The global rejuvenation market is projected to increase significantly, from a valuation of $15 billion in 2016 to $22.61 billion by 2024. This consistent growth reflects the rising annual demand for facial rejuvenation treatments as more individuals aim to regain their youthful appearance.
Facial rejuvenation targets issues like volume loss, sagging skin, and reduced radiance. Although surgical options exist, many specialists advocate for minimally invasive alternatives. Rejuran and Sculptra stand out as safe and effective skin boosters for those considering injectable treatments to address facial skin concerns.
This article will dive into Rejuran vs Sculptra, their active ingredients, mechanisms of action, clinical efficacy, specific skin concerns they address, and the longevity of results.
Key Takeaways
- Rejuran comprises polynucleotides (PN) derived from salmon DNA, while Sculptra contains poly-L-lactic acid (PLLA).
- It is important to note that the US FDA has approved Sculptra for specific applications in the facial area, while Rejuran lacs this approval and clinical evidence to prove its safety and effectiveness.
- Each skin booster treatment offers various benefits that appeal to individuals seeking skin rejuvenation and can cause common side effects after sessions.
- Rejuran treatments generally consist of three to four sessions, each spaced four weeks apart. Sculptra injections typically require two to three treatment sessions over a few months.
- It is essential to seek a medical professional who can help patients understand these skin booster treatments and equip them with comprehensive information about these injectables.
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Composition and Mechanism of Action

When comparing Rejuran vs Sculptra or Rejuran vs Profhilo, patients must first understand its composition and how it works for skin rejuvenation. It is essential to seek a medical professional who can help patients understand these skin booster treatments and equip themselves with comprehensive information about these injectables.
Rejuran comprises polynucleotides (PN) derived from salmon DNA. It facilitates skin regeneration and repair by stimulating cellular growth and enhancing skin elasticity. When injected into the dermis, Rejuran Healer’s PN expedites tissue repair and regeneration, improving skin texture, elasticity, and overall appearance.
Rejuran and Sculptra differ in the active ingredients they utilize in their formulations. Meanwhile, Sculptra consists of poly-L-lactic acid (PLLA), a biocompatible synthetic material that stimulates collagen production, enhancing skin volume and firmness.
Upon injection, the skin absorbs the PLLA microparticles, stimulating and restoring natural collagen production. This process gradually improves skin quality and internal structure, reducing the appearance of facial wrinkles and folds.
Clinical Efficacy and Specific Skin Concerns
Rejuran clinical studies emphasize its highly effective and advanced skin rejuvenation treatment. Its cellular repair properties can reverse the signs of aging, helping you achieve youthful, naturally healthy skin. After the second session, patients can expect reduced fine lines, wrinkles, and firmer skin.
While it requires further clinical evidence to earn the US Food and Drug Administration (FDA) approval, the Korean FDA has allowed Rejuran Healer in their market. It can effectively address specific skin concerns, such as the following:
- Improvement of Skin Elasticity and Fine Wrinkles
- Improvement of Skin Tone and Texture
- Under-Eye Area Rejuvenation
Furthermore, Fabi et al. (2024) reported that injectable PLLA treatments were well tolerated and significantly reduced the severity of moderate to severe cheek lines and wrinkles while enhancing skin quality. The Sculptra effectiveness was sustained over the 12-month study period, with subjects reporting high satisfaction, a natural-looking appearance, and a solid willingness to undergo repeat treatments.
It is important to note that the US FDA has approved Sculptra for specific applications in the facial area. Providers should administer Sculptra injections to adult individuals with healthy immune systems, adhering to its clinically approved uses for the following facial concerns:
- Signs of Facial Fat Loss
- Fine Lines and Wrinkles in the Cheek Region
- Nasolabial Folds, Contour Deficiencies, and Other Facial Wrinkles
- Specific skin concerns targeted by Rejuran
Benefits, Side Effects, and Longevity of Results

Each skin booster treatment offers various benefits that appeal to individuals seeking skin rejuvenation. However, patients need to understand the potential risks associated with Rejuran and Sculptra, allowing them to make informed decisions with their aesthetic procedures.
With the unique polynucleotide derived from salmon DNA, Rejuran Healer provides several advantages for the skin. Patients can maximize these benefits when licensed and trained medical professionals administer these injections.
- Reverses Aging Signs
- Repairs Damaged Skin
- Improves Skin Elasticity, Texture, and Tone
- Stimulates Collagen and Hyaluronic Acid Production
- Enhance Skin Hydration
Backed by poly-L-lactic acid as its primary ingredient, Sculptra works as a beneath-the-skin solution for skin concerns. While it helps stimulate natural collagen production, this skin booster also delivers superb benefits for individuals seeking this injectable.
- Supports and Maintains the Skin’s Inner Structure
- Reduces the Appearance of Wrinkles and Folds
- Gradual Rebuilding of the Skin Structure
- Restores Natural Collagen Production
- Maintains Skin’s Shape and Structure
However, patients must also understand that these treatments can cause common side effects after sessions. Medical practitioners must discuss properly managing these Sculptra or Rejuran side effects to patients to avoid further complications. These typical reactions are generally mild, usually temporary, and may resolve within a few days.
- Common Rejuran Side Effects: Inject site reactions, such as redness, swelling, and bruising at the injection site.
- Common Sculptra Side Effects: Injection site pain, redness, bruising, tenderness, itching and lumps, bleeding, and swelling.
Moreover, Rejuran treatment effects persist for six to twelve months, contingent upon individual skin conditions and maintenance practices. Meanwhile, Sculptra’s effects can endure for up to two years as the treatment progressively stimulates collagen production, resulting in sustained skin volume and firmness enhancements.
Practical Considerations

Rejuran treatments generally consist of three to four sessions, each spaced four weeks apart. On the other hand, Sculptra injections typically require two to three treatment sessions over a few months. The number of injections at each session usually varies based on the treatment plan providers and patients determined.
Regular follow-up treatments may be required to preserve the desired effects. Maintenance treatments are advised every six to twelve months to sustain results. Rejuran treatments typically cost between $500 and $800 per session, whereas Sculptra treatments range from $700 to $1,000 per session, depending on the provider’s expertise, number of injections, and geographic location.
While Rejuran lacks data on patient satisfaction, the Rejuran Healer reviews and before-and-after photos online showcase the skin booster’s efficacy in delivering facial rejuvenation. Given the evidence of its safety and effectiveness, Sculptra has received a 76% rating on RealSelf, highlighting a high ‘worth-it’ rating of patients with the treatment.
Conclusion
Comparing Rejuran vs. Sculptra dives into their active ingredients, clinical efficacy, specific skin concerns addressed, and rejuvenation benefits. Rejuran’s polynucleotides focus on skin regeneration while stimulating collagen and hyaluronic acid production. Sculptra’s poly-L-lactic acid supports and maintains the skin’s inner structure, reduces wrinkles and folds, and gradually rebuilds the skin structure.
Understanding the differences between these two skin boosters is crucial for individuals seeking to address their skin concerns. By consulting with a medical professional, patients can understand Rejuran and Sculptra comprehensively. Both treatments offer unique benefits and have the potential to effectively rejuvenate the skin, providing individuals with options to enhance their natural beauty and achieve youthful, healthy-looking skin.
FAQs
1. What are the active ingredients in Rejuran and Sculptra?
Rejuran contains polynucleotides (PN) derived from salmon DNA, while Sculptra consists of poly-L-lactic acid (PLLA), a biocompatible synthetic material that stimulates collagen production.
2. Which skin concerns do Rejuran and Sculptra address?
Rejuran effectively addresses skin elasticity, fine wrinkles, skin tone, and texture, while Sculptra is used for facial fat loss, fine lines, wrinkles, and contour deficiencies.
3. What are the benefits of Rejuran and Sculptra?
Rejuran reverses aging signs, improves skin elasticity, repairs damaged skin, and stimulates collagen and hyaluronic acid production. Sculptra supports and maintains the skin’s inner structure, reduces the appearance of wrinkles and folds, and gradually rebuilds the skin structure. Both treatments enhance skin hydration and maintain skin shape and structure.
References
- Statista. (2024, February 22). Facial rejuvenation market size worldwide from 2016-2026. https://www.statista.com/statistics/988827/facial-rejuvenation-revenue-global-market/
- REJURAN® PN (polynucleotides). (n.d.). Medicaljj.net. Retrieved August 14, 2024, from https://medicaljj.net/wp-content/uploads/2020/09/REJURAN.pdf