Cortagen (50mg)

What is Cortagen (50 mg)?

Cortagen (50 mg) is a synthetic tetrapeptide classified under Brain, Cognitive & Nootropic Peptides. In laboratory and preclinical research environments, it is studied as a short-chain peptide bioregulator used to investigate peptide-mediated cellular signaling processes, particularly in neurobiological and adaptive-response models. Its compact amino acid sequence allows researchers to examine how small regulatory peptides may influence intracellular communication, gene expression dynamics, and cellular maintenance pathways under controlled experimental conditions.

Cortagen is composed of the four-amino acid sequence Ala–Glu–Asp–Pro (AEDP). Short peptides like this are commonly used in exploratory research focused on transcriptional regulation, protein synthesis pathways, and cellular stress-response mechanisms. In neurobiology research, Cortagen is examined in models that evaluate neuronal cell signaling, adaptive cellular responses, and molecular interactions involved in brain tissue regulation.

Because of its defined molecular structure and relatively low molecular weight, it provides a controlled system for studying peptide–cell interactions without the structural complexity of longer-chain peptides.

Product Specifications

• CAS Number: 335591-03-2
• Peptide Sequence: Ala–Glu–Asp–Pro
• Molecular Formula: C₁₇H₂₇N₅O₈
• Molecular weight: 430.17 g/mol
• Packaging Format: 50 mg lyophilized powder vial
• Storage Conditions: Store at −20 °C; protect from light
• Intended Use: For laboratory research use only

Key Characteristics of Cortagen (50 mg)

• Synthetic tetrapeptide designed for controlled research applications
• Short amino acid sequence (AEDP) suitable for studying regulatory peptide behavior
• Supplied in lyophilized form to enhance long-term stability and minimize degradation
• High purity (≥99%, HPLC verified) to support reproducibility and consistency across assays
• Commonly used in preclinical research focusing on cell signaling, gene expression, and cellular maintenance pathways
• Suitable for in vitro experiments and preclinical research models
• Provides a simplified molecular system for studying peptide–cell interactions
• Verified using standard analytical techniques such as HPLC and mass spectrometry
• Intended exclusively for laboratory research settings, not for therapeutic or clinical use

How Cortagen (50 mg) Supports Research

Cortagen (50 mg) is used in laboratory studies as a molecular tool to explore peptide-driven regulatory mechanisms within cellular systems. Researchers incorporate it into experimental designs to understand how short-chain peptides may influence intracellular signaling pathways, transcriptional activity, and protein expression patterns. Because its structure is clearly defined and relatively simple, it allows for controlled evaluation of peptide–target interactions and reproducible measurement of cellular responses.

In neurobiological research models, Cortagen may be used to investigate signaling pathways relevant to neuronal adaptation, cellular resilience, and tissue-specific regulatory processes. Its defined molecular profile enables researchers to compare the behavior of short regulatory peptides with other peptide classes, supporting broader investigations into peptide-mediated communication. All research applications remain investigational and are conducted within strictly controlled laboratory environments.

Research Applications & Usage Information

Cortagen (50 mg) is commonly included in laboratory studies focused on:

• Neurobiological and cognitive research models: Exploring peptide-driven signaling and brain tissue regulation in controlled systems.
• Cellular signaling and peptide–cell interaction studies: Investigating how small peptides influence intracellular communication and gene expression.
• Exploratory research on peptide bioregulators: Examining short-chain peptide effects on transcriptional regulation and protein synthesis pathways.
• Comparative studies involving short-chain regulatory peptides: Evaluating peptide structure-activity relationships in experimental models.
• Preclinical investigations of adaptive cellular responses: Studying cellular stress responses, tissue remodeling, and maintenance mechanisms under experimental conditions.

All applications remain investigational and are restricted to controlled laboratory environments, with no clinical or therapeutic claims.

Handling and Storage Recommendations

• Store unreconstituted vials at –20 °C for long-term stability
• Protect from light, heat, and moisture
• Allow vial to reach room temperature before reconstitution to minimize condensation
• After reconstitution, store solutions at 2–8 °C and use within protocol-defined timeframes
• Minimize freeze-thaw cycles to preserve peptide integrity
• Follow standard laboratory PPE and SOPs for peptide handling and safety
• Dispose of materials properly in accordance with institutional and local regulatory requirements

Research Use Only Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use. It is not intended for diagnostic, therapeutic, or clinical applications. Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes. Researchers are responsible for ensuring proper handling, storage, and disposal in accordance with institutional, federal, and international guidelines.

References

1. Anisimov SV, Khavinson VKh, Anisimov VN. Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray. Neuro Endocrinol Lett. 2004;25(1-2):87-93.
2. National Center for Biotechnology Information. PubChem Patent Summary for EP-1224212-B1. https://pubchem.ncbi.nlm.nih.gov/patent/EP-1224212-B1.
3. Khavinson V, Ilina A, Kraskovskaya N, et al. Neuroprotective effects of Tripeptides—Epigenetic regulators in mouse model of Alzheimer’s disease. Pharmaceuticals. 2021;14(6):515. doi:10.3390/ph14060515