Tesofensine (500mcg) Tablets x30
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Each peptide batch is tested and verified to meet or exceed 98–99% purity (HPLC). Full analytical reports are available in the Certificate of Analysis section.
Preparation & Handling Notice
Novera Compounds products supplied in tablet or capsule format are provided solely to facilitate identification, storage, and handling within laboratory research environments. The physical presentation of these products does not represent a dosage form. These materials are intended strictly for in-vitro laboratory research purposes only and are not intended for human or animal consumption, ingestion, injection, or any form of administration.
RESEARCH USE ONLY
This product is intended for research use only. It is not for human or veterinary use, not for diagnostic or therapeutic purposes, and should only be handled by qualified professionals.
Strength: 500 mcg
CAS: 195875-84-4
Chemical Formula: C₁₇H₂₃Cl₂NO
Molecular weight: 328.3 g/mol
Synonyms: TE, NS-2330
Storage: Store in a cool, dry place at controlled room temperature. Protect from light and moisture.
Shelf life: 24 months from the manufacturing date.
Tesofensine, also known as NS-2330 or TE, is a synthetic small-molecule compound studied in laboratory research for its interaction with central monoamine transport systems. It is commonly used in experimental models investigating neurotransmitter regulation, appetite-related signaling pathways, and neurochemical mechanisms under controlled research conditions.
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INFORMATION
What is Tesofensine (500 mcg)?
Tesofensine is a synthetic compound often classified with peptide-based metabolic agents in research catalogs. However, Tesofensine is a small-molecule compound, not a peptide.
It has been studied in laboratory settings for its interaction with neurotransmitter transporters, specifically those involved in dopamine, serotonin, and norepinephrine signaling. Due to this mechanism, Tesofensine is commonly used in experimental models that explore central nervous system signaling, energy balance pathways, and neurochemical regulation.
The 500 mcg format allows for precise measurement and controlled experimentation in laboratory environments. Tesofensine (500 mcg) is strictly for research purposes and is not approved for human or veterinary use.
Product Specifications
- Product Name: Tesofensine (500 mcg)
- Synonyms: NS-2330, TE
- CAS Number: 195875-84-4
- Molecular Formula: C₁₇H₂₃Cl₂NO
- Molecular Weight:3 g/mol
- Chemical Class: Synthetic monoamine reuptake inhibitor (research compound)
- Purity: ≥98% (verified by HPLC)
- Packaging Format: 500 mcg per sealed research-grade vial
- Storage Conditions: Store 2–8 °C (≤–20 °C long term). Protect from light.
- Intended Use: For Laboratory Research Use Only
Key Characteristics of Tesofensine (500 mcg)
- Synthetic small-molecule research compound
- Investigated for its interaction with dopamine, serotonin, and norepinephrine transport systems
- High purity verified through laboratory testing methods
- Suitable for in vitro and preclinical experimental models
- Packaged in a low-dose format for controlled research allocation
- Exclusively for controlled laboratory environments
How Tesofensine (500 mcg) Supports Research
Tesofensine (500 mcg) is used in laboratory research to explore the regulation of monoamine neurotransmitters and central nervous system signaling pathways. By interacting with neurotransmitter transport systems, Tesofensine helps researchers study changes in synaptic signaling, neurochemical balance, and the downstream metabolic effects in controlled experimental models.
It is commonly used in studies investigating neurochemical signaling networks, behavioral pathway modeling, and energy balance mechanisms. Its defined chemical structure enables reproducible evaluation in cellular assays and preclinical research.
Research Applications & Usage Information
Tesofensine (500 mcg) is typically used in laboratory research involving:
- Monoamine transporter interaction studies
- Dopamine, serotonin, and norepinephrine pathway research
- Neurochemical signaling and synaptic regulation analysis
- Central nervous system experimental models
- Appetite and energy balance pathway investigations
- Behavioral and neuroendocrine signaling research
- Comparative evaluation of monoaminergic compounds
All applications are investigational and limited to laboratory research settings.
Handling and Storage Recommendations
- Store at 2–8 °C (≤–20 °C long-term). Protect from light.
- Keep the vial tightly sealed to prevent moisture exposure.
- Avoid prolonged exposure to heat or direct light.
- Use appropriate laboratory protective equipment during handling.
- Follow institutional laboratory protocols for preparation and disposal.
Research Use Only Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Appel L, Bergström M, Buus Lassen J, Långström B. Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET. Eur Neuropsychopharmacol. 2014;24(2):251-261. doi:10.1016/j.euroneuro.2013.10.007
- Axel AM, Mikkelsen JD, Hansen HH. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology. 2010;35(7):1464-1476. doi:10.1038/npp.2010.16
- Perez CI, Luis-Islas J, Lopez A, et al. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One. 2024;19(4):e0300544. Published 2024 Apr 24. doi:10.1371/journal.pone.0300544
- Rascol O, Poewe W, Lees A, et al. Tesofensine (NS 2330), a monoamine reuptake inhibitor, in patients with advanced Parkinson disease and motor fluctuations: the ADVANS Study. Arch Neurol. 2008;65(5):577-583. doi:10.1001/archneur.65.5.577
What is Tesofensine (500 mcg)?
Tesofensine is a synthetic compound often classified with peptide-based metabolic agents in research catalogs. However, Tesofensine is a small-molecule compound, not a peptide.
It has been studied in laboratory settings for its interaction with neurotransmitter transporters, specifically those involved in dopamine, serotonin, and norepinephrine signaling. Due to this mechanism, Tesofensine is commonly used in experimental models that explore central nervous system signaling, energy balance pathways, and neurochemical regulation.
The 500 mcg format allows for precise measurement and controlled experimentation in laboratory environments. Tesofensine (500 mcg) is strictly for research purposes and is not approved for human or veterinary use.
Product Specifications
- Product Name: Tesofensine (500 mcg)
- Synonyms: NS-2330, TE
- CAS Number: 195875-84-4
- Molecular Formula: C₁₇H₂₃Cl₂NO
- Molecular Weight:3 g/mol
- Chemical Class: Synthetic monoamine reuptake inhibitor (research compound)
- Purity: ≥98% (verified by HPLC)
- Packaging Format: 500 mcg per sealed research-grade vial
- Storage Conditions: Store 2–8 °C (≤–20 °C long term). Protect from light.
- Intended Use: For Laboratory Research Use Only
Key Characteristics of Tesofensine (500 mcg)
- Synthetic small-molecule research compound
- Investigated for its interaction with dopamine, serotonin, and norepinephrine transport systems
- High purity verified through laboratory testing methods
- Suitable for in vitro and preclinical experimental models
- Packaged in a low-dose format for controlled research allocation
- Exclusively for controlled laboratory environments
How Tesofensine (500 mcg) Supports Research
Tesofensine (500 mcg) is used in laboratory research to explore the regulation of monoamine neurotransmitters and central nervous system signaling pathways. By interacting with neurotransmitter transport systems, Tesofensine helps researchers study changes in synaptic signaling, neurochemical balance, and the downstream metabolic effects in controlled experimental models.
It is commonly used in studies investigating neurochemical signaling networks, behavioral pathway modeling, and energy balance mechanisms. Its defined chemical structure enables reproducible evaluation in cellular assays and preclinical research.
Research Applications & Usage Information
Tesofensine (500 mcg) is typically used in laboratory research involving:
- Monoamine transporter interaction studies
- Dopamine, serotonin, and norepinephrine pathway research
- Neurochemical signaling and synaptic regulation analysis
- Central nervous system experimental models
- Appetite and energy balance pathway investigations
- Behavioral and neuroendocrine signaling research
- Comparative evaluation of monoaminergic compounds
All applications are investigational and limited to laboratory research settings.
Handling and Storage Recommendations
- Store at 2–8 °C (≤–20 °C long-term). Protect from light.
- Keep the vial tightly sealed to prevent moisture exposure.
- Avoid prolonged exposure to heat or direct light.
- Use appropriate laboratory protective equipment during handling.
- Follow institutional laboratory protocols for preparation and disposal.
Research Use Only Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Appel L, Bergström M, Buus Lassen J, Långström B. Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET. Eur Neuropsychopharmacol. 2014;24(2):251-261. doi:10.1016/j.euroneuro.2013.10.007
- Axel AM, Mikkelsen JD, Hansen HH. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology. 2010;35(7):1464-1476. doi:10.1038/npp.2010.16
- Perez CI, Luis-Islas J, Lopez A, et al. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One. 2024;19(4):e0300544. Published 2024 Apr 24. doi:10.1371/journal.pone.0300544
- Rascol O, Poewe W, Lees A, et al. Tesofensine (NS 2330), a monoamine reuptake inhibitor, in patients with advanced Parkinson disease and motor fluctuations: the ADVANS Study. Arch Neurol. 2008;65(5):577-583. doi:10.1001/archneur.65.5.577
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