Selank (5mg)

What is Selank (5 mg)?

Selank (5 mg) is a synthetic heptapeptide (7 amino acids) with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It was developed as an analogue of tuftsin, an endogenous peptide involved in immune signaling.

In research, Selank is often grouped with brain, cognitive, and nootropic peptides. It is used to explore how short peptides can influence central nervous system (CNS) signaling, gene expression, and immune-related pathways in preclinical models.

The 5 mg format is typically chosen for smaller-scale studies, method development, and experiments that require more control over working stocks, while still using the same sequence-defined material from broader Selank research.

Product Specifications

• Peptide Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
• Chemical Formula: C₃₃H₅₇N₁₁O₉
• Molecular Weight: 751.9 g/mol
• CAS Number: 129954-34-3
• Purity: Research-grade synthetic peptide, typically ≥98–99% by HPLC. Identity and molecular mass are commonly verified by HPLC and mass spectrometry, with lot-specific results provided in the certificate of analysis (COA).
• Packaging Format: 5 mg lyophilized (freeze-dried) Selank in a sealed vial, intended for preparing small-volume stocks for cell-based assays, slice preparations, and pilot preclinical study workflows.
• Storage Conditions: Store at −20 °C, protected from light and moisture. Limit temperature cycling to help maintain stability.
• Intended Use: For laboratory research use only; not for human or veterinary use.

Key Characteristics of Selank (5 mg)

• Tuftsin-Derived Peptide Analogue: Selank, also known as Selanc, is structurally based on tuftsin and contains a glyproline (PGP) motif that enhances stability and potential CNS relevance in research.
• Neurochemical Signaling and Gene-Expression Effects: Studies report that Selank can affect the expression of genes involved in GABAergic neurotransmission, such as GABA_A receptor subunits and related proteins. Research also suggests that it affects serotonin systems and brain-derived neurotrophic factor (BDNF).
• Neuroimmune and Cytokine Modulation: Investigations indicate that Selank can influence immune-related transcription patterns, including effects on IL-6 and other cytokines, and may alter Th1/Th2 balance in immune cells.
• Enkephalinase and Peptidase Activity: In enzyme assays, Selank has been studied for its ability to inhibit enkephalin-degrading enzymes, which is useful for experiments on peptide turnover and related signaling mechanisms.
• Practical Small-Quantity Format for Research: The 5 mg presentation is ideal for experiments requiring precise titration and reduced material waste (e.g., pilot assays or protocol optimization), while maintaining the same high-quality analytical documentation (COA/HPLC/MS) as larger formats.

How Selank (5 mg) Supports Research

Selank (5 mg) serves as a small, sequence-defined probe to study the effects of peptides on neurotransmission and immune signaling. Its reported impact on GABA-related gene expression, monoamine pathways, BDNF-related markers, and cytokine profiles allows researchers to investigate how a single peptide may influence multiple signaling layers in brain and immune tissues in preclinical models.

As part of brain, cognitive, and nootropic peptide research, Selank is frequently used in studies of stress-response mechanisms, cognition, and neuroimmune regulation.

Research Applications & Usage Information

• CNS Gene-Expression Studies: Used to track changes in gene expression in brain regions like the hippocampus and frontal cortex, focusing on genes linked to GABA signaling, synaptic plasticity, and stress responses.
• GABAergic and Monoaminergic Pathway Experiments: Selank is applied in rodent studies and ex vivo systems to examine markers of GABA signaling and monoamine metabolism. These studies often compare pathway-level changes with other reference compounds.
• Neuroimmune and Cytokine-Focused Research: Selank is used to measure IL-6 and other cytokine responses in both neural and peripheral tissues, often in models involving stressors or inflammatory stimuli.
• Enkephalinase and Peptidase Assays: In enzyme activity assays, Selank is used to measure changes in enkephalin-degrading enzymes, exploring the effects on endogenous peptide turnover and receptor-ligand availability.
• Systems-Level Neuropharmacology: Integrated into multi-parameter studies (e.g., transcriptomic and neurochemical profiling) to compare Selank’s effects with other CNS-active compounds and understand peptide-specific network effects.

Important Note: Experimental parameters (e.g., concentration, timing, route, controls, and model selection) must be determined by qualified researchers following ethical and regulatory guidelines. No dosing or clinical recommendations are provided or implied.

Handling and Storage Recommendations

• Store the unopened vial at −20 °C, protected from light and moisture.
• Let the vial reach room temperature before opening to reduce condensation.
• Handle with standard lab PPE and follow good laboratory practices for bioactive peptides.
• When preparing solutions, follow your institution’s validated procedures for solvent choice, labeling, stability controls, and disposal.
• Dispose of unused material and contaminated consumables according to institutional and regulatory requirements.

Research Use Only Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in‑vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Volkova A, Shadrina M, Kolomin T, et al. Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Frontiers in Pharmacology. 2016;7:31. doi:10.3389/fphar.2016.00031
2. Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. Selank, peptide analogue of tuftsin, protects against Ethanol-Induced memory impairment by regulating of BDNF content in the hippocampus and prefrontal cortex in rats. Bulletin of Experimental Biology and Medicine. 2019;167(5):641-644. doi:10.1007/s10517-019-04588-9
3. Kolomin T, Shadrina M, Slominsky P, Limborska S, Myasoedov N. A new generation of drugs: synthetic peptides based on natural regulatory peptides. Neuroscience &Amp Medicine. 2013;04(04):223-252. doi:10.4236/nm.2013.44035
4. Zozulya AA, Kost NV, Sokolov OYu, et al. The inhibitory effect of Selank on Enkephalin-Degrading enzymes as a possible mechanism of its anxiolytic activity. Bulletin of Experimental Biology and Medicine. 2001;131(4):315-317. doi:10.1023/a:1017979514274