top brands

In the ever-evolving field of cosmetic medicine, dermal fillers have emerged as game-changers, revolutionizing how we approach facial rejuvenation and volume restoration. With their ability to enhance and restore youthful contours, smoothen lines and wrinkles, and augment facial features, these injectables have become indispensable tools for practitioners striving to create natural-looking yet striking transformations.

At Medica Depot, we understand that selecting the right dermal filler can make all the difference in the outcomes achieved. Our team of experts has meticulously curated a comprehensive catalog of the best dermal fillers available, ensuring that medical professionals have access to products that meet the highest quality standards and deliver exceptional patient satisfaction.

Current Dermal Filler Technologies

Dermal fillers are substances injected into the skin to restore volume, fill in wrinkles, and enhance facial contours. They are commonly used in cosmetic procedures to achieve a more youthful appearance. Here are some different types of dermal fillers, along with their compositions and best uses.

Hyaluronic Acid (HA) Fillers

Hyaluronic acid is a naturally occurring substance in the body that helps maintain hydration and volume in the skin. HA fillers are made from a gel-like form of hyaluronic acid. They are versatile and widely used for various purposes, including smoothing wrinkles, adding volume to lips, and enhancing facial contours. Hyaluronic acid is especially popular among lip filler brands.

Calcium Hydroxylapatite (CaHA) Fillers

CaHA fillers contain microscopic particles of calcium hydroxylapatite suspended in a gel-like solution. They stimulate collagen production, providing both immediate volume and long-term improvement to the treated areas. CaHA fillers are commonly used to treat moderate to severe wrinkles and folds, such as nasolabial folds (smile lines) and marionette lines.

Poly-L-lactic Acid (PLLA) Fillers

PLLA fillers consist of a biocompatible synthetic material that stimulates collagen production. These fillers are typically used to address deeper lines and wrinkles, particularly in the lower face. The effects of PLLA fillers develop gradually over several weeks as collagen production increases, providing a more natural and long-lasting result.

Polymethylmethacrylate (PMMA) Fillers

PMMA fillers contain tiny, non-resorbable microspheres suspended in a collagen-based gel. These fillers provide both immediate volume and stimulate collagen production over time. PMMA fillers are used for treating deeper wrinkles, nasolabial folds, and acne scars. They offer a long-lasting result, as the microspheres remain in place permanently while collagen forms around them.

Best Dermal Fillers and Brands

Now that we’ve seen what types of fillers are available and what is typically used by manufacturers, let’s move on to the brands themselves.

As expected, the market for dermal fillers is incredibly diverse. Many brands and pharmaceutical companies compete for the top spots, honing their products with each iteration.

This not only provides a better selection and competitive pricing, which you can check throughout the Medica Depot website but will also benefit your patients as they’ll receive the highest quality treatments possible today.

In the following section, you’ll find a selection of filler brands that are highly recommended by medical practitioners worldwide. These brands offer something unique and, with their multitude of products, are an excellent choice for clinics that strive to offer both variety and quality.


Juvederm is a prominent brand of dermal fillers manufactured by Allergan, a leading pharmaceutical company. Juvederm fillers are composed of hyaluronic acid (HA), a substance naturally found in the body that helps maintain hydration and volume in the skin. Juvederm offers a range of fillers designed to address various facial concerns and areas.

Juvederm fillers are known for their smooth consistency, making them easy to inject and providing natural-looking results. They are commonly used to smooth wrinkles and fine lines, add volume to lips, and enhance facial contours. The effects of Juvederm fillers are immediately visible, and the results can last from several months to a year, depending on the specific product used and individual factors.

Juvederm is a top dermal filler choice thanks to its different formulations, such as Juvederm Ultra, Juvederm Ultra Plus, Juvederm Voluma, Juvederm Volbella, and Juvederm Vollure. Each product is tailored to meet specific needs, whether it’s addressing fine lines, deep folds, or volumizing specific areas.


Restylane is a renowned brand of dermal fillers manufactured by Galderma, a leading pharmaceutical company specializing in dermatology and aesthetics. Restylane fillers are composed of hyaluronic acid and are similar in their effect to Juvederm’s fillers.

Restylane offers a range of popular products that target specific aesthetic concerns. Restylane Lyft is designed to provide volume and lift to areas like cheeks and hands. Restylane Silk focuses on smoothing lines around the lips and adding subtle volume. Restylane Defyne and Restylane Refyne help soften moderate to severe facial wrinkles and folds while maintaining natural expressions. Restylane Kysse is specifically formulated to enhance and shape the lips, providing a natural-looking result.

The Restylane line of fillers is trusted by professionals and patients worldwide for its efficacy, safety, and ability to achieve natural-looking results. These fillers are known for their versatility and are often regarded as the best facial fillers, providing rejuvenation, volume restoration, and enhancement.


Sculptra is a brand of dermal fillers known for its unique composition and collagen-stimulating properties. Unlike other dermal fillers that primarily provide immediate volume, Sculptra is made of poly-L-lactic acid (PLLA), a synthetic biocompatible material. PLLA stimulates collagen production in the skin, resulting in gradual and natural-looking rejuvenation.

Sculptra fillers are designed to address volume loss and improve the overall texture and appearance of the skin. The treatment involves a series of injections over multiple sessions, stimulating collagen production over time. The effects of Sculptra develop gradually, with results lasting up to two years or more.

The most popular product within the Sculptra line is Sculptra Aesthetic. It is commonly used to treat facial wrinkles and folds, particularly nasolabial folds, marionette lines, and chin wrinkles. Sculptra Aesthetic restores lost volume and provides a more youthful and rejuvenated appearance.


Belotero is one of the top dermal fillers manufactured by Merz Pharmaceuticals, one of the oldest and most respected companies in the business.

Belotero fillers are known for their versatility, flexibility, and ability to provide natural-looking results. The gel-like consistency of these fillers allows for precise injection and integration into the skin, ensuring a smooth and even outcome. The effects of Belotero fillers are immediate and can last several months to a year, depending on the specific product used and individual factors.

As a brand, Belotero is best known for its range of dermal fillers based on hyaluronic acid. It is considered the best face filler catering to specific treatment goals. There are several options depending on the area being treated and the desired result, with some of the products also containing lidocaine as an additional anesthetic.


Products from Radiesse (formerly known as Radiance) are designed to treat deeper wrinkles and other skin imperfections. They’re best used for restoring lost volume and smoothing out prominent wrinkles and folds.

Radiesse fillers are known for their durability, typically lasting longer than many other dermal fillers, as they’re made from calcium hydroxylapatite (CaHA). Depending on individual factors and the treatment area, the effects can last up to a year or more. Radiesse fillers not only provide immediate volume but also stimulate collagen production, leading to prolonged rejuvenation.

These fillers come in either 1 ml or 3 ml pre-filled syringes. There is also Radiesse+ available, which offers enhanced properties for a more comfortable injection experience thanks to the integration of lidocaine in its formula.


As you can see, many amazing brands of lip fillers are currently available. The variety of products on offer, including their contents, makes for an exciting market where you can pick and choose the ideal products for your and your patient’s needs. Of course, alongside the above-mentioned brands, many other manufacturers deliver standout products that provide similar results.


What dermal filler is the best?

Any of the brands listed on this page are a great choice, each offering something unique. Of course, they’re all very effective as dermal fillers, providing impressive rejuvenation results.

Which are the safest fillers?

Dermal fillers based on hyaluronic acid are currently considered the safest. The reason is that hyaluronic acid is a substance that naturally occurs in human bodies, so injecting it won’t cause the filler to be rejected by the patient’s immune system. It’s also a vegan product, as it’s synthesized from bacteria.

Which dermal fillers last the longest?

For patients who want the best dermal fillers and the longest-lasting ones, Juvederm and Restylane are the best choices.