Did you know that the body naturally produces hyaluronic acid? This substance is found in the body’s connective tissues and fluids, including the joints, where it lubricates and cushions them for improved mobility.
Hyaluronic acid (HA) has gained popularity in the aesthetic and medical fields for its ability to maintain skin hydration and address symptoms of knee osteoarthritis (OA). Although OA is incurable, HA-based injections can offer temporary relief from pain and symptoms. Specifically, Monovisc knee injections can benefit individuals with knee OA who have not found relief from first-line therapies.
This article will explore the Monovisc generic name, hyaluronan, its pharmacological properties, and how it works to relieve knee osteoarthritis symptoms.
Key Takeaways
- Hyaluronan is a naturally occurring substance in the body, typically found in the joint’s synovial fluid.
- Individuals with mild to moderate knee osteoarthritis (OA) can find Monovisc or hyaluronan beneficial in relieving symptoms caused by degenerative joint disease.
- It delivers comparable pain relief and functional improvement, with effects lasting up to six months with its recommended Monovisc dosage of 4 mL.
- With the approval of the US Food and Drug Administration, medical professionals and individuals can trust the proven safety and efficacy of hyaluronan.
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What Is Hyaluronan?
Monovisc knee injection contains ultra-pure hyaluronic acid (HA) derived from non-avian sources. The medical field can address the Monovisc generic name as hyaluronan or HA. Hyaluronan is a naturally occurring substance in the body, typically found in the joint’s synovial fluid.
Hyaluronan is a high-molecular-weight substance containing repeating disaccharide units of glucuronic acid and N-acetylglucosamine. Moreover, hyaluronan has various benefits for the body, including the joint.
- Natural Occurrence in the Body: Hyaluronan is crucial in maintaining skin hydration, lubrication, and shock absorber in the skin, eyes, and joints, respectively.
- Importance in Joint Health: This substance offers lubrication and cushioning properties. It helps reduce friction between bones to prevent pain and inflammation.
Fortunately, individuals with mild to moderate knee osteoarthritis (OA) can find Monovisc or hyaluronan beneficial in relieving symptoms caused by degenerative joint disease. It can improve joint function and reduce discomfort, enhancing quality of life.
Pharmacological Properties of Hyaluronan
Hyaluronan offers a highly purified, partially crosslinked hyaluronic acid (HA) in a phosphate-buffered saline solution for its formulation. This structure mimics and replenishes the lost HA in the joint’s synovial fluid for pain-free movement.
Even when comparing treatments like Monovisc vs Durolane, these viscosupplements work in a similar mechanism of action. When medical professionals administer hyaluronan into the affected joint, it restores the synovial fluid’s viscoelastic properties in the joints. This results in symptomatic relief from knee OA, bringing the following benefits:
- Pain and Swelling Reduction
- Enhances Lubrication and Cushioning
- Offers Shock Absorption
- Improves Joint Mobility and Function
- Enhances Patients’ Quality of Life
Furthermore, compared to other viscosupplements, hyaluronan provides the advantage of a single-injection regimen. It delivers comparable pain relief and functional improvement, with effects lasting up to six months with its recommended Monovisc dosage of 4 mL. Its non-avian sources also minimize the risk of allergic reactions.
Development and Composition of Hyaluronan
The Monovisc injection manufacturer produced the hyaluronan through bacterial fermentation and meticulous purification. The hyaluronic acid (HA) is extracted and purified to ensure high-molecular-weight and ultra-purity. The process also involves partially crosslinking the substance to provide longer-lasting outcomes and enhance viscoelastic properties.
The Monovisc injection manufacturer also designed other treatments for addressing knee osteoarthritis (OA) symptoms. Aside from this single-injection therapy, other HA viscosupplement include their multi-injection regimen of Orthovisc and combination treatments of Cingal. Individuals must seek the guidance and expertise of medical professionals to ensure patient suitability and safety.
With the approval of the US Food and Drug Administration, medical professionals and individuals can trust the proven safety and efficacy of hyaluronan. This viscosupplement has adhered to stringent safety and purity standards, highlighting its biocompatible, resorbable, and free from animal-derived ingredients.
Moreover, Monovisc has undergone rigorous testing, ensuring it meets regulatory requirements for sterility, non-pyrogenicity, and non-inflammatory components.
Clinical Efficacy of Hyaluronan in Osteoarthritis Treatment
According to Dernek et al. (2016), there were no significant differences in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS) scores among patients with knee osteoarthritis who received Monovisc or another hyaluronic acid injection in short-term evaluations. Both have showcased significant improvements in treated patients.
Furthermore, a controlled trial indicated that Monovisc demonstrated a significantly higher rate of patient success, defined as at least a 50% improvement and a minimum of 20 mm absolute improvement from baseline in WOMAC pain scores through Week 26, compared to the saline.
Monovisc’s single-injection intra-articular hyaluronic acid is a safe and effective treatment for achieving a clinically meaningful reduction in knee pain. Moreover, these patients have also shared their positive experiences with Monovisc knee injection, emphasizing how it delivered symptomatic knee OA relief.
Medical professionals often recommend Monovisc for its proven safety and efficacy based on their FDA approval and convenience. Patients with mild to moderate knee OA may find this injection beneficial for their condition. Clinical guidelines highlight its role in improving joint function and quality of life, making it a preferred choice among viscosupplements.
Conclusion
Individuals can benefit from the unique formulation and mechanisms of Monovisc knee injections. This injectable, also known as hyaluronan, highlights the potency of hyaluronic acid (HA) in relieving individuals with mild to moderate knee osteoarthritis (OA) by reducing pain and swelling and improving joint function.
Furthermore, the safety and efficacy of Monovisc are underscored by its approval by the US Food and Drug Administration and rigorous testing to meet regulatory requirements for safety and purity. The information presented underlines the significance of hyaluronan in addressing knee OA symptoms and its potential to enhance the quality of life for individuals with this condition.
FAQs
1. What is Monovisc, and how does it work?
Monovisc is a knee injection containing hyaluronic acid (HA) derived from non-avian sources. This naturally occurring substance helps lubricate and cushion the joints, reducing friction between bones and preventing pain and inflammation in individuals with mild to moderate knee osteoarthritis (OA).
2. What are the benefits of using hyaluronan or Monovisc?
Hyaluronan, found in Monovisc, can provide pain relief and functional improvement with its recommended dosage for up to six months. It reduces pain and swelling, enhances lubrication and cushioning, offers shock absorption, and improves joint mobility and function, ultimately enhancing the quality of life for individuals with knee OA.
3. Is hyaluronan treatment safe and approved?
Monovisc has been approved by the US Food and Drug Administration, indicating its proven safety and efficacy. It is highly purified, non-avian sourced, and has undergone rigorous testing to meet regulatory requirements for sterility, non-pyrogenicity, and non-inflammatory components, making it a safe and reliable treatment option for knee osteoarthritis.
References
- Dunkin, M. A. (n.d.). Osteoarthritis and Hyaluronic Acid Injections. WebMD. https://www.webmd.com/osteoarthritis/hyaluronic-acid-injections-for-osteoarthritis
- Petterson, S. C., & Plancher, K. D. (2019). Single intra-articular injection of lightly cross-linked hyaluronic acid reduces knee pain in symptomatic knee osteoarthritis: a multicenter, double-blind, randomized, placebo-controlled trial. Knee surgery, sports traumatology, arthroscopy: official journal of the ESSKA, 27(6), 1992–2002. https://doi.org/10.1007/s00167-018-5114-0
