GHRP-2 (10mg)

What is GHRP-2 (10 mg)?

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide widely used in laboratory research as a model compound for studying growth hormone secretagogue receptor (GHSR-1a) activation. It is also associated with endocrine signaling pathways.

GHRP-2 belongs to a class of peptides known as growth hormone secretagogues (GHS). These compounds are investigated for their ability to interact with ghrelin-associated receptors in experimental systems. Unlike endogenous growth hormone–releasing hormone (GHRH), which acts primarily through hypothalamic–pituitary signaling, GHRP-2 is studied for its receptor-mediated effects via the GHSR pathway. This makes it valuable for examining alternative or complementary mechanisms of growth hormone–related signaling in controlled research environments.

Product Specifications

• CAS Number: 158861-67-7
• Synonyms: GHRP-2, Pralmorelin, Growth Hormone Releasing Peptide-2
• Peptide Sequence: H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
• Peptide Class: Synthetic hexapeptide
• Molecular Formula: C₄₅H₅₅N₉O₆
• Molecular Weight: 817.97 g/mol
• Purity: ≥95% (typically verified by HPLC and mass spectrometry)
• Packaging Format: 10 mg lyophilized powder in sealed research vial
• Storage Conditions: Store at −20 °C; protect from light and moisture
• Intended Use: For laboratory research use only

Key Characteristics of GHRP-2 (10 mg)

• Synthetic hexapeptide designed for controlled laboratory research
• Specifically interacts with growth hormone secretagogue receptors (GHSR-1a)
• Frequently used in endocrine and metabolic signaling studies
• Lyophilized presentation supports long-term stability under proper storage
• Analytical validation typically performed using HPLC and mass spectrometry
• Suitable for receptor-binding and signal-transduction research models
• Requires cold-chain storage to preserve molecular integrity

GHRP-2’s relatively small size and defined amino acid composition make it particularly suitable for mechanistic studies focused on receptor specificity and intracellular signaling dynamics.

How GHRP-2 (10 mg) Supports Research

In laboratory research, GHRP-2 is primarily used to investigate growth hormone–associated signaling mechanisms. It is studied for its ability to activate GHSR-1a receptors, which are expressed in the pituitary gland and various peripheral tissues in experimental models.

Because GHRP-2 acts through ghrelin-associated pathways rather than directly at GHRH receptors, it allows researchers to compare distinct yet overlapping endocrine regulatory mechanisms. This makes it useful for studies examining:

• Receptor activation dynamics
• Signal amplification and downstream kinase activity
• Feedback regulation within endocrine systems
• Cross-talk between metabolic and hormonal pathways

Its defined receptor interaction profile also enables comparative research with other growth hormone secretagogues or GHRH analogs. All findings derived from GHRP-2 remain investigational and are limited to preclinical or in vitro settings.

Research Applications & Usage Information

GHRP-2 (10 mg) is commonly incorporated into laboratory studies involving:

• Growth hormone secretion pathway research
• GHSR-1a receptor binding and activation studies
• Endocrine signaling and hormone-regulation models
• Peptide–protein interaction assays
• Intracellular signaling pathway mapping (e.g., calcium flux, MAPK activation)
• Comparative analysis of short-acting secretagogues
• Metabolic signaling and energy-balance research models

Researchers often use GHRP-2 to explore signaling kinetics, receptor sensitivity, and peptide stability under controlled experimental conditions. All applications are restricted to laboratory and preclinical research environments.

Handling and Storage Recommendations

To maintain structural stability and research integrity:

• Store unopened vials at −20 °C in a dry, light-protected environment
• Avoid prolonged exposure to room temperature
• Allow vial to equilibrate to room temperature before opening to reduce condensation
• After reconstitution, store at 2–8 °C and use within laboratory-defined timeframes
• Avoid repeated freeze–thaw cycles to minimize degradation
• Follow institutional safety and peptide-handling protocols

Proper storage and handling are essential for preserving reproducibility and experimental reliability.

Research Use Only Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Laferrère B, Abraham C, Russell CD, Bowers CY. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005;90(2):611-614. doi:10.1210/jc.2004-1719
2. Laferrère B, Hart AB, Bowers CY. Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake. Obesity (Silver Spring). 2006;14(6):1056-1063. doi:10.1038/oby.2006.121
3. National Center for Biotechnology Information. PubChem Compound Summary for CID 6918245, Pralmorelin. https://pubchem.ncbi.nlm.nih.gov/compound/Pralmorelin.
4. Yin Y, Li Y, Zhang W. The growth hormone secretagogue receptor: its intracellular signaling and regulation. Int J Mol Sci. 2014;15(3):4837-4855. Published 2014 Mar 19. doi:10.3390/ijms15034837