LIPORASE® (Hyaluronidase) 1500U

LIPORASE® Key Features and Benefits

LIPORASE® is a hyaluronidase-based injectable solution used to dissolve hyaluronic acid fillers, enhance lipodissolving procedures, and treat skin complications. It works by breaking down hyaluronic acid and improving fluid diffusion in tissues.

Furthermore, Liporase can deliver these multiple benefits that professional derma and patients can achieve with proper adherence to the recommended treatment protocol, dosage, and administration.

• Filler Correction: Liporase can efficiently dissolve hyaluronic acid fillers in aesthetic procedures.
• Treatment of Granulomas and Fibrosis: Helps manage dermal fillers and cellulite fibrosis complications.
• Post-Surgery Edema Reduction: Reduces swelling and fibrosis following cosmetic surgeries.
• Enhanced Lipodissolving Effects: Increases the effectiveness of lipolytic injections when combined.
• Pre-Surgical Preparation: Used to prepare skin for plastic surgery by improving skin texture and circulation.

The Hyaluronidase Filler Indications

LIPORASE® is recommended for corrective and aesthetic applications, particularly in aesthetic medicine and plastic surgery. This hyaluronidase treatment can ensure that the natural hyaluronic acid in the body remains unaffected during the dissolving process of the synthetic hyaluronic acid components of dermal fillers.

• Dissolution of Hyaluronic Acid Fillers: Eliminates unwanted hyaluronic acid-based fillers.
• Treatment of Fibrous Cellulite: Breaks down fibrotic deposits in stubborn cellulite.
• Correction of Post-Surgical Defects: Reduces irregularities after lipolytic procedures or breast surgery.
• Edema and Hemorrhage Management: Helps resolve swelling and bruising in the dermis.
• Prevention of Skin Necrosis: Improves tissue oxygenation and prevents tissue damage.
• Correction of the Tyndall Effect: Clears blueish skin pigmentation caused by superficial filler placement.

LIPORASE® Ingredients

LIPORASE® consists of a highly effective hyaluronidase enzyme formulation.

• Active Ingredient:
  • Hyaluronidase: Breaks down hyaluronic acid, facilitating filler removal and enhanced fluid absorption.
• Excipients:
  • Saline Solution: Used for reconstitution and dilution.
  • Lidocaine (optional combination): Enhances comfort during injection procedures.

This solution demonstrates high enzymatic activity, aiding in the dissolution of hyaluronic acid fillers that may have been improperly applied, while also providing additional health benefits.

• Reduces lymphatic stasis
• Body contouring and anti-cellulite effects
• Enhances blood circulation

How To Use This Hyaluronidase Filler

LIPORASE® is administered via injection, alone or in combination with lipolytic agents, depending on the intended use. Medical professionals must administer these dissolving injections to ensure patient safety and product efficacy.

Each vial of the product contains 1500 IU of hyaluronidase. The typical preparation involves mixing with 3 ml of sodium chloride and refrigerating the solution once it has been reconstituted. However, medical professionals may also use these dilution processes to dissolve hyaluronic acid and enhance lipodissolving.

Hyaluronic Acid Filler Dissolution

• Dilution: Mix 3cc of saline with 1 vial of Liporase. The package does not include saline; 3cc can dissolve 3cc of hyaluronic acid.
• Injection Technique:
  • Inject directly into the area where the unwanted filler was placed.
  • Hyaluronic acid starts dissolving immediately and is absorbed within hours.

Lipodissolving Injection Enhancement

• Dilution:
  • Mix 5cc of saline with 1 vial of Liporase.
  • If using a 30cc lipodissolving injection, add 2 vials.
• Injection Process:
  • Inject evenly into the fat layer, combined with a lipodissolving agent.
  • Perform 15-minute massages daily for 7 days.
  • Apply hot compress after massage for enhanced absorption.

LIPORASE Side Effects

While the Korea FDA has approved the use of Liporase hyaluronidase procedures, practitioners should understand the potential risks associated with these dissolving injections. They should equip patients with medical advice on the risks, enabling them to make informed treatment decisions.

Liporase is generally well-tolerated, but some localized reactions can occur.

• Common Side Effects:
  • Redness, swelling, or mild discomfort at the injection site.
  • Bruising or irritation following injection.
  • Mild burning sensation during administration.
• Rare Complications:
  • Hypersensitivity or allergic reactions.
  • Temporary irregularities in skin texture after filler dissolution.
  • Infection at the injection site (if not administered under sterile conditions).

LIPORASE Clinical Studies

This Liporase solution has been evaluated in multiple clinical settings, showing high efficacy and safety for filler correction and fat reduction procedures.

Filler Dissolution Studies

• 98% success rate in removing unwanted fillers within 24 hours.
• No long-term adverse reactions reported in clinical applications.

Lipodissolving Combination Studies

• 60% improvement in fat reduction when used alongside lipolytic injections.
• Faster recovery and reduced swelling compared to lipodissolving injections alone.

LIPORASE® Manufacturer Information

• Manufacturer: Maypharm Co., Ltd.
• Contact: Available via official website and distributors.
• Regulatory Status: Certified for aesthetic and medical use.

Clinicians and Patients’ LIPORASE® FAQ

1. How long does LIPORASE® take to dissolve fillers?

• Results are typically visible within hours, with full absorption in 24-48 hours.

2. Can LIPORASE® be used with fat-dissolving injections?

• Yes, it enhances lipodissolving effects, leading to faster fat breakdown.

3. Is LIPORASE® painful to use?

• Some mild discomfort or burning may occur, but lidocaine can be added for pain relief.

4. Can LIPORASE® cause allergic reactions?

• While rare, allergic reactions to hyaluronidase may occur. A patch test is recommended before treatment.

5. How often can LIPORASE® be used?

• Treatments can be repeated as needed, but sessions should be spaced at least one week apart.