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Manufacturer: Daewoong Pharmaceutical Co. Ltd
Active Substance(s): BOTULINUM TOXIN TYPE A
Strength: 100u
Pack Size: 1 x 100 Units Vial
Nabota Botulinum toxin type A is indicated for the temporary improvement in the appearance of the upper respiratory tract (forehead lines, crow’s feet and forehead lines) in adults. Botulinum toxin type A (Nabota) is indicated for the prevention of headaches in adults with chronic migraine.
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INFORMATION
NABOTA® (JEUVEAU®) 100u Product Information
NABOTA® (JEUVEAU®) 100u is a botulinum toxin type A injectable product designed to improve the appearance of moderate to severe glabellar lines (frown lines) in adults. It acts as a neuromuscular blocking agent, temporarily inhibiting the release of acetylcholine, which reduces muscle activity in targeted areas. The product is supplied as a vacuum-dried powder in single-use vials.
Key Features and Benefits of NABOTA® (JEUVEAU®) 100u
NABOTA® 100u offers a combination of efficacy and safety for cosmetic purposes:
- Targeted Treatment: Effectively reduces glabellar lines by relaxing specific muscles.
- Proven Efficacy: Delivers visible results within days, lasting up to 3–4 months.
- Safe Formulation: Developed with purified botulinum toxin type A, ensuring high safety standards.
- Minimal Downtime: Patients can return to normal activities shortly after treatment.
Reconstitution Chart for NABOTA® (JEUVEAU®) 100u
Reconstitution of the product is essential for accurate dosing. Use preservative-free 0.9% Sodium Chloride Injection, USP for dilution.
- Dilution Instructions:
- Add 2.5 mL of saline to achieve a concentration of 4 Units per 0.1 mL.
- Inject the saline slowly into the vial to avoid foaming.
- Gently swirl (do not shake) until the solution is clear and colorless.
Storage Post-Reconstitution:
- Keep refrigerated at 2–8°C.
- Use the reconstituted solution within 24 hours.
Storage Information for NABOTA® (JEUVEAU®) 100u
Proper storage ensures product stability and effectiveness:
- Store unopened vials at 2–8°C in the original packaging to protect from light.
- Do not freeze.
- After reconstitution, store at 2–8°C and discard any unused solution after 24 hours.
Treatment Areas for NABOTA® (JEUVEAU®) 100u
The primary indication for NABOTA® 100u is the treatment of moderate to severe glabellar lines caused by the activity of the corrugator and procerus muscles.
- Injection Sites:
- Five sites: Two injections into each corrugator muscle and one into the procerus muscle.
- Dose: 0.1 mL (4 Units) per site.
- Total dose: 20 Units.
By targeting specific muscles, the product smooths the appearance of vertical frown lines while maintaining a natural look.
Dosing for NABOTA® (JEUVEAU®) 100u
Accurate dosing ensures efficacy while minimizing risks:
- Glabellar Lines:
- Reconstitute to 4 Units/0.1 mL.
- Administer 20 Units total into five injection sites.
- Retreatment: No sooner than every 3 months.
Side Effects and Precautions for NABOTA® (JEUVEAU®) 100u
Common Side Effects
- Headache: Reported in 9.3% of patients.
- Eyelid Ptosis (Drooping): Affects approximately 2% of patients.
- Upper Respiratory Tract Infection: Observed in 3% of patients.
- Injection Site Reactions: Redness, swelling, or discomfort.
Precautions
- Contraindications:
- Hypersensitivity to botulinum toxin or any component of the formulation.
- Active infection at the injection site.
- Warnings:
- Toxin effects may spread beyond the injection site, causing symptoms like dysphagia or breathing difficulties.
- Use with caution in patients with pre-existing neuromuscular disorders or compromised respiratory function.
Aftercare Following NABOTA® (JEUVEAU®) 100u Treatment
Adhering to aftercare recommendations enhances results and reduces complications:
- Avoid touching or massaging the treated area for 4 hours post-injection.
- Refrain from strenuous activities, excessive heat exposure, or lying down for at least 4–6 hours.
- Use sunscreen to protect the treated area from UV exposure.
- Monitor for adverse effects like drooping eyelids or difficulty swallowing and contact a healthcare provider if symptoms occur.
Drug Interactions with NABOTA® (JEUVEAU®) 100u
Certain medications can potentiate the effects of botulinum toxin:
- Neuromuscular Blockers: Co-administration increases the risk of excessive muscle relaxation.
- Aminoglycosides: May amplify toxin effects.
- Anticholinergics: Can heighten side effects like dry mouth or vision changes.
- Other Botulinum Toxins: Avoid using concurrently to prevent cumulative effects.
NABOTA® (JEUVEAU®) 100u Product Information
NABOTA® (JEUVEAU®) 100u is a botulinum toxin type A injectable product designed to improve the appearance of moderate to severe glabellar lines (frown lines) in adults. It acts as a neuromuscular blocking agent, temporarily inhibiting the release of acetylcholine, which reduces muscle activity in targeted areas. The product is supplied as a vacuum-dried powder in single-use vials.
Key Features and Benefits of NABOTA® (JEUVEAU®) 100u
NABOTA® 100u offers a combination of efficacy and safety for cosmetic purposes:
- Targeted Treatment: Effectively reduces glabellar lines by relaxing specific muscles.
- Proven Efficacy: Delivers visible results within days, lasting up to 3–4 months.
- Safe Formulation: Developed with purified botulinum toxin type A, ensuring high safety standards.
- Minimal Downtime: Patients can return to normal activities shortly after treatment.
Reconstitution Chart for NABOTA® (JEUVEAU®) 100u
Reconstitution of the product is essential for accurate dosing. Use preservative-free 0.9% Sodium Chloride Injection, USP for dilution.
- Dilution Instructions:
- Add 2.5 mL of saline to achieve a concentration of 4 Units per 0.1 mL.
- Inject the saline slowly into the vial to avoid foaming.
- Gently swirl (do not shake) until the solution is clear and colorless.
Storage Post-Reconstitution:
- Keep refrigerated at 2–8°C.
- Use the reconstituted solution within 24 hours.
Storage Information for NABOTA® (JEUVEAU®) 100u
Proper storage ensures product stability and effectiveness:
- Store unopened vials at 2–8°C in the original packaging to protect from light.
- Do not freeze.
- After reconstitution, store at 2–8°C and discard any unused solution after 24 hours.
Treatment Areas for NABOTA® (JEUVEAU®) 100u
The primary indication for NABOTA® 100u is the treatment of moderate to severe glabellar lines caused by the activity of the corrugator and procerus muscles.
- Injection Sites:
- Five sites: Two injections into each corrugator muscle and one into the procerus muscle.
- Dose: 0.1 mL (4 Units) per site.
- Total dose: 20 Units.
By targeting specific muscles, the product smooths the appearance of vertical frown lines while maintaining a natural look.
Dosing for NABOTA® (JEUVEAU®) 100u
Accurate dosing ensures efficacy while minimizing risks:
- Glabellar Lines:
- Reconstitute to 4 Units/0.1 mL.
- Administer 20 Units total into five injection sites.
- Retreatment: No sooner than every 3 months.
Side Effects and Precautions for NABOTA® (JEUVEAU®) 100u
Common Side Effects
- Headache: Reported in 9.3% of patients.
- Eyelid Ptosis (Drooping): Affects approximately 2% of patients.
- Upper Respiratory Tract Infection: Observed in 3% of patients.
- Injection Site Reactions: Redness, swelling, or discomfort.
Precautions
- Contraindications:
- Hypersensitivity to botulinum toxin or any component of the formulation.
- Active infection at the injection site.
- Warnings:
- Toxin effects may spread beyond the injection site, causing symptoms like dysphagia or breathing difficulties.
- Use with caution in patients with pre-existing neuromuscular disorders or compromised respiratory function.
Aftercare Following NABOTA® (JEUVEAU®) 100u Treatment
Adhering to aftercare recommendations enhances results and reduces complications:
- Avoid touching or massaging the treated area for 4 hours post-injection.
- Refrain from strenuous activities, excessive heat exposure, or lying down for at least 4–6 hours.
- Use sunscreen to protect the treated area from UV exposure.
- Monitor for adverse effects like drooping eyelids or difficulty swallowing and contact a healthcare provider if symptoms occur.
Drug Interactions with NABOTA® (JEUVEAU®) 100u
Certain medications can potentiate the effects of botulinum toxin:
- Neuromuscular Blockers: Co-administration increases the risk of excessive muscle relaxation.
- Aminoglycosides: May amplify toxin effects.
- Anticholinergics: Can heighten side effects like dry mouth or vision changes.
- Other Botulinum Toxins: Avoid using concurrently to prevent cumulative effects.
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