregnant four times without harm to babies

Case reports in the literature are scarce; in 2004 Newman et al. described the clinical use and outcomes of a patient who underwent regular Botox treatment for idiopathic cervical dystonia. Due to the severity of her condition, and after assessing the risk and benefits of Botox treatment, the 26-year old patient, with the input of her neonatal neurologist and obstetrician, was recommended to continue with Botox injections even after it was discovered that she was pregnant with her first child. This patient continued receiving Botox treatment through four pregnancies that were carried to full-term with seemingly no complications. The authors also report that there were no indications of any developmental delays in the children.

Women using Botox for facial wrinkles gave birth to unharmed children

In 2007, Monteiro describes the two cases of patients receiving Botox treatment for facial wrinkle correction while pregnant; both were injected in their first trimester and did not experience any complications or adverse effects pertaining to the pregnancy and fetuses.


Because pregnant women with illnesses need safe and effective treatment, determination of safety of a medication during pregnancy is crucial. However, due to the ethical challenges of including pregnant women in clinical trials, research in this special population is sadly lacking.

Can I get botox when pregnant?

There is not enough evidence to say definitively yes or no, the data taken collectively from retrospective and animal studies, surveys of physicians who use Botox to treat patients, and case reports strongly suggest that Botox, if used as recommended, does not impact the fetus of the expecting patient. However, many practitioners practice a “better to be safe than sorry” method, advising their patients not to have Botox injections while they are pregnant unless absolutely necessary. To further establish the safety of Botox use during pregnancy, additional research is warranted.

What makes Botox so popular?

Botox (onabotulinumtoxin A ) is chiefly known as a cosmetic injectable that treats wrinkles; however, its medical uses extend beyond the aesthetic realm. As a neurotoxin, it impacts signal transmission between cholinergic neurons to other cells, and it is for this reason that Botox has many therapeutic applications. For example, Botox is indicated in the treatment of various neuromuscular disorders like cervical dystonia and blepharospasm, and recently has been implicated in conditions associated with pain, such as chronic migraine, and urologic conditions affecting bladder control, like overactive bladder. Botox has helped patients with a wide spectrum of neurological disorders in improving their symptoms.