A medical professional transferring the vial's content into the syringe.

Did you know that polynucleotides are highly effective in combating photoaging? These powerful compounds promote tissue repair and regeneration, improving skin texture, reducing wrinkles, and enhancing overall skin vitality. Their unique ability to restore skin health has made them a sought-after solution for facial rejuvenation.

Polynucleotides are widely recognized in aesthetic medicine for their high biocompatibility and safety. Many top cosmetic brands now incorporate polynucleotides into innovative treatments, offering individuals effective ways to enhance their facial aesthetics and combat signs of aging.

This article will delve into polynucleotide treatments, explaining how they work, their benefits, and their suitability for different patients.

Key Takeaways

  • When considering the role of polynucleotides, it’s important to remember that these polymers are the building blocks of DNA and RNA.
  • When injected into the skin, polynucleotides provide a structural framework that supports cellular division and repair.
  • With their biocompatibility and powerful benefits, polynucleotides effectively target aging skin and enhance skin texture.
  • The typical frequency may involve multiple injection sessions spaced two to four weeks apart.

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What are Polynucleotides?

A close-up shot of a formulation.

Polynucleotides comprise chains or compounds of nucleotides linked together through covalent bonds. Each nucleotide mainly contains three parts: a phosphate group, a 5-carbon sugar, and a nitrogenous base. These polynucleotide chains may be found in two complex types: DNA and RNA, where the sequence of nucleotides results in genetic information.

These polymers serve as the building blocks of DNA and RNA. They can substantially help in both DNA replication and RNA transcription. This process forms complementary strands during DNA replication using its templating mechanism to create similar copies of polynucleotides.

Meanwhile, protein synthesis works when the genetic information stored in DNA is passed to RNA through transcription. This information then reaches protein through translation, ensuring proper cellular function and genetic inheritance.

The Science Behind Polynucleotides

Polynucleotides have shown their safety and efficacy in delivering biorevitalization as the active ingredient in several aesthetic products. They can stimulate the regeneration of damaged cells and increase fibroblast activity, enhancing the body’s natural healing process and promoting collagen and elastin production.

Mechanism of Action in Skin Rejuvenation and Healing

Several minimally invasive treatments harness the potency and abilities of polynucleotides to provide efficient skin rejuvenation to patients. When administered into the skin, these polynucleotides offer a structural framework that facilitates cellular division and repair. Its stimulation of collagen and elastin leads to an improved skin texture and quality.

Benefits of Polynucleotide Treatments

An individual receiving an injection in their midface region.

Understanding the benefits of polynucleotides treatment can make it appealing to providers and patients for subsequent aesthetic procedures. This treatment has proven its comparable efficacy to other non-surgical options by delivering the following advantages:

  • Stimulating Skin Regeneration: Polynucleotides stimulate skin regeneration by enhancing cellular turnover. This leads to the repair of damaged cell tissues, boosts wound healing, and restores the structure of healthy skin layers.
  • Reducing Inflammation: The component also boasts its anti-inflammatory properties, aiding in minimizing swelling and redness when administered to the skin. Polynucleotides calm the irritated skin, making it easier for the skin to recover from dermatological procedures.
  • Promoting Collagen Production: Polynucleotides stimulate fibroblasts and increase collagen and elastin synthesis. This results in improved skin elasticity and firmness and reduced aging signs in the treated area.

Proper administration of polynucleotides treatment can lead to high patient satisfaction. Qualified medical practitioners should perform these procedures to ensure patient safety, improve overall skin texture and appearance, and rejuvenate skin that lasts.

Polynucleotides in Aesthetic Medicine

Non-surgical interventions like dermal fillers or skin boosters are emerging as popular aesthetic options for individuals wanting to restore their youthful glow. Due to their biocompatibility, potent benefits, and mechanism of action, polynucleotides can effectively deliver the following benefits:

  • Treating Signs of Aging: Polynucleotides stimulate collagen and elastin production to reverse signs of aging. This treatment enhances skin elasticity and firmness, effectively reducing wrinkles and fine lines.
  • Improving Skin Texture: Polynucleotides promote cellular regeneration to enhance skin texture. They boost skin hydration, firmness, and tone, resulting in smoother, more youthful-looking skin.
  • Healing Damaged Skin: Polynucleotides promote collagen synthesis and angiogenesis by speeding up wound healing. They minimize scar depth and enhance skin texture, effectively treating acne scars and other skin damage.

Polynucleotides treatments also safeguard against oxidative stress-induced skin cell damage. Moreover, visible results typically appear within weeks and can last up to a year, ensuring long-lasting benefits.

Ideal Patient Candidates for Polynucleotide Treatments

Due to the safe nature of this ingredient, this procedure typically suits adult individuals and patients of all skin types. Notably, ideal candidates involve:

  • Those with facial signs of aging
  • Patients with uneven texture
  • Individuals with dry, sun-damaged, or sensitive skin
  • Those with specific skin concerns or imperfections

However, patients should seek the help of practitioners to evaluate all considerations before treatment, like pre-existing medical conditions. This would include identifying the presence of contraindications that may affect the product’s efficacy and lead to potential complications. These conditions should require meticulous consultation to avoid risks.

  • Active infections
  • Autoimmune diseases
  • Severe skin disorders
  • Individuals with hypersensitivity to specific components
  • Those who are pregnant or nursing individuals and children

Whether getting polynucleotides for rosacea treatment or for minimizing aging signs, each polynucleotide brand offers different treatment protocols. The frequency may depend on their specific formulations, influencing the duration of the effects. Understanding these factors can help patients find the most suitable polynucleotides treatment for their aesthetic enhancements.

The typical frequency may require multiple injection sessions, with treatment spaced within two to four weeks. Each session may last 30 to 60 minutes, with results extending for up to two years at maximum.

Furthermore, combining polynucleotide treatments with aesthetic procedures like laser therapy, microneedling, or hyaluronic acid fillers enhances skin rejuvenation and optimizes results.

Expected Outcomes of Polynucleotide Treatments

Depending on the polynucleotide brands, there are different timelines for aesthetic enhancements after administration. The typical skin improvement timeline may be visible within one to two weeks post-treatment. The noticeable effects may improve with each injection session until the last visit.

Due to polynucleotides’ mechanism of action, patients can receive enhanced skin texture, elasticity, and tone. Polynucleotides treatments offer temporary outcomes yet longer-lasting results. These outcomes can improve over several months and last up to 24 months.

A study involving five patients showed significant improvements in pore and skin thickness and noticeable enhancements in skin tone, melanin levels, wrinkles, and sagging. Intradermal long-chain polynucleotide filler injection provides an effective and safe treatment for skin rejuvenation.

Long-term benefits include sustained skin rejuvenation, reduced fine lines, and improved skin tone. Depending on individual skin conditions and response to the therapy, medical providers may recommend maintenance treatments every 6 to 12 months to maintain results.

Incorporating Polynucleotides into Medical Practices

An individual undergoing a skin consultation.

Professionals administering polynucleotides treatments must complete specialized training to ensure proper technique and safety. Certification programs provide in-depth instruction on product knowledge, treatment protocols, and managing potential side effects.

Moreover, a thorough consultation is crucial to assess the patient’s skin condition, medical history, and aesthetic goals. Patients must be informed about treatment expectations, potential risks, and post-treatment care for a smooth and safe recovery. 

Conclusion

Polynucleotides present an innovative and practical approach to skin rejuvenation, harnessing their natural properties to stimulate cellular repair and enhance overall skin quality. By promoting collagen and elastin production, these treatments address various signs of aging, improve skin texture, and support the body’s natural healing processes.

As awareness and understanding of polynucleotides grow, more individuals seek these non-surgical interventions to enhance their facial aesthetics. However, choosing qualified medical practitioners for treatment remains essential to ensure safety and achieve the best possible outcomes.

FAQs

1. What are polynucleotides, and how do they work?

Polynucleotides are chains of nucleotides that serve as the building blocks of DNA and RNA. When injected into the skin, they provide a structural framework that promotes cellular division and repair and stimulates collagen and elastin production, improving skin texture and rejuvenation.

2.  What are the benefits of polynucleotide treatments for skin?

Polynucleotide treatments stimulate skin regeneration, reduce inflammation, and promote collagen production. These effects help repair damaged skin, minimize redness and swelling, and improve skin elasticity and firmness, effectively decreasing signs of aging.

3. How often should polynucleotide treatments be administered?

Typically, polynucleotide treatments involve multiple injection sessions spaced two to four weeks apart. This allows for optimal skin healing and rejuvenation, ensuring lasting results. Always consult a qualified medical practitioner for personalized recommendations.

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References

  1. Lee, K. W. A., Chan, K. W. L., Lee, A., Lee, C. H., Wan, J., Wong, S., & Yi, K. -H. (2024). Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. International Journal of Molecular Sciences, 25(15), 8224. https://doi.org/10.3390/ijms25158224
  2. Park, K. Y., Seok, J., Rho, N. K., Kim, B. J., & Kim, M. N. (2016). Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients. Dermatologic therapy, 29(1), 37–40. https://doi.org/10.1111/dth.12299