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Stylage vs Juvederm: Similarities and Differences Reviewed

Stylage vs Juvederm: Similarities and Differences Reviewed

While many patients know of the Juvederm brand, smaller, more niche brands like Stylage, a French line of hyaluronic acid fillers, may be comparable and even be more suitable for your patient, depending their aesthetic aims. This article intends to shed some light on these leading brands and examine how they compare to each other.

Similarities between Stylage vs Juvederm

The Juvederm line of dermal fillers are considered an integral component of the aesthetic doctor’s armamentarium. As one of the best-selling dermal filler brands on the market, they are regularly used in many cosmetic injectable procedures. Products include Juvederm Voluma, a highly volumizing filler that is used to add fullness to large areas of the face, Juvederm Volbella, for lip augmentation, and Juvederm Vollure, Ultra, and Ultra Plus for softening lines and wrinkles.

Generally speaking, Juvederm products have high G prime (a measure of the hardness of the gel), but with medium to high cohesivity, resulting in a gel that is smooth and malleable, yet is able to resist deformation.

Stylage is a European brand of injectable dermal fillers that are hyaluronic acid-based. Their products include Stylage S, M and L, three products of varying viscosities used to improve the appearance of wrinkles and lines as well as to rejuvenate the back of the hands. They also have a filler used specifically for lip contouring, Stylage Special Lips.

A unique characteristic that Stylage dermal fillers have is the addition of mannitol into their formulations. This antioxidant is incorporated as a preventative measure against free radical damage, a factor in improving the stability and longevity of the gel in dermal tissue. The antioxidative effects of mannitol also help lessen the ill effects experienced by patients during treatment like swelling and bruising. 

Stylage and Juvederm: how do they compare?

Both the Stylage and Juvederm brand offer a range of products with carrying hyaluronic acid densities to suit various treatment purposes. In this regard, they both cater to a wide variety of aesthetic indications.

Stylage is made using IPN-like Technology, which involves the transformation of individual cross-linked matrices into a monophasic gel by undergoing an interpenetrating network-like (IPN-like) process. This increases the density and degree of cross-linking without the need for additional cross-linking agent. Juvederm products, on the other hand, are made using Hylacross or Vycross Technologies, which both involve a single cross-linking process. In Vycross, high and low molecular weight hyaluronic acid chains are incorporated together to form a monophasic, monodensified gel. The different manufacturing processes results in products with distinguishing physical characteristics that affect the way they integrate with dermal tissue. For instance, microscopic analysis of Juvederm products reveal a cohesive consistency while Stylage has a lighter, less dense structure with fewer continuous networks. When implanted into the dermis, the gel evenly distributes among the area of treatment in large pools.

As mentioned previously, another distinguishing feature is the addition of mannitol in Stylage products. This anti-oxidant is added to preserve the physical characteristics of the gel by preventing damage incurred by free radicals, molecules that are generated by enzymes present as a result of the inflammatory response cause by the injection.

Differences between Stylage and Juvederm

Stylage and Juvederm products share many elements in common as the starting material in both these fillers is hyaluronic acid. However, the differences in the cross-linking technologies used to create the final product has resulted in gels with different rheological and physical properties that affect their behavior within the dermis. In addition, Stylage contains an additional ingredient, mannitol, which is incorporated to decelerate product degradation, thus enhancing longevity of results. It is important for the practitioner to understand these differences to select the right product in order to obtain optimum results.

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*Disclaimer: The contents of this article are not to be constructed as medical advice but for informational purposes only. MedicaDepot staff does not review any of these articles for medical validity. Opinions and views expressed in this article are not endorsed by MedicaDepot. Please always consult your doctor for professional medical advice.

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