Did you know that neuromodulator injections ranked first among minimally invasive procedures, with almost 9.5 million performed in 2023? This remarkable figure underscores the trust that both patients and professionals place in these injections to achieve facial rejuvenation and a youthful appearance.
Neuromodulator injections employ botulinum toxin type A to deliver wrinkle-relaxing treatments to facial areas. These injections effectively smooth facial features, addressing signs of aging. Among various brand-name options, Xeomin and Dysport are distinguished by their demonstrated safety and efficacy in reducing frown lines and wrinkles.
This article will compare Xeomin vs Dysport, their compositions, common treatment areas, duration of results, dosage units, cost, and clinical efficacy.
Key Takeaways
- Xeomin utilizes pure botulinum toxin type A, while Dysport also contains botulinum toxin type A, which includes accessory proteins.
- It’s worth noting that these neuromodulator injections have received the US Food and Drug Administration approval, highlighting their proven safety and efficacy in addressing their approved uses.
- The onset action for Xeomin typically begins to set within three to four days post-injection, while the effects of Dysport injections usually work within two to three days post-treatment.
- Xeomin’s results may last three to six months post-treatment, and Dysport effects may last three to five months, with both injections depending on dosage and individual response.
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Composition, Formulation, and Mechanism of Action
Medical professionals may compare injectables for patients seeking non-surgical solutions for their facial aging signs, like Xeomin vs Botox. Additionally, in determining which neuromodulator injection to utilize between Xeomin vs Dysport, medical professionals must discuss the composition, formulation, and mechanism of action of these injections for interested patients.
Xeomin utilizes pure botulinum toxin type A, offering a highly refined formulation for addressing aesthetic and therapeutic concerns. This neuromodulator’s formulation has undergone double filtration to remove complex proteins in its injection, keeping the purified botulinum toxin type A.
While Dysport also contains botulinum toxin type A, it contains accessory proteins that help it diffuse and stabilize. Dysport is available in single-dose vials containing either 300 or 500 Units of lyophilized powder. Healthcare providers must reconstitute this powder using a preservative-free 0.9% sodium chloride injection.
Despite their difference in the formulation of botulinum toxin type A, these neuromodulator injections work by inhibiting the release of acetylcholine at the neuromuscular junction. This leads to temporary muscle relaxation, reduced muscle activity, and reduced wrinkle appearance.
Clinical Studies and Patient Reviews
Merz Aesthetics announced in 2023 that Xeomin injections had met all primary and secondary endpoints. This neuromodulator has undergone a phase 3 clinical program to demonstrate efficacy and safety in simultaneously treating all three upper facial areas (horizontal forehead lines, glabellar frown lines, and lateral canthal lines).
Xeomin’s distinctive formulation, without the additional proteins, demonstrated an outstanding performance profile. Clinical study data indicated high levels of patient satisfaction and sustained efficacy across multiple treatment cycles. On the other hand, a clinical trial involving Dysport showed it received an average of 97.04% in subject self-assessment compared to the competitor’s 95.28%.
Moreover, this study highlighted Dysport’s safety and effectiveness in treating glabellar lines with a 50-unit dosage for up to 120 days. Patients have also shared their satisfaction with RealSelf, Xeomin, and Dysport in their treatments. These treatments received a 96% and 95% worth it rating on RealSelf, respectively.
Common Treatment Areas
It’s worth noting that these neuromodulator injections have received the US Food and Drug Administration approval, highlighting their proven safety and efficacy in addressing their approved uses. While these injectables can effectively address aging signs in the facial upper region, the following are the common treatment areas and uses of Xeomin and Dysport injections.
- Xeomin’s Common Treatments: Chronic sialorrhea in patients two years of age and older, upper limb spasticity in adults, upper limb spasticity in pediatric patients 2 to 17 years of age, cervical dystonia in adults, and blepharospasm in adults
- Dysport’s Common Treatments: Spasticity in patients two years of age and older and cervical dystonia in adults
Medical professionals may also use these injectables for off-label purposes. However, this would require a more meticulous patient assessment and evaluation to ensure their safety and the injection’s efficacy in delivering the patient’s desired goals and treatment outcomes.
Onset of Action, Duration, and Dosage
Medical professionals should explain these practical considerations to each patient during their thorough consultation and assessment. The onset action for Xeomin typically begins to set within three to four days post-injection, with maximum results noticeable after a few weeks to a month. The duration of results may reach from three to six months post-treatment.
Furthermore, the effects of Dysport injections usually work within two to three days post-injection, with full results showing after a few weeks. Some patients may expect sooner outcomes. The effects of Dysport injections may last from three to five months, based on dosage and individual response.
Medical professionals and patients should understand that the Dysport and Xeomin dosage units depend on the treatment to be done and the injection site. According to the Xeomin prescribing information, Xeomin dosage units may range from 50 to 100 Units or 200 Units of lyophilized powder in a single-dose vial. A maximum of 64 units for upper facial lines may be used.
Dysport dosage typically requires 10 Units each for the five sites, which is 50 Units for glabellar lines. Healthcare providers can assist individuals in selecting the most suitable treatment for glabellar lines. They evaluate multiple factors, including cost, the severity of the condition, current medications, other medical conditions, and overall health.
Cost Comparison
A comprehensive consultation enables providers to develop a personalized treatment plan tailored to each patient’s needs. Patients can also seek these providers’ guidance and expertise regarding the exact cost of Xeomin or Dysport treatments. Depending on the number of units, provider expertise, and geographical location, Xeomin and Dysport treatments can cost around $300 to $500 per session.
Conclusion
Comparing Xeomin vs Dysport can help individuals choose the right neuromodulator injection. Both products are FDA-approved and backed by clinical studies, highlighting their safety and efficacy. Understanding their unique formulations and mechanisms of action is key to selecting the best option based on individual needs.
High patient satisfaction and consistent results with both Xeomin and Dysport make them reliable choices for addressing signs of aging in the upper face. Factors like composition, treatment duration, and target areas can guide the decision when considering non-surgical facial rejuvenation.
FAQs
1. What are the key differences between Xeomin and Dysport?
Xeomin utilizes pure botulinum toxin type A, while Dysport contains botulinum toxin type A and accessory proteins. The onset action for Xeomin typically begins within three to four days post-injection, while Dysport usually works within two to three days.
2. Are Xeomin and Dysport US FDA-approved?
Yes, both Xeomin and Dysport have received approval from the US Food and Drug Administration, highlighting their proven safety and efficacy in addressing their approved uses.
3. What are the common treatment areas for Xeomin and Dysport injections?
Xeomin and Dysport injections are approved for addressing aging signs in the facial upper region, including treating horizontal forehead lines, glabellar frown lines, and lateral canthal lines.
References
- American Society of Plastic Surgeons. 2023 ASPS Procedural Statistics Release. https://www.plasticsurgery.org/documents/news/statistics/2023/plastic-surgery-statistics-report-2023.pdf
- MERZ AESTHETICS ANNOUNCES POSITIVE PHASE 3 DATA DEMONSTRATING EFFICACY AND SAFETY OF XEOMIN® (incobotulinumtoxinA) IN TREATING UPPER FACIAL LINES – Merz Aesthetics. (2023, June 12). Merz Aesthetics. https://merzaesthetics.com/news/merz-aesthetics-announces-positive-phase-3-data-demonstrating-efficacy-and-safety-of-xeomin-incobotulinumtoxina-in-treating-upper-facial-lines/
