EVENITY

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About EVENITY Medication

Evenity (romosozumab-aqqg) is a prescription injectable medication indicated for the treatment of osteoporosis in postmenopausal women at high risk for fracture. It works as a sclerostin inhibitor, both stimulating new bone formation and decreasing bone resorption, leading to a rapid increase in bone mineral density (BMD). Doctors may choose to prescribe Evenity for patients who have experienced osteoporotic fractures, are intolerant to other osteoporosis treatments, or have failed to respond adequately to prior therapies.

The treatment is typically administered by a healthcare professional as two subcutaneous injections once a month for 12 months. After completing the course, patients are usually transitioned to antiresorptive therapy to maintain the gains in bone strength.

Evenity osteoporosis therapy is covered under certain Medicare and insurance plans, and patients should consult their provider for information on eligibility and cost assistance programs.

Key Benefits of EVENITY

Clinical studies have demonstrated that Evenity delivers significant benefits for postmenopausal women with osteoporosis.

In randomized, controlled trials, the medication reduced fracture risk and improved BMD within the first year, with additional benefits when followed by antiresorptive therapy. Key findings include:

• 73–75% relative risk reduction in new vertebral fractures at 12–24 months compared to placebo.
• 50% relative risk reduction in vertebral fractures compared with alendronate at 24 months.
• 8.7% lumbar spine BMD gain vs. alendronate at month 12.
• Increased trabecular and cortical bone mass, leading to improved bone structure and strength.
• Histological analysis confirmed normal bone quality with no mineralization defects.

These results highlight Evenity’s dual mechanism of action and its value in rapidly improving skeletal strength. With proper treatment planning, patient monitoring, and post-therapy maintenance, healthcare providers can help patients achieve long-term fracture risk reduction and improved bone health.

When to Prescribe EVENITY: Clinical Indications

Evenity is a targeted medication designed for the treatment of postmenopausal women with osteoporosis who are at high risk for fracture. Doctors and other qualified healthcare providers may consider osteoporosis Evenity therapy for patients who meet one or more of the following clinical criteria:

• History of osteoporotic fracture: This includes vertebral, hip, or wrist fractures caused by low bone density.
• Multiple risk factors for fracture: These include advanced age, low body mass index, history of smoking, family history of osteoporosis, or chronic glucocorticoid use.
• Failure or intolerance to other osteoporosis therapies: Patients who have not achieved adequate results or have experienced adverse effects from other medications.

Evenity works by stimulating bone formation and reducing bone resorption, making it an important part of the treatment plan for certain high-risk individuals. This type of dual-action therapy can help reduce fracture risk significantly within a short timeframe.

Limitations of use:

The use of Evenity is restricted to 12 consecutive monthly doses due to a reduction in its anabolic effect beyond this period. After completing the 12-month regimen, patients should transition to an antiresorptive agent to maintain bone density gains and reduce fracture risk. This step is critical to sustaining the benefits of the medication and supporting long-term bone health.

Healthcare providers should inform patients about the importance of completing the recommended course and following up with appropriate maintenance therapy.

Clear information about the expected results, potential risks, and necessary follow-up treatments should be discussed before initiating therapy.

Contraindications of EVENITY

Evenity should not be prescribed in the following cases:

• Patients with hypocalcemia: Low calcium levels should be corrected before starting treatment.
• Patients with a history of myocardial infarction or stroke: This is due to a potential increase in cardiovascular risk during therapy.
• Known hypersensitivity to romosozumab-aqqg or any component of the medication: Hypersensitivity reactions can include rash, urticaria, and angioedema.

Before initiating osteoporosis Evenity therapy, the doctor should assess each patient’s complete medical history and cardiovascular status. In addition, baseline laboratory tests, including serum calcium, should be performed.

A detailed risk–benefit discussion ensures that patients are fully informed and prepared for treatment.

EVENITY Ingredients

EVENITY® Ingredients
Each Evenity injection is supplied in a prefilled syringe containing a sterile, preservative-free solution that ranges from colorless to light yellow. The medication has been formulated to deliver both efficacy and safety for postmenopausal women with osteoporosis at high risk for fracture.

• Active ingredient: Romosozumab-aqqg – 105 mg/1.17 mL

Excipients:

• Acetate: 3.8 mg
• Calcium: 0.61 mg
• Polysorbate 20: 0.07 mg
• Sucrose: 70 mg
• Sodium hydroxide: To adjust pH to 5.2
• Water for injection: Sterile, used as the base solution

These carefully measured components ensure that patients receive the correct amount of active therapy with every administration. Evenity works as a targeted anti-sclerostin therapy, supporting bone formation while decreasing bone resorption.

Dosage and Administration of EVENITY

Evenity is a prescription medication for the treatment of osteoporosis in postmenopausal women at high risk for fracture. A qualified healthcare professional must administer the drug Evenity in a controlled medical setting to ensure proper dosing and patient safety.

• Recommended dose: 210 mg subcutaneously once a month for 12 months
• Injection sites: Abdomen, thigh, or outer upper arm
• Injection volume: 1.17 mL per syringe – administer two syringes per monthly dose

Pre-administration preparation:

• Allow syringes to reach room temperature for at least 30 minutes
• Do not shake, freeze, or expose to light
• Nutritional supplementation: Ensure adequate calcium and vitamin D intake throughout treatment to support bone health

Missed doses should be rescheduled promptly, with future doses given at monthly intervals. Timely administration is critical to maintaining the therapeutic effect of this osteoporosis therapy.

Treatment Planning and Patient Considerations

An effective plan for Evenity therapy involves coordination between the prescribing doctor and the patient to ensure adherence over the full 12-month period. Since the anabolic effect of Evenity medication diminishes after a year, therapy is typically followed by an antiresorptive agent to help maintain bone density gains.

Patients should be informed about potential rare risks such as ONJ (osteonecrosis of the jaw) and instructed to maintain good oral hygiene during treatment. Any dental procedures should be discussed with the healthcare provider before starting or while receiving Evenity.

Following the recommended dosing schedule and support measures maximizes the benefits of this drug Evenity while helping protect long-term bone health.

Proper Storage Conditions for EVENITY

Proper storage is essential to maintain the stability, sterility, and effectiveness of Evenity throughout its treatment duration.

• Always store Evenity in its original carton to protect it from light.
• Keep it refrigerated at 2°C to 8°C (36°F to 46°F), and never freeze or shake the prefilled syringes.
• For short-term handling, the medication may be kept at room temperature (up to 25°C / 77°F) for no longer than 30 days.

Once Evenity has been stored outside refrigeration for over 30 days, it should be discarded to ensure patient health and safety. Discard any unused product according to medical waste regulations.

Following these storage recommendations helps preserve the integrity of the drug and supports optimal therapeutic outcomes in osteoporosis treatment.

EVENITY Side Effects

In clinical studies, Evenity was generally well tolerated; however, patients and healthcare providers should be aware of potential side effects and risk factors.

Common adverse reactions (≥5%) include:

• Arthralgia (13.1%)
• Headache (6.6%)
• Injection site reactions (4.9%)

Less frequent events include muscle spasms, edema, and paresthesia.

More serious but rare side effects have also been reported:

• Myocardial infarction and stroke: Elevated risk of major adverse cardiac events (MACE) observed in trials
• Hypocalcemia: Particularly in patients with kidney impairment; monitor calcium levels and supplement when needed
• Osteonecrosis of the jaw (ONJ): Rare, associated with dental surgery, poor oral hygiene, or concurrent use of antiresorptive drugs
• Atypical femoral fractures: Monitor for thigh, hip, or groin pain
• Hypersensitivity reactions: Including angioedema, urticaria, and dermatitis

Healthcare providers should carefully review patient information before initiating treatment to weigh potential benefits against risks, especially in individuals with pre-existing cardiovascular conditions or other significant health concerns.

FAQs About EVENITY®

• How does EVENITY® work?

Evenity contains romosozumab, which works by inhibiting sclerostin—a regulatory protein that affects bone metabolism. By blocking sclerostin, Evenity simultaneously increases bone formation and reduces bone resorption, helping patients with osteoporosis improve bone mineral density (BMD) and reduce fracture risk during the treatment duration.

• What happens after 12 months of treatment?

The recommended duration for Evenity treatment is 12 monthly doses. After completing the course, discontinue Evenity and transition the patient to an antiresorptive agent such as alendronate. This step is critical to maintain the BMD gains achieved during treatment and prevent future bone loss.

• Can EVENITY® be used in patients with cardiovascular risk factors?

Exercise caution when prescribing Evenity to patients with cardiovascular risk factors. Do not initiate treatment in individuals who have experienced a recent myocardial infarction (MI) or stroke within the past 12 months. Closely monitor patients with other health risks to ensure safe and effective treatment outcomes.

• Is EVENITY® appropriate for patients with renal impairment?

No dose adjustment is necessary for Evenity in patients with mild to moderate kidney impairment. However, those with eGFR 15–29 mL/min/1.73 m² or on dialysis may have an increased risk of hypocalcemia. Healthcare providers should monitor serum calcium levels and provide supplementation as needed.

• How quickly does EVENITY® improve bone density?

In clinical studies, Evenity showed rapid and significant BMD improvements:

• 12.7% increase in lumbar spine BMD after 12 months (Study 1)
• 8.7% greater lumbar spine BMD gain compared to alendronate after 12 months (Study 2)

These results highlight the effectiveness of Evenity treatment in improving bone strength and reducing fracture risk in osteoporosis patients.

Where to Buy EVENITY Online

Evenity is a prescription-only biologic therapy approved by the U.S. Food and Drug Administration (FDA) for the treatment of osteoporosis in postmenopausal women at high risk for fracture. Healthcare providers can order Evenity through authorized specialty distributors and licensed pharmacies.

When purchasing online, it is important to ensure you are obtaining Evenity products from legitimate and trusted suppliers to guarantee product authenticity and safety.

Patients seeking affordability Evenity options should discuss coverage and out-of-pocket costs with their healthcare provider and insurance company. Many insurance plans may help pay for the costs of Evenity, and certain assistance programs may reduce pocket costs for eligible patients. Always confirm storage, handling, and shipping conditions to preserve medication quality.

Order EVENITY At Medica Depot

You can order Evenity securely from Medica Depot, a trusted supplier of FDA-approved prescription medications for licensed healthcare professionals. Medica Depot provides a reliable online ordering process and offers free shipping on eligible purchases, ensuring timely delivery of temperature-sensitive Evenity products.

Our customer service team is available to assist with purchase requests, clarify coverage questions, and provide guidance on affordability Evenity options.

Ordering from Medica Depot allows healthcare professionals to manage costs effectively by taking advantage of competitive pricing and bulk purchase discounts. This ensures consistent supply for patient treatment plans while maintaining quality and safety standards.

By sourcing from a reputable distributor, providers can confidently order Evenity knowing they are receiving authentic products that meet strict regulatory requirements.