Did you know the global dermal fillers market is projected to reach $10.16 billion by 2032, up from around $5.08 billion in 2023? This growth highlights the aesthetics industry’s impressive annual expansion rate.
The aesthetic field offers a variety of dermal fillers, each featuring distinct active ingredients. These minimally invasive injections effectively combat facial aging signs, such as wrinkles, fine lines, and volume loss. Among the many options, Harmonyca and Radiesse stand out due to their unique compositions and mechanisms of action, making them popular choices for rejuvenating aging skin.
This article will compare Harmonyca vs Radiesse, discussing their properties, injection techniques, results, benefits, and potential drawbacks.
Key Takeaways
- Allergan Aesthetics developed Harmonyca’s dual-action mechanism through its unique hybrid formulation, while Merz Aesthetics created Radiesse injections to rebuild skin structure.
- Harmonyca and Radiesse fillers have increased in popularity due to their instant outcomes and long-lasting benefits.
- Providers should adhere to the proper injection techniques for Harmonyca and Radiesse to achieve the patient’s desired goals.
- Patients and aesthetic professionals should discuss and determine which injectable dermal filler can ensure patient suitability and safety while providing these optimal benefits.
About: Medica Depot is your trusted all-in-one supplier, offering a range of high-quality medical injectables and supplies. Buy Harmonyca at Medica Depot today! Whether for health professionals, plastic surgeons, dermatologists, licensed estheticians, or other specialists, we can offer genuine, brand-name products you may need. With Medica Depot, we prioritize serving you better to improve the patient’s quality of life.
Introduction to Harmonyca and Radiesse
The aesthetic field has popularized injectable dermal fillers to address various skin concerns. These injectables restore volume, smooth aging signs, and enhance facial contours. Common formulations include hyaluronic acid, calcium hydroxylapatite, and poly-L-lactic acid.
Harmonyca, developed by Allergan Aesthetics, features a unique dual-action mechanism through its hybrid formulation. It combines multiple active ingredients to deliver instant and sustained results. With CE-mark approval, it is available throughout Europe and is known for targeting volume loss and skin texture improvement.
Radiesse, created by Merz Aesthetics, contains calcium hydroxylapatite microspheres that stimulate natural collagen production. Approved by the FDA, Radiesse not only restores volume but also strengthens skin structure, offering both immediate and long-term benefits for skin rejuvenation.
Properties of Harmonyca and Radiesse

Aesthetic professionals often discuss the use of fillers like Harmonyca vs Radiesse or Harmonyca vs Sculptra to determine which filler best suits a patient’s needs. Each product has unique properties catering to specific skin concerns and desired outcomes.
- Composition and Ingredients: Harmonyca is a hybrid filler containing 55.7% CaHA microspheres, 20mg/ml cross-linked HA, and 3mg/ml lidocaine for comfort. In contrast, Radiesse consists of CaHA microspheres in a gel carrier with glycerin and sodium carboxymethylcellulose. Radiesse (+) also includes 0.3% lidocaine.
- Texture and Consistency: Harmonyca features a smooth, gel-like consistency, allowing for easy application and natural integration into the skin. Radiesse has a semi-solid, cohesive texture provides immediate volumizing results, which is ideal for structural enhancement.
- Longevity and Durability: Harmonyca’s results last between 12 to 18 months. Radiesse offers up to two years of enhanced volume and firmness, depending on individual factors like skin metabolism and the area treated.
- Allergenic Potential: Harmonyca should not be used in patients with known hypersensitivity to HA, CaHA, or lidocaine. Similarly, Radiesse is contraindicated for individuals allergic to CaHA or any other components.
Injection Techniques for Harmonyca and Radiesse
A thorough consultation with a medical professional is crucial before the treatment. This helps in discussing the patient’s history, aesthetic goals, and specific concerns to align expectations with the benefits of Harmonyca or Radiesse. Both products require aseptic conditions during administration to avoid complications, and providers should cleanse the treatment area thoroughly.
Harmonyca filler has been approved for treating signs of aging in the mid-face region, such as contouring the cheeks, chin, jowls, and jawline. In contrast, Radiesse has been approved by the US FDA for addressing lower-face wrinkles, jawline contouring, and volume loss in the hands.
For Harmonyca, the filler is injected into the deep dermis using a sterile 27G thin-wall needle, employing a linear threading or cross-hatching technique for optimal distribution. On the other hand, Radiesse is administered into the subdermal layer using a 25 gauge OD—27 gauge ID needle, applying a percutaneous injection method to achieve the desired effects.
Post-Injection Care and Follow-Up
Proper post-injection care is key to ensuring the best results. Providers will offer individualized advice, but general guidelines include:
- Avoid strenuous activities for 24 hours.
- Avoid excessive sun exposure and extreme temperatures.
- Stay hydrated to maintain skin health.
- Use gentle skincare products to avoid irritation.
- Schedule follow-up appointments to monitor progress and address any concerns.
Results and Comparisons
Harmonyca and Radiesse fillers have increased in popularity due to their instant outcomes and long-lasting benefits. Medical professionals may recommend these non-surgical injectables to deliver impressive aesthetic results.
- Immediate Results: Radiesse’s calcium hydroxyapatite (CaHA) formulation can restore immediate volume. Meanwhile, Harmonyca’s hyaluronic acid (HA) instantly improves hydration and volume.
- Long-Term Effects: Their CaHA components ensure that collagen and elastin production improves skin quality and texture for an extended period. Harmonyca and Radiesse stimulate collagen synthesis, leading to long-lasting aesthetic improvements.
Many patients have reported high satisfaction with both fillers. Harmonyca users appreciate the dual benefits of HA and CaHA, while Radiesse patients value its longevity and beneath-the-skin improvements. These Radiesse and Harmonyca before and after photos show significant enhancements in their facial aging skin.




The first two photos highlight Harmonyca’s efficacy in addressing the deep nasolabial folds in patients’ lower face regions. Their appearances showed improvements in skin hydration and firmness after their Harmonyca treatments. Furthermore, the subsequent two patients underwent Radiesse treatments to address their facial aging signs, giving them a more lifted look.
Benefits of Harmonyca and Radiesse
Despite the differences in their formulation, Harmonica and Radiesse can deliver similar benefits to patients. Patients and aesthetic professionals should discuss and determine which injectable dermal filler can ensure patient suitability and safety while providing these optimal benefits.
- Skin Rejuvenation: Both injectables can improve skin quality by enhancing skin texture and elasticity.
- Wrinkle Reduction: When administered in wrinkles and folds, Harmonyca filler and Radiesse can minimize the appearance of visible aging signs.
- Volume Restoration: These injectable fillers can also restore lost volume in certain areas of the lower face region. Interestingly, Radiesse has an additional approved use to add volume to the back of the hands.
- Collagen Stimulation: Their CaHA component stimulates collagen production to ensure longer-lasting and sustained benefits of Harmonyca and Radiesse.
Potential Drawbacks of Harmonyca and Radiesse
Both Harmonyca and Radiesse offer minimal to no downtime after injection sessions. This factor can appeal to individuals who need to return to their daily activities immediately. Additionally, booth injectables only require 30 to 45 minutes to finish one session, depending on the treatment area and severity of the condition.
While most individuals tolerate these dermal fillers well, patients can expect that common Radiesse and Harmonyca side effects may still occur. These are often temporary and may resolve independently within a few days.
- Harmonyca Side Effects: Erythema (redness), edema (swelling), pain, tenderness, and itching.
- Radiesse Side Effects: Bruising, redness, swelling, pain, itching, lumps/bumps at the injection site, difficulty chewing, and other local side effects.
Rare but severe complications of both injections may involve allergic reactions, infections, or granulomas. Patients must seek medical attention for prompt action and proper management if unexpected symptoms or common side effects persist.
Cost Considerations
The cost of Harmonyca and Radiesse fillers varies depending on the number of injections and dosage, the frequency of sessions, and geographical location. Providers can determine these based on the patient’s aesthetic goals and the severity of the skin condition. However, these non-surgical treatments may range from several hundred to a few thousand dollars.
While treatment effects can last up to a year or two, medical professionals may recommend maintenance or touch-up sessions to sustain Harmonyca and Radiesse’s anti-aging effects. Patients should consider these costs when determining which injectable suits their preference.
Conclusion
Harmonyca and Radiesse offer effective solutions for combatting facial aging signs but differ in composition, longevity, and approved uses. Harmonyca’s hybrid formulation provides long-lasting results for 12 to 18 months. In contrast, Radiesse’s calcium hydroxylapatite composition may last up to two years.
Understanding these dermal fillers’ distinct properties, injection techniques, and approved uses is crucial for informed decision-making and optimal treatment outcomes. Consulting with a qualified medical professional can help individuals determine which product aligns best with their unique needs and desired aesthetic goals, ensuring safe and effective rejuvenation of aging skin.
FAQs
1. What are the main differences between Harmonyca and Radiesse?
Harmonyca contains a combination of hyaluronic acid and calcium hydroxylapatite, while Radiesse comprises calcium hydroxylapatite microspheres suspended in a gel carrier.
2. How long do the effects of Harmonyca and Radiesse last?
Harmonyca’s effects can last 12 to 18 months, while Radiesse can provide aesthetic outcomes lasting up to two years.
3. What are the approved uses for Harmonyca and Radiesse injections?
Harmonyca is approved to treat aging signs like contouring and fine lines and wrinkles in the mid-face region, while Radiesse is approved to address lower face wrinkles, jawline contour, and volume loss in the hands.
References
- Dermal Fillers Market Size, Growth and Revenue Analysis [2028]. (2023). Www.fortunebusinessinsights.com. https://www.fortunebusinessinsights.com/industry-reports/dermal-fillers-market-100939
- Radiesse INJECTABLE IMPLANT INSTRUCTIONS FOR USE. (n.d.). Radiesse. Retrieved October 1, 2024, from https://radiesse.com/app/uploads/2024/04/instructions-for-use-radiesse-wrinkles.pdf