A study by Fakih-Gomez and Kadouch (2022) demonstrated the efficacy of combining calcium hydroxylapatite (CaHA) and hyaluronic acid (HA) for facial rejuvenation. The study found that this hybrid mix effectively volumizes and lifts the cheeks and jawline, with benefits lasting up to a year.
CaHA and HA are powerful ingredients widely used in dermal filler injections due to their effectiveness in enhancing facial volume and improving skin texture. Allergan Aesthetics has utilized these properties to create Harmonyca, a hybrid filler specifically designed for facial rejuvenation. This innovative injectable offers an effective solution for individuals looking to address signs of aging, improve skin quality, and achieve long-lasting results.
In this article, we will explore Harmonyca filler in detail—its formulation, mechanism of action, ideal treatment areas, benefits, and contraindications.
Key Takeaways
- Harmonyca filler contains a combination of active ingredients, such as calcium hydroxylapatite and cross-linked hyaluronic acid.
- This hybrid filler also consists of 0.3% lidocaine to reduce pain or discomfort during treatment.
- Individuals should consider Harmonyca’s advantages over minimally invasive injectable options, such as enhanced volume and skin texture.
- A thorough evaluation allows providers to understand a patient’s medical and cosmetic history and discuss potential Harmonyca side effects, contraindications, and benefits.
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What is Harmonyca Filler?

Harmonyca is an innovative hybrid facial filler developed by Allergan Aesthetics for individuals seeking facial rejuvenation. This minimally invasive filler combines calcium hydroxylapatite (CaHA) and cross-linked hyaluronic acid (HA) to deliver immediate and long-lasting results, utilizing the unique properties of both ingredients.
TheHarmonyca filler contains a blend of active ingredients designed for optimal skin improvement:
- Calcium Hydroxylapatite (CaHA) Microspheres (55.7%): These particles, with a diameter of 25-45 microns, stimulate collagen production, providing structure and lift to the skin.
- Cross-linked Sodium Hyaluronate Gel (20 mg/ml): This component adds volume and hydrates the skin upon injection.
- Phosphate Buffer: Maintains the stability and pH balance of the filler.
- Lidocaine Hydrochloride (3 mg/ml): Reduces pain and discomfort during the procedure, making the treatment more comfortable for patients.
Harmonyca filler works through a dual-action mechanism. Upon injection, the hyaluronic acid component immediately volumizes and hydrates the treated area, enhancing the skin’s appearance and providing a smoother texture.
Meanwhile, the CaHA microspheres promote collagen production, gradually strengthening the skin, improving elasticity, and delivering a lifting effect over time. This combination results in both immediate and prolonged facial rejuvenation, enhancing overall skin health and structure.
Ideal Treatment Areas
Harmonyca filler is ideally used to treat specific areas of the face that commonly experience volume loss, sagging, and wrinkles:
- Cheeks: To restore volume and create a lifted appearance.
- Jawline: To define and contour the jaw for a more youthful look.
- Chin: To enhance chin definition and correct any deficiencies.
These areas benefit most from Harmonyca‘s volumizing, hydrating, and collagen-boosting effects, making it a versatile option for addressing facial wrinkles, folds, and skin laxity. Due to its CE-mark approval, medical professionals must evaluate each patient thoroughly and use their expertise to ensure safe and effective outcomes.
Advantages of Harmonyca Filler

Harmonyca offers a range of benefits compared to other minimally invasive injectable options, making it a suitable choice for individuals seeking facial rejuvenation:
- Enhanced Volume and Skin Texture: Combining calcium hydroxylapatite (CaHA) and hyaluronic acid in Harmonyca provides immediate volume and improves skin texture. Hyaluronic acid hydrates and plumps the skin instantly, while CaHA stimulates long-term collagen production, leading to continued enhancement of skin quality and firmness over time.
- Long-Lasting Results: One of the major advantages of Harmonyca fillers is their longevity. The CaHA component continues to stimulate collagen production even after the initial effects of the injection, allowing patients to enjoy enhanced facial volume and lifting effects for 12 to 18 months. This extended duration makes it an attractive option for those seeking fewer touch-ups than other fillers.
- Natural-Looking Outcomes: Harmonyca delivers natural-looking results by subtly enhancing facial contours without creating dramatic or artificial changes. Its gradual and consistent effect ensures that improvements appear seamless, allowing patients to enjoy a refreshed appearance that looks natural. This makes Harmonyca particularly appealing for individuals who want discreet facial rejuvenation without obvious alterations.
Treatment Procedures and Expected Outcomes
Medical professionals and patients should undergo consultation and assessment before the treatment. This evaluation allows providers to understand a patient’s medical and cosmetic history and discuss potential Harmonyca side effects, contraindications, and benefits.
- Preparation: Thoroughly cleanse the treatment area with soap and water and disinfect with an alcohol swab. Providers may add a form of anesthetic for individuals needing to manage pain.
- Injection Process: Harmonyca can address facial soft-tissue augmentation through a deep dermal and subdermal layer using 27G thin-wall needles. Depending on the skin concerns, providers can utilize linear threading or cross-hatching techniques.
Recovery and Aftercare
For the best outcomes, patients must follow the provider’s instructions for recovery and aftercare. The following are standard post-treatment care recommendations for the first 24 hours after treatment:
- Avoid strenuous activities that could increase blood flow to the treatment area.
- Avoid excessive sunlight exposure and extreme weather conditions to prevent irritation.
- Apply cold compresses to reduce swelling and soothe the treated area.
Patients can expect instant volumizing effects immediately following treatment, with gradual improvements continuing over the next few months as collagen production increases. The results of Harmonyca fillers typically last between 12 to 18 months, depending on factors such as skin type, age, and lifestyle.
Providers may schedule follow-up appointments to monitor progress, address any concerns, and determine the need for maintenance sessions to extend the benefits.
Patient Candidacy for Harmonyca Filler

Harmonyca filler is ideal for individuals seeking facial rejuvenation, particularly those experiencing aging-related skin concerns such as volume loss, skin laxity, facial wrinkles, and contour deficiencies. Patients looking to enhance facial features, achieve a more youthful appearance, or improve facial contours may benefit significantly from this hybrid dermal filler.
Before considering Harmonyca, both patients and medical professionals must understand the contraindications to ensure safe treatment and avoid complications. Harmonyca is not recommended for the following individuals:
- Patients with hypersensitivity to any components of the product, including steroids or lidocaine.
- Those with active skin disease or skin conditions in the treatment area.
- Patients suffering from infections at the injection site.
- Individuals with prolonged bleeding disorders.
- Patients with multiple allergies, herpes, or autoimmune diseases.
In addition, Harmonyca is contraindicated for use in areas such as the glabellar lines, periocular regions, lips, and perioral areas. Medical professionals should avoid injecting into blood vessels, the superficial dermis, or highly vascularized regions to prevent adverse effects. Furthermore, pregnant or breastfeeding women and individuals under the age of 18 should not receive this treatment due to potential health risks.
Potential Side Effects and Risks
Like all dermal fillers, Harmonyca may cause some side effects. The most common side effects include erythema (redness), edema (swelling), pain, tenderness, and itching at the injection site. These symptoms are typically mild and are expected to resolve on their own within a few days to a week. If symptoms persist, patients should consult their healthcare provider for proper management.
Regular follow-up and monitoring are essential to ensure a smooth recovery. Patients are encouraged to promptly report any unexpected symptoms to their healthcare provider to help ensure effective facial rejuvenation and minimize risks.
Conclusion
Harmonyca filler offers a new solution for individuals seeking facial rejuvenation. This hybrid dermal filler provides immediate volumization and long-term efficacy through collagen production by harnessing the power of calcium hydroxylapatite and cross-linked hyaluronic acid. The inclusion of lidocaine ensures a more comfortable treatment experience for patients.
With its dual-action mechanism, Harmonyca enhances skin structure, elasticity, and overall health over time, providing natural-looking results and long-lasting effects over a year. Through thorough evaluation and assessment, providers can discuss potential side effects, contraindications, and benefits with patients, ensuring safe and satisfactory results.
FAQs
1. What are the main ingredients of Harmonyca filler?
Harmonyca filler contains calcium hydroxylapatite microspheres, cross-linked sodium hyaluronate gel, phosphate buffer, and lidocaine hydrochloride.
2. How long do the results of Harmonyca filler last?
Patients can expect results to last between 12 to 18 months due to the calcium hydroxylapatite component’s continued collagen production and lifting effect.
3. What are the ideal treatment areas for Harmonyca filler?
The ideal treatment areas for Harmonyca filler include facial wrinkles, folds, and lines in the cheeks, jawline, and chin.
References
- Fakih-Gomez, N., & Kadouch, J. (2022). Combining Calcium Hydroxylapatite and Hyaluronic Acid Fillers for Aesthetic Indications: Efficacy of an Innovative Hybrid Filler. Aesthetic plastic surgery, 46(1), 373–381. https://doi.org/10.1007/s00266-021-02479-x
- Instructions for Use HARMONYCATM LIDOCAINE – INJECTABLE FACIAL IMPLANT. (n.d.). Allergan Aesthetics. Retrieved September 27, 2024, from https://media.allergan.com/actavis/actavis/media/allergan-pdf-documents/HArmonyCa%E2%84%A2_with_lidocaine_IFU_GR.pdf