BDNF (Brain-derived neurotrophic factor) (10mg)

What is BDNF (Brain-Derived Neurotrophic Factor) (10 mg)?

BDNF (Brain-Derived Neurotrophic Factor) is a research peptide studied for its role in neuronal growth, cell survival, and communication within the central nervous system. Experimental work often uses BDNF to examine synaptic plasticity, activity-dependent signaling, and trophic support in neurons and glial cells, under tightly controlled in-vitro and preclinical conditions.

Product Specifications

• Peptide Name: BDNF (Brain-Derived Neurotrophic Factor)
• Subcategory: Brain, Cognitive & Nootropic Peptides
• CAS Number: 218441-99-7
• Peptide Sequence: Derived from Brain-Derived Neurotrophic Factor (research peptide format)
• Purity: ≥ 95% (analytical verification by standard laboratory methods)
• Packaging Format: Lyophilized powder, 10 mg vial
• Storage Conditions: Store at 2–8 °C (≤ –20 °C for long-term storage). Protect from light.
• Intended Use: For laboratory research use only

Key Characteristics of BDNF (Brain-Derived Neurotrophic Factor) (10 mg)

• Supplied as a high-purity, lyophilized research peptide
• Suitable for cell-based and molecular biology research
• Frequently used in neuron and glia culture systems to study trophic support, synaptic plasticity, and activity-dependent signaling in brain-derived cell models
• Commonly used in studies related to neuronal signaling, protein interactions, and cellular communication
• Stable under recommended storage conditions
• Compatible with standard laboratory peptide handling procedures
• Verified for identity and consistency using routine analytical techniques

How BDNF (Brain-Derived Neurotrophic Factor) (10 mg) Supports Research

In research settings, BDNF is used to examine how neurons and their associated glial cells respond to neurotrophic signals. Researchers use BDNF to explore cell communication, TrkB-linked signaling cascades, and cellular adaptation in neuronal and glial cultures, organotypic slices, and other nervous-system models.

Its value in research lies in helping scientists study fundamental biological processes rather than producing therapeutic outcomes. BDNF supports investigations into how cells maintain structure, communicate, and respond to environmental or experimental changes.

Research Applications & Usage Information

BDNF (Brain-Derived Neurotrophic Factor) (10 mg) is commonly used in laboratory research for:

• Studies of neuronal signaling and communication, including activity-dependent changes in synaptic function.
• Protein interaction and receptor-binding research involving neurotrophic receptors and associated signaling complexes.
• Cell survival and adaptation models in neuron and glia cultures exposed to stressors or experimental interventions.
• Exploratory research in brain and nervous system biology, including trophic factor networks and plasticity-related mechanisms.
• Comparative peptide and molecular signaling studies where BDNF is used as a reference neurotrophic factor.

All research use is limited to in-vitro and preclinical experimental models.

Handling and Storage Recommendations

To preserve peptide quality and ensure consistent experimental results, follow these guidelines:

• Storage of Lyophilized Peptide: Store unopened vials of BDNF at 2–8 °C, with ≤–20 °C recommended for long-term storage. Protect from light and moisture. Keep vials tightly sealed and, if possible, within secondary containment to limit exposure to air and humidity. Brief exposure to room temperature is acceptable during transport or shipping.
• Reconstitution: Reconstitute BDNF using sterile water, buffered aqueous solutions, or other appropriate laboratory solvents as required by the experimental protocol. Gently swirl or invert to dissolve; avoid extended vigorous vortexing or foaming, which may stress the peptide.
• Aliquoting and Storage of Solutions: Immediately prepare single-use or limited-use aliquots after reconstitution to avoid multiple freeze-thaw cycles. For short-term use, store aliquots at −20°C; for longer-term storage, lower temperatures (e.g., −80°C) are generally preferred, in accordance with institutional guidance. Inspect solutions visually and discard any that show particulates, cloudiness, or discoloration according to local waste procedures.

Safety and Disposal

Handle only in a laboratory setting, using appropriate personal protective equipment (lab coat, gloves, eye protection) and standard biosafety practices. Dispose of unused material, solutions, and contaminated consumables as chemical or biohazardous waste in accordance with local, national, and institutional regulations.

Research Use Only Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci. 2015;11(6):1164-1178. doi:10.5114/aoms.2015.56342
2. Mohammadi A, Amooeian VG, Rashidi E. Dysfunction in Brain-Derived Neurotrophic Factor Signaling Pathway and Susceptibility to Schizophrenia, Parkinson’s and Alzheimer’s Diseases. Curr Gene Ther. 2018;18(1):45-63. doi:10.2174/1566523218666180302163029
3. Azman KF, Zakaria R. Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases. Int J Mol Sci. 2022;23(12):6827. Published 2022 Jun 19. doi:10.3390/ijms23126827