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Manufacturer: Merz Pharma
Active Substance(s): BOTULINUM TOXIN TYPE A
Strength: 100u
Pack Size: 1 x 100u Powder Single Use Vial
Accessories: Package insert

BOCOUTURE® is a botulinum toxin for cosmetic treatments that blocks nerve signals to temporarily paralyze muscles and is used to treat the appearance of glabellar lines and crow’s feet in adults. Bocouture has been purified to remove complexing proteins, which means it is less likely to cause an immune reaction. If the body does not have an immune reaction, it will not produce antibodies that make the drug less effective over time. For this reason, many doctors switch to Bocouture when Botox starts to become less effective after many uses,Complexing proteins have been removed by an extensive purification process from the botulinum toxin complex. In contrast to the other commercially available preparations, Bocouture® contains the pure 150 kD neurotoxin.


Frequently Asked Questions

BOCOUTURE® 100u (Xeomin) has a variety of cosmetic and medical uses, and can be a great addition to a cosmetic clinic or a medical clinic. If you are a licensed medical practitioner such as a dermatologist, cosmetic surgeon, other doctor, hospital or clinic, you can order wholesale BOCOUTURE® 100u (Xeomin) online from You can also phone our helpful customer service team to buy BOCOUTURE® 100u (Xeomin) today for fast and friendly service. Whether your patients want to treat wrinkles and facial lines, or if they suffer from a medical disorder, you can buy BOCOUTURE® 100u (Xeomin) to help them look and feel better.

BOCOUTURE® 100u (Xeomin) is suitable to treat patients with:

Increased muscle stiffness in the arm of adults with upper limb spasticity;
Abnormal head position and neck pain in adults with spasmodic torticollis;
Abnormal spasms of the eyelids (blepharospasm) in adults.

Do not treat the patient with BOCOUTURE® 100u (Xeomin) if they have a history of hypersensitivity to botulinum toxin or to any of the other components of this product. Do not inject into infected skin. Do not use this medication in nursing or pregnant women. The safety profile of this product has not yet been established in patients below 18 years of age.

This product is meant for intramuscular injection only. BOCOUTURE® is indicated for various sites in and around the eyelids (medial and lateral orbicularis oculi muscle of the upper lid, lateral orbicularis oculi muscle of the lower lid, and additional sites in the brow area and upper facial area) for the treatment of blepharospasm. Inject into the muscles responsible for controlling head position for the treatment of spasmodic torticollis. As well, inject into the specific muscles involved in the spasticity for the treatment of upper limb spasticity (e.g. flexor carpi ulnaris and flexor carpi radialis in the case of a flexed wrist).

Movement disorders arise as a result of neurological conditions that cause increased abnormal movements. These conditions can often be painful and debilitating. The types of movement disorders BOCOUTURE® can treat include spasmodic torticollis, a condition involving spasms or contractions of the neck muscles that cause abnormal head movement; blepharospasm, a condition where there is involuntary contraction or twitching of the eyelid; and upper limb spasticity, which refers to muscle stiffness in various regions in the upper limb, such as flexed elbow or wrist, clenched fist, pronated forearm, thumb-in-palm, or rotated/adducted/extended, to name a few.

BOCOUTURE® alleviates symptoms of these disorders by acting on the nerves of the muscles involved in the abnormal movement to temporarily cease muscle contractions underneath the treatment area. This product is made of a neurotoxin isolated from the bacterium Clostridium botulinum that acts on nerve endings to prevent the release of acetylcholine, a neurotransmitter. This action effectively stops nerve signaling in the affected area, resulting in paralysis. This effect is temporary, and will gradually cease once signaling is re-established by the formation of new nerve endings.

Only an authorized medical practitioner with specialist knowledge of treatment with Botulinum neurotoxin type A may administer this treatment.

Prior to treatment, fully inform your prospective patient on the indications, contraindications, precautions, and potential adverse events associated with this treatment. Take down a complete medical history of the patient before proceeding.

BOCOUTURE® should be reconstituted prior to intramuscular injection. Reconstitute BOCOUTURE® with 0.9% sodium chloride solution.

The optimum dose, frequency, and number of injection sites in the treated muscle should be customized to the individual patient. The results of initial treatment with BOCOUTURE® should be evaluated and may require a dose adjustment until the desired therapeutic effect is achieved. Recommended starting doses for each indication are as follows:

Twisted neck (spasmodic torticollis): Up to 50 units per injection site, with the maximum dose for the first treatment session is 200 units. Doses up to 300 units may be given in subsequent courses depending on the response. Usually, the first onset of effect is observed within 7 days after injection.
Spasticity of the upper limb: Up to 500 units per treatment session, with no more than 250 units administered to the shoulder muscles. Patients reported the onset of action 4 days after treatment. An improvement of muscle tone is usually perceived within 4 weeks.

The duration of effect of BOCOUTURE® varies by indication:

Blepharospasm: The effect of each treatment generally lasts for about 3–4 months. The treatment can be repeated if required.
Spasmodic torticollis: The effect of each treatment usually lasts for about 3–4 months. Treatment intervals of less than 12 weeks are not recommended.
Upper limb spasticity: The treatment effect typically lasts 12 weeks. The period between each treatment session should be a minimum of 12 weeks.

BOCOUTURE® is made using a state-of-the-art manufacturing process that minimizes the quantity of accessory or complexed proteins. As a result, this toxin is less prone to triggering immunogenic reactions in the patient, which in turn increases the success rate of a repeat treatment.

As with all medications, injection with this product may cause unintended effects. Advise your patient to seek medical attention immediately if he or she experiences an allergic reaction.

Swallowing difficulties and excessive muscle weakness are other side effects that may occur when BOCOUTURE® acts to relax muscles in sites distal to the injection site. This is more likely to happen if using BOCOUTURE® to treat spasmodic torticollis.

The most common side effects observed with BOCOUTURE® treatment are mild inflammatory reactions at the site of injection, which may include redness, itching, edema or bruising at the site of injection. These reactions are typically not severe and will spontaneously resolve within a week.

Other side effects may be associated with a specific indication. Refer to the product pamphlet for a complete list of possible reactions.

There is no recovery time for botulinum toxin injections. Patients may resume their daily activities immediately following a treatment session.

In the United States, a BOCOUTURE® injection typically costs an average of $450. The price varies depending on the number of units administered.

BOCOUTURE® is an injectable wrinkle relaxer that is an alternative to other products like BOTOX®. BOCOUTURE®, also known as incobotulinumtoxinA, is made from botulinum toxin type A, just like BOTOX®. Doctors often treat their patients with BOCOUTURE® to save money or to continue treating patients that are experiencing BOTOX® burnout when the injections become less effective after a while.

Wrinkles often form when your patients constantly use their muscles for facial expressions such as squinting, smiling, and frowning. BOCOUTURE® helps to block this wrinkle development by relaxing your patient’s facial muscles, especially around the frown lines between their eyebrows. When you inject BOCOUTURE® into your patient’s facial muscles, it blocks the release of acetylcholine, a chemical messenger that usually transmits a signal from the nerve terminals to muscle fibers, causing them to contract. When your patient’s muscles are no longer as active, wrinkles are less likely to form and existing wrinkles will fade away. The result is smoother, younger-looking skin.

BOCOUTURE® cosmetic treatments can help your older patients who have wrinkles on their mature skin, or your patients both young and old that are bothered by moderate to severe facial lines such as frown lines, also known as glabellar lines, that form between their eyebrows. BOCOUTURE® can also help your patients who are suffering from a variety of medical conditions involving muscle spasms, such as cervical dystonia (CD), which causes neck pain and an abnormal head position, blepharospasm, which is eyelid spasms or excessive blinking, spasmodic torticollis, which is when the head tilts in one direction, spasmodic dysphonia of the vocal chords, oromandibular dystonia of the mouth, tongue and pharynx, which causes twitching, and writer’s cramp. You can also inject BOCOUTURE® to help your patients who have migraines, overactive bladder, excessive underarm sweating, and strabismus, which is crossed eyes. Whether your patients are suffering from a muscular disorder or they are just looking for an effective anti-aging treatment, BOCOUTURE® can help.

BOCOUTURE® is made from botulinum toxin, which is the same substance that causes Botulism in larger quantities. This means there is a rare chance that the BOCOUTURE® could spread to other parts of your patient’s body, causing flu-like symptoms, muscle weakness, trouble breathing or swallowing, and trouble speaking. More common BOCOUTURE® side effects your patient might experience include pain or discomfort at the injection site, dry mouth, headache, neck pain, fatigue, muscle weakness, and eye problems such as dry eyes, blurred or double vision, swollen eyelids, or drooping eyelids. There is also a rare chance that your patient could have an allergic reaction to BOCOUTURE® aesthetic treatments. However, BOCOUTURE® has been used by doctors around the world since 2005 to treat a variety of conditions successfully, including wrinkle treatments.

Unlike dermal fillers, botulinum toxin products like BOCOUTURE® do take a few days to start reducing the look of your patient’s wrinkles or severe lines after the cosmetic treatment. Some doctors and patients have observed that BOCOUTURE® starts to work faster than its rival product, BOTOX®. How long BOCOUTURE® lasts varies from patient to patient, but generally your patients should enjoy smoother skin for about three to six months before they return for their next BOCOUTURE® cosmetic injection.

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