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Brand: ZO®


Quantity Price
1 - 5 $119.00
6 - 10 $109.00
11 - 20 $104.00
21+ $99.00

Manufacturer: ZO Skin Health
Active Substance(s): RETINOL
Strength: 0,25%
Pack Size: 50ml
Accessories: Package insert

ZO® RETINOL SKIN BRIGHTENER 0.25% is a powerful retinol based skin brightening solution that helps to reduce the appearance of fine lines, wrinkles, and dark spots. It also contains potent antioxidants that protect the skin from environmental damage and promote a healthy, youthful-looking complexion.


Frequently Asked Questions

You can order ZO Brightenex online from, or you can phone our friendly customer service associates to inquire about this and other medical supplies. When you order ZO® Brightenex from Medica Depot, you can help your patients with hyperpigmentation brighten their skin for a more even tone.

Each package contains:

1-50ml pump bottle;
And 1 packaging insert.

ZO RETINOL BRIGHTENER is a skin brightener and correcting lotion for aging and sun-damaged skin. This skin health lotion includes ingredients such as retinol, vitamins C and E, glutathione, isoflavonoids, glucosamine, and herbal extracts. Patients with aging and sun-damaged skin affected by hyperpigmentation may use this skin lotion as a brightener for a more even tone.

The main ingredients in ZO RETINOL SKIN BRIGHTENER are high-potency retinol and ascorbic acid-2 glucoside, which help exfoliate dead skin cells, increasing cell turnover and breaking up existing skin pigmentation to help brighten skin tone. The Stachys officinalis herbal extract has soothing properties and may help block messengers that trigger melanogenesis, reducing melanin production to limit dark spots. Glutathione, soy isoflavones, and n-acetyl glucosamine can help prevent new age spots and uneven pigmentation from forming, while vitamins C and E can act as antioxidants, helping protect skin from free radicals which can cause damage. Together, the ingredients help brighten the skin for a more even tone.

Aqua/Water/Eau, Cetearyl Isononanoate, Cyclopentasiloxane, Glycerin, Prunus Amygdalus Dulcis (Sweet Almond) Oleosomes, Cyclohexasiloxane, Cetearyl Alcohol, Steareth-20, Cetyl Alcohol, Pentylene Glycol, Ascorbyl Glucoside, Polysorbate 20, Retinol, Propylheptyl Caprylate, Acetyl Glucosamine, Cetearyl Glucoside, Lecithin, Acrylamide/Ammonium Acrylate Copolymer, Alcohol, 1,2-Hexanediol, Caprylyl Glycol, Carbomer, Glutathione, Nylon-12, Polysorbate 80, Sodium Hydroxide, Polyisobutene, Ascorbyl Palmitate, Tocopheryl Acetate, Disodium EDTA, Maltodextrin, Prunus Armeniaca (Apricot) Kernel Oil, Lavandula Angustifolia (Lavender) Oil, Stachys Officinalis Flower/Leaf/Stem Extract, Pelargonium Graveolens Flower Oil, Linalool, Limonene, Geraniol, Coumarin, Citronellol, Citral, Zea Mays (Corn) Oil, Soy Isoflavones, Beta-Carotene, BHT, BHA, Potassium Sorbate, Sodium Metabisulfite, Sodium Sulfite.

To use ZO RETINOL SKIN BRIGHTENER, your patients should first cleanse their skin, and then apply 1–2 pumps of brightener to their fingertips. They should then gently massage the lotion into their skin, covering their entire face but avoiding their eyes.

Your patients should start by using ZO RETINOL SKIN BRIGHTENER twice a week, then gradually increase to once every day, if their skin can tolerate it. Around 3–7 days after first using this skin brightener, your patients will experience dryness, peeling, and irritation as the ingredients help exfoliate dead cells from the skin’s surface. If the irritation and burning sensation persist, your patients should stop using ZO Brightenex until these symptoms subside, then gradually begin using the skin brightener again to build their tolerance. If your patients need a less-aggressive skin brightener, they can mix equal parts ZO RETINOL SKIN BRIGHTENER and ZO Restoracalm, and use this mixture once a week.

This product can be used on the face and other areas to be treated for hyperpigmentation.

If used as recommended, this product helps to correct areas of discoloration and even out skin tone. After completion of the course of treatment, results are enduring provided the patient prevents formation of hyperpigmentation by taking the necessary protective steps.

Doctors recommend ZO RETINOL SKIN BRIGHTENER to their patients who have signs of aging and sun damage, such as age spots and other types of hyperpigmentation. Sometimes doctors may recommend this skin brightener as an initial treatment for hyperpigmentation, or they may recommend ZO RETINOL BRIGHTENER after prescription treatments to help maintain brighter skin.

Consider ZO Brigthtenex for a versatile yet effective treatment of hyperpigmentation of all stages—without the use of hydroquinone. This product is available in 2 concentrations of retinol for a personalized treatment specific to the degree of discoloration and area treated.

Possible side effects can include dryness, peeling skin, skin irritation, burning sensation, rash, and sun sensitivity. The first week your patients use ZO RETINOL BRIGHTENER, they will likely experience dryness, peeling skin, and skin irritation as their dead skin cells are exfoliated. If your patients develop a persistent rash, burning sensation, or other irritation, they should stop using this brightening lotion and contact a doctor. These may not be all the possible side effects.

Your patients should not use ZO RETINOL SKIN BRIGHTENER if they are allergic or sensitive to any of its ingredients. Your patients should not use ZO RETINOL BRIGHTENER if they are pregnant or breastfeeding. This skin brightening lotion is for external use only. If your patients get this skin health lotion in their eyes, they should rinse thoroughly with cool water. Since ZO RETINOL SKIN BRIGHTENER can increase sun sensitivity, your patients should use a sunscreen, wear protective clothing, and limit their sun exposure while using this skin brightener and for 1 week afterwards.

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