Did you know that over half of individuals with symptomatic knee osteoarthritis (OA) are younger than 65 years old? According to Deshpande et al. (2016), approximately 14 million people experience symptomatic knee OA, with advanced OA accounting for more than half of those cases.
Knee osteoarthritis is a degenerative joint disease characterized by joint pain, swelling, and limited mobility. These symptoms significantly impact quality of life, prompting affected individuals to seek innovative solutions. One such solution is Durolane, a potent single-injection therapy that leverages the unique properties of sodium hyaluronate.
This article will dive into the Durolane ingredients, sodium hyaluronate and its role in providing lubrication and cushioning to the joints, the formulation process, and its safety and effectiveness.
Key Takeaways
- Durolane capitalizes on the potency of sodium hyaluronate in its formulation to deliver joint lubrication and cushioning.
- When injected directly into the joint, Durolane replenishes the natural fluid in the knee joint affected by osteoarthritis, reducing friction and protecting the joint.
- Compared to Euflexxa or other viscosupplements, Durolane’s formulation utilizes the patented NASHA technology, resulting in a gel-bead structure.
- Durolane’s proven safety and efficacy in clinical trials and studies have significantly improved individuals’ quality of life through its single-injection therapy.
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The Primary Ingredient
Durolane offers single-injection therapy for individuals suffering from knee osteoarthritis (OA) who have not responded to first-line treatments, such as simple analgesics and physical therapy. This viscosupplementation capitalizes on the potency of sodium hyaluronate in its formulation to deliver joint lubrication and cushioning.
This injectable requires the administration of the 3 mL pre-filled syringe directly into the affected knee joint to provide optimal symptomatic relief. Sodium hyaluronate is a naturally occurring substance in the body, specifically in the joint tissue and synovial fluid.
Furthermore, this substance acts as a lubricant and shock absorber, allowing smooth movement within the joint. As sodium hyaluronate increases the viscosity of synovial fluid, it cushions the joints and reduces pain associated with knee OA.
When injected directly into the joint, Durolane replenishes the natural fluid in the knee joint affected by osteoarthritis, reducing friction and protecting the joint. This treatment can also ease the pain and improve overall movement. Medical professionals often use Durolane for mild to moderate knee OA, which can be repeated.
Formulation Process of Durolane
Bioventus meticulously formulated Durolane to treat patients grappling with the chronic symptoms of knee osteoarthritis (OA). The hyaluronic acid in Durolane mirrors the composition of the natural hyaluronic acid produced by your body. However, it is uniquely stabilized in a highly concentrated formulation to counteract OA-induced degradation.
When comparing Durolane vs Euflexxa or other viscosupplements, the former’s formulation utilizes the patented NASHA technology, resulting in a gel-bead structure. This unique composition enhances Durolane’s resistance to degradation over time, offering sustained pain relief through a single injection.
Moreover, patients must also understand Durolane’s unique properties to provide significant relief and improvement from knee OA symptoms.
- High Concentration: Durolane contains a highly concentrated form of HA, maximizing its therapeutic impact.
- Stabilization: The HA in Durolane is uniquely stabilized, allowing for prolonged joint lubrication and cushioning.
- Single Injection: A single injection provides sustained relief, making it a convenient treatment option for knee osteoarthritis.
Effectiveness of Durolane in Treating Osteoarthritis
In a randomized study, Durolane demonstrated a more significant reduction in visual analog scale (VAS) pain scores at 3 and 6 months compared to Synvisc-One. Durolane achieved a remarkable 41% lower VAS pain score at six months than the other hyaluronic acid viscosupplement.
Only Durolane maintained a significant reduction compared to the baseline at six months. Furthermore, in clinical trials, Durolane demonstrated noninferiority to steroids at the six-week mark. From weeks 12 to 26, Durolane outperformed steroids in reducing pain, improving function, and alleviating stiffness.
Additionally, hyaluronic acid (HA) injections led to a treatment course-dependent delay in total knee replacement surgery. Specifically, patients who received five or more courses of HA treatment experienced a postponement of total knee replacement by approximately 3.6 years.
In line with this proven safety and efficacy of Durolane in clinical trials and studies, its single-injection therapy resulted in significant improvements across all Knee and Osteoarthritis Outcome Score (KOOS) parameters within just two weeks. These positive effects endured for up to 24 weeks, providing sustained relief for individuals with knee osteoarthritis.
Conclusion
Durolane offers a promising single-injection therapy for knee osteoarthritis. It leverages the potency of its primary ingredient, sodium hyaluronate, to provide joint lubrication and cushioning. Utilizing patented NASHA technology, the unique formulation process results in a gel-bead structure that allows for prolonged joint lubrication and shock absorption, offering sustained pain relief through a single injection.
Durolane’s proven safety and efficacy in clinical trials and studies demonstrate significant improvements in individuals’ quality of life, making it a compelling option for knee osteoarthritis patients. Its high concentration, stabilization, and convenience of a single injection set it apart from other viscosupplements in managing the chronic symptoms of knee osteoarthritis.
FAQs
1. What is Durolane, and what is it used for?
Durolane is a single-injection therapy for knee osteoarthritis (OA) using sodium hyaluronate to provide joint lubrication and cushioning.
2. How does Durolane work, and what are its primary ingredients?
Durolane replenishes the natural fluid in the knee joint, reduces friction, and protects the joint. It uses sodium hyaluronate to increase the viscosity of the synovial fluid, cushion the joints, and reduce pain associated with knee OA.
3. What sets Durolane apart from other viscosupplements?
Durolane utilizes patented NASHA technology, resulting in a gel-bead structure that provides prolonged joint lubrication and cushioning and offers sustained pain relief through a single injection.
References
- Deshpande, B. R., Katz, J. N., Solomon, D. H., Yelin, E. H., Hunter, D. J., Messier, S. P., Suter, L. G., & Losina, E. (2016). Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity. Arthritis care & research, 68(12), 1743–1750. https://doi.org/10.1002/acr.22897
- Science-driven results. (n.d.). Durolane. Retrieved August 1, 2024, from https://durolane.com/en/durolane/science-driven-results/
