PE-22-28 (10mg)
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99% PURITY GUARANTEE
99% PURITY GUARANTEE
Each peptide batch is tested and verified to meet or exceed 98–99% purity (HPLC). Full analytical reports are available in the Certificate of Analysis section.
Preparation & Handling Notice
The product is delivered in powdered (lyophilized) form and must be properly reconstituted prior to research use.
RESEARCH USE ONLY
This product is intended for research use only. It is not for human or veterinary use, not for diagnostic or therapeutic purposes, and should only be handled by qualified professionals.
Strength: 10 mg
CAS: 1801959-12-5
Chemical Formula: C₃₅H₅₅N₁₁O₉
Molecular weight: 773.8947 g/mol
Peptide Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.
PE-22-28 is a synthetic peptide supplied for laboratory research. It is typically used as a sequence-specific tool in exploratory studies of peptide activity, including cell culture assays and pathway screening, where investigators compare responses across models. Work is generally limited to controlled in vitro or ex vivo systems. This material is not intended for diagnostic, therapeutic, or consumer use.
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Novera Research delivers high-quality research peptides developed under strict manufacturing and quality-control standards. Each product is carefully synthesized, tested, and handled to ensure consistency, reliability, and transparency for advanced research applications.
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- Analytical testing to verify quality and composition
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- Stored and shipped under controlled conditions
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INFORMATION
What is PE-22-28 (10mg)?
PE-22-28 (10mg) is a synthetic research peptide categorized within the broader Peptides class, commonly grouped under Brain, Cognitive & Nootropic Peptides due to its application in central nervous system (CNS)-related experimental models. In published research, PE-22-28 is identified as a short spadin-derived peptide that has been studied as a TREK-1 (KCNK2) channel inhibitor in controlled laboratory systems.
Researchers typically use PE-22-28 as a sequence-defined tool to explore ion-channel biology, neuronal signaling, and related preclinical research questions under standardized conditions, such as cell-based assays and animal models.
Product Specifications
- CAS Number: 1801959-12-5
- Category: Peptides
- Subcategory: Brain, Cognitive & Nootropic Peptides
- Peptide Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR)
- Chemical Formula: C₃₅H₅₅N₁₁O₉
- Molecular Weight: 773.88–773.89 g/mol
- Purity: ≥99% typical (≥95% confirmed)
- Packaging Format: 10mg
- Storage Conditions: Store at -20°C; avoid light exposure
Key Characteristics of PE-22-28 (10mg)
- Research Focus: Frequently used in CNS-oriented research, particularly for exploring TREK-1 channel biology.
- Defined Peptide Identity: Supplied with a documented molecular weight and formula to support traceability and reproducibility.
- High Purity Standard: ≥99% purity, minimizing variability from peptide-related impurities in analytical and biological assays.
- Common In Vitro Use: Suitable for cell-based experiments that monitor ion-channel–linked functional readouts.
- Preclinical Research Context: Referenced in studies investigating CNS-relevant outcomes, such as neurogenesis and recovery-related endpoints (for research use only).
- Stability-Aware Storage: Stored frozen and protected from light to maintain peptide integrity.
How PE-22-28 (10mg) Supports Research
PE-22-28 is primarily used as a research tool to help scientists study TREK-1 channel inhibition and its downstream effects in controlled systems. Published research has characterized PE-22-28 as a high-affinity inhibitor of TREK-1 in vitro, with reported IC₅₀ values in the sub-nanomolar range for specific assay formats.
As a short, defined peptide, PE-22-28 also supports comparative study designs, such as evaluating sequence variants, controls, or response differences across experimental models.
Research Applications & Usage Information
PE-22-28 (10mg) is commonly used in laboratory research for:
- Ion-Channel Research: Studies focusing on TREK-1 (KCNK2) function and inhibition-related readouts.
- Neurobiology Model Studies: Used in CNS-focused assays to explore signaling changes related to channel modulation.
- Mechanistic Screening: Applied in exploratory studies comparing responses across conditions, models, or peptide controls.
- Preclinical Model Research: Referenced in rodent research settings, particularly for investigating functional outcomes in ischemia/stroke-related models (for research use only).
- Assay Development: Supports method setup or optimization, where consistent peptide identity is essential for reproducible results.
Handling and Storage Recommendations
- Store at -20°C when not in use.
- Protect from light by keeping the vial in its original packaging or a light-protective container.
- Reduce temperature cycling by avoiding repeated warming and refreezing when possible to preserve integrity.
- Handle peptide materials with appropriate personal protective equipment (PPE) and follow your facility’s standard operating procedures (SOPs).
- Maintain traceability by recording the lot number, receipt/open dates, and storage location for internal quality control.
Research Use Only Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017;8:643. Published 2017 Sep 12. doi:10.3389/fphar.2017.00643
- Pietri M, Djillani A, Mazella J, Borsotto M, Heurteaux C. First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology. 2019;158:107715. doi:10.1016/j.neuropharm.2019.107715
- Daziano G, Blondeau N, Béraud-Dufour S, et al. Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway. Pharmacol Res. 2021;167:105539. doi:10.1016/j.phrs.2021.105539
- Djillani A, Pietri M, Mazella J, Heurteaux C, Borsotto M. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin. Pharmacol Ther. 2019;194:185-198. doi:10.1016/j.pharmthera.2018.10.003
What is PE-22-28 (10mg)?
PE-22-28 (10mg) is a synthetic research peptide categorized within the broader Peptides class, commonly grouped under Brain, Cognitive & Nootropic Peptides due to its application in central nervous system (CNS)-related experimental models. In published research, PE-22-28 is identified as a short spadin-derived peptide that has been studied as a TREK-1 (KCNK2) channel inhibitor in controlled laboratory systems.
Researchers typically use PE-22-28 as a sequence-defined tool to explore ion-channel biology, neuronal signaling, and related preclinical research questions under standardized conditions, such as cell-based assays and animal models.
Product Specifications
- CAS Number: 1801959-12-5
- Category: Peptides
- Subcategory: Brain, Cognitive & Nootropic Peptides
- Peptide Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR)
- Chemical Formula: C₃₅H₅₅N₁₁O₉
- Molecular Weight: 773.88–773.89 g/mol
- Purity: ≥99% typical (≥95% confirmed)
- Packaging Format: 10mg
- Storage Conditions: Store at -20°C; avoid light exposure
Key Characteristics of PE-22-28 (10mg)
- Research Focus: Frequently used in CNS-oriented research, particularly for exploring TREK-1 channel biology.
- Defined Peptide Identity: Supplied with a documented molecular weight and formula to support traceability and reproducibility.
- High Purity Standard: ≥99% purity, minimizing variability from peptide-related impurities in analytical and biological assays.
- Common In Vitro Use: Suitable for cell-based experiments that monitor ion-channel–linked functional readouts.
- Preclinical Research Context: Referenced in studies investigating CNS-relevant outcomes, such as neurogenesis and recovery-related endpoints (for research use only).
- Stability-Aware Storage: Stored frozen and protected from light to maintain peptide integrity.
How PE-22-28 (10mg) Supports Research
PE-22-28 is primarily used as a research tool to help scientists study TREK-1 channel inhibition and its downstream effects in controlled systems. Published research has characterized PE-22-28 as a high-affinity inhibitor of TREK-1 in vitro, with reported IC₅₀ values in the sub-nanomolar range for specific assay formats.
As a short, defined peptide, PE-22-28 also supports comparative study designs, such as evaluating sequence variants, controls, or response differences across experimental models.
Research Applications & Usage Information
PE-22-28 (10mg) is commonly used in laboratory research for:
- Ion-Channel Research: Studies focusing on TREK-1 (KCNK2) function and inhibition-related readouts.
- Neurobiology Model Studies: Used in CNS-focused assays to explore signaling changes related to channel modulation.
- Mechanistic Screening: Applied in exploratory studies comparing responses across conditions, models, or peptide controls.
- Preclinical Model Research: Referenced in rodent research settings, particularly for investigating functional outcomes in ischemia/stroke-related models (for research use only).
- Assay Development: Supports method setup or optimization, where consistent peptide identity is essential for reproducible results.
Handling and Storage Recommendations
- Store at -20°C when not in use.
- Protect from light by keeping the vial in its original packaging or a light-protective container.
- Reduce temperature cycling by avoiding repeated warming and refreezing when possible to preserve integrity.
- Handle peptide materials with appropriate personal protective equipment (PPE) and follow your facility’s standard operating procedures (SOPs).
- Maintain traceability by recording the lot number, receipt/open dates, and storage location for internal quality control.
Research Use Only Notice
This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.
References
- Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017;8:643. Published 2017 Sep 12. doi:10.3389/fphar.2017.00643
- Pietri M, Djillani A, Mazella J, Borsotto M, Heurteaux C. First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology. 2019;158:107715. doi:10.1016/j.neuropharm.2019.107715
- Daziano G, Blondeau N, Béraud-Dufour S, et al. Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway. Pharmacol Res. 2021;167:105539. doi:10.1016/j.phrs.2021.105539
- Djillani A, Pietri M, Mazella J, Heurteaux C, Borsotto M. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin. Pharmacol Ther. 2019;194:185-198. doi:10.1016/j.pharmthera.2018.10.003
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