Vesugen (50mg)

What is Vesugen (50 mg)?

Vesugen (50 mg) is a synthetic tripeptide made up of three amino acids: Lysine (Lys), Glutamic acid (Glu), and Aspartic acid (Asp) (KED). It is a type of bioregulator peptide commonly studied for its role in vascular and endothelial cell behavior.

In laboratory research, Vesugen (also known as the T-38 peptide) is used to investigate how short peptides like KED can influence endothelial cell behavior, gene expression, and stress responses in experimental models of vascular aging, atherosclerosis, and neuroimmunoendocrine regulation.

Product Specifications

• Peptide Sequence: Lys-Glu-Asp (KED)
• Chemical Formula: C₁₅H₂₆N₄O₈
• Molecular Weight: 390.39 g/mol
• Purity: ≥99% (research-grade; HPLC/MS verified)
• Packaging Format: 50 mg lyophilized powder in a sealed research-grade vial
• Storage Conditions (unreconstituted): Store at −20 °C, protect from light, keep vial tightly closed
• Intended Use: For laboratory research use only; not for human or veterinary use

Key Characteristics of Vesugen (50 mg)

• Ultra-Short Vascular Bioregulator Peptide: Vesugen is a KED tripeptide under investigation for its potential to influence vascular health. It is derived from vascular wall-associated proteins and is used to explore vascular protection and endothelial cell behavior.
• Endothelial and Vascular Research: Preclinical studies have shown that KED can affect endothelial cell functions, including proliferation, apoptosis, and gene expression (including markers such as Ki-67, endothelin-1, and connexins), in normal and diseased vascular systems, including atherosclerotic models.
• Gene-Regulatory and Epigenetic Research: Vesugen is being studied for its potential effects on gene regulation, particularly DNA and histone interactions, which may impact endothelial function and the aging process of cells.
• Neuroimmunoendocrine and Aging-Related Research: In organ cultures of neuroimmunoendocrine tissues, Vesugen has been observed to support markers of renewal (such as Ki-67) and reduce markers of aging (such as p53), particularly in older animal models.
• Links to Metabolic and SIRT1 Pathways: Some studies have explored the relationship between Vesugen and SIRT1 expression, which is involved in oxidative stress resistance and vascular aging. Mechanistic understanding is still being developed.
• High-Purity, Lyophilized Research Material: Supplied as a ≥99% purity lyophilized peptide, verified by HPLC/MS, ensuring reliable use across biochemical, cellular, and animal research workflows.

How Vesugen (50 mg) Supports Research

Vesugen (50 mg) is used as an investigative molecule to explore how vascular bioregulation and cellular aging mechanisms work. It supports studies examining:

• Gene expression patterns linked to endothelial function
• Proliferation and apoptosis balance in endothelial cells
• Markers of dysfunction (e.g., endothelin-1, connexin changes)
• Oxidative-stress and senescence pathways in vascular cells

In organ cultures of neuroimmunoendocrine tissues, KED has been reported to alter markers of renewal (Ki-67, p53), supporting research into tissue-specific peptide regulation during aging. Preclinical studies also discuss its effects on vascular integrity and transcriptional programs related to aging.

Vesugen is positioned as a research tool for exploring endothelial senescence, vascular aging, and peptide-linked gene regulation, without implying therapeutic use.

Research Applications & Usage Information

Vesugen (50 mg) is typically used in controlled in vitro, ex vivo, and animal research designs. Common applications include:

• Endothelial Cell and Vascular Wall Studies: Measuring proliferation, apoptosis, and gene expression markers (such as Ki-67, p53, endothelin-1, connexins) in cultures from normal, atherosclerotic, or restenotic vessels. Also used to explore endothelial senescence, vessel stiffness, and microcirculatory regulation in vascular aging and injury models.
• Neuroimmunoendocrine and Aging Research: Using organ cultures (such as from the pineal gland) to assess renewal markers and age-related shifts in cell proliferation and apoptosis patterns.
• Metabolic and SIRT1-Associated Pathways: Investigating oxidative-stress defense signaling and how endothelial function is related to redox balance in experimental systems.
• Epigenetic and Gene-Regulatory Studies: Studying how short peptides interact with chromatin targets (DNA/histones) and gene promoter regions, with a focus on transcription changes (e.g., MKI67).
• Neurovascular Integration and Plasticity Models: Exploring neurovascular markers and plasticity-related changes, including studies in invertebrate learning models (e.g., honeybees).
• Infection/Inflammation Adjunct Studies: Used in keratitis models to explore interactions with antibiotics and inflammation-related markers.

Note: Experimental parameters (such as concentration, exposure time, and model selection) must be defined by researchers based on study goals, prior research, and institutional oversight. No dosing or clinical guidance is provided or implied.

Handling and Storage Recommendations

• Store unopened vials at −20 °C, protected from light, tightly sealed. For short-term storage, keep it at 2–8 °C.
• Allow the vial to reach room temperature before opening to reduce condensation.
• If preparing solutions, use aseptic technique and follow your lab’s SOPs for aliquoting, stability controls, and disposal.

Research Use Only Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in‑vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Chalisova NI, Lopatina NG, Kamishev NG, et al. Effect of tripeptide Lys-Glu-AsP on physiological activity of neuroimmunoendocrine system cells. Bulletin of Experimental Biology and Medicine. 2012;153(4):569-572. doi:10.1007/s10517-012-1768-7
2. Kozlov KL, Bolotov II, Linkova NS, et al. [Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis]. PubMed. Published 2016. https://pubmed.ncbi.nlm.nih.gov/28539025/
3. Khavinson V, Ilina A, Kraskovskaya N, et al. Neuroprotective effects of Tripeptides—Epigenetic regulators in mouse model of Alzheimer’s disease. Pharmaceuticals. 2021;14(6):515. doi:10.3390/ph14060515
4. Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. Published 2021 Nov 22. doi:10.3390/molecules26227053