Did you know that as we age, our faces naturally lose subcutaneous fat, making facial muscles work closer to the skin’s surface? According to the American Society of Plastic Surgeons, this process emphasizes smile lines and crow’s feet while causing the skin to stretch slightly, leading to a loss of facial volume.
Hyaluronic acid fillers have emerged as a popular non-surgical solution, thanks to their ability to attract water and maintain skin hydration. Among the leading brands, Revofil and Restylane use advanced cross-linked hyaluronic acid formulations to effectively address aging skin concerns and deliver long-lasting results.
This article will compare Revofil vs Restylane, examining their formulations, intended applications, longevity, and patient outcomes to help you choose the best filler for your aesthetic needs.
Key Takeaways
- CAREGEN developed Revofil fillers by integrating biomimetic peptide technology with cross-linked hyaluronic acid in their injection formulations.
- Conversely, Restylane’s range of fillers employs two patented technologies in their hyaluronic acid formulations: NASHA and XpresHAn.
- While Revofil fillers are still pending approval from the US Food and Drug Administration, the regulatory agency has already approved the Restylane collection.
- Ideal candidates for these treatments should have no contraindications to the compositions or formulations of Revofil or Restylane to prevent complications during or after the procedure.
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Understanding Revofil and Restylane
Revofil originated from South Korea’s CAREGEN Research Center to design dermal fillers that can address various facial concerns of individuals. These new-generation Revofil fillers capitalize on the potency of hyaluronic acid (HA) and utilize a unique technology to ensure lasting and impressive treatment outcomes.
Meanwhile, Restylane came from the known Galderma Laboratories to deliver facial rejuvenation to individuals. These fillers also harness the abilities of HA to restore facial volume and smooth facial aging signs. Moreover, Restylane fillers use two cross-linking technologies to ensure the potency of their formulations’ gel texture and consistencies.
Formulation and Composition

When comparing Revofil vs Restylane, aesthetic providers should understand that their technologies differ despite using cross-linked hyaluronic acid (HA) similarly. Understanding these differences can help providers determine which treatment and product best suit the patient’s needs and goals for their aesthetics.
CAREGEN formulated Revofil fillers by combining biomimetic peptide technology and cross-linked HA in their collection of injections. This results in a high-quality gel viscosity and elasticity for smoother administration. Furthermore, the HA ensures longer-lasting results, while the peptides stimulate collagen and elastin production, promoting a more youthful appearance.
On the other hand, Restylane’s collection of fillers uses two patented technologies for their HA formulations: NASHA and XpresHAn. NASHA creates a firm gel texture intended for a more pronounced lift, while XpresHAn offers a soft gel texture with high flexibility and integrates into the tissue.
Both brands can ensure effective facial aesthetics treatment, but the key differences lie in their compositions and technologies. Revofil’s combination of HA and peptides and biomimetic peptide technology is designed for face and tissue remodeling. In contrast, Restylane only uses the HA component, but it uses two different technologies: NASHA and XpresHAn.
Intended Applications
Both injectables provide a collection of dermal fillers, each with different indications and target treatment areas. Selecting the most suitable product for a patient’s concern can ensure high patient satisfaction with impressive treatment outcomes.
Revofil offers three injections in its collection: Fine, Plus, and Ultra. While Revofil fillers await approval from the US Food and Drug Administration, the Restylane collection has received the green light from the regulatory agency. This includes Restylane, Restylane-L, Contour, Defyne, Kysse, Lyft, Refyne, Silk, and Eyelight.
Intended Applications
- Revofil: Can correct superficial wrinkles, fine lines, and caved scars. It can also fill moderate to deeply pronounced facial wrinkles and tissue. Revofil can offer volumization in the cheeks, chin, and temporal area, lip contour, and redefinition of facial contours.
- Restylane: Can correct moderate to severe facial wrinkles and folds, perioral and upper wrinkles, augment lips, chin, and cheeks, and improve under-eye hollows.
Patient Outcomes and Longevity
Other considerations that patients should explore include the longevity of the effects and other patients’ previous outcomes. Individuals may find longer-lasting results appealing, and visual evidence of their efficacy can help them better compare Revofil vs Restylane.
- Longevity of Results with Revofil: Nine to Twelve Months
- Longevity of Results with Restylane: Six to Eighteen Months
The duration of the results of both Revofil and Restylane can vary based on factors such as the treated area, the individual’s skin type, and lifestyle choices. Furthermore, these patients have shown high satisfaction with the effectiveness of Revofil and Restylane in addressing their facial skin concerns, specifically their nasolabial folds.


Despite the lack of approval from the US FDA, Revofil’s effects are comparable to Restylane. Both brands ensure safety and effectiveness, making them favored options for non-surgical facial rejuvenation.
Choosing Between Revofil and Restylane
According to the FDA, dermal fillers have been approved for individuals aged 22 and above. These minimally invasive injectables can be used for concerns like facial wrinkles and skin folds, facial contour augmentation, or volume restoration. Providers and patients can choose Revofil or Restylane to address these facial skin concerns with non-surgical solutions.
Ideal candidates for these treatments should not have any contraindications to Revofil or Restylane’s compositions or formulations to avoid further complications during or post-treatment. They should also seek the guidance and expertise of licensed practitioners to ensure patient safety, suitability, and maximum efficacy of the injections.
These practitioners can equip patients with comprehensive information about the treatment, including common Restylane and Revofil side effects, benefits, and proper aftercare. This allows patients to make informed decisions for their aesthetic goals.
Furthermore, thorough consultations with practitioners allow them to tailor treatment plans for each patient, aligning which product best suits the individual’s needs and goals. Other patient considerations should be discussed with aesthetic professionals, such as:
- Product’s Advantages and Risks
- Natural-Looking Results
- Duration of Outcomes
- Cost Considerations
- Suitability with Patient
Conclusion
Revofil and Restylane offer non-surgical solutions for facial rejuvenation, each with unique strengths. Revofil incorporates biomimetic peptides to stimulate collagen production and enhance treatment outcomes, making it a versatile choice for subtle and natural enhancements. Restylane, with its FDA-approved and well-established technology, provides a diverse range of fillers tailored for various aesthetic needs.
Choosing between the two depends on individual goals and preferences. Consulting an experienced provider is essential to understanding the differences, ensuring proper administration, and achieving safe, effective results. Both brands have the potential to deliver impressive transformations, helping individuals achieve a more youthful and vibrant appearance.
FAQs
1. What are Revofil and Restylane?
Revofil and Restylane are injectable dermal fillers that use cross-linked hyaluronic acid to address various facial aesthetic concerns, such as wrinkles and loss of volume. CAREGEN develops Revofil in South Korea, while Galderma Laboratories produces Restylane.
2. What are the key differences in formulation between Revofil and Restylane?
Revofil combines biomimetic peptide technology with cross-linked hyaluronic acid, enhancing moisture retention and stimulating collagen production. In contrast, Restylane employs two patented technologies: NASHA for firm texture and XpresHAn for a softer, more flexible gel, focusing solely on hyaluronic acid.
3. Are Revofil fillers FDA-approved?
No, Revofil fillers are still awaiting approval from the US Food and Drug Administration, while the Restylane collection has been approved and is available for use.
References
- American Society of Plastic Surgeons. (n.d.). Dermal Fillers. American Society of Plastic Surgeons. Retrieved December 3, 2024, from https://www.plasticsurgery.org/cosmetic-procedures/dermal-fillers
- Treatment | REVOFIL. (n.d.). Revofil.co.kr. Retrieved December 3, 2024, from http://www.revofil.co.kr/treatment.html