XEOMEEN (XEOMIN®) 100u (Spanish)

XEOMEEN (XEOMIN®) 100u – Key Features and Benefits

XEOMEEN® (internationally known as XEOMIN®) is a purified botulinum toxin type A, free from accessory (complexing) proteins. It is used to treat neuromuscular disorders and aesthetic conditions such as glabellar frown lines. Its pure formula may reduce the risk of antibody formation, making it a suitable long-term option for patients.

• Highly purified botulinum toxin type A, without complexing proteins

• Presentation: 100-unit vial for reconstitution and intramuscular injection

• Used in both aesthetic and therapeutic applications

• Reduced risk of immune resistance compared to other botulinum toxins

• Onset of action: 3–7 days; duration: up to 3–4 months

• Alternative to other brands such as Botox® and Dysport®

• Allows for targeted, reversible muscle relaxation

XEOMEEN (XEOMIN®) 100u – Indications

XEOMEEN® is indicated for adults only, and is used in both cosmetic and medical contexts. It works by blocking the release of acetylcholine, temporarily weakening targeted muscles.

• Aesthetic indication:

  • Temporary treatment of moderate to severe glabellar lines (frown lines between the eyebrows)

• Therapeutic indications:

  • Blepharospasm (eyelid muscle spasms)

  • Cervical dystonia (spasmodic torticollis)

  • Post-stroke upper limb spasticity

• Not approved for use in:

  • Children

  • Pregnant or breastfeeding women

  • Patients with neuromuscular disorders without medical supervision

XEOMEEN (XEOMIN®) 100u – Ingredients

The formulation contains only essential excipients and is supplied as a lyophilized powder to be reconstituted with saline before use.

• Active ingredient:

  • Botulinum toxin type A (purified, without complexing proteins)

• Excipients:

  • Human albumin

  • Sucrose

• Form:

  • White lyophilized powder for injection

• Dilution:

  • Reconstituted with preservative-free 0.9% sodium chloride

  • Use within 24 hours of reconstitution

XEOMEEN (XEOMIN®) 100u – How To Use

XEOMEEN® must be administered by qualified medical professionals experienced in the use of botulinum toxins. Treatment is tailored to each patient depending on condition and muscle mass.

• Route: Intramuscular injection (targeted based on indication)

• Preparation:

  • Dilute powder with sterile 0.9% saline without preservatives

  • Typical reconstitution volumes vary depending on application (e.g., 2.5 mL = 4 units per 0.1 mL)

• Dosage:

  • Depends on indication, severity, and previous response

  • Cosmetic use (glabellar lines): Typically 20 units divided across 5 injection points

• Frequency:

  • Effects appear in 3–7 days and last about 12–16 weeks

  • Retreatment no more frequently than every 3 months

• Storage:

  • Store powder in refrigerator (2–8°C); protect from light

  • Use reconstituted solution within 24 hours

XEOMEEN (XEOMIN®) 100u – Side Effects

Most side effects are mild and temporary, related to local muscle weakening or injection site reactions. However, some may be serious and require medical attention.

Common side effects:

• Headache

• Injection site pain or swelling

• Eyelid drooping (ptosis)

• Muscle weakness

• Flu-like symptoms

Less common or serious side effects:

• Difficulty swallowing (dysphagia)

• Breathing difficulties

• Allergic reactions (rash, itching, facial swelling)

• Vision disturbances

• Dry eyes or excessive tearing

Warnings:

• Not recommended in patients with myasthenia gravis, ALS, or other neuromuscular diseases

• Risk of systemic botulinum toxin spread—seek urgent care for breathing/swallowing issues

XEOMEEN (XEOMIN®) 100u – Clinical Studies

XEOMEEN® has been evaluated in clinical trials for both aesthetic and therapeutic uses, demonstrating safety and efficacy comparable to other botulinum toxins.

• Glabellar line trials showed significant wrinkle reduction by day 7, lasting up to 4 months

• Blepharospasm and cervical dystonia trials demonstrated improved symptom control and quality of life

• Lower incidence of neutralizing antibodies than with toxins containing complexing proteins

• Considered a safe alternative for patients previously resistant to other botulinum toxin brands

XEOMEEN (XEOMIN®) 100u – Manufacturer Information

XEOMEEN® is manufactured by Merz Pharmaceuticals GmbH, a German pharmaceutical company specializing in neurotoxins and aesthetics. It is distributed under the XEOMIN® brand in international markets.

• Manufacturer: Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany

• International name: XEOMIN®

• Marketing authorization holder: Merz Pharmaceuticals

• Storage conditions:

  • Store unopened vial at 2–8°C

  • Reconstituted solution must be refrigerated and used within 24 hours

• Packaging: Vial with 100 units of powder for injection

XEOMEEN (XEOMIN®) 100u – FAQ

Is XEOMEEN® the same as XEOMIN®?
Yes. XEOMEEN® is the Spanish-market name for XEOMIN®, both containing botulinum toxin type A without complexing proteins.

How long does XEOMEEN® last?
Effects typically last 12 to 16 weeks after a single injection session.

How many units are used for glabellar lines?
Usually 20 units spread across 5 injection sites in the glabellar region.

When does XEOMEEN® start working?
You may begin to see results within 3 to 7 days, with full effect by 14 days.

Can XEOMEEN® cause droopy eyelids?
Yes, eyelid ptosis is a known side effect if injected too close to the levator palpebrae muscle. Proper technique minimizes risk.

What makes XEOMEEN® different from Botox®?
XEOMEEN® is free of complexing proteins, which may reduce antibody formation and resistance risk over time.

Is XEOMEEN® safe for long-term use?
Yes, when administered by qualified professionals and with appropriate dosing intervals (≥3 months between sessions).