STYLAGE® M BI-FLEX® with Lidocaine

STYLAGE® M BI-FLEX® with Lidocaine — Injectable HA Dermal Filler for Deep Wrinkles, Volume Restoration & Hand Rejuvenation

Product Specifications

• Drug Class: Injectable hyaluronic acid dermal filler (cross-linked HA with IPN-Like Technology™, mannitol, and lidocaine)
• Active Ingredients: Hyaluronic acid (cross-linked) 20mg/g; Mannitol 9mg/mL; Lidocaine 3mg/mL
• Manufacturer: Laboratories VIVACY
• Brand: STYLAGE®
• Country of Origin: France
• Strength: 20mg/g HA; 9mg/mL Mannitol; 3mg/mL Lidocaine
• Dosage Form: Injectable gel — 2 × 1mL prefilled syringes (patented syringe system; formerly Bi-SOFT®) + 2 × 30G ½ needles
• FDA Status: Not currently approved by the US FDA
• Regulatory Status: CE-marked (EU); current as of 2026

Mechanism of Action — STYLAGE® M BI-FLEX® with Lidocaine injection

Like other hyaluronic acid injectable dermal fillers, STYLAGE® M BI-FLEX® integrates into dermal tissue, binds water, and restores volume, helping to smooth deep wrinkles such as nasolabial folds and marionette lines. HA-based fillers are widely used to address facial volume loss, contour changes, and static lines associated with aging.

• IPN-Like Technology™ creates an interpenetrating network of HA polymers, giving the BI-FLEX® gel cohesivity, elasticity, and resistance to mechanical deformation while still allowing soft integration with surrounding tissue.
• Mannitol (9mg/mL) acts as a free radical scavenger, reducing oxidative degradation of HA, and is associated with extended longevity in the STYLAGE® range.
• Lidocaine 3mg/mL is co-formulated in the gel, providing local anesthesia during lidocaine administration and reducing the need for a separate anesthetic injection.

As with other HA fillers, STYLAGE® M BI-FLEX® can be degraded by hyaluronidase, allowing reversibility in cases of overcorrection or vascular compromise, in line with standard aesthetic medicine protocols.

About STYLAGE® M BI-FLEX® with Lidocaine

STYLAGE® M BI-FLEX® with Lidocaine is part of the STYLAGE® portfolio of hyaluronic acid dermal fillers developed by Laboratories VIVACY, combining cross-linked HA, mannitol, and lidocaine. The range is CE-marked and used by trained professionals for wrinkle correction, facial contouring, and hand rejuvenation in suitable candidates.

The BI-FLEX® designation reflects a rheological profile designed for smooth, controlled injections and natural tissue behavior across multiple treatment areas. The patented syringe system (formerly Bi-SOFT®) improves ergonomics and dosing precision for more consistent gel placement.

When practitioners evaluate whether STYLAGE® is a good filler, commonly cited factors include IPN-Like Technology™, mannitol-associated longevity, the patented syringe system, and the BI-FLEX® rheological profile. The range is CE-marked and supported by clinical data in aesthetic medicine.

Practitioners wishing to buy STYLAGE® M BI-FLEX® with Lidocaine wholesale should contact Medica Depot’s support representatives for sourcing information and documentation support.

Indications & Clinical Use

STYLAGE® M BI-FLEX® with Lidocaine is indicated for moderate wrinkle correction in areas such as nasolabial folds and marionette lines, typically using a mid-dermal injection plane. It may also be used for perioral rhytids where additional structural support is needed around the mouth.

For volume restoration, the product can be placed in the cheeks, chin, and selected lip filler indications in the mid-to-deep dermis or superficial subcutaneous layer to address age-related volume loss and contour changes. STYLAGE® M BI-FLEX® is also used for hand rejuvenation on the dorsum of the hands, where subcutaneous injection helps mask veins and tendons by restoring soft-tissue volume.

Patient selection should consider the severity of volume loss, the condition of the patient’s skin, skin type, and specific goals for each treatment area. STYLAGE® M BI-FLEX® with Lidocaine is for licensed aesthetic medicine professionals only, who must use aseptic technique, screen for contraindications, and avoid intravascular injection in line with dermal filler safety guidance.

Administration, Side Effects & Safety

Injection depth is typically mid-dermis for wrinkle correction and subcutaneous for volumizing and hand rejuvenation; the exact plane and technique (e.g., linear threading or fanning) should be tailored to anatomy and indication.

STYLAGE® M BI-FLEX® with Lidocaine injection delivers 3mg/mL lidocaine with the gel, improving comfort and often reducing the need for additional injectable anesthetics. Topical anesthetic remains an option at the practitioner’s discretion.

After treatment, patients should be advised to avoid sun exposure, intense heat, and vigorous exercise until swelling and redness resolve, and not to massage treated areas unless instructed.

Common Adverse Effects

• Transient redness
• Swelling
• Tenderness
• Bruising at the injection site

Serious Adverse Events (Rare)

Serious but rare adverse events include vascular occlusion, skin necrosis, and visual disturbances. These require rapid recognition and management in accordance with dermal filler complication protocols and the product’s IFU. Patients should be screened for hypersensitivity to hyaluronic acid, mannitol, or amide-type anesthetics, coagulation disorders, and active infection in the treatment area, as well as other contraindications listed in the IFU.

Practitioners must consult the full Instructions for Use (IFU) provided with the product for the complete list of contraindications, warnings, precautions, and adverse event management protocols before administering STYLAGE® M BI-FLEX® with Lidocaine.

Legal & Regulatory Status

STYLAGE® M BI-FLEX® with Lidocaine is CE-marked and manufactured in France by Laboratories VIVACY for professional aesthetic use. In CE-recognizing markets, it may be used for wrinkle correction, facial volume restoration, and hand rejuvenation when administered by appropriately trained, licensed medical professionals.

As of 2026, STYLAGE® dermal fillers are not approved by the US Food and Drug Administration. Practitioners are responsible for confirming the most up-to-date regulatory status in their own jurisdiction, including any local registrations or restrictions, before ordering or using the product. Information on this page is current as of 2026 and is subject to change.

Practitioners wishing to buy STYLAGE® or buy dermal fillers may reach out to Medica Depot’s support representatives for documentation support and sourcing information.

Citations

1. Mojallal A. Efficacy and Safety of Stylage XL Lidocaine for the Restoration and/or Augmentation of Facial Volume: The Beauty Volume Study. Aesthet Surg J Open Forum. 2023;5:ojad056. Published 2023 Jun 26. doi:10.1093/asjof/ojad056
2. Wongprasert P, Dreiss CA, Murray G. Evaluating hyaluronic acid dermal fillers: A critique of current characterization methods. Dermatol Ther. 2022;35(6):e15453. doi:10.1111/dth.15453
3. US Food and Drug Administration. Dermal fillers (soft tissue fillers). https://www.fda.gov/medical-devices/aesthetic-cosmetic-devices/dermal-fillers-soft-tissue-fillers

The contents of this page are meant for licensed medical professionals. They serve informational purposes only and are not to be taken as medical advice.