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Manufacturer: Pharma Research Bio
Active Substance(s): BOTULINUM TOXIN TYPE A
Strength: 200u
Pack Size: 1 x 200u Vial
Re N Tox™ 200units (RENTOX) is an innovative premium type A preparation (botulinum toxin) for correcting forehead wrinkles glabellar lines and crow’s feet.
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INFORMATION
Re N Tox™ 200u Key Features and Benefits
Re N Tox™ 200u is a botulinum toxin type A injectable used for the temporary improvement of moderate to severe glabellar lines caused by the activity of corrugator and procerus muscles. Key features include its high purity (99.6%), consistent efficacy, and ease of reconstitution. Its molecular weight (927 kDa) ensures its stability and bioactivity.
- Applications: Glabellar lines and other indications as deemed appropriate by professionals.
- Purity: Manufactured using advanced purification processes, ensuring 99.6% purity.
- Stability: Reliable molecular weight confirmed through analysis.
- Efficacy: Proven to offer comparable results to Botox® in electromyography studies.
Re N Tox™ 200u Reconstitution Chart
Re N Tox™ 200u is supplied as a lyophilized powder and must be reconstituted with 0.9% preservative-free sodium chloride (saline).
- Diluent Volumes and Resulting Dosages:
- 1.0 mL saline yields 10 Units per 0.1 mL.
- 2.0 mL saline yields 5 Units per 0.1 mL.
- 4.0 mL saline yields 2.5 Units per 0.1 mL.
- Reconstitution Guidelines:
- Gently inject saline into the vial to avoid denaturation.
- Mix by rotating the vial—avoid vigorous shaking.
- Ensure the solution is clear, colorless, and free from particulate matter.
- Use within 24 hours of reconstitution.
Re N Tox™ 200u Storage Information
To maintain efficacy, Re N Tox™ 200u must be stored under proper conditions:
- Temperature Range: 2–8°C.
- Storage Requirements:
- Keep away from direct light and freezing temperatures.
- Reconstituted solution should also be refrigerated and used within 24 hours.
Re N Tox™ 200u Treatment Areas
Re N Tox™ 200u is specifically designed for treatment of glabellar lines and other facial wrinkles caused by muscular activity.
- Injection Sites:
- Glabellar lines: Target the corrugator and procerus muscles.
- Total dose: 20 Units divided across five sites (0.1 mL per injection).
Re N Tox™ 200u Dosing for Different Indications
The recommended dose depends on the muscle group and individual patient response. For glabellar lines:
- Standard Dose: 20 Units divided across five injection sites (0.1 mL per site).
- Frequency of Use: Treatments last 3–4 months; repeated injections should not occur more frequently than this.
Re N Tox™ 200u Side Effects and Precautions
Potential Side Effects:
- Common: Redness, swelling, bruising, or discomfort at the injection site.
- Rare: Ptosis, headache, or muscle weakness.
Precautions:
- Avoid injecting near the levator palpebrae superioris to prevent ptosis.
- Proper placement of injections at least 1 cm above the bony supraorbital ridge is critical.
- Avoid vascular injection to minimize complications.
Re N Tox™ 200u Aftercare
Proper aftercare ensures optimal results and minimizes side effects:
- Avoid lying down for at least 4 hours post-treatment.
- Refrain from strenuous physical activity, alcohol, and exposure to heat or UV rays for 24–48 hours.
- Do not rub or massage treated areas to prevent the spread of the toxin.
Re N Tox™ 200u Drug Interactions
Caution should be taken when used alongside other medications that affect neuromuscular transmission.
- Potential Interactions:
- Aminoglycosides
- Anticholinergic drugs
- Other botulinum toxin products
- Guidance: Inform the practitioner of all medications being taken before treatment to avoid adverse effects.
Clinical Studies and Outcomes
Re N Tox™ 200u has undergone extensive pre-clinical and clinical studies:
- In Vivo Studies:
- Demonstrated equivalent efficacy to Botox® in electromyography tests.
- Pre-Clinical Safety: Proven safety through repeated dose toxicology studies in rats and monkeys.
- Dosages ranged from 3 to 150 Units/kg, depending on the study duration and species.
Manufacturer and Regulatory Information
Re N Tox™ 200u is produced by PharmaResearch BIO Co., Ltd., a certified manufacturer known for its stringent quality standards.
- Compliance: Fully adheres to global standards for botulinum toxin manufacturing.
- Contact Information:
- Address: 4F, 74, Pangyo-ro 255beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea.
- Website: www.pr-bio.co.kr.
Re N Tox™ 200u Key Features and Benefits
Re N Tox™ 200u is a botulinum toxin type A injectable used for the temporary improvement of moderate to severe glabellar lines caused by the activity of corrugator and procerus muscles. Key features include its high purity (99.6%), consistent efficacy, and ease of reconstitution. Its molecular weight (927 kDa) ensures its stability and bioactivity.
- Applications: Glabellar lines and other indications as deemed appropriate by professionals.
- Purity: Manufactured using advanced purification processes, ensuring 99.6% purity.
- Stability: Reliable molecular weight confirmed through analysis.
- Efficacy: Proven to offer comparable results to Botox® in electromyography studies.
Re N Tox™ 200u Reconstitution Chart
Re N Tox™ 200u is supplied as a lyophilized powder and must be reconstituted with 0.9% preservative-free sodium chloride (saline).
- Diluent Volumes and Resulting Dosages:
- 1.0 mL saline yields 10 Units per 0.1 mL.
- 2.0 mL saline yields 5 Units per 0.1 mL.
- 4.0 mL saline yields 2.5 Units per 0.1 mL.
- Reconstitution Guidelines:
- Gently inject saline into the vial to avoid denaturation.
- Mix by rotating the vial—avoid vigorous shaking.
- Ensure the solution is clear, colorless, and free from particulate matter.
- Use within 24 hours of reconstitution.
Re N Tox™ 200u Storage Information
To maintain efficacy, Re N Tox™ 200u must be stored under proper conditions:
- Temperature Range: 2–8°C.
- Storage Requirements:
- Keep away from direct light and freezing temperatures.
- Reconstituted solution should also be refrigerated and used within 24 hours.
Re N Tox™ 200u Treatment Areas
Re N Tox™ 200u is specifically designed for treatment of glabellar lines and other facial wrinkles caused by muscular activity.
- Injection Sites:
- Glabellar lines: Target the corrugator and procerus muscles.
- Total dose: 20 Units divided across five sites (0.1 mL per injection).
Re N Tox™ 200u Dosing for Different Indications
The recommended dose depends on the muscle group and individual patient response. For glabellar lines:
- Standard Dose: 20 Units divided across five injection sites (0.1 mL per site).
- Frequency of Use: Treatments last 3–4 months; repeated injections should not occur more frequently than this.
Re N Tox™ 200u Side Effects and Precautions
Potential Side Effects:
- Common: Redness, swelling, bruising, or discomfort at the injection site.
- Rare: Ptosis, headache, or muscle weakness.
Precautions:
- Avoid injecting near the levator palpebrae superioris to prevent ptosis.
- Proper placement of injections at least 1 cm above the bony supraorbital ridge is critical.
- Avoid vascular injection to minimize complications.
Re N Tox™ 200u Aftercare
Proper aftercare ensures optimal results and minimizes side effects:
- Avoid lying down for at least 4 hours post-treatment.
- Refrain from strenuous physical activity, alcohol, and exposure to heat or UV rays for 24–48 hours.
- Do not rub or massage treated areas to prevent the spread of the toxin.
Re N Tox™ 200u Drug Interactions
Caution should be taken when used alongside other medications that affect neuromuscular transmission.
- Potential Interactions:
- Aminoglycosides
- Anticholinergic drugs
- Other botulinum toxin products
- Guidance: Inform the practitioner of all medications being taken before treatment to avoid adverse effects.
Clinical Studies and Outcomes
Re N Tox™ 200u has undergone extensive pre-clinical and clinical studies:
- In Vivo Studies:
- Demonstrated equivalent efficacy to Botox® in electromyography tests.
- Pre-Clinical Safety: Proven safety through repeated dose toxicology studies in rats and monkeys.
- Dosages ranged from 3 to 150 Units/kg, depending on the study duration and species.
Manufacturer and Regulatory Information
Re N Tox™ 200u is produced by PharmaResearch BIO Co., Ltd., a certified manufacturer known for its stringent quality standards.
- Compliance: Fully adheres to global standards for botulinum toxin manufacturing.
- Contact Information:
- Address: 4F, 74, Pangyo-ro 255beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea.
- Website: www.pr-bio.co.kr.
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