A recent systematic review published in Polymers highlights the impressive capabilities of PLLA injectable treatments in enhancing dermal thickness and delivering significant aesthetic improvements that can last over 25 months. These findings underscore the growing clinical recognition of PLLA’s role in effective skin rejuvenation.
Among these treatments, Lanluma stands out as a cutting-edge, non-surgical aesthetic solution that works by stimulating the body’s natural collagen production to subtly restore facial volume and refine contours. This innovative approach offers a refreshing alternative for those seeking natural-looking rejuvenation without invasive procedures.
In this article, we’ll explore what Lanluma is, delve into its key benefits, and compare it with other popular treatments to help you understand why it’s rapidly gaining traction in the world of aesthetic medicine.
Key Takeaways
- Lanluma is a poly-L-lactic acid (PLLA) injectable that stimulates natural collagen production to restore volume and improve skin texture and elasticity gradually.
- It is used for both facial rejuvenation and body contouring as well as treating delicate areas like the under eyes and décolleté.
- Unlike hyaluronic acid fillers, Lanluma promotes a biological response that enhances skin quality over time, offering long-lasting, natural-looking results.
- Proper clinical protocols involving product preparation, tailored dosing, precise injection techniques, and post-treatment care are essential for safe and effective outcomes.
- Lanluma has a favorable safety profile but requires ongoing regulatory approval, including from the FDA, to confirm its long-term safety and efficacy.
- Patients seeking subtle, sustained aesthetic improvement may find Lanluma a compelling alternative to traditional fillers or surgical options.
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What Is Lanluma Made Of and How Does It Work?

Whether for a Lanluma bum lift or facial rejuvenation, this poly-L-lactic acid (PLLA)-based injectable offers a minimally invasive treatment option. It provides a biocompatible and biodegradable synthetic polymer that naturally boosts collagen and elastin production.
PLLA has long been utilized in medical devices, such as dissolvable sutures, and when used in Lanluma, it effectively stimulates the body’s regenerative processes. After injection, the PLLA particles in Lanluma act as powerful bio-stimulants. They activate fibroblasts, which gradually produce natural collagen over time.
This slow, steady process leads to enhanced volume and improved tissue texture. It delivers a natural, long-lasting aesthetic improvement that can endure for up to two years. Over several weeks, collagen synthesis enhances volume and refines tissue texture, creating a refreshed and youthful appearance.
What Is Lanluma Used For – Indications and Treatment Areas

As a biostimulatory injectable, PLLA is also widely used in dissolvable sutures. However, Sinclair’s Lanluma has specific indications that aesthetic professionals should understand and adhere to in order to avoid complications.
Furthermore, the key to its impressive Lanluma before and after photos lies in strictly following clinical protocols that emphasize the following:
- Proper reconstitution
- Precise injection techniques
- Tailored treatment planning
The indications and treatment areas include:
- Facial Rejuvenation: Restoring volume in the cheeks, temples, and jawline; reducing wrinkles and folds.
- Periorbital Enhancement: Lessening dark circles and fine lines around the eyes.
- Body Contouring: Enhancing buttocks contours (notably via the Lanluma bum lift), reducing cellulite, and smoothing the texture on the thighs and abdomen.
- Hand and Décolleté Refinement: Improving skin quality and structure in these delicate areas.
What Sets Lanluma Apart From HA Fillers and Other Injectables?
Lanluma and other poly-L-lactic acid (PLLA) treatments gradually stimulate collagen synthesis, distinguishing them from other minimally invasive aesthetic options. Unlike hyaluronic acid (HA) fillers, which provide instant volume by immediately filling the treatment area, Lanluma initiates a biological response that enhances tissue quality over time.
While HA fillers deliver rapid volumization as their primary mechanism, Lanluma works beneath the skin to stimulate collagen production and gradually improve skin texture. The results from Lanluma tend to develop slowly but last significantly longer. On the other hand, HA and many different dermal fillers often offer immediate but shorter-lived effects.
Additionally, Lanluma has indications for both facial and body rejuvenation, whereas HA fillers are typically limited to facial enhancements. This versatility, along with its unique formulation, makes Lanluma a preferred choice for those seeking natural, long-term rejuvenation.
It is vital to note that Lanluma still requires additional regulatory approvals, including those from the US Food and Drug Administration (FDA), to fully confirm its safety and efficacy.
What Is the Clinical Protocol for Lanluma Use?

Aesthetic professionals should follow the recommended clinical protocol for administering Lanluma injections as provided by Sinclair. Proper preparation, injection technique, and post-treatment care are essential for achieving optimal aesthetic outcomes and ensuring patient safety.
- Preparation: Clinicians reconstitute Lanluma by adding 40–60 mL of sterile water per vial. Practitioners gently swirl the mixture to achieve a uniform suspension without foam. They then allow it to hydrate for the recommended period.
- Dosage: The Lanluma dosage is adjusted based on individual patient characteristics and the targeted treatment area for best results.
- Injection Process: Lanluma is injected into the deep subcutaneous tissue using techniques such as fanning or linear threading. Small aliquots, typically 0.1 to 0.2 mL per injection site, ensure even distribution of the product.
- Post-Treatment Care: Patients should follow specific aftercare instructions, which include gentle massage, avoiding strenuous activity, and attending scheduled follow-ups to monitor progress.
This structured protocol, based on Sinclair’s official documentation, helps maximize Lanluma’s effectiveness while minimizing risks.
Conclusion
Lanluma represents an innovative approach to aesthetic enhancement through its PLLA-based formulation that stimulates collagen production for natural and lasting results. This treatment addresses not only facial rejuvenation but also provides effective solutions for body contouring and improving skin quality in sensitive areas.
Its gradual, regenerative approach sets it apart from traditional fillers, offering a more sustainable outcome for those seeking long-term improvements. As non-surgical aesthetic options continue to evolve, understanding Lanluma’s protocols and applications is crucial for both clinicians and patients. With ongoing research and regulatory progress, Lanluma has strong potential to become a preferred choice in the field of aesthetic medicine.
FAQs
1. What is Lanluma, and how does it work?
Aesthetic professionals use Lanluma, a poly-L-lactic acid (PLLA)-based injectable treatment, for aesthetic enhancements. It works by stimulating the body’s natural collagen production, gradually improving facial volume and skin texture over time.
2. What treatment areas can benefit from Lanluma injections?
Practitioners use Lanluma for various treatments, including facial rejuvenation (cheeks, temples, and jawline), periorbital enhancement (dark circles and fine lines around the eyes), body contouring (buttocks, thighs, and abdomen), and refining skin quality in the hands and décolleté.
3. How does Lanluma compare to traditional HA fillers?
Unlike hyaluronic acid (HA) fillers that provide immediate volume, Lanluma gradually stimulates collagen production, leading to longer-lasting results. Additionally, Lanluma is versatile for both facial and body rejuvenation, whereas HA fillers primarily target facial enhancements.
References
- Signori R, de Paula Barbosa A, Cezar-dos-Santos F, et al. Efficacy and Safety of Poly-l-Lactic Acid in Facial Aesthetics: A Systematic Review. Polymers. 2024;16(18):2564-2564. doi:https://doi.org/10.3390/polym16182564
- Vleggaar D, Fitzgerald R, Lorenc ZP. Composition and Mechanism of Action of Poly-L-Lactic Acid in Soft Tissue Augmentation – JDDonline – Journal of Drugs in Dermatology. JDDonline – Journal of Drugs in Dermatology. Published April 2014. Accessed June 3, 2025. https://jddonline.com/articles/composition-and-mechanism-of-action-of-poly-l-lactic-acid-in-soft-tissue-augmentation-S1545961614S0029X