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INFORMATION

What is MGF IGF‑1Ec (5mg)?

MGF IGF‑1Ec (5mg) is a synthetic C‑terminal peptide fragment corresponding to the E‑domain of the mechano growth factor (MGF) isoform of insulin‑like growth factor‑1 (IGF‑1Ec). IGF‑1Ec/MGF is a splice variant of the IGF‑1 gene that is upregulated in skeletal muscle and other tissues after mechanical overload or cellular stress.

In muscle growth and performance research, MGF IGF‑1Ec (Mechano Growth Factor C‑terminal) is used to study mechano‑sensitive signaling involved in myogenic activation, proliferation, and repair pathways.

Product Specifications

Peptide Sequence: Tyr‑Gln‑Pro‑Pro‑Ser‑Thr‑Asn‑Lys‑Asn‑Thr‑Lys‑Ser‑Gln‑Arg‑Arg‑Lys‑Gly‑Ser‑Thr‑Phe‑Glu‑Glu‑Arg‑Lys‑Cys
Chemical Formula: C₁₂₄H₂₀₄N₄₂O₄₁S₁
Molecular Weight: 2971.99 g/mol
Purity: Supplied as a high‑purity research peptide (typically ≥98–99% by HPLC), with identity and purity assessed via chromatographic methods and mass spectrometry; lot‑specific values are documented in a certificate of analysis (COA).
Packaging Format: 5 mg lyophilized (freeze‑dried) MGF IGF‑1Ec peptide in a sealed vial, suitable for reconstitution with an appropriate solvent or buffer prior to experimental use.
Storage Conditions: Store at −20°C, protected from light and moisture; avoid repeated freeze–thaw cycles to help maintain structural integrity and experimental performance.
Intended Use: For laboratory research use only; not for human or veterinary use.

Key Characteristics of MGF IGF‑1Ec (5mg)

E-Domain Fragment of IGF-1Ec (MGF): Represents the C-terminal region linked to IGF-1 splicing patterns that rise after mechanical stress or tissue strain in research models.
Muscle Cell Behavior Studies: Preclinical work uses MGF-related fragments to examine myoblast and satellite-cell activity, often focusing on early-phase responses such as proliferation and activation timing.
Pathway Mapping: Researchers evaluate how MGF-associated signaling may connect with IGF-1 receptor–linked pathways (e.g., PI3K/Akt) and other intracellular cascades, while also exploring effects that may not fully depend on the IGF-1 receptor.
Tool for Local vs Systemic IGF-1 Biology: Helps compare “local” splice-variant responses (IGF-1Ec/MGF) with effects typically attributed to other IGF-1 isoforms in mechanistic designs.
Research-Grade Consistency: Supplied as a sequence-defined, lyophilized peptide with standard analytical documentation (HPLC/MS/CoA) to support reproducibility across experiments.

How MGF IGF‑1Ec (5mg) Supports Research

MGF IGF‑1Ec (5mg) supports research by providing a defined E‑domain peptide derived from the IGF‑1Ec/MGF splice variant, enabling investigators to isolate and study mechano‑responsive signaling separate from full‑length IGF‑1.

In skeletal muscle models, this peptide helps clarify how local IGF‑1 isoforms contribute to satellite‑cell activation, myogenic proliferation, and subsequent repair programs following mechanical loading or injury.

Since MGF expression is closely linked to mechanical stress and damage, synthetic MGF IGF‑1Ec peptides are also used to explore how splice‑variant–specific responses differ across tissues (muscle, heart, nervous system) and how E‑domain fragments complement or diverge from canonical IGF‑1 receptor signaling.

Research Applications & Usage Information

Muscle Damage, Repair, and Regeneration Models: Used to track changes in regeneration markers, myogenic regulators (e.g., MyoD), and repair kinetics after overload or injury in preclinical systems.
Satellite‑Cell Activation and Myogenic Signaling: Applied in muscle cell cultures to study activation/proliferation timing and compare responses to mature IGF-1, including analysis of PI3K/Akt, ERK, and related pathways.
Mechano‑Sensitive Gene Expression and Splicing: Supports studies examining how mechanical inputs influence IGF-1 splicing patterns and early response gene signatures in controlled models.
Neuro‑Muscular and Neurogenic Models: Included in experimental designs exploring neuromuscular signaling and cell-survival endpoints in defined disease or stress models.
Cardiac and Ischemia‑Related Research: Used in preclinical cardiac research to examine remodeling, inflammation markers, and stress-response signaling—strictly as a mechanistic tool.

Note: Experimental protocols (e.g., concentrations, exposure durations, dosing schedules, and routes of administration) vary widely between studies and must be defined by qualified investigators. No specific protocol, dosing guidance, or clinical use is recommended or implied here.

Handling and Storage Recommendations

Keep lyophilized peptide at −20°C or colder, dry, and protected from light.
Let the sealed vial warm to room temperature to reduce condensation.
Use a sterile solvent/buffer suitable for your assay; mix gently until dissolved.
Divide into small, labeled portions to limit freeze–thaw cycles. Store at 2-8°C for short-term storage and at -20°C for long-term storage.
Use standard PPE and dispose of materials per institutional waste procedures.

Research Use Only Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in‑vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References