A recent study revealed that hyaluronic acid fillers were detectable in patients for at least two years, with one case showing longevity up to 15 years. These findings highlight the long-lasting effects of hyaluronic acid in aesthetic treatments and its impact on filler management practices.
Hyaluronic acid is a key ingredient in skin rejuvenation, offering hydration and improving skin texture. Two popular treatments, Neauvia Hydro Deluxe and Profhilo, each use hyaluronic acid in unique ways to boost skin elasticity, firmness, and overall quality.
In this article, we will compare Neauvia Hydro Deluxe vs Profhilo, discussing their formulations, how they work, and which one is best suited for your skin rejuvenation needs.
Key Takeaways
- When comparing hyaluronic acid formulations, Neauvia vs Profhilo may offer advanced injectable treatments to enhance skin rejuvenation.
- Neauvia Hydro Deluxe uses other ingredients besides HA, and Profhilo capitalizes primarily on HA concentrations.
- Neauvia Hydro Deluxe provides deep hydration and stimulates collagen, making it ideal for dry and sun-damaged skin.
- While Neauvia and Profhilo showed safety and efficacy in their clinical studies, their duration of effects may differ.
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Introduction to Neauvia Hydro Deluxe and Profhilo

Soft-tissue fillers have closely competed with neuromodulator injections as the most conducted non-surgical cosmetic procedure in 2023. Aesthetic providers boast these injections’ ability to offer facial rejuvenation with their unique formulations and active ingredients. However, most brands utilize hyaluronic acid for their injectables.
Manufacturers have developed various hyaluronic acid (HA) formulations for safe and effective injectables. When comparing HA formulations, Neauvia vs Profhilo may offer advanced injectable treatments to enhance skin rejuvenation.
Both utilize HA and differ in their specific formulations and applications. Understanding factors, such as ingredients, approved uses, longevity of results, and contraindications, can lead to safer procedures and optimal treatment outcomes.
Formulation and Composition
Neauvia Hydro Deluxe contains an 18 mg/ml concentration of non-crosslinked hyaluronic acid (HA), utilizing a biodegradable linear HA hydrogel. While Profhilo entirely uses HA, Neauvia Hydro Deluxe also added L-Proline, Glycine, and Calcium Hydroxyapatite in its formulation.
In contrast, Profhilo mainly comprises high- and low-molecular-weight HA. This combination of HA deeply hydrates the skin and leads to skin rejuvenation. This injectable has only capitalized on the potency of HA instead of adding other components to offer a skin booster with an added lifting effect.
Despite being similar skin boosters, both have unique characteristics in their formulas. Neauvia Hydro Deluxe uses other ingredients besides HA, while Profhilo capitalizes primarily on HA concentrations. This difference in composition results in differing mechanisms of action.
Mechanism of Action
When injected into the dermis and epidermis, hyaluronic acid works synergistically with the amino acids and calcium hydroxyapatite to stimulate collagen and elastin production in the skin. It can restore volume, enhance skin quality, and offer longer-lasting results.
Meanwhile, Profhilo utilizes high and low hyaluronic acid concentrations to stimulate collagen and elastin production and deeply hydrate the skin. The BAP injection technique is recommended to ensure evenness and efficacy in bio-remodeling the skin or treatment area.
While both injectables stimulate collagen and elastin production, Neauvia Hydro Deluxe can restore volume while hydrating and rejuvenating the skin. On the other hand, Profhilo does not restore volume but deeply hydrates and promotes bio-remodeling to improve skin laxity and sagging.
Ideal Applications for Skin Rejuvenation
Practitioners and individuals should consider the specific concern and treatment area when determining which treatment to choose between Neauvia and Profhilo. By adhering to these injectables’ indications and ideal applications, patients can achieve high satisfaction with their treatments.
- Suitable Candidates for Neauvia Hydro Deluxe: Adult individuals with dehydrated, sagging, and aging skin can opt for this treatment. It suits men and women seeking to enhance skin volume, hydration, elasticity, firmness, and quality.
- Suitable Candidates for Profhilo: Adults experiencing signs of aging, loss of elasticity, and dry skin can choose Profhilo injections. They are ideal for male or female patients wishing natural-looking skin rejuvenation without adding volume.
Neauvia Hydro Deluxe provides deep hydration and stimulates collagen, making it ideal for dry and sun-damaged skin. In contrast, Profhilo addresses aging signs such as fine lines and skin laxity, enhancing skin elasticity and firmness through bio-remodeling without adding volume.
Effectiveness and Duration of Results

A case study by Bocsa (2024) highlights the success of a Smart Combination Therapy using Neauvia Hydro Deluxe and LaserMe sessions to provide natural and rejuvenated results. The skin booster and technology synergistically deliver immediate aesthetic concerns and promote long-term skin health and regeneration.
An open-label evaluation demonstrated consistent subjective and objective improvements in facial parameters, aligning with Profhilo’s bio-remodeling goals. These improvements remained statistically significant throughout the study, with investigators and respondents rating the product’s tolerability and safety as good or excellent.
Furthermore, patients and providers should also discuss and consider the longevity of results before selecting an aesthetic treatment. While Neauvia and Profhilo showed safety and efficacy in their clinical studies, their duration of effects may differ.
- Neauvia Hydro Deluxe: The longevity of results may differ depending on the Neauvia product. Hydro Deluxe may last six to nine months or more, with regular maintenance sessions scheduled at least three months post-treatment for sustained outcomes.
- Profhilo: The typical duration of Profhilo may last around six to nine months, depending on frequency and dosage. Maintenance sessions can offer extended longevity of results.
Despite their efficacy, it’s worth noting that common Profhilo and Neauvia side effects may still occur. Typical symptoms like redness, swelling, or tenderness at the injection site can subside over a few days to a week. However, if these persist, individuals should seek immediate medical attention.
Patient Satisfaction and Testimonials
Unfortunately, patient satisfaction studies and reviews are lacking for Neauvia Hydro Deluxe and Profhilo. Nonetheless, individuals and practitioners can look at the before and after photos of individuals who have received these aesthetic treatments for facial skin rejuvenation. These Neauvia and Profhilo-treated patients have shown the benefits of the fillers in delivering optimal treatment outcomes.


Conclusion
Neauvia Hydro Deluxe and Profhilo each offer distinct benefits for skin rejuvenation, making them popular choices among aesthetic experts. Neauvia Hydro Deluxe not only boosts hydration but also restores volume thanks to its additional ingredients, while Profhilo focuses on deep hydration and bio-remodeling through its highly concentrated hyaluronic acid.
Choosing the right treatment depends on your individual skin concerns and goals. If you’re looking for a more volumizing effect, Neauvia Hydro Deluxe may be the better option. On the other hand, if you prefer a natural-looking glow without added volume, Profhilo could be the ideal choice. Consulting with a qualified practitioner is key to finding the treatment that best suits your needs.
FAQs
1. What are the key differences between Neauvia Hydro Deluxe and Profhilo?
Neauvia Hydro Deluxe contains non-crosslinked hyaluronic acid and other ingredients like L-proline and Calcium Hydroxyapatite, focusing on deep hydration and volume restoration. In contrast, Profhilo primarily comprises high- and low-molecular-weight hyaluronic acid, emphasizing skin hydration and bio-remodeling without adding volume.
2. Who should consider Neauvia Hydro Deluxe over Profhilo?
Neauvia Hydro Deluxe is ideal for individuals with dehydrated, sagging, and aging skin seeking enhanced volume, elasticity, and overall skin quality. It is especially suitable for those with dry or sun-damaged skin.
3. How long do the effects of Neauvia Hydro Deluxe and Profhilo typically last?
Neauvia Hydro Deluxe and Profhilo have shown safety and efficacy in clinical studies, but the duration of results may vary. Neauvia often provides more noticeable volume restoration, while Profhilo focuses on hydration and skin remodeling. Depending on individual factors, effects last for several months.
References
- Master, M., Azizeddin, A., & Master, V. (2024). Hyaluronic Acid Filler Longevity in the Mid-face: A Review of 33 Magnetic Resonance Imaging Studies. Plastic and Reconstructive Surgery – Global Open, 12(7), e5934. https://doi.org/10.1097/gox.0000000000005934
- Sparavigna, A., & Tenconi, B. (2016). Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clinical, cosmetic and investigational dermatology, 9, 297–305. https://doi.org/10.2147/CCID.S114450