HCG (12000iu)

What is HCG (12000iu)?

HCG (12,000 IU) is a laboratory preparation of human chorionic gonadotropin (hCG)—a naturally occurring glycoprotein hormone produced mainly by placental trophoblast cells. In research, it is commonly grouped within sexual health and hormonal peptides and is used to study hormone signaling and reproductive biology in controlled experimental models.

Researchers also use hCG as a standardized reference hormone to examine how gonadotropin signals bind to receptors, trigger endocrine responses, and function as measurable biomarkers in assay development.

Product Specifications

• Synonyms: Human chorionic gonadotropin; chorionic gonadotropin; choriogonin; Gonabion; (classified within endocrine gonadotropin hormones)
• Chemical Formula: C₁₁₀₅H₁₇₇₀N₃₁₈O₃₃₆S₂₆
• Molecular Weight: ~36.7 kDa (37,000 Da)
• CAS Number: 9002‑61‑3​
• Packaging Format: 12,000 IU of lyophilized (freeze‑dried) HCG in a sealed laboratory vial, intended for reconstitution prior to experimental use.
• Storage Conditions: Store at −20°C, protected from light; avoid exposure to moisture and repeated freeze–thaw cycles to maintain structural integrity.
• Intended Use: For laboratory research use only; not for human or veterinary use.

Key Characteristics of HCG (12000iu)

• Two-Subunit Glycoprotein: Includes a common alpha subunit and an hCG-specific beta subunit, supporting receptor-selective signaling studies.
• Physiologic Relevance: Naturally produced by placental trophoblasts and reported in some pituitary and tumor contexts, making it relevant to reproductive and oncology research models.
• Model Gonadotropin: Frequently used to study luteotropic and reproductive signaling pathways in controlled systems.
• Assay Reference Analyte: Commonly used in development and validation of serum/urine hCG detection methods (e.g., immunoassays).
• Lyophilized Format: Freeze-dried to support stability and routine handling in research settings.
• Broad Experimental Use: Compatible with in vitro and in vivo designs when handled according to institutional protocols.

How HCG (12000iu) Supports Research

HCG (12000 IU) provides researchers with a defined, bioactive glycoprotein that enables investigation into gonadotropin signaling and its downstream effects in model systems.

This includes studying how HCG influences target tissues, receptor activity, and biochemical signaling cascades relevant to early pregnancy and hormone-responsive tumors.

Its well-characterized molecular structure and use as a clinical analyte make it a valuable reference in assay calibration, particularly for immunoassay development and analytical method validation in laboratory environments.

Research Applications & Usage Information

• Reproductive Endocrinology Models: Investigating corpus luteum support, hormone production, and gestational hormone signaling
• Placental and Trophoblast Biology: Studying trophoblast differentiation, invasion, and placental development signaling networks
• Oncology and Tumor Marker Research: Modeling HCG-producing tumors and analyzing its behavior as a research biomarker
• Assay Development and Method Validation: Reference standard for calibrating HCG detection assays in biological samples
• Structure–Function Studies: Exploring how glycosylation and subunit interactions affect hormone-receptor binding and activity

No specific protocols, dosing schemes, or administration routes are recommended or implied. All experimental parameters should be determined by qualified researchers in accordance with institutional guidelines.

Handling and Storage Recommendations

• Keep lyophilized vials at −20°C or colder, dry, and protected from light.
• Let the sealed vial reach room temperature to reduce condensation.
• For short-term storage, store at 2-8°C, while long-term storage requires -20°C, per your lab’s stability practices.
• Use standard PPE and dispose of waste according to institutional requirements.

Research Use Only Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in‑vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Betz D, Fane K. Human chorionic gonadotropin. StatPearls – NCBI Bookshelf. Published April 27, 2025. https://www.ncbi.nlm.nih.gov/books/NBK532950/
2. Ogino MH, Tadi P. Physiology, chorionic gonadotropin. StatPearls – NCBI Bookshelf. Published November 7, 2022. https://www.ncbi.nlm.nih.gov/books/NBK556118/
3. Heidegger H, Jeschke U. Human chorionic gonadotropin (HCG)—An endocrine, regulator of gestation and cancer. International Journal of Molecular Sciences. 2018;19(5):1502. doi:10.3390/ijms19051502
4. Boime I, Ben-Menahem D. Glycoprotein hormone structure-function and analog design. PubMed. Published 1999. https://pubmed.ncbi.nlm.nih.gov/10548880/
5. Human Chorionic Gonadotropin. ScienceDirect. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/human-chorionic-gonadotropin
6. Chorionic Gonadotropin Alpha. ScienceDirect. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/chorionic-gonadotropin-alpha