A medical professional administering a knee injection to a patient.

A 2021 observational study revealed the long-lasting impact of hyaluronic acid (HA) injections on osteoarthritis patients. The treatment provided an average of 466.8 days of pain relief, underscoring the effectiveness of HA injectables in managing osteoarthritis symptoms.

Osteoarthritis (OA) manifests through joint pain, stiffness, limited movement, and swelling. This lifelong condition may not have a cure, but a single-injection treatment can minimize its symptoms. Durolane has innovatively used hyaluronic acid to produce this minimally invasive therapy. This injectable provides prolonged relief and improved quality of life to OA patients while showcasing HA’s potent ability beyond skincare.

In this article, we will explore how Durolane works, its benefits, side effects, and who can be a candidate for the injection treatment.

Key Takeaways

  • Durolane is a unique injectable for osteoarthritis knee pain. It utilizes the powerful properties of hyaluronic acid to act as a lubricant and shock absorber.
  • Durolane’s convenience lies in its single-injection treatment session, which can offer temporary outcomes to individuals, lasting up to six (6) months.
  • Durolane uses patented NASHA technology to create a gel-bead structure, which allows Durolane to have a longer-lasting effect on patients.
  • The science behind Durolane’s efficacy involves replenishing the synovial fluid in the affected joint. This substance works as a lubricant and shock absorber in the knee joint.
  • When researching a potential solution for your joints, it’s essential to understand its benefits, such as pain reduction, longer-lasting effects, delaying surgery, etc.

Introduction to Durolane as a Single-Injection Treatment

Hyaluronic acid became known in aesthetic medicine for restoring volume in various facial parts and delivering facial rejuvenation. This potent ingredient also reached orthopedic treatment, offering a temporary yet effective solution to address osteoarthritis symptoms. Specifically, Durolane offers their hyaluronic acid injection for OA treatment.

Knowing the Durolane ingredients is necessary before understanding how the process works. This injectable treatment boasts high-molecular-weight hyaluronic acid, making the injection effective.

  • Stabilized Sodium Hyaluronate (20mg)
  • Sodium Chloride (9mg)
  • Potassium Dihydrogen Phosphate (0.03mg)
  • Disodium Hydrogen Phosphate Dihydrate (0.14mg)
  • Water for Injection

So, how does Durolane work? Durolane is a unique injectable for osteoarthritis knee pain. It utilizes the powerful properties of hyaluronic acid to act as a lubricant and shock absorber. Professionals typically recommend Durolane to individuals when medications may not effectively treat the symptoms. It’s best to ensure that a healthcare professional injects Durolane directly into the joint.

Moreover, Durolane’s convenience lies in its single-injection treatment session. This treatment can lead to pain reduction in patients suffering from knee OA. So, how long does Durolane last? This single-injection therapy offers temporary outcomes to individuals, lasting up to six (6) months.

A Durolane injection can deliver long-lasting relief to OA patients, allowing them to return to their daily activities. A tailored treatment plan from a trusted healthcare professional can recommend that patients maintain their Durolane treatment after their initial injection.

The Science Behind Durolane

The Durolane single-injection therapy product.

Photo Source: Durolane

Durolane uses patented NASHA technology to create a gel-bead structure, which allows Durolane to have a longer-lasting effect on patients. The injectable contains sodium hyaluronate, mainly found in joint tissue and fluid. The concentration of this sodium hyaluronate and its benefits may reduce over time in osteoarthritis joints.

When professionals directly inject Durolane into the joint, it increases sodium hyaluronate. This ingredient activates lubrication and cushioning, relieving pain during physical or active activities. In a 2018 meta-analysis, Durolance significantly improves OA patients’ pain, physical function, and quality of life. This proves that this injectable offers an effective treatment option for OA pain relief.

The science behind Durolane’s efficacy involves replenishing the synovial fluid in the affected joint. This substance works as a lubricant and shock absorber in the knee joint. Viscosupplementation, which involves injecting hyaluronic acid into the affected joints, can restore the synovial fluid’s physiologic viscoelasticity.

Benefits of Durolane vs. Other Treatment Modalities

Durolane offers numerous benefits for professionals and their patients. The Durolane manufacturer introduced the single-injection treatment in 2001 and has been known for its safety and efficacy in relieving OA symptoms. When researching a potential solution for your joints, it’s essential to understand the benefits it can deliver.

  • Pain Reduction: Once injected, Durolane efficiently minimizes joint pain. It can also enhance patients’ physical activity, mobility, and quality of life. Patients who have taken medications and did not work found a solution in Durolane injections for pain relief.
  • Made From Non-Animal Stabilized HA: According to the patient information, Durolane came from non-animal stabilized hyaluronic acid.
  • Delay or Avoid Surgery: Durolane’s ability to make individuals return to their usual activities can delay or avoid surgical operations. Maintenance of this treatment can help them prevent potential replacement surgery over time.
  • Minimally Invasive: A minimally invasive, single-injection treatment would require minimal downtime. Individuals can notice positive changes a few days after the treatment and achieve the total outcome after a week or two.
  • Long-Term Relief: Professionals may recommend Durolane for their patients due to its longer-lasting results. An injection treatment can offer up to six (6) months of effects and may vary depending on an individual’s metabolism and other factors.
  • Repeatable Treatment: A thorough consultation with your trusted doctor can give you an overview of the potential treatments you can get yearly. Durolane is clinically proven to be a safe, repeatable therapy for individuals.

Durolane can offer long-lasting relief to OA patients after a single-injection treatment. It can prolong up to six months due to its highly purified, stabilized, and non-animal-derived sodium hyaluronate. Thanks to the NASHA technology, the gel-bead structure takes time to degrade.

Unlike other treatments, like corticosteroid injections or oral medications, Durolane can provide an extended duration of relief. Due to its more prolonged effects, individuals may only need reduced frequent injections. Durolane’s single-injection approach makes it a safer alternative to repeated steroid injections and offers a more convenient option to professionals and patients alike.

Durolane Testimonials and Case Studies

Durolane shares a few testimonials from patients who received the injectable to treat their osteoarthritis. These individuals dealt with pain and swelling in the affected joint, limiting their movements and affecting their usual activities. After researching the injectable and listening to their doctors’ recommendations for this treatment, they experienced Durolane’s relief effect.

A few days after their initial treatment, patients felt a positive change in their joints. Furthermore, a patient mentioned that he has been using Durolane for the past few years to maintain a pain-free lifestyle. Another patient mentioned how fast and easy the treatment with Durolane was.

A screenshot from a Durolane patient testimonial video.

Photo Source: Bioventus via YouTube

In a single injection session with his trusted doctor, he experienced no side effects, and the pain started to ease up in the following weeks. The patient also mentioned that he was able to go six months between the injections, making it a convenient option for individuals suffering from OA.

An observational study also revealed that the injectable HA delivered symptomatic relief to the patients approximately 15 months after their initial treatment. The patients maintained the effects through subsequent injection treatments with their trusted doctors.

Moreover, a clinical evidence review showed that the NASHA technology offers safe and significant efficacy in Durolane’s single-injection procedure. This study marked this technology as the most effective in minimizing pain, improving knee function, and enhancing quality of life. It also provides longer-lasting effects, benefitting the patients by allowing them to live comfortably.

Addressing Common Questions and Concerns

A patient consulting their doctor about a treatment.

After receiving the US Food and Drug Administration (FDA) approval, Durolane can be considered safe for patients who do not respond to oral medications or other treatments. However, patients should not receive a Durolane injection if:

  • Patients who have infections or skin diseases at the injection site
  • Patients are known to be sensitive to hyaluronic acid-based product
  • Pregnant or breastfeeding women
  • Children

Moreover, Durolane also provides a list of warnings that professionals and individuals must note. Knowing these warnings can help avoid potential adverse effects.

  • Do not inject if the synovial joint is infected or severely inflamed.
  • Do not inject if an active skin disease or infection occurs at or near the injection site.
  • Do not inject intravascularly or extraarticular or in the synovial tissues or capsule.

Like any other treatment, Durolane injections can cause side effects. Patients should strictly follow medical professionals’ advice to safely recover from side effects and therapy without compromising health. If any of these persist, promptly contact your trusted doctor for medical advice. Typically, patients can experience side effects for a short period after the injection.

  • Warmth
  • Pain
  • Redness
  • Stiffness
  • Bruising
  • Puffiness
  • Nausea
  • Stomach Pain
  • Swelling in Hands or Feet
  • Back Pain, Joint Pain, Muscle Pain
  • Numbness
  • Headache or Dizziness

Durolane offers a treatment for knee osteoarthritis that finishes within 10 to 15 minutes. Individuals should seek a qualified and trusted healthcare provider to administer the Durolane injection and ensure safe and optimal results. Professionals will administer the single injection into the affected joint.

As mentioned above, this single-injection Durolane has a few contraindications and warnings. In addition, Durolane has yet to test for younger individuals aged 21 years and below. Aside from those, Durolane is generally safe for most individuals to treat their osteoarthritis symptoms.

It is crucial to consider these candidacy criteria to ensure a smooth and successful injection treatment. Medical professionals know the proper directions for a Durolane injection, which patients should know.

  • Preparation: Professionals should swab the injection with alcohol or other antiseptic solution. Afterward, professionals may recommend topical or subcutaneous anesthetic before injection.
  • Joint Effusion Removal: Authorized physicians or medical professionals should administer Durolane injections into the knee joint. They should remove the joint effusion using an appropriate gauge needle.
  • Injection: Healthcare providers must prepare Durolane before the injection. If the blister is opened or damaged, avoid using it. Professionals should secure the needle tightly while firmly holding the hub. Inject all the contents of the syringe intraarticularly into the knee synovial capsule. Use a separate syringe for each knee.

Healthcare professionals must follow the proper discarding of these syringes. Durolane is for single use only and should not be re-sterilized. On the other hand, medical professionals should also note the appropriate storage and shelf life of Durolane injections.

  • Shelf Life: Durolane can last for 36 months on shelves. Providers must use the injectable before the expiration date printed on the package.
  • Storage: Medical professionals should store Durolane in its original packaging between 0-30°C. Transient spikes up to 40°C can be permitted if it does not exceed 24 hours. It should not freeze, and refrigeration is not necessary.


Durolane is a unique treatment solution for individuals suffering from knee osteoarthritis. The injectable offers a range of benefits and properties that set it apart from other options. It provides longer-lasting pain relief for up to six months after a single injection treatment. Professionals can repeat treatments if necessary to maintain the pain relief effects.

This treatment offers a minimally invasive option for those individuals whom oral medications failed to address. The hyaluronic acid acts as the lubricant and shock absorber for the knee joints. The impact of Durolane goes beyond its clinical benefits and delivers the potential to transform lives.

Relieving the pain can enhance an individual’s physical function and quality of life. Due to its non-surgical nature and effective results, Durolane allows patients to return to daily activities a few days after treatment. Pain relief and improved mobility can significantly impact an individual’s mental health, reducing stress and anxiety often associated with chronic pain.

Durolane offers treatment for OA knee pain and also a hope for a better quality of life. By effectively restoring mobility and minimizing pain, Durolane injections empower patients to reclaim their lives from this degenerative joint disease. Its unique formulation, clinical efficacy, safety, and convenience make Durolane a valuable tool in OA knee pain management.

About: Medica Depot is your trusted all-in-one supplier, offering a range of high-quality medical injectables and supplies. We offer a worry-free experience in searching for the best and most popular products on the market, like Durolane. Whether for health professionals, plastic surgeons, dermatologists, licensed estheticians, or other specialists, we can offer genuine, brand-name products you may need. With Medica Depot, we prioritize serving you better to improve the patient’s quality of life.


  1. Carney, G., Harrison, A., & Fitzpatrick, J. (2021). Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients. Open access rheumatology: research and reviews, 13, 285–292. https://doi.org/10.2147/OARRR.S331562
  2. PATIENT INFORMATION DUROLANE ®. (n.d.). In Food and Drug Administration. Retrieved March 21, 2024, from https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170007C.pdf