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Manufacturer: Huons Global Co., Ltd
Active Substance(s): BOTULINUM TOXIN TYPE A
Strength: 100u
Pack Size: 1 x 100 Units Vial
Accessories: Package Insert
Meditoxin® 100U is an injectable that, similarly to Botox, temporarily corrects certain types of medium to deep facial wrinkles by relaxing the muscles into which it was applied. It is suitable not only for therapeutic cosmetic procedures but also for medical treatment of various conditions including blepharospasm, TMJ and stroke recovery.
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INFORMATION
MEDITOXIN® 100u Key Features and Benefits
MEDITOXIN® 100u is a purified botulinum toxin type A complex used worldwide for aesthetic and medical purposes. It is marketed under various brand names like Siax®, Botulift®, Cunox®, and Neuronox®. The product has been clinically proven to deliver efficacy and safety comparable to OnabotulinumtoxinA (e.g., Botox®) in various applications.
- Global Reach: Registered in 27 countries and sold under different names globally.
- Versatile Options: Available in 50, 100, and 200-unit vials, catering to various medical and aesthetic needs.
- Proven Efficacy: Clinical studies confirm its effectiveness in glabellar frown lines, essential blepharospasm, pediatric cerebral palsy, and upper limb spasticity.
- Cost-Effective: Offers economic advantages for patients and ease of use for physicians.
MEDITOXIN® 100u Reconstitution Chart
MEDITOXIN® 100u must be reconstituted with 0.9% sodium chloride solution before injection. The dilution varies based on the intended dosage.
- Dilution Guide:
- 1.0 mL of diluent: 10 U/0.1 mL.
- 2.0 mL of diluent: 5 U/0.1 mL.
- 4.0 mL of diluent: 2.5 U/0.1 mL.
- 8.0 mL of diluent: 1.25 U/0.1 mL.
- Reconstituted solution should be stored at 2–8°C and used within 24 hours.
MEDITOXIN® 100u Storage Information
- Form: Lyophilized white powder in a colorless transparent vial.
- Storage Conditions:
- Before reconstitution: Store at 2–8°C or below -5°C.
- After reconstitution: Maintain at 2–8°C for up to 24 hours.
- Shelf Life: 36 months from the manufacturing date.
MEDITOXIN® 100u Treatment Areas
- Aesthetic Uses:
- Glabellar frown lines: Reduces moderate to severe wrinkles caused by muscle activity.
- Medical Indications:
- Essential blepharospasm: Treatment for eyelid muscle spasms.
- Pediatric cerebral palsy: Manages equinus foot deformity.
- Upper limb spasticity: Addresses muscle spasticity in stroke patients.
MEDITOXIN® 100u Dosing for Different Indications
- Blepharospasm:
- Initial dose: 1.25–2.5 U injected into the medial and lateral pre-tarsal orbicularis oculi.
- Maximum dose: 200 U per 30-day period.
- Pediatric Cerebral Palsy:
- Dose: 4–6 U/kg body weight, depending on unilateral or bilateral spasticity.
- Maximum dose: 200 U per session.
- Glabellar Wrinkles:
- Total dose: 20 U injected across five sites.
- Duration of effect: 3–4 months.
- Upper Limb Spasticity:
- Doses tailored based on muscle size and severity, ranging from 10–200 U per muscle.
MEDITOXIN® 100u Side Effects and Precautions
- Common Adverse Events:
- Eyelid ptosis: Reported in 3.2% of cases.
- Muscle weakness: Limited to treated areas.
- Severe Reactions: Rare, including systemic effects.
- Precautions:
- Avoid injections near vascular areas.
- Monitor for signs of acute reactions, especially in pediatric patients.
MEDITOXIN® 100u Aftercare
- Avoid strenuous activities, UV exposure, and makeup application for at least 24 hours post-treatment.
- Apply cold compresses to minimize swelling and redness.
- Monitor for prolonged or severe side effects, reporting them to a medical professional.
MEDITOXIN® 100u Drug Interactions
- Avoid concurrent use with aminoglycosides, anticholinergic agents, or other botulinum toxins, as these may potentiate the effects of MEDITOXIN® 100u.
- Not recommended for patients undergoing treatment with drugs affecting neuromuscular transmission.
Clinical Studies and Outcomes
- Glabellar Lines: Comparable to OnabotulinumtoxinA, with 16.1% adverse events reported versus 27.6% for Botox®.
- Essential Blepharospasm: Equivalent efficacy, with no significant differences in safety profiles.
- Cerebral Palsy: Demonstrated improvement in spasticity with similar safety outcomes.
- Post-Stroke Spasticity: Showed comparable effectiveness and tolerability to OnabotulinumtoxinA.
Manufacturer and Regulatory Information
- Manufacturer: Medytox Inc.
- Brand Variants: Sold globally under names like Siax®, Botulift®, Cunox®, and Neuronox®.
- Regulatory Approvals: Registered in 27 countries and in the process of registration in 30 additional markets.
MEDITOXIN® 100u Key Features and Benefits
MEDITOXIN® 100u is a purified botulinum toxin type A complex used worldwide for aesthetic and medical purposes. It is marketed under various brand names like Siax®, Botulift®, Cunox®, and Neuronox®. The product has been clinically proven to deliver efficacy and safety comparable to OnabotulinumtoxinA (e.g., Botox®) in various applications.
- Global Reach: Registered in 27 countries and sold under different names globally.
- Versatile Options: Available in 50, 100, and 200-unit vials, catering to various medical and aesthetic needs.
- Proven Efficacy: Clinical studies confirm its effectiveness in glabellar frown lines, essential blepharospasm, pediatric cerebral palsy, and upper limb spasticity.
- Cost-Effective: Offers economic advantages for patients and ease of use for physicians.
MEDITOXIN® 100u Reconstitution Chart
MEDITOXIN® 100u must be reconstituted with 0.9% sodium chloride solution before injection. The dilution varies based on the intended dosage.
- Dilution Guide:
- 1.0 mL of diluent: 10 U/0.1 mL.
- 2.0 mL of diluent: 5 U/0.1 mL.
- 4.0 mL of diluent: 2.5 U/0.1 mL.
- 8.0 mL of diluent: 1.25 U/0.1 mL.
- Reconstituted solution should be stored at 2–8°C and used within 24 hours.
MEDITOXIN® 100u Storage Information
- Form: Lyophilized white powder in a colorless transparent vial.
- Storage Conditions:
- Before reconstitution: Store at 2–8°C or below -5°C.
- After reconstitution: Maintain at 2–8°C for up to 24 hours.
- Shelf Life: 36 months from the manufacturing date.
MEDITOXIN® 100u Treatment Areas
- Aesthetic Uses:
- Glabellar frown lines: Reduces moderate to severe wrinkles caused by muscle activity.
- Medical Indications:
- Essential blepharospasm: Treatment for eyelid muscle spasms.
- Pediatric cerebral palsy: Manages equinus foot deformity.
- Upper limb spasticity: Addresses muscle spasticity in stroke patients.
MEDITOXIN® 100u Dosing for Different Indications
- Blepharospasm:
- Initial dose: 1.25–2.5 U injected into the medial and lateral pre-tarsal orbicularis oculi.
- Maximum dose: 200 U per 30-day period.
- Pediatric Cerebral Palsy:
- Dose: 4–6 U/kg body weight, depending on unilateral or bilateral spasticity.
- Maximum dose: 200 U per session.
- Glabellar Wrinkles:
- Total dose: 20 U injected across five sites.
- Duration of effect: 3–4 months.
- Upper Limb Spasticity:
- Doses tailored based on muscle size and severity, ranging from 10–200 U per muscle.
MEDITOXIN® 100u Side Effects and Precautions
- Common Adverse Events:
- Eyelid ptosis: Reported in 3.2% of cases.
- Muscle weakness: Limited to treated areas.
- Severe Reactions: Rare, including systemic effects.
- Precautions:
- Avoid injections near vascular areas.
- Monitor for signs of acute reactions, especially in pediatric patients.
MEDITOXIN® 100u Aftercare
- Avoid strenuous activities, UV exposure, and makeup application for at least 24 hours post-treatment.
- Apply cold compresses to minimize swelling and redness.
- Monitor for prolonged or severe side effects, reporting them to a medical professional.
MEDITOXIN® 100u Drug Interactions
- Avoid concurrent use with aminoglycosides, anticholinergic agents, or other botulinum toxins, as these may potentiate the effects of MEDITOXIN® 100u.
- Not recommended for patients undergoing treatment with drugs affecting neuromuscular transmission.
Clinical Studies and Outcomes
- Glabellar Lines: Comparable to OnabotulinumtoxinA, with 16.1% adverse events reported versus 27.6% for Botox®.
- Essential Blepharospasm: Equivalent efficacy, with no significant differences in safety profiles.
- Cerebral Palsy: Demonstrated improvement in spasticity with similar safety outcomes.
- Post-Stroke Spasticity: Showed comparable effectiveness and tolerability to OnabotulinumtoxinA.
Manufacturer and Regulatory Information
- Manufacturer: Medytox Inc.
- Brand Variants: Sold globally under names like Siax®, Botulift®, Cunox®, and Neuronox®.
- Regulatory Approvals: Registered in 27 countries and in the process of registration in 30 additional markets.
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