Mastelli is a recognized Italian pharmaceutical company with a history dating back to 1952. Over the decades, Mastelli has established itself as a global player in developing innovative therapies, particularly in polynucleotide-based skin regeneration. Their commitment to scientific research and product quality has positioned them at the forefront of aesthetic medicine, offering solutions that emphasize both safety and natural-looking results.
One of Mastelli’s most notable innovations is Plinest, a dermal injectable that utilizes highly purified polynucleotides derived from natural sources. Unlike traditional fillers, Plinest stimulates the body’s collagen and elastin production, promoting improved skin hydration, elasticity, and overall rejuvenation. This minimally invasive treatment enhances skin texture while also helping protect skin cells from oxidative stress, offering a comprehensive approach to facial and body revitalization.
In this article, we will explore the history and scientific foundation of Mastelli Plinest, examine its clinical applications, and highlight the rigorous standards that support its safety and efficacy.
Key Takeaways
- Mastelli, founded in 1952, is a leading Italian pharmaceutical company specializing in dermatology and regenerative aesthetic medicine.
- The company developed PN‑HPT® (Polynucleotide High Purification Technology), a proprietary extraction method used in its flagship injectable, Plinest, to ensure high biocompatibility and purity.
- Plinest works by stimulating fibroblast activity to promote collagen and elastin production, resulting in improved skin hydration, elasticity, and texture.
- Clinical studies support Plinest’s efficacy in skin revitalization, particularly for nasolabial folds and dermal texture improvement.
- While Plinest holds CE certification in Europe, it has not yet received FDA approval for use in the United States, though ongoing research and global expansion efforts are underway.
- Mastelli maintains strict manufacturing standards in line with cGMP guidelines, conducting regular audits and quality checks to ensure safety and consistency.
- The Plinest product line now includes Plinest Fast, Plinest Eye, and Plinest Hair, allowing for personalized treatment across facial, ocular, and scalp concerns.
- As Mastelli continues to expand globally, it remains a trusted name in non-surgical rejuvenation, merging clinical science with innovative skincare solutions.
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The History and Innovation Journey of Mastelli and Plinest
Mastelli has been a trailblazer in biopharmaceutical innovation since its founding in 1952 in Sanremo, Italy. With a longstanding focus on dermatology, wound healing, aesthetic medicine, and regenerative therapies, the company has continuously contributed to advancing skin treatment technologies that blend science with patient-centered care.
One of Mastelli’s most notable contributions is its polynucleotide-HPT (High-Purification Technology)—a proprietary method that ensures the highest purity and biocompatibility of polynucleotides for medical use. This groundbreaking innovation ultimately led to the development of Mastelli’s Plinest, a product that has since defined a new standard in non-surgical facial rejuvenation.
Key milestones in Mastelli’s development include:
- 1952: Mastelli is established, specializing in pharmaceutical and dermatological solutions.
- 1980s: Research into polynucleotides and their regenerative potential begins.
- 2005: Plinest is introduced as the first polynucleotide-based aesthetic injectable.
- Present: Mastelli continues refining its proprietary technology and expanding its global presence in regenerative medicine.
Scientific Research and Clinical Evidence Supporting Plinest
Mastelli offers Plinest and its related innovations across Italy and various global markets. Using PN‑HPT®, this injectable delivers highly purified trout-derived polynucleotides that activate fibroblasts, boost collagen production, and enhance skin hydration—collectively improving skin elasticity, radiance, and structure.
If you’ve ever wondered what is Plinest, it is an injectable biostimulatory treatment that does not simply fill lines, but instead works at a cellular level to rejuvenate and repair the skin.
A study by Araco, Araco, & Raichi (2022) found that PN‑HPT® significantly improved skin texture and the appearance of nasolabial folds, particularly in patients with moderate to severe facial aging. Moreover, it showed potential for prolonging the effects of cross-linked hyaluronic acid treatments, offering more comprehensive and lasting outcomes.
That said, more clinical trials and regulatory approvals are still needed—especially for U.S. markets. Once FDA approval is secured, Mastelli’s reach could expand significantly. When this happens, they could bring Plinest to even more patients seeking safe and effective skin rejuvenation.
Manufacturing Standards and Quality Control Behind Plinest
Practitioners often ask, “What is Plinest and how is it made?” As a member of Farmindustria, the Association of Italian Pharmaceutical Industries, Mastelli adheres to Good Manufacturing Practices (cGMP) and enforces stringent quality control standards at every stage of production.
Plinest’s development leverages advanced purification technologies that minimize contaminants, improve biocompatibility, and ensure consistent product performance. The use of High-Purification Technology ensures that every vial meets exacting quality benchmarks.
Regular audits, process validation, and batch testing maintain safety and product integrity, aligning with both European and international pharmaceutical standards. These controls are critical for maintaining patient trust and clinical reliability.
Expanding the Mastelli Portfolio Beyond Plinest
While Plinest remains the company’s flagship product, Mastelli continues to evolve its portfolio of aesthetic and regenerative medicine. In addition to Plinest, the company offers:
- Plinest Fast: For rapid rejuvenation
- Plinest Eye: Targeting delicate periocular skin
- Plinest Hair: Stimulating scalp vitality and follicle health
These formulations use the same polynucleotide technology but are optimized for targeted applications, ensuring clinicians can customize treatment for eyes, scalp, and facial skin. Each formulation reflects Mastelli’s focus on minimally invasive, high-efficacy approaches to aesthetic care.
Continuous R&D ensures the brand remains at the forefront of the global regenerative aesthetic market. The company aims to provide clinicians with a scientifically grounded and results-driven product line that meets evolving patient expectations.
Conclusion: Mastelli’s Legacy and Future with Plinest
Mastelli Plinest represents more than just a product—it reflects a legacy of scientific innovation, safety, and aesthetic excellence. With over 70 years of research and development, Mastelli has built a reputation anchored in clinical reliability, high-purity formulations, and a deep commitment to regenerative skincare.
As global interest in polynucleotide-based therapies grows, Mastelli is well-positioned to expand its influence. With increasing demand for natural-looking rejuvenation and science-backed treatments, Plinest is set to play an even larger role in the future of aesthetic medicine. Once its regulatory approvals extend to broader markets like the U.S., its scientific pedigree and quality assurance will make it a standout in the aesthetic landscape.
FAQs
1. What is Plinest, and what are its benefits?
Plinest is a facial rejuvenation product from Italian manufacturer Mastelli that utilizes high-purity polynucleotide technology. It enhances skin hydration, stimulates collagen production, and improves skin texture, providing noticeable anti-aging effects with minimally invasive treatments.
2. Is there clinical evidence to prove Plinest’s outcomes?
Research found that Plinest improved skin texture and quality for individuals with moderate to severe nasolabial folds. The study emphasized the effectiveness of the PN‑HPT® technology in activating fibroblasts and promoting collagen production. These findings highlight its ability to enhance the results of treatments that use cross-linked hyaluronic acid.
3. How does Mastelli ensure the safety and quality of Plinest?
As a member of Farmindustria, Mastelli follows strict manufacturing protocols and quality control measures. The company utilizes advanced purification technologies. They also adhere to international cGMP guidelines, ensuring that every batch of Plinest meets high safety and efficacy standards.
References
- Cohen, J. (2017). Impact of Comprehensive, Minimally Invasive, Multimodal Aesthetic Treatment on Satisfaction With Facial Appearance: The HARMONY Study. Aesthetic Surgery Journal, 38(5), 540–556. https://www.academia.edu/55552804/Impact_of_Comprehensive_Minimally_Invasive_Multimodal_Aesthetic_Treatment_on_Satisfaction_With_Facial_Appearance_The_HARMONY_Study
- Araco, A., Araco, F., & Raichi, M. (2022). Clinical efficacy and safety of polynucleotides highly purified technology (PN‐HPT®) and cross‐linked hyaluronic acid for moderate to severe nasolabial folds: A prospective, randomized, exploratory study. Journal of Cosmetic Dermatology, 22(1), 146–155. https://doi.org/10.1111/jocd.15064
