NABOTA® (JEUVEAU®)

About NABOTA®

NABOTA® is a purified botulinum toxin type A preparation containing prabotulinumtoxinA as the active ingredient. It is indicated for the temporary improvement of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adults. The formulation is characterized by a high degree of purity achieved through advanced purification technology, ensuring consistent potency and safety.

• Active Ingredient: PrabotulinumtoxinA (botulinum toxin type A)

• Formulation: Lyophilized powder for solution

• Mechanism of Action: Inhibition of acetylcholine release at the neuromuscular junction, leading to temporary chemodenervation of targeted muscles

Key Benefits of NABOTA®

NABOTA® offers measurable clinical and procedural advantages for aesthetic and therapeutic applications.

• High Purity: Reduced complexing protein content may lower immunogenic potential.

• Predictable Onset: Noticeable results typically within 2–3 days.

• Sustained Duration: Efficacy maintained for up to 4–6 months in most patients.

• Treatment Precision: Optimized particle size and consistent potency support precise dosing.

• Regulatory Approval: Complies with stringent manufacturing and safety standards in multiple jurisdictions, including FDA approval as Jeuveau®.

Clinical Indications for NABOTA®

NABOTA® is indicated for:

• Temporary improvement of moderate to severe glabellar lines in adults.

Off-label uses by qualified practitioners may include:

• Forehead lines

• Lateral canthal lines (crow’s feet)

• Masseteric hypertrophy

• Platysmal banding

• Gummy smile correction

Contraindications:

• Known hypersensitivity to botulinum toxin type A or any excipients

• Presence of infection at the intended injection site

• Patients with neuromuscular disorders such as myasthenia gravis or Lambert-Eaton syndrome

NABOTA® Ingredients

• Active Substance: PrabotulinumtoxinA

• Excipients: Human serum albumin, sodium chloride

• Diluent (for reconstitution): Preservative-free 0.9% sodium chloride injection solution

NABOTA® Administration Technique

Administration should be performed only by trained healthcare professionals familiar with botulinum toxin injection techniques and relevant facial anatomy.

Reconstitution Guidelines:

• Reconstitute with 0.9% sodium chloride

• Recommended dilution volume: 2.5 mL for 100 units (yielding 4 units per 0.1 mL)

• Use a sterile 21-gauge needle for reconstitution, then replace with a fine-gauge injection needle (e.g., 30G) for administration

• Gently rotate the vial to dissolve; avoid shaking vigorously

Injection Technique for Glabellar Lines:

• Total recommended dose: 20 units divided across 5 injection points

• Procerus muscle: 1 injection point (4 units)

• Corrugator muscles: 2 injection points per side (4 units each)

• Injection depth: intramuscular

• Angle: perpendicular to the skin surface

NABOTA® Storage Conditions

Here’s how to store NABOTA®.

• Store lyophilized vials at 2–8°C (refrigerated)

• Protect from light

• Use immediately after reconstitution or store reconstituted solution in a refrigerator for up to 24 hours

• Do not freeze the reconstituted solution

NABOTA® Side Effects

Here’s a list of possible side effects of NABOTA®.

Common Adverse Reactions:

• Headache

• Eyelid ptosis

• Localized pain, swelling, or bruising at the injection site

• Upper respiratory tract infection

Less Common but Serious Risks:

• Muscle weakness beyond the intended area

• Dysphagia

• Dyspnea

• Allergic reactions (urticaria, anaphylaxis)

Prevention and Management:

• Adherence to precise dosing and anatomical guidelines

• Immediate medical intervention for hypersensitivity or respiratory compromise

NABOTA® Clinical Studies

Clinical trials have demonstrated NABOTA®’s non-inferiority to other botulinum toxin type A preparations in terms of efficacy and safety. Key findings include:

• Onset: Mean time to noticeable effect was 2.3 days

• Peak Effect: Around day 7 post-injection

• Duration: Mean persistence of effect was 4–6 months

• Safety Profile: Comparable to onabotulinumtoxinA, with similar adverse event rates

NABOTA® FAQs

How soon can patients expect to see results?

Most patients report visible improvement within 2–3 days, with full effect at 7 days.

Can NABOTA® be combined with other aesthetic treatments?

Yes, but sequencing and spacing of procedures should follow established safety guidelines.

Is there any downtime after NABOTA® injections?

Minimal; patients can resume most activities immediately, avoiding lying flat or strenuous activity for 4–6 hours post-treatment.

What if the results are unsatisfactory?

Results will gradually wear off; touch-ups can be scheduled after effect onset is fully assessed.

Where to Buy NABOTA®

Ordering from a reputable source ensures product integrity, cold chain compliance, and consistent clinical results.
If you’re looking to order NABOTA® online, contact our customer support. They will instruct you on how to do so.