A recent systematic review highlighted the growing role of polynucleotides (PN) in aesthetic medicine, showing improvements in skin elasticity and hydration. The study also pointed to the potential of polynucleotides in skin regeneration, making them a promising option for those seeking non-surgical skin treatments.
As alternatives to hyaluronic acid in dermal fillers, polynucleotides and polydeoxyribonucleotides are gaining popularity. Leading brands like Nucleofill and Rejuran have proven effective in rejuvenating and repairing skin, delivering impressive results in various aesthetic treatments.
In this article, we’ll dive into a comparison of Nucleofill vs Rejuran, exploring their mechanisms of action, application areas, treatment protocols, and the results you can expect from each injectable.
Key Takeaways
- Nucleofill derived polynucleotides from their natural origin, while Rejuran garnered its polydeoxyribonucleotides from salmon DNA.
- Both aesthetic treatments offer collagen stimulation and tissue regeneration, setting themselves apart from traditional dermal fillers.
- A Nucleofill cycle typically involves two to four sessions spaced two to four weeks apart; Rejuran requires three to four sessions spaced four months apart.
- Nucleofill suits individuals looking for hydration, skin firmness, and improved elasticity, while Rejuran fits individuals who are more focused on skin repair and regeneration.
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Understanding Nucleofill and Rejuran
Polynucleotides (PN) and polydeoxyribonucleotides (PDRN) are potent ingredients in aesthetic medicine. Treatments like Nucleofill and Rejuran tap into the powerful benefits of these ingredients, offering facial rejuvenation and addressing the visible signs of aging in a minimally invasive way.
Nucleofill derived its PN from its natural origin, while Rejuran garnered its PDRN component from salmon DNA. While they are often confused with one another, PDRN is known as a subtype of PN, as it mainly consists of deoxyribonucleotides than PN’s ribonucleotides and deoxyribonucleotides.
Despite the minimal difference in the primary component of their formulations, both injectables can target facial aging signs and provide skin rejuvenation in the treatment area.
Mechanism of Action
When administered using the proper injection technique at the Nucleofill injection points, this biostimulator can activate fibroblasts to stimulate collagen and elastin production. Moreover, Nucleofill offers powerful antioxidant action and deep hydration.
In contrast, Rejuran utilizes salmon DNA to repair and regenerate skin cells. This treatment effectively reduces inflammation, promotes tissue repair and growth, stimulates cell proliferation, and enhances skin elasticity.
Both treatments excel at collagen stimulation and tissue regeneration, which sets them apart from traditional dermal fillers. This leads to longer-lasting results with improved skin firmness, elasticity, and overall quality.
Application Areas and Treatment Protocols
Nucleofill is primarily used for facial rejuvenation, but it’s versatile enough to address other areas of the body as well. With its various formulations like Nucleofill Eyes, Medium, Strong, and Hair, it can be tailored to treat specific concerns. Common application areas include:
- Face (cheeks, jawline, etc.)
- Eye region
- Neck
- Chest
- Hair (for stimulating hair growth)
On the other hand, Rejuran Healer has received approval from the Korean Food and Drug Administration to address various facial skin concerns. These include the following issues:
- Skin Elasticity and Fine Wrinkles
- Skin Tone and Texture
- Under-Eye Area Rejuvenation
When comparing Nucleofill vs Profhilo or Nucleofill vs Rejuran, it’s important to understand how often these treatments are needed to see results.
- Treatment Protocols for Nucleofill: This biostimulator involves a series of tiny injections into the Nucleofill injection points. A treatment cycle typically recommends two to four sessions, two to four weeks apart, to achieve optimal outcomes.
- Treatment Protocols for Rejuran: The typical administration of Rejuran involves microinjections into the treatment area. The standard protocol requires three to four sessions, spaced four weeks apart, for best results.
Results and Patient Selection
Nucleofill and Rejuran treatments provide natural-looking outcomes. They address the skin’s deep layers to provide youthful skin with improved elasticity, firmness, and hydration. They effectively reduce visible aging signs, enhancing the texture and quality.
However, Nucleofill offers more skin rejuvenation. It suits individuals looking for hydration, skin firmness, improved elasticity, and prevention of sagging skin. This product works deeper within the skin due to its production of collagen and elastin.
Meanwhile, Rejuran can fit individuals more focused on skin repair and regeneration. This treatment can target acne scars, damaged skin cells, or fine lines to improve skin tone and heal the skin’s surface.
Both treatments may suit adults with healthy immune systems who prefer minimally invasive aesthetic treatments. However, to prevent complications, pregnant women, lactating women, pediatric patients, or individuals with contraindications to Nucleofill or Rejuran should avoid these products.
- Patient Selection for Nucleofill: Ideal candidates are individuals with fine lines, wrinkles, skin laxity, or those seeking to enhance their facial contours.
- Patient Selection for Rejuran: Ideal candidates are individuals with fine lines, acne scars, poor skin texture, or seeking comprehensive skin rejuvenation.
Patients should seek thorough consultation and assessment with aesthetic providers to determine the most suitable injectable, ensure their safety, and maximize the benefits of the injection treatment.
Conclusion
While both Nucleofill and Rejuran offer fantastic results in aesthetic medicine, understanding their differences is crucial in choosing the right treatment. They both harness the power of polynucleotides and polydeoxyribonucleotides to rejuvenate the skin and tackle signs of aging, leaving you with natural-looking results. However, Nucleofill might be better suited for those looking for overall skin rejuvenation, while Rejuran is particularly effective for skin repair and regeneration.
In terms of treatment schedules, Nucleofill usually requires two to four sessions, whereas Rejuran involves three to four treatments. Knowing how each treatment works, where it’s applied, and what kind of results to expect helps individuals make more informed choices based on their unique skincare needs.
FAQs
1. What are the key differences between Nucleofill and Rejuran?
Nucleofill is derived from natural polynucleotides and focuses on hydration, skin firmness, and improved elasticity, while Rejuran utilizes polydeoxyribonucleotides from salmon DNA, targeting skin repair and regeneration.
2. How many treatment sessions are typically recommended for Nucleofill and Rejuran?
Nucleofill typically requires two to four sessions spaced two to four weeks apart, while Rejuran usually involves three to four sessions spaced four months apart.
3. What skin concerns do Nucleofill and Rejuran address?
Nucleofill is suitable for individuals seeking hydration, skin firmness, and improved elasticity, while Rejuran is ideal for those focused on skin repair and regeneration, targeting issues like acne scars, damaged skin cells, and fine lines.
References
- Alvin, W., Chan, L., Lee, A., Cheuk Hung Lee, Wan, J., Wong, S., & Yi, K.-H. (2024). Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. International Journal of Molecular Sciences, 25(15), 8224–8224. https://doi.org/10.3390/ijms25158224
- 리쥬란. (n.d.). Rejuran.co.kr. Retrieved October 16, 2024, from https://rejuran.co.kr/#6
