A practitioner holding an aesthetic injection.

A recent systematic review published in Aesthetic Plastic Surgery highlights the effectiveness of poly-L-lactic acid (PLLA) biostimulators in improving skin texture, elasticity, and volume. The study found that treatments combining PLLA with other modalities, such as botulinum toxin and energy-based devices, demonstrated significant aesthetic improvements, reinforcing PLLA’s important role in non-surgical rejuvenation.

Building on these findings, PLLA-based biostimulators like Lanluma and Sculptra have gained popularity for their ability to stimulate collagen production and enhance skin quality. These treatments offer long-lasting results, making them preferred choices for individuals seeking subtle yet effective aesthetic enhancements.

In this article, we will compare Lanluma and Sculptra, examining their benefits, limitations, and indications to help you determine the best option for your aesthetic goals.

Key Takeaways

  • Lanluma and Sculptra are both poly-L-lactic acid (PLLA) biostimulators that promote natural collagen production for skin rejuvenation, offering gradual and long-lasting aesthetic improvements.
  • Lanluma is more versatile, with flexible dosing options tailored for both facial and body contouring, making it suitable for patients seeking volume and tightening in larger treatment areas.
  • Sculptra is primarily focused on facial volumization and wrinkle correction, with standardized protocols ideal for addressing fine lines and facial contour loss.
  • Both treatments require specialized training for practitioners to ensure safe and effective administration, with certification programs provided by their respective manufacturers.
  • The choice between Lanluma and Sculptra depends on individual patient needs, target areas, lifestyle factors, and desired outcomes, emphasizing the importance of a personalized consultation.

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Lanluma vs Sculptra: What They Share as PLLA Biostimulators

An individual receiving a facial injection.

When comparing Lanluma vs Sculptra, aesthetic professionals often point out their similarity as poly-L-lactic acid (PLLA) injectables. By harnessing PLLA’s potency, its mechanism of action jumpstarts the body’s natural collagen production. This process restores the skin’s lost volume and enhances overall skin quality.

Their manufacturers have also confirmed the gradual yet long-lasting aesthetic enhancements of these treatments. Both products work by stimulating collagen, resulting in a regenerative process. This unique action makes Lanluma and Sculptra valuable options for minimally invasive facial rejuvenation.

While many clinical studies and the US FDA approval support the safety and efficacy of Sculptra, Lanluma’s before and after photos demonstrate the product’s effectiveness. It’s essential for patients to seek the expertise and guidance of aesthetic professionals to ensure suitability and optimal outcomes.

Lanluma vs Sculptra Differences in Indications and Usage

While Lanluma and Sculptra have a similar mechanism of action due to their utilization of poly-L-lactic acid, it’s worth noting that they target distinct aesthetic concerns. Understanding their indications can help patients achieve their aesthetic goals without further complications.

Lanluma is versatile, serving both facial and body contouring needs. It offers flexible dosing with two different vial options: Lanluma V for smaller areas and Lanluma X for larger zones. This dosing flexibility enables clinicians to tailor treatment plans for optimal volumetric correction and natural contour enhancement, specifically designed for each patient’s unique anatomy.

In contrast, Sculptra is primarily focused on facial volumization and rejuvenation. Its standardized dilution and reconstitution protocols ensure a consistent administration process. According to Galderma’s official guidelines, Sculptra stimulates collagen gradually over consecutive sessions, which results in subtle and predictable improvements in facial structure.

Lanluma vs Sculptra: Protocols, Handling, and Training Needs

A dermatologist putting on gloves.

Aesthetic professionals should be aware of the most suitable treatment for each patient, tailored to their individual needs and specific factors. They should also consider the treatment’s protocols, proper handling, and required training for safety and effectiveness.

  • Lanluma: Offers a simplified reconstitution process along with flexible dosing options. Lanluma’s adaptability means clinicians can easily tailor treatments based on the size of the treatment area.
  • Sculptra: Utilizes a fixed dilution protocol in conjunction with standardized administration methods.

In addition, practitioners are required to undergo specialized training for each product. Sinclair and Galderma require clinicians to complete dedicated certification programs that cover injection techniques, complication management, and precise product handling. These rigorous training requirements ensure that treatment is performed safely and effectively, leading to predictable aesthetic improvements.

Which to Choose – Lanluma vs Sculptra Based on Practice Focus

A practitioner discussing a patient's aesthetic treatment and goals.

A thorough consultation with practitioners can determine which product can effectively address the patient’s concerns. They should assess the patient’s severity of problems, other medical conditions, lifestyle characteristics, and other relevant factors that may impact product selection and efficacy.

Lanluma can tighten the body’s or face’s skin, increase fullness, and add volume. Practitioners can use this treatment as a prevention solution or to improve aesthetic appearance. Meanwhile, providers should administer Sculptra to individuals with healthy immune systems and concerns with the nasolabial fold contour, fine lines and wrinkles in the cheek, and other facial regions.

Additionally, these products reflect distinct strategies in achieving natural, long-term rejuvenation. Practitioners determine the most appropriate filler by also considering the targeted treatment area, the need for dosing flexibility, and the specific aesthetic outcomes desired by the patient.

Conclusion

Both Lanluma and Sculptra offer effective solutions for individuals seeking non-surgical facial rejuvenation through the stimulation of collagen production. Each product brings unique advantages to the table, with Lanluma providing versatile options for body and facial contouring, while Sculptra is specifically designed for facial volumization. Understanding the differences between them is crucial for achieving optimal aesthetic results.

When considering which biostimulator to choose, a personalized consultation with a trained aesthetic professional is crucial. They can assess individual concerns, treatment goals, and suitability to determine the most appropriate option, ensuring a safe and satisfying outcome for patients.

FAQs

1. What are Lanluma and Sculptra used for?

Lanluma and Sculptra are both poly-L-lactic acid (PLLA) biostimulators designed to stimulate collagen production, enhancing skin quality and volume. Lanluma is versatile for both facial and body contouring, while Sculptra primarily targets facial volumization and rejuvenation.

2. How do the dosing options differ between Lanluma and Sculptra?

Lanluma offers flexible dosing with two types of vials: Lanluma V for smaller areas and Lanluma X for larger areas, allowing for tailored treatments. In contrast, Sculptra has a standardized dilution and administration protocol for consistent treatment delivery.

3. What is required for practitioners administering these treatments?

Both Lanluma and Sculptra require specialized training for practitioners. Clinicians must complete certification programs that cover injection techniques and safety protocols to ensure effective and safe administration of these PLLA biostimulators.

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References

  1. Tam E, Choo JPS, Rao P, Webb WR, Carruthers JDA, Rahman E. A Systematic Review on the Effectiveness and Safety of Combining Biostimulators with Botulinum Toxin, Dermal Fillers, and Energy-Based Devices. Aesthetic Plastic Surgery. Published online December 24, 2024. doi:https://doi.org/10.1007/s00266-024-04627-5
  2. 258.SUMMARY of SAFETY and EFFECTIVENESS DATA (SSED). US Food and Drug Administration. Accessed May 30, 2025. https://www.accessdata.fda.gov/cdrh_docs/pdf3/P030050S039B.pdf