Neuromodulator injections were the most popular minimally invasive procedure in 2022, with over 8.7 million treatments performed. This impressive figure reflects the growing confidence of both patients and professionals in these injections for achieving facial rejuvenation and a more youthful appearance.
These treatments utilize botulinum toxin to relax facial muscles, effectively smoothing wrinkles and reducing visible signs of aging. Among the many available options, Nabota and Xeomin stand out for their proven safety and effectiveness in addressing frown lines and other facial wrinkles.
In this article, we will compare Nabota and Xeomin, focusing on their composition, clinical efficacy, side effects, and the duration of their results.
Key Takeaways
- While Xeomin uses a double-filtration process to create a highly purified solution free of complex proteins, Nabota uses its patented HI Pure Technology for a purified formulation.
- Both injectables have received the US Food and Drug Administration’s (FDA) approval for treating frown lines, emphasizing the thorough process of clinical trials, testing, and evaluation that Nabota and Xeomin underwent.
- Their unique formulations garnered positive attention from medical experts, who targeted these products in their clinical studies to prove their potency.
- A thorough consultation with a medical professional allows them to discuss the treatment procedure, benefits, and potential side effects of Nabota and Xeomin.
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Understanding Nabota and Xeomin
Nabota, developed by Daewoong Pharmaceuticals, and Xeomin, produced by Merz Pharmaceuticals, are botulinum toxin type A injectables used for both aesthetic and therapeutic purposes. While both products share the same active ingredient, their formulations differ significantly, affecting their performance and potential side effects.
When comparing Nabota vs Botulax or Nabota vs Xeomin, patients should understand their compositions. Although they have similar active ingredients, they differ primarily in their purification processes and the presence of accessory proteins.
- Nabota uses its patented HI Pure Technology, which results in a highly purified formulation that still contains some inactive components, including accessory proteins.
- In contrast, Xeomin undergoes a double-filtration process that removes complexing proteins, leaving only the active botulinum toxin.
The absence of accessory proteins in Xeomin reduces the risk of the body forming antibodies, potentially decreasing the treatment’s effectiveness over time. While Nabota is also highly purified, its remaining inactive proteins may influence its long-term safety and efficacy compared to Xeomin’s pure formulation.
Clinical Efficacy
Understanding the clinical efficacy of these botulinum toxin type A injections can help determine the most suitable treatment for each individual’s concerns. Both injectables have undergone rigorous clinical trials and studies to prove their safety and efficacy.
A clinical study demonstrates the safety and effectiveness of Nabota (Jeuveau) in addressing glabellar lines. Adult subjects with moderate to severe glabellar lines received Jeuveau injections into their frown lines. The results showed that administering a single dose of 20 units of prabotulinumtoxinA effectively and safely treated glabellar lines.
Clinical studies have also established Xeomin’s safety and efficacy. In two separate studies, 97.7% and 98.3% of patients reported significant improvements in their upper facial lines by Day 30. Additionally, two randomized, double-blind, multicenter clinical trials confirmed that Xeomin effectively and temporarily enhanced the appearance of moderate to severe glabellar lines in adult patients.
Both injectables have received the US Food and Drug Administration for treating frown lines, emphasizing the thorough process of clinical trials, testing, and evaluation that Nabota and Xeomin had undergone. With the proper Xeomin and Nabota reconstitution and the provider’s guidance and expertise, patients can maximize the benefits of these neuromodulators in addressing their wrinkles and fine lines.
Side Effects and Safety
A thorough consultation with a medical professional allows them to discuss the treatment procedure, benefits, and potential side effects of Nabota and Xeomin. Like other minimally invasive treatments, patients should expect common Xeomin and Nabota side effects to occur after their sessions. These are typically temporary and may resolve independently within a few days.
- Nabota Side Effects: Mild pain, swelling, itching, and bruising at the injection site.
- Xeomin Side Effects: Localized pain, swelling, and bruising at the injection site.
With the rare occurrence of severe side effects, it’s best to seek medical attention for prompt action and management. Both treatments are generally safe and well-tolerated by most individuals; however, safety considerations for both products include:
- Known hypersensitivity to botulinum toxin type A or other components
- Skin infection or disease at the injection site
Medical professionals can provide more information about Nabota and Xeomin’s safety considerations. They can also equip patients with comprehensive information about the treatment and products, empowering them to make informed treatment decisions.
Duration of Results
Among many considerations, patients should also understand how long the results of Nabota and Xeomin last. Understanding the longevity of these neuromodulators’ effects can help them decide which may fit their aesthetic goals and preferences.
- Nabota: The reported onset of action of Nabota is as early as two days post-treatment. Typically, the effects can last three to four months.
- Xeomin: According to Xeomin Aesthetic, the onset of action typically shows three to four days after treatment. On average, the effects may last three to four months.
Individual responses may vary, and several factors can affect the duration of Nabota and Xeomin results. Medical professionals may also discuss these factors with patients, allowing them to understand what influences treatment outcomes.
- Individual Differences and Metabolism
- Treatment Area and Injection Dosage
- Proper Reconstitution and Precise Administration
- Proper Post-Treatment Care and Lifestyle
Consulting with a healthcare provider can determine the best option for each individual’s needs. A tailored treatment plan can align the Nabota or Xeomin procedure to the patient’s goals and concerns for higher satisfaction and optimal outcomes.
Expert Opinions and Clinical Studies
Many clinical studies highlight the safety and efficacy of Nabota and Xeomin in aesthetic treatments, particularly in addressing glabellar lines. Their unique formulations garnered positive attention from medical experts, who targeted these products in their clinical studies to prove their potency.
A study result for Nabota shows that 85.4% of subjects two days after administration improved their glabellar frown lines at maximum frown, and 51.2% improved their glabellar lines at rest, with the proportion of subjects improving over time.
Meanwhile, the findings indicate that all Xeomin doses were well tolerated, aligning with the established safety profile of 20 Units. Additionally, increasing the dose extends the duration of the effect for glabellar frown lines.
While no specific studies compare Nabota vs Xeomin, medical professionals and patients can conclude that these neuromodulators can offer practical solutions for aesthetic concerns.
Conclusion
Nabota and Xeomin offer effective solutions for individuals considering neuromodulator injections for facial rejuvenation. Their distinct compositions highlight the importance of understanding each formulation’s unique characteristics. Clinical studies have demonstrated the safety and effectiveness of Nabota and Xeomin in addressing glabellar line concerns, emphasizing their credibility as aesthetic treatments.
While both products have generally well-tolerated side effects, individuals with specific medical conditions should seek professional guidance before opting for these treatments. The choice between Nabota and Xeomin depends on individual goals, medical history, unique needs, and preferences.
FAQs
1. What are the key differences between Nabota vs Xeomin?
Nabota contains accessory proteins, while Xeomin is a “naked” toxin-free of complex proteins. This impacts their long-term effectiveness and safety when administered.
2. What are the common Xeomin and Nabota side effects?
Common side effects include mild pain, swelling, itching, and bruising at the injection site for Nabota and localized pain, swelling, and bruising for Xeomin.
3. Are Nabota and Xeomin safe for everyone?
Both treatments are generally safe and well-tolerated by most individuals. However, individuals with known hypersensitivity to botulinum toxin type A or other components, or those with a skin infection or disease at the injection site, should consult a medical professional before considering these treatments.
References
- 2022 Minimally Invasive Procedures. (2023). American Society of Plastic Surgeons. https://www.plasticsurgery.org/documents/News/Statistics/2022/minimally-invasive-procedure-trends-2022.pdf
- Kerscher, M., Fabi, S., Fischer, T., Gold, M., Joseph, J., Prager, W., Rzany, B., Yoelin, S., Roll, S., Klein, G., & Maas, C. (2021). IncobotulinumtoxinA Demonstrates Safety and Prolonged Duration of Effect in a Dose-Ranging Study for Glabellar Lines. Journal of drugs in dermatology: JDD, 20(10), 1052–1060. https://doi.org/10.36849/JDD.6377
- Physicians Resources – Clinical Results – Xeomin Aesthetic. (n.d.). Xeomin Aesthetic. Retrieved August 28, 2024, from https://www.xeominaesthetic.com/professionals/clinical-results
