NUCLEOFILL™ MEDIUM

NUCLEOFILL™ MEDIUM Product Summary

NUCLEOFILL™ MEDIUM is a bio-restructuring injectable gel formulated with natural polynucleotides. It is specifically designed to provide hydration, anti-aging benefits, and skin rejuvenation for mild to moderate signs of aging. The product offers biostimulation at the dermal level, enhancing skin quality and elasticity.

• Formulation: Polynucleotide-based gel with high viscosity.
• Packaging: Pre-filled syringe (1.5 mL) with 30G needles included.
• pH: 6.8–7.2 for physiological compatibility.

NUCLEOFILL™ MEDIUM Key Features and Benefits

NUCLEOFILL™ MEDIUM provides a holistic approach to skin rejuvenation by addressing hydration, antioxidant protection, and fibroblast stimulation.

• Hydration: Retains water molecules, offering deep and long-lasting hydration.
• Antioxidant Protection: Neutralizes free radicals, reducing oxidative stress at the cellular level.
• Fibroblast Activation: Stimulates collagen Type I production, improving skin texture and elasticity.
• Bio-Lifting Effect: Provides a subtle lifting effect through myofibroblast activation.
• Skin Renewal: Promotes autologous tissue regeneration for a healthier dermal matrix.

NUCLEOFILL™ MEDIUM Composition

The advanced formulation ensures effective hydration and anti-aging action.

• Polynucleotide Concentration: 2%.
• Molecular Weight: 2,500 kDa for optimal dermal bioavailability.
• Viscosity: 28–43 Pa*s, allowing precise application and integration into tissues.

NUCLEOFILL™ MEDIUM Intended Purpose / Indications

This product is ideal for the prevention and treatment of early signs of aging and skin damage.

• Primary Indications:
  • Hydration and bio-restructuring of the dermis.
  • Prevention of mild wrinkles and fine lines.
  • Treatment of small atrophic scars, such as acne scars.
• Targeted Areas: Recommended for the face, neck, décolleté, and hands.

NUCLEOFILL™ MEDIUM Injection and Treatment Areas

NUCLEOFILL™ MEDIUM is suitable for various treatment zones to achieve optimal biorestructuring.

• Injection Areas:
  • Face: Cheeks, nasolabial folds, and under-eye area.
  • Neck and décolleté: To improve elasticity and hydration.
  • Hands: For skin rejuvenation and reduction of fine lines.
• Injection Depth: Dermis or subcutaneous layer, depending on the treatment goals.

NUCLEOFILL™ MEDIUM Reconstitution and Preparation Guidelines

The product is pre-filled and ready for immediate use without requiring additional preparation.

• Preparation Steps:
  • Open the sterile packaging under aseptic conditions.
  • Attach the included 30G needle securely to the syringe.
  • Expel any air bubbles before beginning the injection.

NUCLEOFILL™ MEDIUM Administration and Dosage

Proper administration techniques ensure effective results and patient safety.

• Injection Techniques:
  • Utilize a multi-puncture or linear threading technique.
  • Apply 0.1 mL per injection point at a spacing of 1 cm.
• Dosage:
  • Administer 1.5 mL per session, with adjustments based on the treatment area.

NUCLEOFILL™ MEDIUM Storage Instructions

Correct storage practices maintain product quality and efficacy.

• Store between 2–30°C in a dry, cool environment.
• Protect from direct sunlight and freezing temperatures.
• Ensure use before the expiration date printed on the packaging.

NUCLEOFILL™ MEDIUM Contraindications

The product should not be used in specific cases to avoid complications.

• Do Not Use:
  • In patients allergic to polynucleotides or any component of the formulation.
  • On areas with active infections, inflammation, or lesions.
  • In pregnant or breastfeeding individuals.
  • In patients with autoimmune disorders or severe chronic illnesses.

NUCLEOFILL™ MEDIUM Precautions and Warnings

Adherence to safety guidelines ensures successful treatment outcomes.

• Avoid injecting into vascular areas to prevent intravascular complications.
• Do not combine with other fillers or aesthetic procedures in the same session.
• Ensure thorough patient consultation regarding medical history and allergies.

NUCLEOFILL™ MEDIUM Post-Treatment Care

Following post-treatment guidelines maximizes results and reduces recovery time.

• Recommendations:
  • Avoid makeup and skincare products for 12 hours post-procedure.
  • Protect the treated area from UV exposure and extreme temperatures for 48 hours.
  • Use a gentle moisturizer and SPF 50 sunscreen daily.

NUCLEOFILL™ MEDIUM Side Effects and Adverse Reactions

NUCLEOFILL™ MEDIUM is generally well-tolerated, with mild and temporary side effects.

• Common Side Effects:
  • Redness, swelling, or bruising at the injection site.
  • Temporary tenderness or itching.
• Rare Reactions:
  • Hypersensitivity or granuloma formation.

NUCLEOFILL™ MEDIUM Patient Eligibility

This product is suitable for adults seeking minimally invasive rejuvenation.

• Ideal Candidates:
  • Individuals with mild to moderate skin aging signs.
  • Patients with dehydrated or stressed skin.
• Not recommended for individuals under 18 years or with unrealistic expectations.

NUCLEOFILL™ MEDIUM Follow-Up and Maintenance

Regular treatments sustain results and improve long-term skin quality.

• Treatment Protocol:
  • Initial sessions: Three treatments spaced 2–3 weeks apart.
  • Maintenance: One session every 4–6 months.

NUCLEOFILL™ MEDIUM Manufacturer and Regulatory Information

NUCLEOFILL™ MEDIUM is manufactured under stringent safety and quality standards.

• Manufacturer: Biosimil Aesthetics.
• Certifications: CE-marked for safety and efficacy.