According to RealSelf, dermal fillers have received an impressive average rating of 90% from users who have undergone the procedure. Out of 659 ratings on the platform, a majority of 591 patients expressed satisfaction, affirming the treatment’s effectiveness in addressing various skin concerns.
Injectable dermal fillers have become safe and effective non-surgical solutions for addressing facial skin concerns. Among various brands, medical professionals frequently compare Jalupro and Profhilo due to their biorevitalization properties for skin rejuvenation. Beyond restoring volume, these injectables provide comprehensive skin enhancement in their targeted treatment areas.
This article will compare Jalupro and Profhilo, their compositions, mechanisms of action, clinical efficacy, and practical considerations.
Key Takeaways
- It’s worth noting that Profhilo and Jalupro have similar effects on individuals, but their difference lies in their respective vital ingredients and mechanisms of action.
- Jalupro’s blend of HA and amino acids provides dual benefits: surface hydration and structural skin support. Profhilo spreads out in the treatment area, hydrating the skin and stimulating collagen and elastin growth.
- While clinical trials comparing Jalupro and Profhilo are unavailable, the treatment choice depends on each individual’s skin and concerns.
- While these injectables have specific indications in the facial area, medical professionals also utilize them for other body regions.
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Understanding Jalupro and Profhilo

It’s essential to consider various options when finding the most suitable dermal filler treatment for each patient. Jalupro and Profhilo injections offer skin boosters that can restore volume while stimulating collagen production over time. Understanding these injections can help medical professionals and patients determine the best treatment.
Professional Derma developed Jalupro injections to address aging signs and improve skin texture, hydration, and overall skin quality. Meanwhile, IBSA created Profhilo as an injectable to reduce aging signs and improve hydration, elasticity, and skin texture.
It’s worth noting that Profhilo and Jalupro have similar effects on individuals, but their difference lies in their respective vital ingredients and mechanisms of action. Both can deliver safe and effective results to patients with the expertise of medical professionals.
Composition and Mechanism of Action

Jalupro is a skin booster that combines hyaluronic acid (HA) with a unique blend of amino acids, such as glycine, leucine, proline, and lysine. These components nourish the connective tissues beneath the skin and stimulate collagen and elastin production, leading to a healthier, more youthful complexion.
Jalupro’s blend of HA and amino acids provides dual benefits: surface hydration and structural skin support. HA’s power maintains skin hydration and elasticity, while the amino acids support fibroblasts in collagen synthesis, resulting in longer-lasting benefits.
On the other hand, Profhilo capitalizes on HA’s potency. It consists of pure, concentrated HA to stimulate collagen and elastin production in the skin to restore and sustain healthy and youthful skin. Unlike traditional dermal fillers, Profhilo does not add volume but remodels the skin from within.
This injectable’s distinctive formulation utilizes low—and high-molecular-weight HA. Profhilo spreads out in the treatment area, hydrating the skin and stimulating collagen and elastin growth. This dual action produces plumper skin with reduced fine lines and wrinkles.
Clinical Efficacy
A clinical and instrumental study demonstrates Jalupro’s efficacy and tolerance as a biorevitalizing filler. The findings showed excellent biorevitalizing effects, significantly improving common signs of skin aging and photoaging. Importantly, participants tolerated the treatments very well, with no adverse events related to Jalupro.
Meanwhile, an open-label study highlights the positive changes that persisted and remained statistically significant. Profhilo received a tolerability and safety rating of good or excellent and emphasized that low—and high-molecular-weight hyaluronic acid contributes to effective bio-remodeling.
However, individuals in their late 30s may opt for Profhilo to restore the skin’s natural elasticity and youthfulness. Slightly younger individuals aged late 20s to early 30s may opt for Jalupro to counteract early signs of aging and maintain the skin’s structural integrity.
While clinical trials comparing Jalupro and Profhilo are unavailable, the treatment choice depends on each individual’s skin and concerns. These skin boosters have similar mechanisms, making them valuable options for skin rejuvenation.
Practical Considerations

Medical professionals and patients can mainly consider Jalupro and Profhilo treatment areas as factors on which skin booster suits the individual’s concerns and skin condition. While these injectables have specific indications in the facial area, medical professionals also utilize them for other body regions. Providers must administer at the precise Profhilo and Jalupro injection points for optimal results.
- Treatment Areas for Jalupro: Face, neck, hands, underarms, décolletage, abdomen, inner thighs, and knee region.
- Treatment Areas for Profhilo: Face (cheeks, nasolabial folds, forehead, temples), neck (reducing wrinkles and improving skin laxity), and hands and arms.
Another factor to consider before starting an injection treatment is the longevity of results. These non-surgical options offer temporary but long-lasting outcomes, and the effects may also vary from one individual to another. Regular maintenance sessions for these injections are recommended for optimal outcomes.
- Jalupro: Its effects typically last six months or more.
- Profhilo: Its effects may last between six to nine months.
Patient satisfaction matters because it leads to loyalty, better outcomes, compliance, and fewer malpractice suits. The clinical trials involving these two injectables showed increased patient satisfaction with their Jalupro and Profhilo treatments due to their safety and effectiveness. Furthermore, effective communication is crucial in managing patient expectations and overall satisfaction.
While these injectables are well-tolerated by most individuals, patients must understand that potential side effects may occur after treatments. Medical professionals must advise and explain how to recognize these symptoms, proper management, and when to seek immediate medical attention.
- Jalupro: Mild swelling, redness, bruising, or itching at injection sites.
- Profhilo: Mild redness, swelling, pain, itching, bruising, or tenderness at the injection sites.
Conclusion
The comparison between Jalupro and Profhilo reveals two distinct yet effective approaches to non-surgical skin rejuvenation. While both treatments aim to address skin aging and improve texture and hydration, they differ in their compositions. Jalupro combines hyaluronic acid and amino acids, while Profhilo focuses on pure, concentrated HA.
The clinical efficacy of both treatments demonstrates positive results, and the choice between Jalupro and Profhilo depends on individual skin concerns and conditions. Understanding the differences and treatment areas for each option is crucial for medical professionals and patients when considering non-surgical solutions for skin enhancement.
FAQs
1. What are Jalupro and Profhilo?
Jalupro and Profhilo are injectable dermal fillers, specifically skin boosters, designed to address skin aging and improve skin texture, hydration, and overall quality.
2. What are the main differences between Jalupro and Profhilo?
Jalupro combines hyaluronic acid (HA) with amino acids to provide surface hydration and structural skin support, while Profhilo consists of pure, concentrated HA to stimulate collagen and elastin production in the skin without adding volume.
3. What are the treatment areas for Jalupro and Profhilo?
Jalupro can be used on the face, neck, hands, underarms, décolletage, abdomen, inner thighs, and knee region. In contrast, Profhilo is typically used on the face, neck, hands, and arms to reduce wrinkles and improve skin laxity.
References
- Dermal Fillers Reviews | Was it Worth It? | RealSelf. (2024, February 22). RealSelf.com. https://www.realself.com/reviews/dermal-fillers
- Sparavigna, A., & Tenconi, B. (2016). Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clinical, cosmetic and investigational dermatology, 9, 297–305. https://doi.org/10.2147/CCID.S114450