KPV (10mg)

What is KPV (10mg)?

KPV (10mg) is a synthetic tripeptide made of lysine–proline–valine (Lys-Pro-Val). It matches the C-terminal fragment of α-MSH and is commonly studied within healing and regenerative peptide research for its relevance to inflammatory signaling, epithelial function, and tissue remodeling.

In laboratory settings, researchers use KPV as a controlled probe to examine how short melanocortin-related fragments may influence immune and inflammation pathways and cellular repair responses, strictly within preclinical models and without implying therapeutic use.

Product Specifications

• Peptide Sequence: Lys‑Pro‑Val​​
• Chemical Formula: C₁₆H₃₀N₄O₄​
• Molecular Weight: 342.43 g/mol​
• CAS Number: 112965-21-6
• Purity: Research‑grade peptide, typically ≥99% purity by HPLC, with identity and composition confirmed by mass spectrometry; lot‑specific data are provided in the accompanying certificate of analysis.​​
• Packaging Format: 10 mg lyophilized (freeze‑dried) peptide in a sealed research vial, designed for reconstitution in an appropriate solvent or buffer immediately before experimental use.
• Storage Conditions: Store at −20°C, protected from light and moisture; avoid repeated freeze–thaw cycles to help maintain structural integrity and performance in assays.​​
• Intended Use: For laboratory research use only; not for human or veterinary use.

Key Characteristics of KPV (10mg)

• α-MSH Fragment: A short melanocortin-related peptide designed for mechanistic signaling studies, without the pigment-related activity associated with full α-MSH.
• Inflammation-Focused Research Use: Commonly investigated in experimental models of intestinal and epithelial inflammation.
• Pathway-Level Effects in Models: Preclinical work has examined KPV in relation to signaling pathways such as NF-κB and MAPK, including downstream cytokine and immune markers.
• Transport Studies: Often used in studies of PepT1-mediated peptide uptake, especially where PepT1 expression changes during inflammation.
• Reproducible Research Reagent: Supplied as a lyophilized peptide with standard analytical documentation (CoA, HPLC, MS) to support consistency across experiments.

How KPV (10mg) Supports Research

KPV (10mg) enables research into how short peptides derived from α‑MSH influence inflammatory pathways, cellular repair, and immune signaling.

In experimental settings, KPV enables studies of how receptor engagement influences cellular responses under inflammatory or stress conditions, without the full complexity of the parent peptide.

It provides researchers with a tool to examine signaling dynamics in epithelial, immune, and fibroblast models, as well as their effects on tissue integrity and protein regulation.

Research Applications & Usage Information

• Intestinal and Mucosal Models: Used in colitis models (e.g., DSS, TNBS) to assess colon histology, MPO activity, cytokine expression, and body‑weight trajectories under KPV exposure.
• Transport and Delivery Studies: Used to study PepT1-mediated transport in intestinal tissues, especially under inflammatory conditions where PepT1 expression is upregulated.
• Epithelial and Airway Inflammation: Applied in airway epithelial models to evaluate chemokine signaling, macrophage recruitment, and receptor interactions (e.g., MC3R).
• Skin, Wound, and Matrix Research: Investigated in dermal models to study fibroblast activity, collagen pathways, and extracellular matrix remodeling in wound-healing contexts.
• Melanocortin System Mechanistic Studies: Used to dissect receptor-dependent and receptor-independent contributions in melanocortin signaling and systemic inflammation.

Handling and Storage Recommendations

• Keep lyophilized vials at −20°C, dry, and protected from light.
• Let the sealed vial reach room temperature to reduce condensation.
• Aliquot promptly and store refrigerated or frozen based on your lab’s stability guidance; avoid repeated freeze–thaw cycles.
• Use standard PPE and discard unused material and contaminated items per institutional waste procedures.

Research Use Only Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in‑vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Brzoska T, Luger TA, Maaser C, Abels C, BöHm M. Α-Melanocyte-Stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of Immune-Mediated Inflammatory Diseases. Endocrine Reviews. 2008;29(5):581-602. doi:10.1210/er.2007-0027
2. Kannengiesser K, Maaser C, Heidemann J, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases. 2007;14(3):324-331. doi:10.1002/ibd.20334
3. Gravina AG, Pellegrino R, Durante T, et al. The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials. Cells. 2023;12(14):1889. doi:10.3390/cells12141889
4. Dalmasso G, Charrier–Hisamuddin L, Nguyen HTT, Yan Y, Sitaraman S, Merlin D. PEPT1-Mediated Tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2007;134(1):166-178. doi:10.1053/j.gastro.2007.10.026
5. Land SC. Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. Published June 23, 2012. https://pmc.ncbi.nlm.nih.gov/articles/PMC3403564/
6. Peptide Biologix. KPV: Comprehensive Research Monograph and Technical Review | Peptide Biologix. Peptide Biologix. https://peptidebiologix.com/kpv