Treatment for deep laugh lines
$209.00 / pack
(you save $0)
Add 5 more units to your cart and save $60.00.
Quantity Our Price
1 - 5 pack(s) $209.00 USD
6 - 10 pack(s) $199.00 USD
11 - 20 pack(s) $194.00 USD
21+ pack(s) USD$189.00 189.00USD
Manufacturer: Galderma
Active Substance(s) : Hyaluronic acid, lidocaine
Strength: 20mg/ml, 3mg/ml
Pack Size: 1-1ml prefilled syringe
Other Known Names: EMERVEL DEEP
Accessories: Package insert, 2-27G 1/2” needles, 2 traceability labels

leaflet icon Download product leaflet (3.83 MB)

Where can I buy this product?

Restylane Defyne is a dermal filler made of hyaluronic acid that provides a high level of volume to the skin. You can buy Restylane Defyne online from or you can phone our friendly customer service team to order this and other dermal fillers. When you order wholesale Restylane Defyne from Medica Depot, you can help smooth the look of deep wrinkles to give your patients more youthful-looking skin.

Product Information

What is Restylane Defyne?

Restylane Defyne is an injectable, viscoelastic gel containing non-animal, cross-linked hyaluronic acid and Lidocaine, for pain relief. Restylane Defyne is suitable for use as a dermal filler to correct deep wrinkles, folds, or other skin defects when injected into the deep dermis or upper subcutaneous layer. Results of a Restylane Defyne treatment usually last about 6 to 9 months, and sometimes as long as 12 months. Only authorized personnel, in accordance with local legislation, should administer Restylane Defyne.

Restylane Defyne is also known as Emervel Deep Lidocaine and it is one of the products within the popular Emervel Collection.

Accessories or items included

  • 1-1ml prefilled syringe
  • 2 sterile 27G1/2” needles
  • Package insert
  • Patient record labels

What are the benefits of this product?

Many dermal fillers use non-crosslinked hyaluronic acid to adjust the thickness of their product, but it can degrade quickly without providing a filling effect. However, Restylane Defyne adjusts its formula without using free hyaluronic acid. The makers of Emervel use Optimal Balance Technology™ to adjust the level of cross-linking in their products, creating a softer or firmer gel for different applications. They also pass the Emervel gel through different sizes of mesh to sort out particle sizes, using the larger particles and firmer gel for deeper dermal fillers like Restylane Defyne.

How does this product work?

Restylane Defyne is made of hyaluronic acid derived from non-animal origin that has been stabilized by a proprietary process called Optimal Balance Technology (known as XpresHAn Technology™ in the U.S.). The resultant product is an injectable dermal implant that adds volume and definition to treated facial areas, lifting the skin to correct skin depressions and volume loss. 

What are the ingredients?

  • Cross-linked Hyaluronic Acid 20mg/ml
  • Lidocaine Hydrochloride 3mg/ml
  • Physiological Buffer pH 7 qs ad 1ml

Use Instructions

How to inject/administer this product

Before proceeding with treatment, inform your patient of the expected outcomes, precautions, warnings, and possible side effects that may occur. You should also take down the patient’s medical history. Plan out and mark the sites of injection. Prior to injection, disinfect the site to be treated with a suitable antiseptic. Attach the supplied needle to the injection syringe securely, following the full instructions on the leaflet. Inject the gel slowly with even pressure. Follow standard practices and guidelines (e.g. aseptic technique) to mitigate the possibility of cross-infection.

When should I use this product?

Restylane Defyne is suited for improving deep lines and folds, and for augmenting facial tissue by volume restoration.

What areas can I treat with this product?

You should inject Restylane Defyne into the deep dermis or the upper subcutaneous layer. With its particular particle size, Restylane Defyne is suitable for injections into deep wrinkles and folds, including marionette lines that run from the mouth to the chin and nasolabial folds that run between the nose and the mouth. Restylane Defyne can help fill these deep skin defects to give the skin a smoother appearance.

How long do results last?

Like other dermal fillers made with hyaluronic acid, Restylane Defyne gives your patients immediate results. As you inject Restylane Defyne into the deep dermis or subcutaneous layer, the hyaluronic acid binds moisture to provide volume within the skin. This fills in deep wrinkles and folds and supports the top layers of skin, giving the skin a smoother appearance. The results of a Restylane Defyne treatment can last for about 6 to 9 months, and sometimes even 12 months. As the results of a Restylane Defyne injection start to fade, your patients can return for another treatment to maintain their smooth skin.

Frequently Asked Questions

Who is an ideal candidate for this product?

Patients who are suitable for treatment are individuals with severe skin depressions and folds, and are above the age of 18. These individuals should not have a history of hypersensitivity to hyaluronic acid or lidocaine.

Why should I purchase this product?

If you have patients who have deep wrinkles and severe facial folds, you should purchase Restylane Defyne for your dermatology or plastic surgery clinic. Restylane Defyne can effectively fill these deep skin defects, such as nasolabial folds and marionette lines, with less chance of swelling, redness, and other side effects according to clinical studies. Order wholesale Restylane Defyne from Medica Depot to help give your patients smoother skin for a more youthful appearance.

Are there any side effects?

Common Restylane Defyne side effects include skin redness or erythema, itching, swelling, mild pain and tenderness, although these side effects usually disappear within a few days after the injection. You should not inject Restylane Defyne into areas where there is already a permanent or temporary dermal filler. Contraindications of Restylane Defyne injections include use in areas with chronic or acute skin lesions, use on pregnant or breastfeeding women, and use on patients who have porphyria, an autoimmune disorder, severe allergies, or a hypersensitivity or allergy to hyaluronic acid, lidocaine, or the amide anesthetics that are found in lidocaine formulas.

*This website offers only genuine products made by their original manufacturer. All brands are trademarks of their respective owners. This website is not operated by, supported by, or affiliated with the manufacturer in any way. Product packaging may not be exactly as shown.

Customer Reviews
Based on 2 ratings
Nice box
I like the new box better
Good product
Good product in general with a solid syringe. Would recommend it

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