In 2019, over 2.8 million hyaluronic acid (HA) filler procedures were performed globally. By 2022, this number surged by 70%, solidifying HA fillers as the second most-performed non-surgical cosmetic procedure. This growing popularity highlights their effectiveness in addressing volume loss and enhancing skin appearance, making them a cornerstone of modern aesthetic treatments.
Hyaluronic acid fillers like Aliaxin and Juvederm have gained widespread acclaim for their ability to hydrate the skin, restore volume, and deliver natural-looking results. These fillers leverage varying molecular weights of HA to penetrate different skin layers and achieve tailored outcomes, catering to diverse patient needs.
This article provides a comprehensive comparison of Aliaxin Filler vs Juvederm, exploring their formulations, applications, clinical effectiveness, patient outcomes, and safety to help you make an informed decision.
Key Takeaways
- Aliaxin filler combines different molecular weights of hyaluronic acid for effective facial contouring and hydration but lacks FDA approval.
- Juvederm utilizes Vycross Technology to enhance the stability and longevity of its hyaluronic acid fillers, with multiple options for various facial concerns.
- Both fillers can address issues like fine lines, wrinkles, and volume loss in different areas of the face, including lips and nasolabial folds.
- Juvederm boasts a strong safety profile and high patient satisfaction ratings, while Aliaxin shows promise but requires more data on its effectiveness and safety.
About: Medica Depot is your trusted all-in-one supplier, offering a range of high-quality medical injectables and supplies. Buy Aliaxin Fillers wholesale at Medica Depot today! Whether for health professionals, plastic surgeons, dermatologists, licensed estheticians, or other specialists, we can offer genuine, brand-name products you may need. With Medica Depot, we prioritize serving you better to improve the patient’s quality of life.
What is Aliaxin Filler?
Aliaxin filler, a monophasic dermal filler, combines various hyaluronic acid molecular weights to create a potent formulation. It integrates seamlessly into the skin, providing natural contouring, lifting, and hydration. The versatile Aliaxin filler product range suits multiple facial areas, including cheeks, lips, jawline, and nasolabial folds.
These injectables effectively address facial imperfections, offering both immediate and long-lasting results. The cross-linking process creates a ready-to-use gel that requires no additional fragmentation or manipulation. It has a low cross-linking percentage and minimal BDDE residue, allowing safer and easier administration.
Aliaxin SR, FL, GP, LV, EV, and SV can target specific facial areas that practitioners and patients may find appealing in addressing their aesthetic concerns, such as:
- Facial contouring
- Fine lines, wrinkles, and folds
- Lip augmentation
- Volume restoration
What is Juvederm?
Juvederm provides a variety of hyaluronic acid-based dermal fillers designed for facial rejuvenation. Its smooth gel consistency allows easy injection and effective integration into the treated skin area. Additionally, each product in the Juvederm line uses a modified form of hyaluronic acid, ensuring immediate and long-lasting effects.
The formulation employs Vycross Technology to create cross-linked hyaluronic acid. This process enhances the filler’s stability and longevity, resulting in a smooth and efficiently cross-linked product. Juvederm also includes lidocaine, a local anesthetic, to reduce discomfort during injections.
Juvederm Voluma XC, Vollure XC, Ultra Plus XC, Volbella XC, Ultra XC, and Volux XC have proven safety and efficacy in addressing various facial concerns of individuals. They can smooth fine lines and wrinkles, restore volume, contour facial features, and hydrate the skin for a youthful appearance in the following areas:
- Cheeks
- Chin
- Lips
- Jawline
- Undereyes
- Temple
Clinical Effectiveness
A study by Sparavigna et al. (2018) revealed that Aliaxin EV effectively reduced nasolabial folds, delivering a satisfying aesthetic performance with well-tolerated results, both with and without lidocaine. Both formulations significantly reduced wrinkle severity with minimal side effects.
After over nine months, 75% of Juvederm Ultra-treated and 81% of Juvederm Ultra Plus-treated nasolabial folds maintained a clinically significant correction. Additionally, 78% of nasolabial folds treated with Juvederm Ultra Plus showed a clinically important improvement beyond one year.
Juvederm has received an average 90% rating from RealSelf users, highlighting its high patient satisfaction with its treatments. In contrast, Aliaxin has insufficient information regarding its minimally invasive procedures, including patient satisfaction ratings. However, both injectables have proven their safety and efficacy with the following before and after photos of patients undergoing Aliaxin filler and Juvederm treatments.


Safety and Side Effects
Juvederm products have received approval from the US Food and Drug Administration (FDA), underscoring their proven safety and efficacy for facial rejuvenation. Unfortunately, Aliaxin has yet to receive its green light from the US FDA, which makes Juvederm a more compelling choice for individuals and practitioners with aesthetic concerns.
Moreover, both hyaluronic acid-based dermal fillers may still cause common side effects post-treatment. These typical injection site-related reactions are often mild and temporary and can resolve within a few days to a week. Patients must consult their trusted medical professionals for proper management if the following reactions persist:
- Redness
- Swelling
- Pain
- Tenderness
When comparing Aliaxin filler vs Juvederm, both injectables have favorable safety profiles with minimal adverse events. IBSA developed Aliaxin, focusing on biocompatibility, efficacy, and minimal adverse reactions, making it a reliable choice. However, Juvederm’s FDA approval and extensive clinical use support its safety and effectiveness, which stand out among other dermal fillers.
Duration of Results

Consulting with experienced providers is essential for the safe application of fillers and optimal results. The duration of dermal filler results depends on several factors, including the treatment area, individual metabolism, the amount of filler used, and post-treatment care. Moreover, proper injection technique and practitioner expertise are crucial in achieving the best outcomes.
- Longevity of Aliaxin Filler: 6-12 Months
- Longevity of Juvederm: 12-24 Months
Cost Comparison
Individuals should ask their medical professionals about Aliaxin and Juvederm’s potential cost, as this factor may depend on the severity of the aesthetic concerns, treatment area, and injectable filler used. While both filler brands can offer good value for money, determining the most suitable injectable can help achieve optimal treatment outcomes.
- Average Cost of Aliaxin Filler: An Aliaxin filler treatment session costs $350 to $450.
- Average Cost of Juvederm: The average price of a Juvederm treatment ranges from $500 to $975 per syringe.
Prices may vary based on the clinic and the practitioner’s expertise. Additionally, Aliaxin filler is more affordable, whereas Juvederm is widely available and offers various formulations to meet different needs.
Conclusion
Both Aliaxin and Juvederm fillers provide exceptional solutions for individuals seeking facial rejuvenation. Aliaxin’s versatility and ability to deliver natural-looking results across various facial areas make it a reliable choice. At the same time, Juvederm’s long-standing reputation, FDA approval, and proven safety profile set it apart in the aesthetic market. Both options are highly effective in improving volume and hydration, offering noticeable and satisfying results for patients.
Ultimately, the decision between Aliaxin and Juvederm depends on the patient’s unique goals, treatment areas, and preferences. A consultation with a qualified practitioner is essential to assess individual needs and determine the most suitable filler for achieving the desired outcome. By tailoring the treatment approach, patients can enjoy enhanced confidence and a rejuvenated appearance.
FAQs
1. What are the main differences between Aliaxin filler and Juvederm?
Aliaxin filler uses various molecular weights of hyaluronic acid for natural contouring and hydration, while Juvederm employs Vycross Technology for a smooth, stable formulation. Juvederm has FDA approval, making it a more trusted option for patients, while Aliaxin is still awaiting regulatory approval.
2. What areas can Aliaxin and Juvederm treat?
Both fillers can be used for facial contouring, lip augmentation, and wrinkle reduction. Specifically, Aliaxin targets areas like cheeks, lips, jawline, and nasolabial folds, while Juvederm is effective for cheeks, chin, undereyes, and other facial features.
3. How do the safety profiles of Aliaxin and Juvederm compare?
Juvederm has received FDA approval, indicating a proven safety profile. Aliaxin, on the other hand, has not yet been approved by the FDA, which may raise concerns for some patients. Both fillers can cause mild, temporary side effects like redness and swelling at the injection site.
References
- American Society of Plastic Surgeons (ASPS). (2023, September 26). 2022 ASPS Procedural Statistics Release. American Society of Plastic Surgeons. https://www.plasticsurgery.org/documents/News/Statistics/2022/plastic-surgery-statistics-report-2022.pdf
- Sparavigna, A., Tenconi, B., & Penna, L. L. (2018, December 1). Comparative efficacy and safety of a resorbable filler (Aliaxin® EV) with and without lidocaine for filling nasolabial folds. ResearchGate. https://www.researchgate.net/publication/330597904_Comparative_efficacy_and_safety_of_a_resorbable_filler_AliaxinR_EV_with_and_without_lidocaine_for_filling_nasolabial_folds