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Treatment for osteoarthritis
$119.00 / pack
(you save $0)
Quantity Our Price
1 - 5 pack(s) $119.00 USD
6 - 10 pack(s) $114.00 USD
11 - 20 pack(s) $109.00 USD
21+ pack(s) USD$107.00 107.00USD
Manufacturer: BioPolymer
Active Substance(s) : Sodium hyaluronate, lidocaine
Strength: 14mg/ml, 3mg/ml
Pack Size: 1-2ml prefilled syringe
Accessories: Package insert, 4 traceability labels

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Crespine Gel+ is a single, intra-articular injection of cross-linked and non-crosslinked sodium hyaluronate, used to treat symptoms of osteoarthritis. The sodium hyaluronate is non-animal and ultra-pure. Crespine Gel+ is indicated as a viscoelastic supplement or a replacement for synovial fluid in human joints. Crespine Gel+ offers the knee, hip, or other joint lubrication and mechanical support to relieve symptoms such as point pain. This product is for single-patient use only and must not be re-sterilized. Only qualified medical practitioners trained in injection techniques should administer Crespine Gel+.

Where can I buy this product?

You can order Crespine Gel+ online from or you can phone our friendly customer service associates to order this and other medical supplies. When you order Crespine Gel+ from Medica Depot, you can help your patients relieve their osteoarthritis symptoms for more comfortable movement.

What does this product come with?

  • 1-2.0ml prefilled syringe
  • Packaging insert
  • 4 traceability labels

What are the benefits of this product?

Crespine Gel+ is a viscosupplement injectable containing both crosslinked and non-crosslinked sodium hyaluronate from a non-animal origin. This intra-articular implant is a highly pure, viscous gel that can help lubricate and cushion joints affected by osteoarthritis. The gel also contains prilocaine, an anesthetic that helps make treatment more comfortable.

How does this product work?

Crespine Gel+ is a viscous gel, similar to the synovial fluid found naturally in joints. The gel forms a layer on the surface of the cartilage, helping to lubricate the joint and cushion the joint with movement. This helps reduce the painful grinding of cartilage within the joint, helping reduce osteoarthritis pain and making movement easier for the patient. The prilocaine within the gel is an anesthetic that can help relieve pain, making the injections more comfortable.

What are the ingredients?

Sodium hyaluronate, crosslinked 14.0mg; sodium hyaluronate 1.0mg; prilocaine 3.0mg.

Use Instructions

How to inject this product

Only qualified medical professionals should administer Crespine Gel+. To use Crespine Gel+, first take a full medical history, advise your patient of precautions and possible adverse effects, and use an antiseptic to prepare the treatment area. Remove the syringe from its package, remove the cap covering the syringe tip, and attach a needle to the syringe. Before injecting the gel, minimize the chance of intravascular injection by performing aspiration first. If blood is present, reposition the needle. The absence of blood does not guarantee the injection is not into a blood vessel. Inject Crespine Gel+ intraarticularly, into the synovial cavity of the affected joint. The injection technique is important to the outcome of a Crespine Gel+ treatment. You can treat both knees and other joints, such as the hip, at the same time.

When should I use this product?

This viscosupplement is administered in a single dose, single injection treatment that takes 10–20 minutes to administer.

What areas can I treat with this product?

Crespine Gel+ is indicated for treatment of the knee, the hip, or other joints affected by osteoarthritis.

How long do results last?

The results of a Crespine Gel+ treatment, involving a single injection, usually last about 6 to 8 months, so you will likely repeat these treatments about every 8 to ten months to maintain the results. Your patients will likely start to feel pain relief about 5 to 7 days after the treatment.

Frequently Asked Questions

Who is an ideal candidate for this product?

Crespine Gel+ is ideally used in the treatment of patients afflicted with osteoarthritis pain in the knee who do not respond to other treatments for mild to moderate osteoarthritis.  Doctors may use Crespine Gel+ to replace other treatments such as oral drugs, to supplement drugs or other treatments, or to delay knee or hip replacement surgery. Patients who are not suitable for treatment with Crespine Gel+ are those with a known hypersensitivity to hyaluronate or prilocaine, and those with infection, skin disease or severe inflammation at the planned injection site.

Why should I purchase this product?

Doctors such as orthopedic surgeons, orthopedists, and rheumatologists use Crespine Gel+ to help alleviate symptoms of osteoarthritis such as pain, limited movement, and poor joint function. Place your order of Crespine Gel+ today to help your patients regain their mobility with a simple quick single injection treatment.

Are there any side effects?

Side effects of Crespine Gel+ can include pain, temporary redness, swelling, sensation of heat, and reduced mobility. Rarer Crespine Gel+ side effects can include: signs and symptoms of depressed cardiovascular function from a vasovagal reaction, hypersensitivity reaction with erythema (redness) and swelling, and allergic reaction with skin lesions, urticaria (hives), edema (swelling), or anaphylaxis. Most side effects usually spontaneously disappear within 2 to 5 days. Hypersensitivity reactions are usually mild to moderate and last less than 2 weeks. These may not be all the possible side effects of Crespine Gel+.

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